Potential role of potassium and chloride channels in regulation of silymarin-induced apoptosis in Candida albicans.

abstract：:The multifaceted relationship between mitochondria and the rest of the cell is reviewed in the context of myocardial ischemia. Paradoxically, mitochondria can exacerbate the ischemic damage, especially at the onset of reperfusion. Indeed, the recovery of oxidative phosphorylation in the presence of an excessive energy...

journal_title：IUBMB life

authors： Di Lisa F

更新日期：2001-09-01 00:00:00

abstract：:The existence of a genetic component in mycobacterial disease susceptibility is no longer in doubt and the investigations now being conducted aim to determine which genes are involved, to what extent, and in which disease phenotype they are relevant. In certain rare instances of susceptibility to poorly pathogenic myc...

journal_title：IUBMB life

authors： Hoal EG

更新日期：2002-04-01 00:00:00

abstract：:Triclosan, a well-known inhibitor of Enoyl Acyl Carrier Protein Reductase (ENR) from several pathogenic organisms, is a promising lead compound to design effective drugs. We have solved the X-ray crystal structures of Plasmodium falciparum ENR in complex with triclosan variants having different substituted and unsubst...

journal_title：IUBMB life

authors： Maity K,Bhargav SP,Sankaran B,Surolia N,Surolia A,Suguna K

更新日期：2010-06-01 00:00:00

abstract：:Advanced glycation end-products comprise a complex and heterogeneous group of compounds that have been implicated in diabetes-related complications. The importance of the Maillard reaction is depicted by the formation of reactive intermediate products known as α-oxoaldehydes, such as 3-deoxyglucosone (3-DG). This prod...

journal_title：IUBMB life

authors： Ashraf JM,Ahmad S,Rabbani G,Jan AT,Lee EJ,Khan RH,Choi I

更新日期：2014-10-01 00:00:00

abstract：:Nur77 is a member of nuclear receptor superfamily that acts as a transcription factor and regulates expression of multiple genes. Subcellular localization of Nur77 protein plays an important role in the survival and cell death. In this study, we have predicted and confirmed alternatively spliced two new transcripts of...

journal_title：IUBMB life

authors： Rehman SU,Sarwar T,Husain MA,Ishqi HM,Tabish M

更新日期：2017-02-01 00:00:00

abstract：:Epidemiological evidence demonstrates that diets rich in fruit and vegetables promote health, and attenuate, or delay, the onset of various diseases, including cardiovascular disease, diabetes, certain cancers, and several other age-related degenerative disorders. The chemical components and the physiological and mole...

journal_title：IUBMB life

authors： Fraga CG

更新日期：2007-04-01 00:00:00

abstract：:Matrix metalloproteinase-9 (MMP-9) regulates remodeling of the left ventricle after myocardial infarction (MI) and is tightly linked to the inflammatory response. The inflammatory response serves to recruit leukocytes as part of the wound healing reaction to the MI injury, and infiltrated leukocytes produce cytokines ...

journal_title：IUBMB life

authors： Deleon-Pennell KY,Altara R,Yabluchanskiy A,Modesti A,Lindsey ML

更新日期：2015-08-01 00:00:00

abstract：:Fructose 2,6-bisphosphate is a potent metabolic regulator in eukaryotic organisms; it affects the activity of key enzymes of the glycolytic and gluconeogenic pathways. The enzymes responsible for its synthesis and hydrolysis, 6-phosphofructo-2-kinase (PFK-2) and fructose-2,6-bisphosphatase (FBPase-2) are present in re...

journal_title：IUBMB life

authors： Michels PA,Rigden DJ

更新日期：2006-03-01 00:00:00

abstract：:Carbon monoxide (CO) is a gaseous transmitter that is known to be involved in several physiological processes, but surprisingly it is also becoming a promising molecule to treat several pathologies including stroke and cancer. CO can cross the plasma membrane and activate guanylate cyclase, increasing the cGMP concent...

journal_title：IUBMB life

authors： Retamal MA,León-Paravic CG,Ezquer M,Ezquer F,Del Rio R,Pupo A,Martínez AD,González C

更新日期：2015-06-01 00:00:00

abstract：:Exosomes are nano-sized extracellular vesicles containing a cell-specific biologically active cargo of proteins and genetic materials. Exosomes are constitutively released from almost all cell-types and affect neighboring or distant cells through a complex intercellular exchange of the genetic information and/or regul...

journal_title：IUBMB life

authors： Zhou R,Wang L,Zhao G,Chen D,Song X,Momtazi-Borojeni AA,Yuan H

更新日期：2020-12-01 00:00:00

abstract：:Cancers have a clonal origin, yet their chromosomes and genes are non-clonal or heterogeneous due to an inherent genomic instability. However, the cause of this genomic instability is still debated. One theory postulates that mutations in genes that are involved in DNA repair and in chromosome segregation are the prim...

journal_title：IUBMB life

authors： Duesberg P,Fabarius A,Hehlmann R

更新日期：2004-02-01 00:00:00

abstract：:Implantation is a complex developmental event that is initiated by recognition and adhesion of the embryo to the endometrial epithelium. sLeX is an oligosaccharide antigen acting as the ligand of L-selectin, and is stage-specifically expressed in the endometrial epithelium. The adhesion system mediated by L-selectin a...

journal_title：IUBMB life

authors： Liu S,Zhang Y,Liu Y,Qin H,Wang X,Yan Q

更新日期：2008-07-01 00:00:00

abstract：:A pool of Plasmodium falciparum casein kinase 1 (PfCK1) has been shown to localize to the host red blood cell (RBC) membrane and be secreted to the extracellular medium during trophozoite stage of development. We attempted to identify mechanisms for secretion of PfCK1 and its appearance on the RBC membrane. We found t...

journal_title：IUBMB life

authors： Batty MB,Schittenhelm RB,Dorin-Semblat D,Doerig C,Garcia-Bustos JF

更新日期：2020-06-01 00:00:00

abstract：:Recent structural studies of proteins mediating membrane fusion reveal intriguing similarities between diverse viral and mammalian systems. Particularly striking is the close similarity between the transmembrane envelope glycoproteins from the retrovirus HTLV-1 and the filovirus Ebola. These similarities suggest simil...

journal_title：IUBMB life

authors： Poumbourios P,Center RJ,Wilson KA,Kemp BE,Kobe B

更新日期：1999-08-01 00:00:00

abstract：:We investigated signaling pathways leading to tumor necrosis factor (TNF) alpha-induced intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 expression in chondrosarcoma cells, and determined the functional significance of their expression by examining Jurkat T cell adhesion. TNFalpha ...

journal_title：IUBMB life

authors： Ju JW,Kim SJ,Jun CD,Chun JS

更新日期：2002-11-01 00:00:00

abstract：:Since about 60 years a phenomenon now called permeability transition is known in mitochondria. It involves a large pore in the inner mitochondrial membrane, the permeability transition pore (PTP) whose molecular structure is still unknown. Year after year, new hypotheses have been developed how this pore could look li...

journal_title：IUBMB life

authors： Siemen D,Ziemer M

更新日期：2013-03-01 00:00:00

abstract：:Small extracellular vesicle (sEV) has precise impacts on tumor microenvironment and play vital functions in intercellular interaction. However, the functional role of sEV miRNA on laryngeal squamous cell carcinoma (LSCC) is largely unresolved. Here, the expression of miR-1246 in LSCC tissues and plasma sEV was examine...

journal_title：IUBMB life

authors： Huang Q,Hsueh CY,Guo Y,Wu XF,Li JY,Zhou L

更新日期：2020-07-01 00:00:00

abstract：:The members of the GATA family of transcription factors have homologous zinc fingers and bind to similar sequence motifs. Recent advances in genome-wide technologies and the integration of bioinformatics data have led to a better understanding of how GATA factors regulate gene expression; GATA-factor-induced transcrip...

journal_title：IUBMB life

authors： Romano O,Miccio A

更新日期：2020-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterized by the presence of senile plaques and neurofibrillary tangles in the brain. The beta-amyloid peptide (Abeta) is the primary constituent of the senile plaques, and has been proposed to be a key contributor to the neurodegeneration observed in AD. The molecular mechanisms underl...

journal_title：IUBMB life

authors： Gong X,Lu X,Zhan L,Sui H,Qi X,Ji Z,Niu X,Liu L

更新日期：2010-03-01 00:00:00

abstract：:We previously found a novel glycosylphosphatidylinositol (GPI)-anchored glycoprotein designated GPI-80 that modulates complement receptor 3 integrin-dependent adhesion and in vitro transendothelial migration of neutrophils. In this study, we show that antibody-mediated cross-linking of GPI-80 led to rapid tyrosine pho...

journal_title：IUBMB life

authors： Yu Y,Araki Y,Sendo F

更新日期：2000-01-01 00:00:00

abstract：:In this study, the impact of pancreatic cancer cell interaction with macrophages on the differentiation and function of macrophages and the behaviors of pancreatic cancer cells in vitro is evaluated. The expression of immunocompetent cell-associated markers in 22 pancreatic cancer specimens was characterized by immuno...

journal_title：IUBMB life

authors： Meng F,Li C,Li W,Gao Z,Guo K,Song S

更新日期：2014-12-01 00:00:00

abstract：:The reaction between nitric oxide ((.)NO) and oxygen yields reactive species capable of oxidizing and nitrosating proteins, as well as deaminating DNA bases. Although this reaction is considered too slow to be biologically relevant, it has been shown that membranes, lipoproteins, mitochondria and possibly proteins can...

journal_title：IUBMB life

authors： Möller MN,Li Q,Lancaster JR Jr,Denicola A

更新日期：2007-04-01 00:00:00

abstract：:Interferon regulatory factors (IRFs) were originally discovered in the context of type I interferon (IFN-alpha/beta) gene induction, and subsequent studies on these transcription factors have revealed their remarkable functional diversity in regulating immune systems. Indeed, the critical involvement of IRF members in...

journal_title：IUBMB life

authors： Honda K,Taniguchi T

更新日期：2006-05-01 00:00:00

abstract：:Insulin-like growth factor-1 (IGF-1) signaling is a key pathway in the control of cell growth and survival. Three critical nodes in the IGF-1 signaling pathway have been described in cardiomyocytes: protein kinase Akt/mammalian target of rapamycin (mTOR), Ras/Raf/extracellular signal-regulated kinase (ERK), and phosph...

journal_title：IUBMB life

authors： Troncoso R,Díaz-Elizondo J,Espinoza SP,Navarro-Marquez MF,Oyarzún AP,Riquelme JA,Garcia-Carvajal I,Díaz-Araya G,García L,Hill JA,Lavandero S

更新日期：2013-07-01 00:00:00

abstract：:Nucleotides of transfer RNAs (tRNAs) are highly modified, particularly at the anticodon. Bacterial tRNAs that read A-ending codons are especially notable. The U34 nucleotide canonically present in these tRNAs is modified by a wide range of complex chemical constituents. An additional two A-ending codons are not read b...

journal_title：IUBMB life

authors： Nilsson EM,Alexander RW

更新日期：2019-08-01 00:00:00

abstract：:Renal ischemia/reperfusion (I/R) is an alternation of renal hemodynamics, which results in diverse postischemic responses and eventually acute kidney injury. Although renal ischemic preconditioning (IPC) is known to protect the kidney from I/R injury, the precise renoprotective mechanisms are not completely understood...

journal_title：IUBMB life

authors： Li JR,Ou YC,Wu CC,Wang JD,Lin SY,Wang YY,Chen WY,Chen CJ

更新日期：2019-03-01 00:00:00

abstract：:A large amount of evidence suggests a pathogenic link between cholesterol homeostasis dysregulation and Alzheimer's disease (AD). In cell culture systems, the production of amyloid-β (Aβ) is modulated by cholesterol, and studies on animal models have consistently demonstrated that hypercholesterolemia is associated wi...

journal_title：IUBMB life

authors： Ricciarelli R,Canepa E,Marengo B,Marinari UM,Poli G,Pronzato MA,Domenicotti C

更新日期：2012-12-01 00:00:00

abstract：:This review describes recent progress in the field of fibroblast growth factor receptors (FGFRs) with an emphasis on the role of FGFR mutants in skeletal malformations. This family of four receptors contains the most frequent germline mutations in humans. More than 75 mutations have been recorded, which account for mo...

journal_title：IUBMB life

authors： Kannan K,Givol D

更新日期：2000-03-01 00:00:00

abstract：:Stem cells from human exfoliated deciduous teeth (SHEDs) are highly proliferative, clonogenic, and multipotent stem cells with a neural crest cell origin. This property could be a desirable option for potential therapeutic applications. In this study, we focus on the effects of Rho kinase inhibitors Y-27632 and Noggin...

journal_title：IUBMB life

authors： Yang S,Xin C,Zhang B,Zhang H,Hao Y

更新日期：2020-04-01 00:00:00

abstract：:Our results demonstrate that open reading frame (ORF) YHR076w on chromosome VIII of Saccharomyces cerevisiae that was previously described as a hypothetical gene is expressed. This ORF is transcribed as an mRNA of approximately 1,100 nucleotides. A 41.2-kDa polypeptide and three others predicted to be modified forms o...

journal_title：IUBMB life

authors： Ramos CW,Güldener U,Klein S,Hegemann JH,Gonzalez S,Rodríguez-Medina JR

更新日期：2000-12-01 00:00:00