Abstract:
:S-Nitrosation is rapidly emerging as a regulatory mechanism in vascular biology, with particular importance in the onset of hyperpermeability induced by pro-inflammatory agents. This review focuses on the role of endothelial nitric oxide synthase (eNOS)-derived nitric oxide (NO) in regulating S-Nitrosation of adherens junction proteins. We discuss evidence for translocation of eNOS, via caveolae, to the cytosol and analyze the significance of eNOS location for S-Nitrosation and onset of endothelial hyperpermeability to macromolecules.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Durán WN,Beuve AV,Sánchez FAdoi
10.1002/iub.1204subject
Has Abstractpub_date
2013-10-01 00:00:00pages
819-26issue
10eissn
1521-6543issn
1521-6551journal_volume
65pub_type
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