Abstract:
:The formation, maturation, and dissolution of focal adhesions are basic prerequisites of cell migration and rely on the recruitment, signalling, and endocytosis of integrins. In many instances, extracellular matrix molecules are recognised by a number of integrins, and it is the sequential involvement of different integrins that allows establishment of cell polarity and migration towards a matrix stimulus. In this review, we consider both the similarities and differences between two key fibronectin receptors, alpha(v)beta(3) and alpha(5)beta(1) integrin. By considering the GTPase and kinase signalling and trafficking of two such closely-related receptors, we begin to understand how cell migration is coordinated.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Morgan MR,Byron A,Humphries MJ,Bass MDdoi
10.1002/iub.200subject
Has Abstractpub_date
2009-07-01 00:00:00pages
731-8issue
7eissn
1521-6543issn
1521-6551journal_volume
61pub_type
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