Binding of the coenzyme and formation of the transketolase active center.

abstract：:The activation and incorporation of selenium into selenocysteine containing selenoproteins has been well established in an Escherichia coli model system but there is little specific information concerning the transport and intracellular trafficking of selenium in biological systems in general. A selenium transport rol...

journal_title：IUBMB life

authors： Self WT,Pierce R,Stadtman TC

更新日期：2004-08-01 00:00:00

abstract：:Heart disease is the most common cause of morbidity and mortality in Western society and the incidence is projected to increase significantly over the next few decades as our population ages. Heart failure occurs when the heart is unable to pump blood at a rate to commensurate with tissue metabolic requirements and re...

journal_title：IUBMB life

authors： Graham RM,Bishopric NH,Webster KA

更新日期：2002-08-01 00:00:00

abstract：:Although the amino acid sequences and the structures of pyruvate kinase (PYK) isozymes are highly conserved, allosteric regulations differ. This suggests that amino acids with low conservation play important roles in the allosteric mechanism. The current work exploits a 'natural screen'- the 122 point mutations identi...

journal_title：IUBMB life

authors： Pendergrass DC,Williams R,Blair JB,Fenton AW

更新日期：2006-01-01 00:00:00

abstract：:Mutations in the breast cancer susceptibility gene BRCA1 predispose individuals to breast and ovarian cancers. Cofactor of BRCA1 (COBRA1), a novel protein, was isolated as a BRCA1-interacting protein. However, the role of COBRA1 in breast cancer is poorly understood. In this study, we demonstrate that COBRA1 mRNA was ...

journal_title：IUBMB life

authors： Zhu J,Song S,Jiang Z,Yan J,Lu Q,Huang C,Ye Q

更新日期：2004-03-01 00:00:00

abstract：:Cancer seriously impairs human health and survival. Many perturbations, such as increased oxidative stress, pathogen infection, and inflammation, promote the accumulation of DNA mutations, and ultimately lead to carcinogenesis. Tea is one of the most highly consumed beverages worldwide and has been linked to improveme...

journal_title：IUBMB life

authors： Fan X,Xiao X,Mao X,Chen D,Yu B,Wang J,Yan H

更新日期：2021-02-01 00:00:00

abstract：:The multifaceted relationship between mitochondria and the rest of the cell is reviewed in the context of myocardial ischemia. Paradoxically, mitochondria can exacerbate the ischemic damage, especially at the onset of reperfusion. Indeed, the recovery of oxidative phosphorylation in the presence of an excessive energy...

journal_title：IUBMB life

authors： Di Lisa F

更新日期：2001-09-01 00:00:00

abstract：:The best known NADPH oxidase is that of phagocytes-neutrophils and monocytes. In these cells, the enzyme manufactures large quantities of O2- and other reactive oxidants that are used for the purpose of killing invading microorganisms. Recent studies, however, have suggested that a number of other tissues contain NADP...

journal_title：IUBMB life

authors： Babior BM

更新日期：2000-10-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the presence of senile plaques and neurofibrillary tangles in the brain. The beta-amyloid peptide (Abeta) is the primary constituent of the senile plaques, and has been proposed to be a key contributor to the neurodegeneration observed in AD. The molecular mechanisms underl...

journal_title：IUBMB life

authors： Gong X,Lu X,Zhan L,Sui H,Qi X,Ji Z,Niu X,Liu L

更新日期：2010-03-01 00:00:00

abstract：:Hepatocyte mitochondrial aquaporin-8 (mtAQP8) works as a multifunctional membrane channel protein that facilitates the uptake of ammonia for its detoxification to urea as well as the mitochondrial release of hydrogen peroxide. Since early oligonucleotide microarray studies in liver of cholesterol-fed mice showed an AQ...

journal_title：IUBMB life

authors： Danielli M,Capiglioni AM,Marrone J,Calamita G,Marinelli RA

更新日期：2017-05-01 00:00:00

abstract：:The posttranscriptional regulation of miRNAs is important for organism development. To investigate the role of miRNAs in angiogenesis, we performed a loss-of-function screening assay in human umbilical vein endothelial cells (HUVECs) and found that knockdown of 7 miRNAs (miR-95a, miR-126, miR-129, miR-137, miR-139, mi...

journal_title：IUBMB life

authors： Li YX,Liu DQ,Zheng C,Zheng SQ,Liu M,Li X,Tang H

更新日期：2011-07-01 00:00:00

abstract：:Tetrameric haemoglobins display a cooperative ligand binding behaviour, which has been attributed to the functional interrelationship between multiple ligand binding sites. The quantitative description of this feature was initially carried out with a phenomenological approach, which was limited to the functional effec...

journal_title：IUBMB life

authors： Ciaccio C,Coletta A,De Sanctis G,Marini S,Coletta M

更新日期：2008-02-01 00:00:00

abstract：:The complex life cycle of intracellular parasitic protozoans entails multiple rounds of DNA replication and mitosis followed by cytokinesis to release daughter parasites. To gain insights into mitotic events it is imperative to identify the biomarkers that constitute the chromosome segregation machinery in the parasit...

journal_title：IUBMB life

authors： Verma G,Surolia N

更新日期：2018-08-01 00:00:00

abstract：:The pathways for ligand entry and exit in myoglobin have now been well established by a wide variety of experimental results, including pico- to nano- to microsecond transient absorbance measurements and time-resolved X-ray crystallographic measurements. Trp insertions have been used to block, one at a time, the three...

journal_title：IUBMB life

authors： Olson JS,Soman J,Phillips GN Jr

更新日期：2007-08-01 00:00:00

abstract：:Lysosomal storage disorders (LSDs) are inherited metabolic diseases caused by deficiencies in lysosomal proteins, which result in accumulation of undegraded metabolites and disruption of lysosomal proteostasis. Despite significant progress in the molecular genetics and biochemistry underlying the cellular pathogenesis...

journal_title：IUBMB life

authors： Segatori L

更新日期：2014-07-01 00:00:00

abstract：:Triclosan, a well-known inhibitor of Enoyl Acyl Carrier Protein Reductase (ENR) from several pathogenic organisms, is a promising lead compound to design effective drugs. We have solved the X-ray crystal structures of Plasmodium falciparum ENR in complex with triclosan variants having different substituted and unsubst...

journal_title：IUBMB life

authors： Maity K,Bhargav SP,Sankaran B,Surolia N,Surolia A,Suguna K

更新日期：2010-06-01 00:00:00

abstract：:Unique opportunities are provided by phylogenetically closely related organisms thriving in stably cold, or temperate milieus to study adaptive modifications of structurally homologous molecules. These modifications are of keen interest in basic science as well as in biotechnology. This review highlights structural an...

journal_title：IUBMB life

authors： Alimenti C,Vallesi A,Pedrini B,Wüthrich K,Luporini P

更新日期：2009-08-01 00:00:00

abstract：:During the hand plate development, the processes of cell differentiation and control of cell death are relevant to ensure a correct shape of the limb. The progenitor cell pool that later will differentiate into cartilage to form the digits arises from undifferentiated mesenchymal cells beneath the apical ectodermal ri...

journal_title：IUBMB life

authors： Chimal-Monroy J,Abarca-Buis RF,Cuervo R,Díaz-Hernández M,Bustamante M,Rios-Flores JA,Romero-Suárez S,Farrera-Hernández A

更新日期：2011-10-01 00:00:00

abstract：:The ATP-sensitive potassium (K(ATP)) channel is expressed in most excitable tissues and plays a critical role in numerous physiological processes by coupling intracellular energetics to electrical activity. The channel is comprised of four Kir6.x subunits associated with four regulatory sulfonylurea receptors (SUR). I...

journal_title：IUBMB life

authors： Akrouh A,Halcomb SE,Nichols CG,Sala-Rabanal M

更新日期：2009-10-01 00:00:00

abstract：:The yeast Saccharomyces cerevisiae is an excellent model for gaining insights into the molecular basis of human mitochondrial disorders, particularly those resulting from impaired mitochondrial metabolism. Yeast is a very well characterized system and most of our current knowledge about mitochondrial biogenesis in hum...

journal_title：IUBMB life

authors： Barrientos A

更新日期：2003-02-01 00:00:00

abstract：:Small extracellular vesicle (sEV) has precise impacts on tumor microenvironment and play vital functions in intercellular interaction. However, the functional role of sEV miRNA on laryngeal squamous cell carcinoma (LSCC) is largely unresolved. Here, the expression of miR-1246 in LSCC tissues and plasma sEV was examine...

journal_title：IUBMB life

authors： Huang Q,Hsueh CY,Guo Y,Wu XF,Li JY,Zhou L

更新日期：2020-07-01 00:00:00

abstract：:Acid fibroblast growth factor (aFGF) binds to its cell-surface receptors in a heparin-dependent manner. In an attempt to define the aFGF recognition site on fibroblast growth factor receptor 1 (FGFR1), we developed a screening strategy for identifying FGF ligands that bind to the receptor-binding region of FGF. To ret...

journal_title：IUBMB life

authors： Fan H,Liu Y,Zhou H,Wang L,Li W,Guo L,Roeske RW

更新日期：2000-06-01 00:00:00

abstract：:Cancers have a clonal origin, yet their chromosomes and genes are non-clonal or heterogeneous due to an inherent genomic instability. However, the cause of this genomic instability is still debated. One theory postulates that mutations in genes that are involved in DNA repair and in chromosome segregation are the prim...

journal_title：IUBMB life

authors： Duesberg P,Fabarius A,Hehlmann R

更新日期：2004-02-01 00:00:00

abstract：:Synucleinopathies are neurodegenerative diseases characterized by the accumulation of either neuronal/axonal or glial insoluble proteinaceous aggregates mainly composed of α-synuclein (α-syn). Among them, the most common disorders are Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and some fo...

journal_title：IUBMB life

authors： Longhena F,Faustini G,Brembati V,Pizzi M,Bellucci A

更新日期：2020-04-01 00:00:00

abstract：:In this article, the experiments used to construct the ambient pH-signaling network involved in the secretion of enzymes by filamentous fungi have been reviewed, focusing on the phosphate-repressible phosphatases in Aspergillus nidulans. Classic and molecular genetics have been used to demonstrate that proteolysis of ...

journal_title：IUBMB life

authors： Rossi A,Cruz AH,Santos RS,Silva PM,Silva EM,Mendes NS,Martinez-Rossi NM

更新日期：2013-11-01 00:00:00

abstract：:The invasion and chemoresistance are crucial causes of morbidity and relapse for cancer patients. Axl is implicated in the modulation of cell invasion, cancer metastasis, and chemosensitivity in human breast carcinoma cell lines. Both breast cancer cell lines and tissues displayed increased expression of Axl, and it o...

journal_title：IUBMB life

authors： Li Y,Jia L,Ren D,Liu C,Gong Y,Wang N,Zhang X,Zhao Y

更新日期：2014-07-01 00:00:00

abstract：:The immunosuppressant cyclosporin A (CsA)-sensitive nuclear factor of activated T cells 1 (NFAT1) has been known to be a transcriptional regulator of cytokine and viral genes during the immune response. By analyses of serial deletion, mutation, and heterologous promoter assay, we report here that the CsA-sensitive NFA...

journal_title：IUBMB life

authors： Lee JH,Rho HM

更新日期：2001-04-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) play important roles in the initiation and progression of various cancers, including laryngeal squamous cell carcinoma (LSCC). Recently, lncRNA Sox2 overlapping transcript (SOX2-OT) has been identified as an oncogene in various cancers. However, the functional role and the regulatory mech...

journal_title：IUBMB life

authors： Tai Y,Ji Y,Liu F,Zang Y,Xu D,Ma S,Qin L,Ma J

更新日期：2019-09-01 00:00:00

abstract：:Transfected human apoptosis signal-regulating kinase 1 (ASK1) produces a 150 kDa protein. However, we have detected endogenous ASK1 predominantly as 39 and 50 kDa C-terminal and 75 and 110 kDa N-terminal fragments in a panel of nontransfected cancer cell lines and HUVEC endothelial cells. This suggests that in nonapop...

journal_title：IUBMB life

authors： Stordal B,Davey R

更新日期：2008-03-01 00:00:00

abstract：:Role of nitric oxide (NO) on the expression of organic anion transporter 2 (OAT2) located in sinusoidal domain of hepatocytes has been investigated. Effect of NO generated in vivo in rat and delivered in vitro to hepatocytes was determined. Lipopolysaccharide (LPS) and spermine NONOate (SPER/NO) were selected as the N...

journal_title：IUBMB life

authors： Cha SH,Kim HP,Jung NH,Lee WK,Kim JY,Cha YN

更新日期：2002-09-01 00:00:00

abstract：:This study examined whether cell cycle regulatory proteins, such as cyclin-dependent kinases (CDKs), cyclins, and CDK inhibitors, regulate type II collagen expression and mediate interlukin-1 (IL-1beta)-induced suppression of type II collagen expression in articular chondrocytes. IL-1beta inhibited type II collagen ex...

journal_title：IUBMB life

authors： Hwang SG,Song SM,Kim JR,Park CS,Song WK,Chun JS

更新日期：2007-02-01 00:00:00