Involvement of PIN-like domain nucleases in tRNA processing and translation regulation.

abstract：:SARS-CoV-2 is the causative agent for the ongoing COVID19 pandemic, and this virus belongs to the Coronaviridae family. Like other members of this family, the virus possesses a positive-sense single-stranded RNA genome. The genome encodes for the nsp12 protein, which houses the RNA-dependent-RNA polymerase (RdRP) acti...

journal_title：IUBMB life

authors： Narayanan N,Nair DT

更新日期：2020-10-01 00:00:00

abstract：:Cancers have a clonal origin, yet their chromosomes and genes are non-clonal or heterogeneous due to an inherent genomic instability. However, the cause of this genomic instability is still debated. One theory postulates that mutations in genes that are involved in DNA repair and in chromosome segregation are the prim...

journal_title：IUBMB life

authors： Duesberg P,Fabarius A,Hehlmann R

更新日期：2004-02-01 00:00:00

abstract：:Transketolase (TK) is a homodimer, the simplest representative of thiamine diphosphate (ThDP)-dependent enzymes. It was first ThDP-dependent enzymes the crystal structure of which has been solved and revealed the general fold for this class of enzymes and the interactions of the non-covalently bound coenzyme ThDP with...

journal_title：IUBMB life

authors： Kochetov G,Sevostyanova IA

更新日期：2005-07-01 00:00:00

abstract：:Hepatitis C virus (HCV) is an enveloped positive-strand RNA virus of the Flaviviridae family. It has a genome of about 9,600 nucleotides encoding a large polyprotein (about 3,000 amino acids) that is processed by cellular and viral proteases into at least 10 structural and nonstructural viral proteins. A novel HCV pro...

journal_title：IUBMB life

authors： Vassilaki N,Mavromara P

更新日期：2009-07-01 00:00:00

abstract：:T cell (TC) activation requires the coordinated signaling of the T cell receptor (TCR) and coreceptor molecules, allowing TCs to respond to lower degrees of TCR occupancy. Coreceptor molecules set the threshold for TC activation by controlling different regulatory signaling loops. The Cbl family members prevent undesi...

journal_title：IUBMB life

authors： Pedraza-Alva G,Mérida LB,del Rio R,Fierro NA,Cruz-Muñoz ME,Olivares N,Melchy E,Igras V,Holländer GA,Burakoff SJ,Rosenstein Y

更新日期：2011-10-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common malignancies with poor prognosis. Oxaliplatin-based chemotherapy is an important treatment for CRC; however, the cells develop resistance to therapy. The mechanisms underlying oxaliplatin resistance are complex and unclear. There is increasing evidence that microRNAs (...

journal_title：IUBMB life

authors： Moradi Marjaneh R,Khazaei M,Ferns GA,Avan A,Aghaee-Bakhtiari SH

更新日期：2019-10-01 00:00:00

abstract：:Blood glucose is the primary cellular substrate and in vivo must be tightly maintained. The liver plays a key role in glucose homeostasis increasing or decreasing glucose output and uptake during fasting and feeding. Glucokinase (GCK) is central to this process. Its activity is modulated in a coordinated manner via a ...

journal_title：IUBMB life

authors： Massa ML,Gagliardino JJ,Francini F

更新日期：2011-01-01 00:00:00

abstract：:Recently, cytochrome P450 170A1 (CYP170A1) has been found to be a bifunctional protein, which catalyzes both monooxygenase activity and terpene synthase activity by two distinct active sites in the well-established P450 protein structure. Therefore, CYP170A1 is identified clearly as a moonlighting protein. The known a...

journal_title：IUBMB life

authors： Zhao B,Waterman MR

更新日期：2011-07-01 00:00:00

abstract：:Small extracellular vesicle (sEV) has precise impacts on tumor microenvironment and play vital functions in intercellular interaction. However, the functional role of sEV miRNA on laryngeal squamous cell carcinoma (LSCC) is largely unresolved. Here, the expression of miR-1246 in LSCC tissues and plasma sEV was examine...

journal_title：IUBMB life

authors： Huang Q,Hsueh CY,Guo Y,Wu XF,Li JY,Zhou L

更新日期：2020-07-01 00:00:00

abstract：:Changes in the status of DNA methylation are one of the most common molecular alterations in human neoplasia. We aimed to identify epigenetic molecular markers in serum for early detection of breast cancer. Authors analyzed retrospectively the methylation status of RARβ2 and APC genes in serum samples from 121 breast ...

journal_title：IUBMB life

authors： Swellam M,Abdelmaksoud MD,Sayed Mahmoud M,Ramadan A,Abdel-Moneem W,Hefny MM

更新日期：2015-01-01 00:00:00

abstract：:Lead (Pb) is a toxic heavy metal that is harmful to humans, especially male reproductive organs. Luteolin (LUT) is a naturally occurring flavonoid with numerous biological activities. Our aim was to investigate the possible reproprotective effect of LUT against testicular deficits induced by Pb intoxication. In the pr...

journal_title：IUBMB life

authors： Al-Megrin WA,Alomar S,Alkhuriji AF,Metwally DM,Mohamed SK,Kassab RB,Abdel Moneim AE,El-Khadragy MF

更新日期：2020-08-01 00:00:00

abstract：:Ten-eleven translocation (TET) family enzymes convert 5-methylcytosine to 5-hydroxymethylcytosine in DNA. However, the role of TET enzymes in human gastric cancer remains unknown. Here, we show that TET2 mRNA and protein levels are downregulated in human gastric cancer tissues when compared with normal gastric mucosa....

journal_title：IUBMB life

authors： Deng W,Wang J,Zhang J,Cai J,Bai Z,Zhang Z

更新日期：2016-05-01 00:00:00

abstract：:Anthracyclines are a class of antitumor drugs widely used for the treatment of a variety of malignancy, including leukemias, lymphomas, sarcomas, and carcinomas. Different mechanisms have been proposed for anthracycline antitumor effects including free-radical generation, DNA intercalation/binding, activation of signa...

journal_title：IUBMB life

authors： Mordente A,Meucci E,Martorana GE,Giardina B,Minotti G

更新日期：2001-07-01 00:00:00

abstract：:The best known NADPH oxidase is that of phagocytes-neutrophils and monocytes. In these cells, the enzyme manufactures large quantities of O2- and other reactive oxidants that are used for the purpose of killing invading microorganisms. Recent studies, however, have suggested that a number of other tissues contain NADP...

journal_title：IUBMB life

authors： Babior BM

更新日期：2000-10-01 00:00:00

abstract：:Transketolase (TK, EC 2.2.1.1), the key enzyme of the non-oxidative branch of pentose phosphate pathway of hydrocarbon transformation, plays an important role in a system of substrate rearrangement between pentose shunt and glycolysis, acting as a reversible link between the two metabolic pathways. In addition, it sup...

journal_title：IUBMB life

authors： Kochetov GA,Sevostyanova IA

更新日期：2010-11-01 00:00:00

abstract：:The extensive post-transcriptional modification of U2 snRNA is required for spliceosome assembly and pre-mRNA splicing in vertebrates. However, the rare modification of U2 snRNA in yeast implies a different mechanism for regulating spliceosome biogenesis in single-celled eukaryotes. To understand the evolutionary patt...

journal_title：IUBMB life

authors： Huang ZP,Zhou H,Qu LH

更新日期：2005-10-01 00:00:00

abstract：:Immune infiltration of tumors has been increasingly accepted as a prognostic factor in colon cancer. Here, we aim to develop a novel immune signature, based on estimated immune landscape from tumor transcriptomes, to predict the overall survival of patients with colon cancer. The compositions of 22 immune cell subtype...

journal_title：IUBMB life

authors： Peng D,Wang L,Li H,Cai C,Tan Y,Xu B,Le H

更新日期：2019-11-01 00:00:00

abstract：:Cellular nucleic acid binding protein (CNBP) has been implicated in vertebrate craniofacial development and in myotonic dystrophy type 2 (DM2) and sporadic inclusion body myositis (sIBM) human diseases. In these seemingly unrelated biological processes, CNBP appears to be involved in controlling cell death and prolife...

journal_title：IUBMB life

authors： Calcaterra NB,Armas P,Weiner AM,Borgognone M

更新日期：2010-10-01 00:00:00

abstract：:The posttranscriptional regulation of miRNAs is important for organism development. To investigate the role of miRNAs in angiogenesis, we performed a loss-of-function screening assay in human umbilical vein endothelial cells (HUVECs) and found that knockdown of 7 miRNAs (miR-95a, miR-126, miR-129, miR-137, miR-139, mi...

journal_title：IUBMB life

authors： Li YX,Liu DQ,Zheng C,Zheng SQ,Liu M,Li X,Tang H

更新日期：2011-07-01 00:00:00

abstract：:Mutations in the breast cancer susceptibility gene BRCA1 predispose individuals to breast and ovarian cancers. Cofactor of BRCA1 (COBRA1), a novel protein, was isolated as a BRCA1-interacting protein. However, the role of COBRA1 in breast cancer is poorly understood. In this study, we demonstrate that COBRA1 mRNA was ...

journal_title：IUBMB life

authors： Zhu J,Song S,Jiang Z,Yan J,Lu Q,Huang C,Ye Q

更新日期：2004-03-01 00:00:00

abstract：:In the Antarctic, fishes of dominant suborder Notothenioidei have evolved in a unique thermal scenario. Phylogenetically related taxa of the suborder live in a wide range of latitudes, in Antarctic, sub-Antarctic and temperate oceans. Consequently, they offer a remarkable opportunity to study the physiological and bio...

journal_title：IUBMB life

authors： Verde C,Giordano D,di Prisco G

更新日期：2008-01-01 00:00:00

abstract：:The sodA gene coding for manganese superoxide dismutase (Mn-SOD) from the marine microorganism Vibrio parahaemolyticus was cloned, sequenced, and overexpressed in Escherichia coli by use of the pET20b (+) expression vector. The full-length gene consisted of a 588-bp open reading frame and encoded a polypeptide of 196 ...

journal_title：IUBMB life

authors： Shyu YC,Lin FP

更新日期：1999-09-01 00:00:00

abstract：:Red blood cells of yellow-spotted river turtles (Podocnemis unifilis, Pleurodira, Chelonia, REPTILIA) have two hemoglobin (Hb) components, Hb A and Hb D. We purified the hemoglobin component homologous to amniote (reptiles, birds, and mammals) adult Hb A which comprises two identical α(A) -globin polypeptides and two ...

journal_title：IUBMB life

authors： Hasegawa T,Shishikura F,Kuwada T

更新日期：2011-03-01 00:00:00

abstract：:The members of the GATA family of transcription factors have homologous zinc fingers and bind to similar sequence motifs. Recent advances in genome-wide technologies and the integration of bioinformatics data have led to a better understanding of how GATA factors regulate gene expression; GATA-factor-induced transcrip...

journal_title：IUBMB life

authors： Romano O,Miccio A

更新日期：2020-01-01 00:00:00

abstract：:We have adapted the Java Molecular Viewer (JMV) to virtual reality display environments, through a number of extensions to the Java 3D code. Phylogenetic information derived from multiple alignments (temporal information) can be overlaid onto molecule structures (spatial information). The number of sequences included ...

journal_title：IUBMB life

authors： Quon GT,Gordon P,Sensen CW

更新日期：2003-04-01 00:00:00

abstract：:The 10th jubilee conference (IPK2019) took place on September 15-19, 2019 in Warsaw, on the Ochota campus as the IUBMB Focused Meeting entitled "Inhibitors of Protein Kinases. Kinase inhibitors in target biology and disease". ...

journal_title：IUBMB life

authors： Poznanski J,Fabbro D

更新日期：2020-06-01 00:00:00

abstract：:Availability of the human genome data has enabled the exploration of a huge amount of biological information encoded in it. There are extensive ongoing experimental efforts to understand the biological functions of the gene products encoded in the human genome. However, computational analysis can aid immensely in the ...

journal_title：IUBMB life

authors： Pandit SB,Balaji S,Srinivasan N

更新日期：2004-06-01 00:00:00

abstract：:Nasal-type natural killer/T-cell lymphoma (NKTCL) is an aggressive malignancy with poor survival outcomes that is relatively resistant to chemotherapy. N6-Methyladenosine (m6A) modification, the most prevalent modification of eukaryotic messenger RNA, is involved in the progression of various tumors. However, it is un...

journal_title：IUBMB life

authors： Ma H,Shen L,Yang H,Gong H,Du X,Li J

更新日期：2020-11-17 00:00:00

abstract：:The pathways for ligand entry and exit in myoglobin have now been well established by a wide variety of experimental results, including pico- to nano- to microsecond transient absorbance measurements and time-resolved X-ray crystallographic measurements. Trp insertions have been used to block, one at a time, the three...

journal_title：IUBMB life

authors： Olson JS,Soman J,Phillips GN Jr

更新日期：2007-08-01 00:00:00

abstract：:Silymarin, which is derived from the seeds of Silybum marianum, has been widely used to prevent and treat liver diseases. In our previous study, we reported that at concentrations above the minimal inhibitory concentration (MIC), silymarin exhibited antifungal activity against Candida albicans by targeting its plasma ...

journal_title：IUBMB life

authors： Lee W,Lee DG

更新日期：2018-03-01 00:00:00