Does a redox cycle provide a mechanism for setting the capacity of neuroglobin to protect cells from apoptosis?

abstract：:Ten-eleven translocation (TET) family enzymes convert 5-methylcytosine to 5-hydroxymethylcytosine in DNA. However, the role of TET enzymes in human gastric cancer remains unknown. Here, we show that TET2 mRNA and protein levels are downregulated in human gastric cancer tissues when compared with normal gastric mucosa....

journal_title：IUBMB life

authors： Deng W,Wang J,Zhang J,Cai J,Bai Z,Zhang Z

更新日期：2016-05-01 00:00:00

abstract：:Mutations in the breast cancer susceptibility gene BRCA1 predispose individuals to breast and ovarian cancers. Cofactor of BRCA1 (COBRA1), a novel protein, was isolated as a BRCA1-interacting protein. However, the role of COBRA1 in breast cancer is poorly understood. In this study, we demonstrate that COBRA1 mRNA was ...

journal_title：IUBMB life

authors： Zhu J,Song S,Jiang Z,Yan J,Lu Q,Huang C,Ye Q

更新日期：2004-03-01 00:00:00

abstract：:The invasion and chemoresistance are crucial causes of morbidity and relapse for cancer patients. Axl is implicated in the modulation of cell invasion, cancer metastasis, and chemosensitivity in human breast carcinoma cell lines. Both breast cancer cell lines and tissues displayed increased expression of Axl, and it o...

journal_title：IUBMB life

authors： Li Y,Jia L,Ren D,Liu C,Gong Y,Wang N,Zhang X,Zhao Y

更新日期：2014-07-01 00:00:00

abstract：:How cells regulate Gq efficacy (initiation and termination of Gq signaling) to effect response remains a central question in pharmacology and drug discovery. Phospholipase C-β1 (PLC-β1) is an effector and a GTPase activating protein (GAP) specific to Gαq. The physiological function of PLC-β1 GAP remains unclear and co...

journal_title：IUBMB life

authors： Litosch I

更新日期：2013-11-01 00:00:00

abstract：:Human ecto-ATPase (ecto-nucleoside triphosphate diphosphohydrolase 2 [eNTPDase2], also known as CD39L1) has been expressed and characterized in COS cells. It exhibits some unusual enzymology that is similar to a few members of this class of proteins but different from the majority of the family members. Hydrolysis of ...

journal_title：IUBMB life

authors： Hicks-Berger CA,Kirley TL

更新日期：2000-07-01 00:00:00

abstract：:Tilorone hydrochloride, a low-molecular-weight synthetic compound, induces interferon production and has been reported to have both antiviral and antitumor activities. Here, we have demonstrated the ability of tilorone to activate NK cells and specific subpopulations of cytotoxic CD4+ and CD8+ T lymphocytes that recog...

journal_title：IUBMB life

authors： Sharapova TN,Romanova EA,Sashchenko LP,Yashin DV

更新日期：2019-03-01 00:00:00

abstract：:The posttranscriptional regulation of miRNAs is important for organism development. To investigate the role of miRNAs in angiogenesis, we performed a loss-of-function screening assay in human umbilical vein endothelial cells (HUVECs) and found that knockdown of 7 miRNAs (miR-95a, miR-126, miR-129, miR-137, miR-139, mi...

journal_title：IUBMB life

authors： Li YX,Liu DQ,Zheng C,Zheng SQ,Liu M,Li X,Tang H

更新日期：2011-07-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is one of the most common endocrine-metabolic disorders; however, its pathophysiology is still unclear. Certain polymorphisms of luteinizing hormone beta-subunit (LHβ) and LH/choriogonadotrophin receptor (LHCGR) genes may lead to changes in the bioactivity of this hormone. We aimed to ...

journal_title：IUBMB life

authors： El-Shal AS,Zidan HE,Rashad NM,Abdelaziz AM,Harira MM

更新日期：2016-01-01 00:00:00

abstract：:The immunosuppressant cyclosporin A (CsA)-sensitive nuclear factor of activated T cells 1 (NFAT1) has been known to be a transcriptional regulator of cytokine and viral genes during the immune response. By analyses of serial deletion, mutation, and heterologous promoter assay, we report here that the CsA-sensitive NFA...

journal_title：IUBMB life

authors： Lee JH,Rho HM

更新日期：2001-04-01 00:00:00

abstract：:The cancer microenvironment and the interactions between cancer and surrounding tissue cells are thought to play a pivotal role in tumor development and progression. Glycosaminoglycans (GAGs)/proteoglycans (PGs) are major constituents of the extracellular matrix, the composition of which may affect various cellular fu...

journal_title：IUBMB life

authors： Chatzinikolaou G,Nikitovic D,Asimakopoulou A,Tsatsakis A,Karamanos NK,Tzanakakis GN

更新日期：2008-05-01 00:00:00

abstract：:In this study, the impact of pancreatic cancer cell interaction with macrophages on the differentiation and function of macrophages and the behaviors of pancreatic cancer cells in vitro is evaluated. The expression of immunocompetent cell-associated markers in 22 pancreatic cancer specimens was characterized by immuno...

journal_title：IUBMB life

authors： Meng F,Li C,Li W,Gao Z,Guo K,Song S

更新日期：2014-12-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common malignancies with poor prognosis. Oxaliplatin-based chemotherapy is an important treatment for CRC; however, the cells develop resistance to therapy. The mechanisms underlying oxaliplatin resistance are complex and unclear. There is increasing evidence that microRNAs (...

journal_title：IUBMB life

authors： Moradi Marjaneh R,Khazaei M,Ferns GA,Avan A,Aghaee-Bakhtiari SH

更新日期：2019-10-01 00:00:00

abstract：:Cancer seriously impairs human health and survival. Many perturbations, such as increased oxidative stress, pathogen infection, and inflammation, promote the accumulation of DNA mutations, and ultimately lead to carcinogenesis. Tea is one of the most highly consumed beverages worldwide and has been linked to improveme...

journal_title：IUBMB life

authors： Fan X,Xiao X,Mao X,Chen D,Yu B,Wang J,Yan H

更新日期：2021-02-01 00:00:00

abstract：:Recent successes in identifying the genes and associated proteins underlying several familial neurodegenerative conditions have not always resulted in accounts as to why the associated patterns of neuronal damage are so specific and limited. Here, with reference to Huntington's disease, we present a general scheme to ...

journal_title：IUBMB life

authors： Mitchell IJ,Griffiths MR

更新日期：2003-06-01 00:00:00

abstract：:Cellular nucleic acid binding protein (CNBP) has been implicated in vertebrate craniofacial development and in myotonic dystrophy type 2 (DM2) and sporadic inclusion body myositis (sIBM) human diseases. In these seemingly unrelated biological processes, CNBP appears to be involved in controlling cell death and prolife...

journal_title：IUBMB life

authors： Calcaterra NB,Armas P,Weiner AM,Borgognone M

更新日期：2010-10-01 00:00:00

abstract：:Immune infiltration of tumors has been increasingly accepted as a prognostic factor in colon cancer. Here, we aim to develop a novel immune signature, based on estimated immune landscape from tumor transcriptomes, to predict the overall survival of patients with colon cancer. The compositions of 22 immune cell subtype...

journal_title：IUBMB life

authors： Peng D,Wang L,Li H,Cai C,Tan Y,Xu B,Le H

更新日期：2019-11-01 00:00:00

abstract：:Selenium is an essential component of several enzymes and proteins in a number of methane-producing archae. Information concerning accessory proteins that function in selenium transport processes, however, is limited. A novel selenium-binding protein with a potential transport role and a selenocysteine lyase that serv...

journal_title：IUBMB life

authors： Stadtman T

更新日期：2004-07-01 00:00:00

abstract：:It is known that that human serum albumin (HSA) and alpha-lactalbumin (LA) possess DNA-binding sites. Electrophoretically homogeneous HSA and LA containing no canonical enzymes were isolated from human sera and milk. Here we have analyzed for the first time the possibility of DNA hydrolysis by these proteins. It was s...

journal_title：IUBMB life

authors： Soboleva SE,Guschina TA,Nevinsky GA

更新日期：2018-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is a devastating neurodegenerative disorder that results in loss of memory and cognitive function, eventually leading to dementia. A key neuropathological event in AD is the cerebral accumulation of senile plaques formed by aggregates of amyloid-β-peptides (Aβ). Aβ results from two sequential ...

journal_title：IUBMB life

authors： Tamagno E,Guglielmotto M,Monteleone D,Vercelli A,Tabaton M

更新日期：2012-12-01 00:00:00

abstract：:This study was expected to reveal the regulatory effects of lncRNA UCA1 on pancreatic cancer cell progression through targeting miR-96/FOXO3. Microarray analysis was carried out on 36 cases of pancreatic cancer tissues and 16 cases of adjacent tissues among them. Expression levels of lncRNA UCA1, miR-96, and FOXO3 in ...

journal_title：IUBMB life

authors： Zhou Y,Chen Y,Ding W,Hua Z,Wang L,Zhu Y,Qian H,Dai T

更新日期：2018-04-01 00:00:00

abstract：:A pool of Plasmodium falciparum casein kinase 1 (PfCK1) has been shown to localize to the host red blood cell (RBC) membrane and be secreted to the extracellular medium during trophozoite stage of development. We attempted to identify mechanisms for secretion of PfCK1 and its appearance on the RBC membrane. We found t...

journal_title：IUBMB life

authors： Batty MB,Schittenhelm RB,Dorin-Semblat D,Doerig C,Garcia-Bustos JF

更新日期：2020-06-01 00:00:00

abstract：:Although vitamin E has been recognized as a critical micronutrient to neuronal health for more than half a century, vitamin E transport and regulation in the brain remain a mystery. Currently, the majority of what is known about vitamin E transport has been delineated in the liver. However, clues from the pathogenesis...

journal_title：IUBMB life

authors： Lee P,Ulatowski LM

更新日期：2019-04-01 00:00:00

abstract：:Pilins or fimbrilins are a class of proteins found in bacterial surface pilus, a hair-like surface appendage. Both the Gram-negative and -positive bacteria produce pilins to assemble pili on their cell-surface for different purposes including adherence, twitching motility, conjugation, immunomodulation, biofilm format...

journal_title：IUBMB life

authors： Krishnan V

更新日期：2015-07-01 00:00:00

abstract：:Increasing evidence suggests a role for intracellular reactive oxygen species (ROS) as mediators of normal and pathological signal transduction pathways. In particular, a growing list of recent reports have demonstrated a rapid and significant increases in intracellular ROS following growth factor or cytokine stimulat...

journal_title：IUBMB life

authors： Finkel T

更新日期：2001-07-01 00:00:00

abstract：:Since about 60 years a phenomenon now called permeability transition is known in mitochondria. It involves a large pore in the inner mitochondrial membrane, the permeability transition pore (PTP) whose molecular structure is still unknown. Year after year, new hypotheses have been developed how this pore could look li...

journal_title：IUBMB life

authors： Siemen D,Ziemer M

更新日期：2013-03-01 00:00:00

abstract：:We propose a new hypothesis for the molecular mechanism by which neuroglobin exerts its protective effect in hypoxia-induced cell death. Our recent observation of a very rapid electron-transfer reaction between ferrous neuroglobin and ferric cytochrome c is central to this hypothesis. In contrast to previously suggest...

journal_title：IUBMB life

authors： Fago A,Mathews AJ,Brittain T

更新日期：2008-06-01 00:00:00

abstract：:Peroxynitrite is an inorganic toxin of physiological interest, formed from the diffusion-controlled reaction of superoxide and nitrogen monoxide with a rate constant of (1.6 +/- 0.3) x 10(10) M(-1) s(-1). On the basis of three experiments we conclude that homolysis of the O-O bond in peroxynitrous acid is unlikely: (1...

journal_title：IUBMB life

authors： Kissner R,Nauser T,Kurz C,Koppenol WH

更新日期：2003-10-01 00:00:00

abstract：:Release of arachidonic acid from membrane glycerophospholipids by cytosolic phospholipase A2 (cPLA2) is a key step in the generation of platelet-activating factor (PAF), recognized as the most proximal mediator of inflammatory events triggered by bacterial infection. Here, we report on the role of cPLA2 in the disturb...

journal_title：IUBMB life

authors： Slomiany BL,Slomiany A

更新日期：2006-04-01 00:00:00

abstract：:Pancreatic islet beta-cells are poised to generate metabolic messengers in the mitochondria that link glucose metabolism to insulin exocytosis. This is accomplished through the tight coupling of glycolysis to mitochondrial activation. The messenger molecules ATP and glutamate are produced after the metabolism of glyco...

journal_title：IUBMB life

authors： Ishihara H,Wollheim CB

更新日期：2000-05-01 00:00:00

abstract：:High throughput microarrays were initially developed to analyse the expression of many RNA transcripts in parallel. The technology has since been adapted to a variety of applications, one of which is the analysis of the genome to study DNA dosage and sequence content. Advances in microarray fabrication and completion ...

journal_title：IUBMB life

authors： Waddell N

更新日期：2008-07-01 00:00:00