Abstract:
:Recent structural studies of proteins mediating membrane fusion reveal intriguing similarities between diverse viral and mammalian systems. Particularly striking is the close similarity between the transmembrane envelope glycoproteins from the retrovirus HTLV-1 and the filovirus Ebola. These similarities suggest similar mechanisms of membrane fusion. The model that fits most currently available data suggests fusion activation in viral systems is driven by a symmetrical conformational change triggered by an activation event such as receptor binding or a pH change. The mammalian vesicle fusion mediated by the SNARE protein complex most likely occurs by a similar mechanism but without symmetry constraints.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Poumbourios P,Center RJ,Wilson KA,Kemp BE,Kobe Bdoi
10.1080/713803503keywords:
subject
Has Abstractpub_date
1999-08-01 00:00:00pages
151-6issue
2eissn
1521-6543issn
1521-6551journal_volume
48pub_type
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