Abstract:
:Cellular nucleic acid binding protein (CNBP) has been implicated in vertebrate craniofacial development and in myotonic dystrophy type 2 (DM2) and sporadic inclusion body myositis (sIBM) human diseases. In these seemingly unrelated biological processes, CNBP appears to be involved in controlling cell death and proliferation rates. Low levels of CNBP may reduce rate of global protein synthesis, thereby reducing proliferation and increasing apoptosis. Conversely, CNBP might affect transcription of genes required for cell proliferation. Experimental evidences gathered so far make it difficult to ascertain or rule out any of these possibilities. Moreover, both possibilities may not be mutually exclusive. CNBP is a small and strikingly conserved single-stranded nucleic acid binding protein that is able to bind DNA as well as RNA. CNBP has a broad spectrum of targets, ranging from regulatory sites in gene promoters to translational regulatory elements in mRNA untranslated regions. Biochemical experiments have recently shed light on the possible mechanism of action for CNBP, which may act as a nucleic acid chaperone catalyzing the rearrangement of G-rich nucleic acid secondary structures likely relevant for transcriptional and/or translational gene regulation. This review focuses on the involvement of CNBP in vertebrate craniofacial development and human DM2 and sIBM diseases, as well as on the biochemical and structural features of CNBP and its cellular and molecular mechanism of action.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Calcaterra NB,Armas P,Weiner AM,Borgognone Mdoi
10.1002/iub.379subject
Has Abstractpub_date
2010-10-01 00:00:00pages
707-14issue
10eissn
1521-6543issn
1521-6551journal_volume
62pub_type
杂志文章,评审相关文献
IUBMB LIFE文献大全abstract::The current landscapes of novel therapeutic approaches rely mostly on gene-targeted technologies, enabling to fight rare genomic diseases, from infections to cancer and hereditary diseases. Although, reaching the action-site for this novel treatments requires to deliver nucleic acids, or other macromolecules into cell...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1257
更新日期:2014-03-01 00:00:00
abstract::Hepatitis C virus (HCV) is an enveloped positive-strand RNA virus of the Flaviviridae family. It has a genome of about 9,600 nucleotides encoding a large polyprotein (about 3,000 amino acids) that is processed by cellular and viral proteases into at least 10 structural and nonstructural viral proteins. A novel HCV pro...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.201
更新日期:2009-07-01 00:00:00
abstract::Cell-surface-bound extracellular DNA (csbDNA) is present on the outer membrane of blood cells, including both red blood cells and leukocytes. Although less well characterized than cell-free DNA (cfDNA) in plasma and serum, leukocyte and red blood cell csbDNA form a considerable fraction of the blood extracellular nucl...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.2070
更新日期:2019-09-01 00:00:00
abstract::Arginine biosynthesis pathway is crucial to the survival and pathogenesis of Mycobacterium tuberculosis (Mtb). Arginine is a critical amino acid that contributes to the inflection of cellular immune responses during pathogenesis. Argininosuccinate lyase from Mtb (MtArgH), the last enzyme in the pathway, catalyzes the ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1683
更新日期:2017-11-01 00:00:00
abstract::Carbon monoxide (CO) is a gaseous transmitter that is known to be involved in several physiological processes, but surprisingly it is also becoming a promising molecule to treat several pathologies including stroke and cancer. CO can cross the plasma membrane and activate guanylate cyclase, increasing the cGMP concent...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1388
更新日期:2015-06-01 00:00:00
abstract::Diarrhea-predominant irritable bowel syndrome (IBS-D) is one of the most common gastrointestinal disorders in the world, lacking effective therapies. The crucial roles of microRNAs (miRNAs) in IBS-D have attracted increasing attention. The aim of this study is to investigate the effects of miR-495 on the visceral sens...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2270
更新日期:2020-07-01 00:00:00
abstract::Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with impairments in social communication, restricted, repetitive and stereotyped behaviors. Both genetic and environmental factors are known to contribute toward pathophysiology of Autism. Environmental influences on gene expression can be mediate...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2021
更新日期:2019-07-01 00:00:00
abstract::For more than a century, the metabolic role of lactate has intrigued physiologists and biochemists. Yet, for the first half of the last century lactate had been designated as a waste product, and assigned no additional significance besides its controversial role in muscle fatigue. The decline of the lactate hypothesis...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.97
更新日期:2008-09-01 00:00:00
abstract::Myosin light chain kinase (MLCK) is a regulatory protein for smooth muscle contraction, which acts by phosphorylating 20-kDa myosin light chain (MLC20) to activate the myosin ATPase activity. Although this mode of action is well-established, there are numerous reports of smooth muscle contraction that is not associate...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/152165401753366087
更新日期:2001-06-01 00:00:00
abstract::The extensive post-transcriptional modification of U2 snRNA is required for spliceosome assembly and pre-mRNA splicing in vertebrates. However, the rare modification of U2 snRNA in yeast implies a different mechanism for regulating spliceosome biogenesis in single-celled eukaryotes. To understand the evolutionary patt...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540500306983
更新日期:2005-10-01 00:00:00
abstract::Bovine Spongiform Encephalopathy (BSE) is typical of the dementias that affect both animals and man; Scrapie in sheep, Creutzfeldt-Jakob disease in man. Global efforts have been made to determine the nature of the active agents in these diseases. At present the 'protein only hypothesis' of Prusiner holds. It was a sur...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540500097152
更新日期:2005-04-01 00:00:00
abstract::The functional effect of the interaction of E2F1 and hepatitis B virus X protein (HBx) on the promoter of human p53 gene was studied using chloramphenicol acetyl transferase (CAT) assay. E2F1 activated the p53 promoter through E2F1 binding site. As previously reported, HBx repressed the p53 promoter through E-box. Whe...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540213466
更新日期:2002-06-01 00:00:00
abstract::Xanthomonas campestris pv. campestris, a plant-associated pathogenic bacterium, is the causal agent of foliar spots and blights in crucifers. The major outer membrane protein, Omp37, of 37 kDa, has been identified, purified to homogeneity, and its characterization has also been carried out. Native Omp37 behaved as a t...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540213826
更新日期:2002-07-01 00:00:00
abstract::T cell (TC) activation requires the coordinated signaling of the T cell receptor (TCR) and coreceptor molecules, allowing TCs to respond to lower degrees of TCR occupancy. Coreceptor molecules set the threshold for TC activation by controlling different regulatory signaling loops. The Cbl family members prevent undesi...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.554
更新日期:2011-10-01 00:00:00
abstract::During the hand plate development, the processes of cell differentiation and control of cell death are relevant to ensure a correct shape of the limb. The progenitor cell pool that later will differentiate into cartilage to form the digits arises from undifferentiated mesenchymal cells beneath the apical ectodermal ri...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.563
更新日期:2011-10-01 00:00:00
abstract::Epidemiological evidence demonstrates that diets rich in fruit and vegetables promote health, and attenuate, or delay, the onset of various diseases, including cardiovascular disease, diabetes, certain cancers, and several other age-related degenerative disorders. The chemical components and the physiological and mole...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540701230529
更新日期:2007-04-01 00:00:00
abstract::Accumulating evidence indicates that there is a critical role of the ubiquitin/proteasome pathway in the regulation of apoptosis. Among the important molecules that couple these two fundamental cellular activities are members of the inhibitor of apoptosis (IAP) protein family. In addition to their well-studied ability...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540500389013
更新日期:2005-12-01 00:00:00
abstract::Elevated homocysteine levels are known to be a risk factor for congenital cardiac septal defects (CCSDs), but the mechanism underlying this effect is unknown. The genetic variants that were significantly associated with circulating homocysteine concentrations have been systematically identified through the genome-wide...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1651
更新日期:2017-09-01 00:00:00
abstract::In this review we discuss the limited efficacy for current pharmacological agents used in prophylaxis and treatment of thrombosis and highlight targeted delivery of anti-thrombotic agents to fibrin, platelets, red blood cells and endothelium. ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.474
更新日期:2011-08-01 00:00:00
abstract::Oral squamous cell carcinoma (OSCC) is a lethal malignancy and its prognosis remains dismal. Thus, a deeper understanding of the mechanisms is needed to provide a new insight for new therapies. It has been reported that long noncoding RNA (lncRNA) maternally expressed gene 3 (MEG3) was downregulated in OSCC tissues, h...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2012
更新日期:2019-07-01 00:00:00
abstract::We previously found a novel glycosylphosphatidylinositol (GPI)-anchored glycoprotein designated GPI-80 that modulates complement receptor 3 integrin-dependent adhesion and in vitro transendothelial migration of neutrophils. In this study, we show that antibody-mediated cross-linking of GPI-80 led to rapid tyrosine pho...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/713803588
更新日期:2000-01-01 00:00:00
abstract::The best known NADPH oxidase is that of phagocytes-neutrophils and monocytes. In these cells, the enzyme manufactures large quantities of O2- and other reactive oxidants that are used for the purpose of killing invading microorganisms. Recent studies, however, have suggested that a number of other tissues contain NADP...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/713803730
更新日期:2000-10-01 00:00:00
abstract::For 8 years, it was not understood why certain genes of plant mitochondria contain CGG (arginine) codons at positions where tryptophan codons (UGG) are present in the corresponding genes of nonplant species. Identification and sequencing of a tRNA(Trp) gene showed that it is not able to decode the CGG codon. Analysis ...
journal_title:IUBMB life
pub_type: 历史文章,杂志文章,评审
doi:10.1002/iub.277
更新日期:2009-12-01 00:00:00
abstract::Calcium-sensing receptor (CaSR) contributes to maintain homeostatic levels of extracellular calcium. In addition, CaSR controls other cellular activities such as proliferation and migration, particularly in cells not related to extracellular calcium homeostasis, potentially by cross-talking with parallel signaling pat...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1232
更新日期:2013-12-01 00:00:00
abstract::Hydrogen peroxide is a major regulator of plant programmed cell death (PCD) but little is known about the downstream genes from the H(2)O(2)-signaling network that mediate the cell death. To address this question, a novel system for studying H(2)O(2)-induced programmed cell death in Arabidopsis thaliana was used. The ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540500090793
更新日期:2005-03-01 00:00:00
abstract::In most organisms, productive utilization of galactose requires the highly conserved Leloir pathway of galactose metabolism. Yet, if this metabolic pathway is perturbed due to congenital deficiencies of the three associated enzymes, or an overwhelming presence of galactose, this monosaccharide which is abundantly pres...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.262
更新日期:2009-11-01 00:00:00
abstract::Papillary thyroid cancer (PTC) is the most common form of thyroid cancer, comprising 80% of all thyroid malignancies. The phosphoinositide-3-kinase-protein kinase B/Akt (PI3K-PKB/Akt) pathway is a main pathway in control of cell growth. Activated mTOR and Akt are involved in the development and progression of the PTC....
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2388
更新日期:2020-12-01 00:00:00
abstract::Uncoupling proteins (UCPs) mediate inducible proton conductance in the mitochondrial inner membrane. Herein, we summarize our knowledge regarding UCPs in invertebrates. Since 2001, the presence of UCPs has been demonstrated in nematodes, mollusks, amphioxi, and insects. We discuss the following important issues concer...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1535
更新日期:2016-09-01 00:00:00
abstract::Antibiotic resistance in Acinetobacter spp., particularly Acinetobacter baumannii, is increasing rapidly. A. baumannii possesses two intrinsic β-lactamase genes, in addition to weak permeability and efflux systems, that together confer a natural reduced susceptibility to antibiotics. In addition, numerous acquired mec...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.532
更新日期:2011-12-01 00:00:00
abstract::In protein and RNA macromolecules, only a limited number of different side-chain chemical groups are available to function as catalysts. The myriad of enzyme-catalyzed reactions results from the ability of most of these groups to function either as nucleophilic, electrophilic, or general acid-base catalysts, and the k...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540211468
更新日期:2002-02-01 00:00:00