Evolutionary conservation of the membrane fusion machine.

Abstract:

:Recent structural studies of proteins mediating membrane fusion reveal intriguing similarities between diverse viral and mammalian systems. Particularly striking is the close similarity between the transmembrane envelope glycoproteins from the retrovirus HTLV-1 and the filovirus Ebola. These similarities suggest similar mechanisms of membrane fusion. The model that fits most currently available data suggests fusion activation in viral systems is driven by a symmetrical conformational change triggered by an activation event such as receptor binding or a pH change. The mammalian vesicle fusion mediated by the SNARE protein complex most likely occurs by a similar mechanism but without symmetry constraints.

journal_name

IUBMB Life

journal_title

IUBMB life

authors

Poumbourios P,Center RJ,Wilson KA,Kemp BE,Kobe B

doi

10.1080/713803503

keywords:

subject

Has Abstract

pub_date

1999-08-01 00:00:00

pages

151-6

issue

2

eissn

1521-6543

issn

1521-6551

journal_volume

48

pub_type

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