Magnetic nanoparticles for targeted vascular delivery.

abstract：:In the present study we demonstrated Jurkat leukemia cell lines of TIB152 and TIB153 with different sensitivities to recombinant soluble TRAIL cytotoxicity. TRAIL receptor death receptor 5 (DR5) was constitutively localized in the rafts in both cell lines. FADD, caspase-8, and PI3K-p85 subunit were recruited into DR5 ...

journal_title：IUBMB life

authors： Min Y,Shi J,Zhang Y,Liu S,Liu Y,Zheng D

更新日期：2009-03-01 00:00:00

abstract：:Ten-eleven translocation (TET) family enzymes convert 5-methylcytosine to 5-hydroxymethylcytosine in DNA. However, the role of TET enzymes in human gastric cancer remains unknown. Here, we show that TET2 mRNA and protein levels are downregulated in human gastric cancer tissues when compared with normal gastric mucosa....

journal_title：IUBMB life

authors： Deng W,Wang J,Zhang J,Cai J,Bai Z,Zhang Z

更新日期：2016-05-01 00:00:00

abstract：:Synucleinopathies are neurodegenerative diseases characterized by the accumulation of either neuronal/axonal or glial insoluble proteinaceous aggregates mainly composed of α-synuclein (α-syn). Among them, the most common disorders are Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and some fo...

journal_title：IUBMB life

authors： Longhena F,Faustini G,Brembati V,Pizzi M,Bellucci A

更新日期：2020-04-01 00:00:00

abstract：:The yeast Saccharomyces cerevisiae is an excellent model for gaining insights into the molecular basis of human mitochondrial disorders, particularly those resulting from impaired mitochondrial metabolism. Yeast is a very well characterized system and most of our current knowledge about mitochondrial biogenesis in hum...

journal_title：IUBMB life

authors： Barrientos A

更新日期：2003-02-01 00:00:00

abstract：:Transforming growth factorbeta1 (TGFbeta1) is considered to be the principal contributor to liver fibrosis. So in this study the ribozymes against TGFbeta1 were designed. The in vitro cleavage activities of the ribozymes were assayed through incubation of (32)p-labeled target RNAs and (32)p-labeled ribozymes in differ...

journal_title：IUBMB life

authors： Song YH,Zhou XM,Xue XN,Liu NZ,Tian DA,Kong XJ,Wu XL,Lin JS,Jin YX

更新日期：2005-01-01 00:00:00

abstract：:Various strategies have been applied to replace the loss of cardiomyocytes in order to restore reduced cardiac function and prevent the progression of heart disease. Intensive research efforts in the field of cellular reprogramming and cell transplantation may eventually lead to efficient in vivo applications for the ...

journal_title：IUBMB life

authors： Välimäki MJ,Ruskoaho HJ

更新日期：2020-01-01 00:00:00

abstract：:Transketolase (TK, EC 2.2.1.1), the key enzyme of the non-oxidative branch of pentose phosphate pathway of hydrocarbon transformation, plays an important role in a system of substrate rearrangement between pentose shunt and glycolysis, acting as a reversible link between the two metabolic pathways. In addition, it sup...

journal_title：IUBMB life

authors： Kochetov GA,Sevostyanova IA

更新日期：2010-11-01 00:00:00

abstract：:Occlusion of a coronary artery if maintained for longer period of time results in damage of the cardiac tissue. However, restoration of blood flow to previously ischemic tissue can itself induce further cardiac damage, a phenomenon known as myocardial reperfusion injury. Cardiac homoeostasis is supported by a network ...

journal_title：IUBMB life

authors： Rohrbach S,Troidl C,Hamm C,Schulz R

更新日期：2015-02-01 00:00:00

abstract：:Prostate specific antigen (PSA) is a serine protease that is exclusively produced in the prostate, and its detection is the only laboratory test available for screening men for prostate cancer (PC). The interpretation of the assay is difficult since it is specific for prostate tissue and cellular growth, but not for P...

journal_title：IUBMB life

authors： Mener DJ

更新日期：2010-08-01 00:00:00

abstract：:Cooperative effects in ligand binding and dissociation kinetics are much less investigated than steady state kinetics or equilibrium binding. Nevertheless, cooperativity in ligand binding leads necessarily to characteristic properties with respect to kinetic properties of the system. In case of positive cooperativity ...

journal_title：IUBMB life

authors： Hellmann N

更新日期：2011-05-01 00:00:00

abstract：:Small extracellular vesicle (sEV) has precise impacts on tumor microenvironment and play vital functions in intercellular interaction. However, the functional role of sEV miRNA on laryngeal squamous cell carcinoma (LSCC) is largely unresolved. Here, the expression of miR-1246 in LSCC tissues and plasma sEV was examine...

journal_title：IUBMB life

authors： Huang Q,Hsueh CY,Guo Y,Wu XF,Li JY,Zhou L

更新日期：2020-07-01 00:00:00

abstract：:Copper has a wide and important role in biological systems, determining conformation and activity of many metalloproteins and enzymes, such as cytochrome oxidase and superoxide dismutase . Furthermore, due to its possible reactivity with nonspecific proteins and toxic effects, elaborate systems of absorption, concentr...

journal_title：IUBMB life

authors： Inesi G

更新日期：2017-04-01 00:00:00

abstract：:Transfected human apoptosis signal-regulating kinase 1 (ASK1) produces a 150 kDa protein. However, we have detected endogenous ASK1 predominantly as 39 and 50 kDa C-terminal and 75 and 110 kDa N-terminal fragments in a panel of nontransfected cancer cell lines and HUVEC endothelial cells. This suggests that in nonapop...

journal_title：IUBMB life

authors： Stordal B,Davey R

更新日期：2008-03-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) is linked to the etiopathogenesis of Kaposi's sarcoma, a plasma-blastic variant of Castleman's disease and primary effusion lymphoma. KSHV is related to a number of non-human primate viruses. Only a limited number of KSHV proteins are expressed in tumor cells. He...

journal_title：IUBMB life

authors： Sharp TV,Boshoff C

更新日期：2000-02-01 00:00:00

abstract：:Release of arachidonic acid from membrane glycerophospholipids by cytosolic phospholipase A2 (cPLA2) is a key step in the generation of platelet-activating factor (PAF), recognized as the most proximal mediator of inflammatory events triggered by bacterial infection. Here, we report on the role of cPLA2 in the disturb...

journal_title：IUBMB life

authors： Slomiany BL,Slomiany A

更新日期：2006-04-01 00:00:00

abstract：:For more than a century, the metabolic role of lactate has intrigued physiologists and biochemists. Yet, for the first half of the last century lactate had been designated as a waste product, and assigned no additional significance besides its controversial role in muscle fatigue. The decline of the lactate hypothesis...

journal_title：IUBMB life

authors： Sola-Penna M

更新日期：2008-09-01 00:00:00

abstract：:The conformational stability of the homotetrameric Plasmodium falciparum beta-ketoacyl-ACP reductase (FabG) was determined by guanidinium chloride-induced isothermal and thermal denaturation. The reversible unfolding transitions were monitored by intrinsic fluorescence, circular dichroism (CD) spectroscopy and by meas...

journal_title：IUBMB life

authors： Karmodiya K,Sajad S,Sinha S,Maity K,Suguna K,Surolia N

更新日期：2007-07-01 00:00:00

abstract：:How cells regulate Gq efficacy (initiation and termination of Gq signaling) to effect response remains a central question in pharmacology and drug discovery. Phospholipase C-β1 (PLC-β1) is an effector and a GTPase activating protein (GAP) specific to Gαq. The physiological function of PLC-β1 GAP remains unclear and co...

journal_title：IUBMB life

authors： Litosch I

更新日期：2013-11-01 00:00:00

abstract：:The multifaceted relationship between mitochondria and the rest of the cell is reviewed in the context of myocardial ischemia. Paradoxically, mitochondria can exacerbate the ischemic damage, especially at the onset of reperfusion. Indeed, the recovery of oxidative phosphorylation in the presence of an excessive energy...

journal_title：IUBMB life

authors： Di Lisa F

更新日期：2001-09-01 00:00:00

abstract：:Increasing evidence suggests a role for intracellular reactive oxygen species (ROS) as mediators of normal and pathological signal transduction pathways. In particular, a growing list of recent reports have demonstrated a rapid and significant increases in intracellular ROS following growth factor or cytokine stimulat...

journal_title：IUBMB life

authors： Finkel T

更新日期：2001-07-01 00:00:00

abstract：:Unique opportunities are provided by phylogenetically closely related organisms thriving in stably cold, or temperate milieus to study adaptive modifications of structurally homologous molecules. These modifications are of keen interest in basic science as well as in biotechnology. This review highlights structural an...

journal_title：IUBMB life

authors： Alimenti C,Vallesi A,Pedrini B,Wüthrich K,Luporini P

更新日期：2009-08-01 00:00:00

abstract：:Transketolase (TK) is a homodimer, the simplest representative of thiamine diphosphate (ThDP)-dependent enzymes. It was first ThDP-dependent enzymes the crystal structure of which has been solved and revealed the general fold for this class of enzymes and the interactions of the non-covalently bound coenzyme ThDP with...

journal_title：IUBMB life

authors： Kochetov G,Sevostyanova IA

更新日期：2005-07-01 00:00:00

abstract：:Worldwide, one of the most prevalent forms of chronic disease is alcoholic fatty liver, which may progress to more severe forms of liver injury including steatohepatitis, fibrosis, and cirrhosis. The molecular mechanisms by which ethanol consumption causes accumulation of hepatic lipid are multiple and complex. Chroni...

journal_title：IUBMB life

authors： Rogers CQ,Ajmo JM,You M

更新日期：2008-12-01 00:00:00

abstract：:Vibrio cholerae is the causative agent of the diarrheal disease cholera, for which biofilm communities are considered to be environmental reservoirs. In endemic regions, and after algal blooms, which may result from phosphate enrichment following agricultural runoff, the bacterium is released from biofilms resulting i...

journal_title：IUBMB life

authors： Maestre-Reyna M,Huang WC,Wu WJ,Singh PK,Hartmann R,Wang PH,Lee CC,Hikima T,Yamamoto M,Bessho Y,Drescher K,Tsai MD,Wang AH

更新日期：2021-02-01 00:00:00

abstract：:In protein and RNA macromolecules, only a limited number of different side-chain chemical groups are available to function as catalysts. The myriad of enzyme-catalyzed reactions results from the ability of most of these groups to function either as nucleophilic, electrophilic, or general acid-base catalysts, and the k...

journal_title：IUBMB life

authors： Harris TK,Turner GJ

更新日期：2002-02-01 00:00:00

abstract：:Our results demonstrate that open reading frame (ORF) YHR076w on chromosome VIII of Saccharomyces cerevisiae that was previously described as a hypothetical gene is expressed. This ORF is transcribed as an mRNA of approximately 1,100 nucleotides. A 41.2-kDa polypeptide and three others predicted to be modified forms o...

journal_title：IUBMB life

authors： Ramos CW,Güldener U,Klein S,Hegemann JH,Gonzalez S,Rodríguez-Medina JR

更新日期：2000-12-01 00:00:00

abstract：:Selenium is an essential component of several enzymes and proteins in a number of methane-producing archae. Information concerning accessory proteins that function in selenium transport processes, however, is limited. A novel selenium-binding protein with a potential transport role and a selenocysteine lyase that serv...

journal_title：IUBMB life

authors： Stadtman T

更新日期：2004-07-01 00:00:00

abstract：:Extracellular matrix (ECM)-independent survival is an essential prerequisite for tumor metastasis, and a hallmark of epithelial cancer stem cells and epithelial-mesenchymal transition (EMT). Here, we found that loss of TP53I11 enhanced, and overexpression of TP53I11 suppressed the ECM-independent survival, EMT, and mi...

journal_title：IUBMB life

authors： Xiao T,Xu Z,Zhou Y,Zhang H,Geng J,Liang Y,Qiao H,Suo G

更新日期：2019-02-01 00:00:00

abstract：:Cisplatin (CP), as a chemotherapeutic drug, causes nephrotoxicity that has limited the clinical utility of CP. Gliclazide (GLZ), as an antihyperglycemic drug, at low dose has antioxidant property. In this study, we aimed to investigate the protective effect of GLZ against CP-induced acute renal injury. Sixty-four BALB...

journal_title：IUBMB life

authors： Taghizadeh F,Hosseinimehr SJ,Zargari M,Karimpour Malekshah A,Talebpour Amiri FB

更新日期：2020-09-01 00:00:00

abstract：:Bladder carcinoma is an important worldwide health problem. Both cystoscopy and urine cytology used in detecting bladder cancer suffer from drawbacks where cystoscopy is an invasive method and urine cytology shows low sensitivity in low-grade tumors. This study validates easier and less time-consuming techniques for t...

journal_title：IUBMB life

authors： Eissa S,Shabayek MI,Ismail MF,El-Allawy RM,Hamdy MA

更新日期：2010-05-01 00:00:00