MiR-770 promotes oral squamous cell carcinoma migration and invasion by regulating the Sirt7/Smad4 pathway.

abstract：:The ATP-sensitive potassium (K(ATP)) channel is expressed in most excitable tissues and plays a critical role in numerous physiological processes by coupling intracellular energetics to electrical activity. The channel is comprised of four Kir6.x subunits associated with four regulatory sulfonylurea receptors (SUR). I...

journal_title：IUBMB life

authors： Akrouh A,Halcomb SE,Nichols CG,Sala-Rabanal M

更新日期：2009-10-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) is linked to the etiopathogenesis of Kaposi's sarcoma, a plasma-blastic variant of Castleman's disease and primary effusion lymphoma. KSHV is related to a number of non-human primate viruses. Only a limited number of KSHV proteins are expressed in tumor cells. He...

journal_title：IUBMB life

authors： Sharp TV,Boshoff C

更新日期：2000-02-01 00:00:00

abstract：:Cancer seriously impairs human health and survival. Many perturbations, such as increased oxidative stress, pathogen infection, and inflammation, promote the accumulation of DNA mutations, and ultimately lead to carcinogenesis. Tea is one of the most highly consumed beverages worldwide and has been linked to improveme...

journal_title：IUBMB life

authors： Fan X,Xiao X,Mao X,Chen D,Yu B,Wang J,Yan H

更新日期：2021-02-01 00:00:00

abstract：:A large amount of evidence suggests a pathogenic link between cholesterol homeostasis dysregulation and Alzheimer's disease (AD). In cell culture systems, the production of amyloid-β (Aβ) is modulated by cholesterol, and studies on animal models have consistently demonstrated that hypercholesterolemia is associated wi...

journal_title：IUBMB life

authors： Ricciarelli R,Canepa E,Marengo B,Marinari UM,Poli G,Pronzato MA,Domenicotti C

更新日期：2012-12-01 00:00:00

abstract：:Implantation is a complex developmental event that is initiated by recognition and adhesion of the embryo to the endometrial epithelium. sLeX is an oligosaccharide antigen acting as the ligand of L-selectin, and is stage-specifically expressed in the endometrial epithelium. The adhesion system mediated by L-selectin a...

journal_title：IUBMB life

authors： Liu S,Zhang Y,Liu Y,Qin H,Wang X,Yan Q

更新日期：2008-07-01 00:00:00

abstract：:5-Hydroxytryptamine 2C (5-HT2C ) receptor agonists have been suggested to possess an antipsychotic activity in several acute preclinical tests of antipsychotic drugs with low extra-pyramidal side effect liability. However, little is known about the long-term effect associated with chronic use of 5-HT2C receptor agonis...

journal_title：IUBMB life

authors： Chen W,Wang X,Yan M,Wang Y,Xie S,Li H,Li M

更新日期：2016-12-01 00:00:00

abstract：:The mammalian antizyme (AZ) promotes ubiqutin-independent degradation of ornithine decarboxylase, a key enzyme in polyamine biosynthesis. This study shows that AZ suppression in human lung carcinoma A549 cells caused growth defects and death, but made the cells resistant to DNA damaging agents such as gamma-radiation ...

journal_title：IUBMB life

authors： Kim JS,Kim TL,Cho EW,Paik SG,Chung HW,Kim IG

更新日期：2008-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is a devastating neurodegenerative disorder that results in loss of memory and cognitive function, eventually leading to dementia. A key neuropathological event in AD is the cerebral accumulation of senile plaques formed by aggregates of amyloid-β-peptides (Aβ). Aβ results from two sequential ...

journal_title：IUBMB life

authors： Tamagno E,Guglielmotto M,Monteleone D,Vercelli A,Tabaton M

更新日期：2012-12-01 00:00:00

abstract：:Prostate specific antigen (PSA) is a serine protease that is exclusively produced in the prostate, and its detection is the only laboratory test available for screening men for prostate cancer (PC). The interpretation of the assay is difficult since it is specific for prostate tissue and cellular growth, but not for P...

journal_title：IUBMB life

authors： Mener DJ

更新日期：2010-08-01 00:00:00

abstract：:Cell-surface-bound extracellular DNA (csbDNA) is present on the outer membrane of blood cells, including both red blood cells and leukocytes. Although less well characterized than cell-free DNA (cfDNA) in plasma and serum, leukocyte and red blood cell csbDNA form a considerable fraction of the blood extracellular nucl...

journal_title：IUBMB life

authors： Tamkovich S,Laktionov P

更新日期：2019-09-01 00:00:00

abstract：:Exosomes are nano-sized extracellular vesicles containing a cell-specific biologically active cargo of proteins and genetic materials. Exosomes are constitutively released from almost all cell-types and affect neighboring or distant cells through a complex intercellular exchange of the genetic information and/or regul...

journal_title：IUBMB life

authors： Zhou R,Wang L,Zhao G,Chen D,Song X,Momtazi-Borojeni AA,Yuan H

更新日期：2020-12-01 00:00:00

abstract：:Blood glucose is the primary cellular substrate and in vivo must be tightly maintained. The liver plays a key role in glucose homeostasis increasing or decreasing glucose output and uptake during fasting and feeding. Glucokinase (GCK) is central to this process. Its activity is modulated in a coordinated manner via a ...

journal_title：IUBMB life

authors： Massa ML,Gagliardino JJ,Francini F

更新日期：2011-01-01 00:00:00

abstract：:Magnetic targeting has shown promise to improve the efficacy and safety of different classes of therapeutic agents by enabling their active guidance to the site of disease and minimizing dissemination to nontarget tissues. However, its translation into clinic has proven difficult because of inherent limitations of tra...

journal_title：IUBMB life

authors： Chorny M,Fishbein I,Forbes S,Alferiev I

更新日期：2011-08-01 00:00:00

abstract：:The human nuclear estrogen receptors (i.e., ERalpha and ERbeta), as other transcriptional factors, regulate cellular processes inducing genomic events. In addition, the binding of 17beta-estradiol to ERs induces different membrane initiating non-genomic signaling. The non-genomic effects of ER are independent of trans...

journal_title：IUBMB life

authors： Acconcia F,Bocedi A,Ascenzi P,Marino M

更新日期：2003-01-01 00:00:00

abstract：:The current landscapes of novel therapeutic approaches rely mostly on gene-targeted technologies, enabling to fight rare genomic diseases, from infections to cancer and hereditary diseases. Although, reaching the action-site for this novel treatments requires to deliver nucleic acids, or other macromolecules into cell...

journal_title：IUBMB life

authors： de Figueiredo IR,Freire JM,Flores L,Veiga AS,Castanho MARB

更新日期：2014-03-01 00:00:00

abstract：:Tetrameric haemoglobins display a cooperative ligand binding behaviour, which has been attributed to the functional interrelationship between multiple ligand binding sites. The quantitative description of this feature was initially carried out with a phenomenological approach, which was limited to the functional effec...

journal_title：IUBMB life

authors： Ciaccio C,Coletta A,De Sanctis G,Marini S,Coletta M

更新日期：2008-02-01 00:00:00

abstract：:Since about 60 years a phenomenon now called permeability transition is known in mitochondria. It involves a large pore in the inner mitochondrial membrane, the permeability transition pore (PTP) whose molecular structure is still unknown. Year after year, new hypotheses have been developed how this pore could look li...

journal_title：IUBMB life

authors： Siemen D,Ziemer M

更新日期：2013-03-01 00:00:00

abstract：:The invasion and chemoresistance are crucial causes of morbidity and relapse for cancer patients. Axl is implicated in the modulation of cell invasion, cancer metastasis, and chemosensitivity in human breast carcinoma cell lines. Both breast cancer cell lines and tissues displayed increased expression of Axl, and it o...

journal_title：IUBMB life

authors： Li Y,Jia L,Ren D,Liu C,Gong Y,Wang N,Zhang X,Zhao Y

更新日期：2014-07-01 00:00:00

abstract：:Transfected human apoptosis signal-regulating kinase 1 (ASK1) produces a 150 kDa protein. However, we have detected endogenous ASK1 predominantly as 39 and 50 kDa C-terminal and 75 and 110 kDa N-terminal fragments in a panel of nontransfected cancer cell lines and HUVEC endothelial cells. This suggests that in nonapop...

journal_title：IUBMB life

authors： Stordal B,Davey R

更新日期：2008-03-01 00:00:00

abstract：:Large inter-individual variation exists in the response to vitamin E supplementation, and this may influence the outcome of human studies. It is our hypothesis that genetic heterogeneity is an important determinant of vitamin E homeostasis. Therefore we have performed an in silico search for single nucleotide polymorp...

journal_title：IUBMB life

authors： Döring F,Rimbach G,Lodge JK

更新日期：2004-10-01 00:00:00

abstract：:Treatment of microsomes (preferably enriched with endoplasmic reticulum) isolated from bovine pulmonary artery smooth muscle tissue with the O2*- -generating system (hypoxanthine (HPX) plus xanthine oxidase (XO)), markedly stimulated matrix metalloproteinase-2 (MMP-2) activity and also enhanced Ca2+ ATPase activity an...

journal_title：IUBMB life

authors： Mandal A,Chakraborti T,Das S,Ghosh B,Ghosh A,Chakraborti S

更新日期：2004-05-01 00:00:00

abstract：:Recently, cytochrome P450 170A1 (CYP170A1) has been found to be a bifunctional protein, which catalyzes both monooxygenase activity and terpene synthase activity by two distinct active sites in the well-established P450 protein structure. Therefore, CYP170A1 is identified clearly as a moonlighting protein. The known a...

journal_title：IUBMB life

authors： Zhao B,Waterman MR

更新日期：2011-07-01 00:00:00

abstract：:The conformational stability of the homotetrameric Plasmodium falciparum beta-ketoacyl-ACP reductase (FabG) was determined by guanidinium chloride-induced isothermal and thermal denaturation. The reversible unfolding transitions were monitored by intrinsic fluorescence, circular dichroism (CD) spectroscopy and by meas...

journal_title：IUBMB life

authors： Karmodiya K,Sajad S,Sinha S,Maity K,Suguna K,Surolia N

更新日期：2007-07-01 00:00:00

abstract：:Recently the crystal structure of creatine kinase from Torpedocalifornica was determined to 2.1 A. The dimeric structure revealed two different forms in the unit cell: one monomer was bound to a substrate, MgADP, and the other monomer was bound to a transition-state analogue complex composed of MgADP, nitrate and crea...

journal_title：IUBMB life

authors： Wang PF,Flynn AJ,McLeish MJ,Kenyon GL

更新日期：2005-04-01 00:00:00

abstract：:Increasing evidence suggests a role for intracellular reactive oxygen species (ROS) as mediators of normal and pathological signal transduction pathways. In particular, a growing list of recent reports have demonstrated a rapid and significant increases in intracellular ROS following growth factor or cytokine stimulat...

journal_title：IUBMB life

authors： Finkel T

更新日期：2001-07-01 00:00:00

abstract：:S-Nitrosation is rapidly emerging as a regulatory mechanism in vascular biology, with particular importance in the onset of hyperpermeability induced by pro-inflammatory agents. This review focuses on the role of endothelial nitric oxide synthase (eNOS)-derived nitric oxide (NO) in regulating S-Nitrosation of adherens...

journal_title：IUBMB life

authors： Durán WN,Beuve AV,Sánchez FA

更新日期：2013-10-01 00:00:00

abstract：:Traumatic optic neuropathy is an important cause of severe vision loss. So, many attempts were performed to transplant stem cells systemically or locally to regenerate the injured retina. In this study, we investigated the effect of human umbilical cord blood mesenchymal stem cells (hUBMSCs) on histological structure,...

journal_title：IUBMB life

authors： Mohamed EM,Abdelrahman SA,Hussein S,Shalaby SM,Mosaad H,Awad AM

更新日期：2017-03-01 00:00:00

abstract：:Heparin and its various derivatives affect cancer progression in humans. In this study, we show that heparin uptaken intracellularly by melanoma cells activated a signaling cascade, which in turn inhibited melanoma cell adhesion and migration. The reduced ability of M5 cells to adhere onto the fibronectin (FN) substra...

journal_title：IUBMB life

authors： Chalkiadaki G,Nikitovic D,Berdiaki A,Katonis P,Karamanos NK,Tzanakakis GN

更新日期：2011-02-01 00:00:00

abstract：:For 8 years, it was not understood why certain genes of plant mitochondria contain CGG (arginine) codons at positions where tryptophan codons (UGG) are present in the corresponding genes of nonplant species. Identification and sequencing of a tRNA(Trp) gene showed that it is not able to decode the CGG codon. Analysis ...

journal_title：IUBMB life

authors： Grienenberger JM

更新日期：2009-12-01 00:00:00

abstract：:Transforming growth factorbeta1 (TGFbeta1) is considered to be the principal contributor to liver fibrosis. So in this study the ribozymes against TGFbeta1 were designed. The in vitro cleavage activities of the ribozymes were assayed through incubation of (32)p-labeled target RNAs and (32)p-labeled ribozymes in differ...

journal_title：IUBMB life

authors： Song YH,Zhou XM,Xue XN,Liu NZ,Tian DA,Kong XJ,Wu XL,Lin JS,Jin YX

更新日期：2005-01-01 00:00:00