Abstract：
:Specific RNAs can function as sinks for endogenous miRNAs, known as competing endogenous RNAs (ceRNAs). Here, we confirm a miR-124 mediated ceRNA crosstalk between LAMC1 and CD151 in hepatocellular carcinoma (HCC). miR-124 negatively regulates LAMC1 expression through two miRNA binding sites within its 3' untranslated region (3'UTR) and suppresses migration and invasion of HCC cells through regulating LAMC1. The wild type LAMC1 miRNA response elements (MREs) facilitate expression of CD151, and this regulation is miR-124 dependent. In clinical hepatic tissues, LAMC1 and CD151 mRNAs exhibit positive correlation. Importantly, LAMC1 MREs promote HCC malignancy by absorbing miR-124 and by assisting CD151 expression. We conclude that LAMC1 mRNA acts as a trans regulator to stimulate CD151 expression by competing for miR-124 binding in HCC cells. © 2017 IUBMB Life, 69(8):595-605, 2017.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Yang ZP,Ma HS,Wang SS,Wang L,Liu Tdoi
10.1002/iub.1642subject
Has Abstractpub_date
2017-08-01 00:00:00pages
595-605issue
8eissn
1521-6543issn
1521-6551journal_volume
69pub_type
杂志文章相关文献
IUBMB LIFE文献大全abstract：:5-Hydroxytryptamine 2C (5-HT2C ) receptor agonists have been suggested to possess an antipsychotic activity in several acute preclinical tests of antipsychotic drugs with low extra-pyramidal side effect liability. However, little is known about the long-term effect associated with chronic use of 5-HT2C receptor agonis...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.1580
更新日期：2016-12-01 00:00:00
abstract：:The pathways for ligand entry and exit in myoglobin have now been well established by a wide variety of experimental results, including pico- to nano- to microsecond transient absorbance measurements and time-resolved X-ray crystallographic measurements. Trp insertions have been used to block, one at a time, the three...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1080/15216540701230495
更新日期：2007-08-01 00:00:00
abstract：:Traumatic optic neuropathy is an important cause of severe vision loss. So, many attempts were performed to transplant stem cells systemically or locally to regenerate the injured retina. In this study, we investigated the effect of human umbilical cord blood mesenchymal stem cells (hUBMSCs) on histological structure,...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.1608
更新日期：2017-03-01 00:00:00
abstract：:Although proteins and nucleic acids consist of different chemical components, proteins can mimic structures and possibly also functions of nucleic acids. Recently, structural mimicry was observed between two elongation factors in bacterial protein biosynthesis leading to the introduction of the concept of macromolecul...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1080/713803471
更新日期：1999-07-01 00:00:00
abstract：:In this study, the impact of pancreatic cancer cell interaction with macrophages on the differentiation and function of macrophages and the behaviors of pancreatic cancer cells in vitro is evaluated. The expression of immunocompetent cell-associated markers in 22 pancreatic cancer specimens was characterized by immuno...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.1336
更新日期：2014-12-01 00:00:00
abstract：:The formation, maturation, and dissolution of focal adhesions are basic prerequisites of cell migration and rely on the recruitment, signalling, and endocytosis of integrins. In many instances, extracellular matrix molecules are recognised by a number of integrins, and it is the sequential involvement of different int...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1002/iub.200
更新日期：2009-07-01 00:00:00
abstract：:Combining two analytical techniques, HPLC and liquid secondary ion mass spectrometry, the orientation of liposomal membrane-bound melittin was analyzed through its trypsin-digested products. We found that trypsin can access all proteolytic sites of the membrane-bound melittin when the liposomes have no transmembrane p...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1080/152165400300001543
更新日期：2000-09-01 00:00:00
abstract：:The last 15 years of effort in understanding bacterial DNA replication and repair has identified that the donut shaped beta2 sliding clamp is harnessed by very functionally different DNA polymerases throughout the lifecycle of the bacterial cell. Remarkably, the sites of binding of these polymerases, in most cases, ap...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1080/15216540500138246
更新日期：2005-06-01 00:00:00
abstract：:The expression of the cytM gene, which encodes cytochrome cM in Synechocystis sp. PCC 6803, is induced under stress conditions such as low temperature. Results of spectrophotometric studies revealed that cytochrome cM was oxidized by light absorbed by photosystem I in cells that had acclimatized to a low temperature. ...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1080/15216540118716
更新日期：2001-02-01 00:00:00
abstract：:Transketolase (TK, EC 2.2.1.1), the key enzyme of the non-oxidative branch of pentose phosphate pathway of hydrocarbon transformation, plays an important role in a system of substrate rearrangement between pentose shunt and glycolysis, acting as a reversible link between the two metabolic pathways. In addition, it sup...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.395
更新日期：2010-11-01 00:00:00
abstract：:Calcium-sensing receptor (CaSR) contributes to maintain homeostatic levels of extracellular calcium. In addition, CaSR controls other cellular activities such as proliferation and migration, particularly in cells not related to extracellular calcium homeostasis, potentially by cross-talking with parallel signaling pat...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.1232
更新日期：2013-12-01 00:00:00
abstract：:In this study, two different epitope tags (HA, c-myc) were introduced near the N terminus of the yeast PMA1 H(+)-ATPase. The resulting proteins were indistinguishable from the wild-type ATPase in their ability to travel through the secretory pathway, as judged by quantitative immunoblotting of isolated secretory vesic...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1080/15216540050022494
更新日期：2000-02-01 00:00:00
abstract：:Transforming growth factorbeta1 (TGFbeta1) is considered to be the principal contributor to liver fibrosis. So in this study the ribozymes against TGFbeta1 were designed. The in vitro cleavage activities of the ribozymes were assayed through incubation of (32)p-labeled target RNAs and (32)p-labeled ribozymes in differ...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1080/15216540400024470
更新日期：2005-01-01 00:00:00
abstract：:The multifaceted relationship between mitochondria and the rest of the cell is reviewed in the context of myocardial ischemia. Paradoxically, mitochondria can exacerbate the ischemic damage, especially at the onset of reperfusion. Indeed, the recovery of oxidative phosphorylation in the presence of an excessive energy...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1080/15216540152846073
更新日期：2001-09-01 00:00:00
abstract：:Tumstatin is a candidate tumor suppressor that plays an important role in tumor growth and angiogenesis. The purpose of this study was to evaluate the correlation between tumstatin-mRNA expression and the clinicopathologic characteristics, tumor angiogenesis, outcome of patients with non-small cell lung cancer (NSCLC)...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.1016
更新日期：2012-05-01 00:00:00
abstract：:In this study, we intended to determine the detailed function and mechanism of long noncoding RNA (lncRNA) colorectal neoplasia differentially expressed (CRNDE) in liver injury induced by sepsis. Cecal ligation and perforation (CLP) models were adopted to induce sepsis in vivo with rats, and hepatic epithelial cells L...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.2230
更新日期：2020-03-01 00:00:00
abstract：:The disappointing results from large clinical studies of α-tocopherol (αT), the major form of vitamin E in tissues, for prevention of chronic diseases including cancer have cast doubt on not only αT but also other forms of vitamin E regarding their role in preventing carcinogenesis. However, basic research has shown t...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1002/iub.1978
更新日期：2019-04-01 00:00:00
abstract：:The functional effect of the interaction of E2F1 and hepatitis B virus X protein (HBx) on the promoter of human p53 gene was studied using chloramphenicol acetyl transferase (CAT) assay. E2F1 activated the p53 promoter through E2F1 binding site. As previously reported, HBx repressed the p53 promoter through E-box. Whe...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1080/15216540213466
更新日期：2002-06-01 00:00:00
abstract：:The amino acids glutamate and gamma-aminobutyric acid (GABA) have primarily been characterized as the most prevalent excitatory and inhibitory, respectively, neurotransmitters in the vertebrate central nervous system. However, the role of these signaling molecules extends far beyond the synapse. GABA, glutamate, and t...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1002/iub.185
更新日期：2009-05-01 00:00:00
abstract：:We investigated signaling pathways leading to tumor necrosis factor (TNF) alpha-induced intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 expression in chondrosarcoma cells, and determined the functional significance of their expression by examining Jurkat T cell adhesion. TNFalpha ...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1080/15216540215674
更新日期：2002-11-01 00:00:00
abstract：:In protein and RNA macromolecules, only a limited number of different side-chain chemical groups are available to function as catalysts. The myriad of enzyme-catalyzed reactions results from the ability of most of these groups to function either as nucleophilic, electrophilic, or general acid-base catalysts, and the k...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1080/15216540211468
更新日期：2002-02-01 00:00:00
abstract：:Triclosan, a well-known inhibitor of Enoyl Acyl Carrier Protein Reductase (ENR) from several pathogenic organisms, is a promising lead compound to design effective drugs. We have solved the X-ray crystal structures of Plasmodium falciparum ENR in complex with triclosan variants having different substituted and unsubst...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.327
更新日期：2010-06-01 00:00:00
abstract：:Matrix metalloproteinase-9 (MMP-9) regulates remodeling of the left ventricle after myocardial infarction (MI) and is tightly linked to the inflammatory response. The inflammatory response serves to recruit leukocytes as part of the wound healing reaction to the MI injury, and infiltrated leukocytes produce cytokines ...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1002/iub.1408
更新日期：2015-08-01 00:00:00
abstract：:Cocaine is a powerful central nervous stimulant and among the most abused of drugs. Despite decades of efforts, however, no effective pharmacological treatments are available against cocaine addiction or toxic effects. Classical receptor-antagonist therapeutic approaches have not yielded significant effects, although ...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1080/1521654031000138541
更新日期：2003-07-01 00:00:00
abstract：:In Streptomyces fradiae, calcium ions induce alterations in intensity and specificity of the secondary metabolism and stimulate sporulation. Using in vivo labeling, we demonstrate that in S. fradiae phosphorylation of some proteins are also influenced by Ca2+ added exogenously. Calcium ions at physiological concentrat...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1080/713803699
更新日期：2000-08-01 00:00:00
abstract：:Ovarian cancer (OC) is one of the most lethal gynaecological cancers, which usually has a poor prognosis due to late diagnosis. A large percentage of the OC cell population is in a nonproliferating and quiescent stage, which poses a barrier to success when using most chemotherapeutic agents. Recent studies have shown ...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.1035
更新日期：2012-07-01 00:00:00
abstract：:Anthracyclines are a class of antitumor drugs widely used for the treatment of a variety of malignancy, including leukemias, lymphomas, sarcomas, and carcinomas. Different mechanisms have been proposed for anthracycline antitumor effects including free-radical generation, DNA intercalation/binding, activation of signa...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1080/15216540252774829
更新日期：2001-07-01 00:00:00
abstract：:Cyclic AMP metabolism is essential for the survival of the social amoebae Dictyostelium discoideum. Three distinct adenylyl cyclases are expressed and required for the normal development of this simple eukaryote. The adenylyl cyclase expressed during aggregation, ACA, is related to the mammalian and Drosophila G prote...
journal_title：IUBMB life
pub_type： 杂志文章,评审
doi：10.1080/15216540400013887
更新日期：2004-09-01 00:00:00
abstract：:Cisplatin (CP), as a chemotherapeutic drug, causes nephrotoxicity that has limited the clinical utility of CP. Gliclazide (GLZ), as an antihyperglycemic drug, at low dose has antioxidant property. In this study, we aimed to investigate the protective effect of GLZ against CP-induced acute renal injury. Sixty-four BALB...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.2342
更新日期：2020-09-01 00:00:00
abstract：:The posttranscriptional regulation of miRNAs is important for organism development. To investigate the role of miRNAs in angiogenesis, we performed a loss-of-function screening assay in human umbilical vein endothelial cells (HUVECs) and found that knockdown of 7 miRNAs (miR-95a, miR-126, miR-129, miR-137, miR-139, mi...
journal_title：IUBMB life
pub_type： 杂志文章
doi：10.1002/iub.486
更新日期：2011-07-01 00:00:00
