Abstract:
:Recently, three independent laboratories reported the generation of induced pluripotent stem cells (iPSCs) from pig (Sus scrofa). This finding sums to the growing list of species (mouse, human, monkey, and rat, in this order) for which successful reprogramming using exogenous factors has been achieved, and multiple others are possibly forthcoming. But apart from demonstrating the universality of the network identified by Shinya Yamanaka, what makes the porcine model so special? On one side, pigs are an agricultural commodity and have an easy and affordable maintenance compared with nonhuman primates that normally need to be imported. On the other side, resemblance (for example, size of organs) of porcine and human physiology is striking and because pigs are a regular source of food the ethical concerns that still remain in monkeys are not applicable. Besides, the prolonged lifespan of pigs compared with other domestic species can allow exhaustive follow up of side effects after transplantation. Porcine iPSCs may thus fill the gap between the mouse model, which due to its ease is preferred for mechanistic studies, and the first clinical trials using iPSCs in humans. However, although these studies are relevant and have created significant interest they face analogous problems that we discuss herein together with potential new directions.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Esteban MA,Peng M,Deli Z,Cai J,Yang J,Xu J,Lai L,Pei Ddoi
10.1002/iub.307subject
Has Abstractpub_date
2010-04-01 00:00:00pages
277-82issue
4eissn
1521-6543issn
1521-6551journal_volume
62pub_type
杂志文章,评审相关文献
IUBMB LIFE文献大全abstract::Circular RNAs (circRNAs) are novel noncoding RNAs (ncRNAs) with covalently closed-loop structures that play an essential regulatory role in diverse malignancies, including esophageal squamous cell cancer (ESCC). Circ_0000654 expression in ESCC and its mechanism of action remains unclear. Real-time PCR (RT-PCR) was emp...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2202
更新日期:2020-03-01 00:00:00
abstract::Heat shock proteins (Hsps) are a highly conserved family of proteins. The regulation of expression of Hsps in Mycobacterium tuberculosis, is regulated both positively and negatively by alternate sigma factors and transcriptional DNA repressors, respectively. HspR is a negative regulator of expression of hsps, DnaK, Cl...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1438
更新日期:2015-11-01 00:00:00
abstract::Depurinating DNA adducts formed by aromatic hydrocarbons and catechol estrogen quinones play a major role in cancer initiation. Most of these adducts depurinate instantaneously, but some guanine adducts depurinate from DNA with half-lives of hours. We report here, that after 10 h at 37 °C, reaction of estradiol-3,4-qu...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.586
更新日期:2012-02-01 00:00:00
abstract::Altered activity of the proteolytic machine-the 26S proteasome is observed in many disease conditions. Hence, either inhibition or activation of the 26S proteasome is thought to be a novel therapy for treatment of certain diseases such as cancer and neurodegenerative disorders. In this study, we tested the potential o...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1735
更新日期:2018-05-01 00:00:00
abstract::The beta/alpha-barrel motif was once considered to be a single protein domain. In recent years, however, it has been shown to consist of smaller substructures displaying the ability to fold autonomously. Here we review the current status of experimental findings concerning the motif's folding behavior in the light of ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540214924
更新日期:2002-10-01 00:00:00
abstract::The faithful propagation of cellular signals in most organisms relies on the coordinated functions of a large family of protein kinases that share a conserved catalytic domain. The catalytic domain is a dynamic scaffold that undergoes large conformational changes upon activation. Most of these conformational changes, ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2253
更新日期:2020-06-01 00:00:00
abstract::Long noncoding RNAs (lncRNAs) play important roles in the initiation and progression of various cancers, including laryngeal squamous cell carcinoma (LSCC). Recently, lncRNA Sox2 overlapping transcript (SOX2-OT) has been identified as an oncogene in various cancers. However, the functional role and the regulatory mech...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2026
更新日期:2019-09-01 00:00:00
abstract::We previously found a novel glycosylphosphatidylinositol (GPI)-anchored glycoprotein designated GPI-80 that modulates complement receptor 3 integrin-dependent adhesion and in vitro transendothelial migration of neutrophils. In this study, we show that antibody-mediated cross-linking of GPI-80 led to rapid tyrosine pho...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/713803588
更新日期:2000-01-01 00:00:00
abstract::Availability of the human genome data has enabled the exploration of a huge amount of biological information encoded in it. There are extensive ongoing experimental efforts to understand the biological functions of the gene products encoded in the human genome. However, computational analysis can aid immensely in the ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540400006105
更新日期:2004-06-01 00:00:00
abstract::Specific RNAs can function as sinks for endogenous miRNAs, known as competing endogenous RNAs (ceRNAs). Here, we confirm a miR-124 mediated ceRNA crosstalk between LAMC1 and CD151 in hepatocellular carcinoma (HCC). miR-124 negatively regulates LAMC1 expression through two miRNA binding sites within its 3' untranslated...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1642
更新日期:2017-08-01 00:00:00
abstract::Papillary thyroid cancer (PTC) is the most common form of thyroid cancer, comprising 80% of all thyroid malignancies. The phosphoinositide-3-kinase-protein kinase B/Akt (PI3K-PKB/Akt) pathway is a main pathway in control of cell growth. Activated mTOR and Akt are involved in the development and progression of the PTC....
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2388
更新日期:2020-12-01 00:00:00
abstract::Exosomes are nano-sized extracellular vesicles containing a cell-specific biologically active cargo of proteins and genetic materials. Exosomes are constitutively released from almost all cell-types and affect neighboring or distant cells through a complex intercellular exchange of the genetic information and/or regul...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.2396
更新日期:2020-12-01 00:00:00
abstract::High-glucose-induced retinal tissue impairment is the major pathological phenotype of diabetic retinopathy. In an in vitro diabetic apoptosis cell model, we evaluated the function of long noncoding RNA, insulin growth factor 2 antisense (IGF2-AS) in high-glucose-injured human retinal pigment epithelial cells. A human ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2102
更新日期:2019-10-01 00:00:00
abstract::Magnetic targeting has shown promise to improve the efficacy and safety of different classes of therapeutic agents by enabling their active guidance to the site of disease and minimizing dissemination to nontarget tissues. However, its translation into clinic has proven difficult because of inherent limitations of tra...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.479
更新日期:2011-08-01 00:00:00
abstract::Recent structural studies of proteins mediating membrane fusion reveal intriguing similarities between diverse viral and mammalian systems. Particularly striking is the close similarity between the transmembrane envelope glycoproteins from the retrovirus HTLV-1 and the filovirus Ebola. These similarities suggest simil...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/713803503
更新日期:1999-08-01 00:00:00
abstract::In tsRSV-infected NRK (tsNRK) cells, pp60(v-src) reactivation by temperature-shift from a nonpermissive temperature, 39 C, to a permissive one, 32 degrees C, induced the production of inositol phosphates (IPt) and phosphatidylethanol (PEt). This was accompanied by an increase in membrane-associated protein kinase C (P...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/713803467
更新日期:1999-07-01 00:00:00
abstract::Selenium is an essential component of several enzymes and proteins in a number of methane-producing archae. Information concerning accessory proteins that function in selenium transport processes, however, is limited. A novel selenium-binding protein with a potential transport role and a selenocysteine lyase that serv...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540400008911
更新日期:2004-07-01 00:00:00
abstract::Insulin-like growth factor-1 (IGF-1) signaling is a key pathway in the control of cell growth and survival. Three critical nodes in the IGF-1 signaling pathway have been described in cardiomyocytes: protein kinase Akt/mammalian target of rapamycin (mTOR), Ras/Raf/extracellular signal-regulated kinase (ERK), and phosph...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1172
更新日期:2013-07-01 00:00:00
abstract::Studies have shown that despite the decreasing mortality rates of kidney cancer patients, its incidence is increasing. Therefore, a comprehensive re-evaluation of treatment options is necessary to provide appropriate treatments for the increasing number of patients. Moreover, the side effects caused by surgery, which ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.2384
更新日期:2020-11-01 00:00:00
abstract::We investigated the rosiglitazone (RSG) effect on adriamycin (ADM)-induced cardio toxicity in experimental animals. Forty adult Wistar male rats were separated into four groups as follows: normal control; RSG (10 mg/kg)-treated; ADM (10 mg/kg)-administered; and ADM (10 mg/kg) + RSG (10 mg/kg)-treated. Serum lipid leve...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2190
更新日期:2020-04-01 00:00:00
abstract::Nasal-type natural killer/T-cell lymphoma (NKTCL) is an aggressive malignancy with poor survival outcomes that is relatively resistant to chemotherapy. N6-Methyladenosine (m6A) modification, the most prevalent modification of eukaryotic messenger RNA, is involved in the progression of various tumors. However, it is un...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2410
更新日期:2020-11-17 00:00:00
abstract::Although proteins and nucleic acids consist of different chemical components, proteins can mimic structures and possibly also functions of nucleic acids. Recently, structural mimicry was observed between two elongation factors in bacterial protein biosynthesis leading to the introduction of the concept of macromolecul...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/713803471
更新日期:1999-07-01 00:00:00
abstract::Nuclear receptors (NRs) comprise a large family of proteins essential to manipulate various aspects of human biology. The class III of the NR family includes steroid hormone receptors (SHRs) involved in embryonic development, maintenance of differentiated cellular phenotypes, metabolism, and cell death. Dysfunction of...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540601019485
更新日期:2006-12-01 00:00:00
abstract::Cyclic AMP metabolism is essential for the survival of the social amoebae Dictyostelium discoideum. Three distinct adenylyl cyclases are expressed and required for the normal development of this simple eukaryote. The adenylyl cyclase expressed during aggregation, ACA, is related to the mammalian and Drosophila G prote...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540400013887
更新日期:2004-09-01 00:00:00
abstract::In the present study we demonstrated Jurkat leukemia cell lines of TIB152 and TIB153 with different sensitivities to recombinant soluble TRAIL cytotoxicity. TRAIL receptor death receptor 5 (DR5) was constitutively localized in the rafts in both cell lines. FADD, caspase-8, and PI3K-p85 subunit were recruited into DR5 ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.166
更新日期:2009-03-01 00:00:00
abstract::Tetrameric haemoglobins display a cooperative ligand binding behaviour, which has been attributed to the functional interrelationship between multiple ligand binding sites. The quantitative description of this feature was initially carried out with a phenomenological approach, which was limited to the functional effec...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.6
更新日期:2008-02-01 00:00:00
abstract::To explore the oxygen response regulators involved in thiol peroxidase gene (tpx) expression in Escherichia coli, we constructed a single-copy tpx-lacZ operon fusion and monitored tpx-lacZ expression in various genetic backgrounds. Expression of the tpx-lacZ fusion was increased 4-fold by aerobic growth. Anaerobic exp...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/713803496
更新日期:1999-08-01 00:00:00
abstract::We propose a new hypothesis for the molecular mechanism by which neuroglobin exerts its protective effect in hypoxia-induced cell death. Our recent observation of a very rapid electron-transfer reaction between ferrous neuroglobin and ferric cytochrome c is central to this hypothesis. In contrast to previously suggest...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.35
更新日期:2008-06-01 00:00:00
abstract::The multifaceted relationship between mitochondria and the rest of the cell is reviewed in the context of myocardial ischemia. Paradoxically, mitochondria can exacerbate the ischemic damage, especially at the onset of reperfusion. Indeed, the recovery of oxidative phosphorylation in the presence of an excessive energy...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540152846073
更新日期:2001-09-01 00:00:00
abstract::The best known NADPH oxidase is that of phagocytes-neutrophils and monocytes. In these cells, the enzyme manufactures large quantities of O2- and other reactive oxidants that are used for the purpose of killing invading microorganisms. Recent studies, however, have suggested that a number of other tissues contain NADP...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/713803730
更新日期:2000-10-01 00:00:00