Abstract:
:The ATP-sensitive potassium (K(ATP)) channel is expressed in most excitable tissues and plays a critical role in numerous physiological processes by coupling intracellular energetics to electrical activity. The channel is comprised of four Kir6.x subunits associated with four regulatory sulfonylurea receptors (SUR). Intracellular ATP acts on Kir6.x to inhibit channel activity, while MgADP stimulates channel activity through SUR. Changes in the cytosolic [ATP] to [ADP] ratio thus determine channel activity. Multiple mutations in Kir6.x and SUR genes have implicated K(ATP) channels in various diseases ranging from diabetes and hyperinsulinism to cardiac arrhythmias and cardiovascular disease. Continuing studies of channel physiology and pathology will bring new insights to the molecular basis of K(ATP) channel function, leading to a better understanding of the role that K(ATP) channels play in both health and disease.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Akrouh A,Halcomb SE,Nichols CG,Sala-Rabanal Mdoi
10.1002/iub.246subject
Has Abstractpub_date
2009-10-01 00:00:00pages
971-8issue
10eissn
1521-6543issn
1521-6551journal_volume
61pub_type
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