Abstract:
:Although proteins and nucleic acids consist of different chemical components, proteins can mimic structures and possibly also functions of nucleic acids. Recently, structural mimicry was observed between two elongation factors in bacterial protein biosynthesis leading to the introduction of the concept of macromolecular mimicry. Macromolecular mimicry has further been proposed among initiation and release factors, thereby adding a new element to the description of protein synthesis in bacteria. Such mimicry has also been observed in other biological processes such as autoimmunity, DNA repair, and gene regulation, at both transcriptional and translational levels.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Pedersen GN,Nyborg J,Clark BFdoi
10.1080/713803471keywords:
subject
Has Abstractpub_date
1999-07-01 00:00:00pages
13-8issue
1eissn
1521-6543issn
1521-6551journal_volume
48pub_type
杂志文章,评审相关文献
IUBMB LIFE文献大全abstract::Cellular nucleic acid binding protein (CNBP) has been implicated in vertebrate craniofacial development and in myotonic dystrophy type 2 (DM2) and sporadic inclusion body myositis (sIBM) human diseases. In these seemingly unrelated biological processes, CNBP appears to be involved in controlling cell death and prolife...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.379
更新日期:2010-10-01 00:00:00
abstract::Interplay between the apoptosis, DNA damage, and oxidative stress as a host response to dengue viral infections remains unclear. Peripheral blood mononuclear cells (PBMCs) were isolated from 60 dengue infected patients, 20 patients with febrile illness other than dengue (OFI) and 10 non-febrile illness (NFI) patients....
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1925
更新日期:2018-11-01 00:00:00
abstract::Treatment of microsomes (preferably enriched with endoplasmic reticulum) isolated from bovine pulmonary artery smooth muscle tissue with the O2*- -generating system (hypoxanthine (HPX) plus xanthine oxidase (XO)), markedly stimulated matrix metalloproteinase-2 (MMP-2) activity and also enhanced Ca2+ ATPase activity an...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/1521654041000171335
更新日期:2004-05-01 00:00:00
abstract::T cell (TC) activation requires the coordinated signaling of the T cell receptor (TCR) and coreceptor molecules, allowing TCs to respond to lower degrees of TCR occupancy. Coreceptor molecules set the threshold for TC activation by controlling different regulatory signaling loops. The Cbl family members prevent undesi...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.554
更新日期:2011-10-01 00:00:00
abstract::Release of arachidonic acid from membrane glycerophospholipids by cytosolic phospholipase A2 (cPLA2) is a key step in the generation of platelet-activating factor (PAF), recognized as the most proximal mediator of inflammatory events triggered by bacterial infection. Here, we report on the role of cPLA2 in the disturb...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540600732021
更新日期:2006-04-01 00:00:00
abstract::The faithful propagation of cellular signals in most organisms relies on the coordinated functions of a large family of protein kinases that share a conserved catalytic domain. The catalytic domain is a dynamic scaffold that undergoes large conformational changes upon activation. Most of these conformational changes, ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2253
更新日期:2020-06-01 00:00:00
abstract::Extracellular matrix (ECM)-independent survival is an essential prerequisite for tumor metastasis, and a hallmark of epithelial cancer stem cells and epithelial-mesenchymal transition (EMT). Here, we found that loss of TP53I11 enhanced, and overexpression of TP53I11 suppressed the ECM-independent survival, EMT, and mi...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1949
更新日期:2019-02-01 00:00:00
abstract::For 8 years, it was not understood why certain genes of plant mitochondria contain CGG (arginine) codons at positions where tryptophan codons (UGG) are present in the corresponding genes of nonplant species. Identification and sequencing of a tRNA(Trp) gene showed that it is not able to decode the CGG codon. Analysis ...
journal_title:IUBMB life
pub_type: 历史文章,杂志文章,评审
doi:10.1002/iub.277
更新日期:2009-12-01 00:00:00
abstract::Bladder carcinoma is an important worldwide health problem. Both cystoscopy and urine cytology used in detecting bladder cancer suffer from drawbacks where cystoscopy is an invasive method and urine cytology shows low sensitivity in low-grade tumors. This study validates easier and less time-consuming techniques for t...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.325
更新日期:2010-05-01 00:00:00
abstract::In vivo site-directed mutagenesis by single-stranded deoxyribonucleic acid recombineering is a facile method to change the color of fluorescent proteins (FPs) without cloning. Two different starting alleles of GFP were targeted for mutagenesis: gfpmut3* residing in the Escherichia coli genome and egfp carried by a bac...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1041
更新日期:2012-08-01 00:00:00
abstract::In this article, we discuss single molecule observation of rotational catalysis by E. coli ATP synthase (F-ATPase) using small gold beads. Studies involving a low viscous drag probe showed the stochastic properties of the enzyme in alternating catalytically active and inhibited states. The importance of subunit intera...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1134
更新日期:2013-03-01 00:00:00
abstract::Reactive oxygen and nitrogen species (ROS and RNS) have been extensively recognized as important signaling molecules implicated in physiological processes such as gene expression, cell differentiation and immune activation. Nevertheless, continuous production of these species may produce oxidative and/or nitrosative s...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540310001628717
更新日期:2003-10-01 00:00:00
abstract::Cyclic AMP metabolism is essential for the survival of the social amoebae Dictyostelium discoideum. Three distinct adenylyl cyclases are expressed and required for the normal development of this simple eukaryote. The adenylyl cyclase expressed during aggregation, ACA, is related to the mammalian and Drosophila G prote...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/15216540400013887
更新日期:2004-09-01 00:00:00
abstract::Changes in the status of DNA methylation are one of the most common molecular alterations in human neoplasia. We aimed to identify epigenetic molecular markers in serum for early detection of breast cancer. Authors analyzed retrospectively the methylation status of RARβ2 and APC genes in serum samples from 121 breast ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1346
更新日期:2015-01-01 00:00:00
abstract::We have adapted the Java Molecular Viewer (JMV) to virtual reality display environments, through a number of extensions to the Java 3D code. Phylogenetic information derived from multiple alignments (temporal information) can be overlaid onto molecule structures (spatial information). The number of sequences included ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/1521654031000136255
更新日期:2003-04-01 00:00:00
abstract::Cancer seriously impairs human health and survival. Many perturbations, such as increased oxidative stress, pathogen infection, and inflammation, promote the accumulation of DNA mutations, and ultimately lead to carcinogenesis. Tea is one of the most highly consumed beverages worldwide and has been linked to improveme...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.2445
更新日期:2021-02-01 00:00:00
abstract::In this study, the impact of pancreatic cancer cell interaction with macrophages on the differentiation and function of macrophages and the behaviors of pancreatic cancer cells in vitro is evaluated. The expression of immunocompetent cell-associated markers in 22 pancreatic cancer specimens was characterized by immuno...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1336
更新日期:2014-12-01 00:00:00
abstract::Small extracellular vesicle (sEV) has precise impacts on tumor microenvironment and play vital functions in intercellular interaction. However, the functional role of sEV miRNA on laryngeal squamous cell carcinoma (LSCC) is largely unresolved. Here, the expression of miR-1246 in LSCC tissues and plasma sEV was examine...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2274
更新日期:2020-07-01 00:00:00
abstract::Although vitamin E has been recognized as a critical micronutrient to neuronal health for more than half a century, vitamin E transport and regulation in the brain remain a mystery. Currently, the majority of what is known about vitamin E transport has been delineated in the liver. However, clues from the pathogenesis...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.1993
更新日期:2019-04-01 00:00:00
abstract::Vibrio cholerae is the causative agent of the diarrheal disease cholera, for which biofilm communities are considered to be environmental reservoirs. In endemic regions, and after algal blooms, which may result from phosphate enrichment following agricultural runoff, the bacterium is released from biofilms resulting i...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2439
更新日期:2021-02-01 00:00:00
abstract::Over the past decade, following the discovery of the human heme protein neuroglobin, many studies have searched for evidence for this protein's mechanism of action. Much data has accrued showing that high levels of neuroglobin will protect cells from apoptotic cell death, following a wide range of challenges. Various ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.405
更新日期:2010-12-01 00:00:00
abstract::Cocaine is a powerful central nervous stimulant and among the most abused of drugs. Despite decades of efforts, however, no effective pharmacological treatments are available against cocaine addiction or toxic effects. Classical receptor-antagonist therapeutic approaches have not yielded significant effects, although ...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1080/1521654031000138541
更新日期:2003-07-01 00:00:00
abstract::Prostate specific antigen (PSA) is a serine protease that is exclusively produced in the prostate, and its detection is the only laboratory test available for screening men for prostate cancer (PC). The interpretation of the assay is difficult since it is specific for prostate tissue and cellular growth, but not for P...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.355
更新日期:2010-08-01 00:00:00
abstract::The purpose of this study was to confirm protein-protein interaction between cyclooxygenase-1 (COX-1) and caveolins. The interaction of cyclooxygenase-1 and caveolins in the cultured human embryonic kidney (HEK 293) cells was investigated using immuno-precipitation and Western blot analysis. In HEK 293 cells, high lev...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1080/15216540410001699312
更新日期:2004-04-01 00:00:00
abstract::Upregulation of haptoglobin (Hp) expression in the rat during the acute phase (AP) response is the result of synergistic effects of IL-6-, IL-1beta-, and corticosterone-activated signaling pathways. IL-6 signaling terminates in cis-trans interactions of the Hp gene hormone-responsive element (HRE) with transcription f...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.313
更新日期:2010-03-01 00:00:00
abstract::Nasal-type natural killer/T-cell lymphoma (NKTCL) is an aggressive malignancy with poor survival outcomes that is relatively resistant to chemotherapy. N6-Methyladenosine (m6A) modification, the most prevalent modification of eukaryotic messenger RNA, is involved in the progression of various tumors. However, it is un...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2410
更新日期:2020-11-17 00:00:00
abstract::Toll-like receptors (TLRs) are a subset of pattern recognition receptors (PRR) in innate immunity and act as a connecting link between innate and adaptive immune systems. During Leishmania infection, the activation of TLRs influences the pathogen-specific immune responses, which may play a decisive role in determining...
journal_title:IUBMB life
pub_type: 杂志文章,评审
doi:10.1002/iub.2129
更新日期:2019-11-01 00:00:00
abstract::Papillary thyroid cancer (PTC) is the most common form of thyroid cancer, comprising 80% of all thyroid malignancies. The phosphoinositide-3-kinase-protein kinase B/Akt (PI3K-PKB/Akt) pathway is a main pathway in control of cell growth. Activated mTOR and Akt are involved in the development and progression of the PTC....
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.2388
更新日期:2020-12-01 00:00:00
abstract::Prostate cancer (PCa) is considered the most common malignancy in men. The aim of this study is to assess the role of serum miR-15a and miR-16-1 expression in PCa development, diagnosis and prognosis aiming to find a specific noninvasive biomarker. This study comprised 70 patients with PCa, 70 patients complaining of ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.1733
更新日期:2018-05-01 00:00:00
abstract::Cooperative effects in ligand binding and dissociation kinetics are much less investigated than steady state kinetics or equilibrium binding. Nevertheless, cooperativity in ligand binding leads necessarily to characteristic properties with respect to kinetic properties of the system. In case of positive cooperativity ...
journal_title:IUBMB life
pub_type: 杂志文章
doi:10.1002/iub.459
更新日期:2011-05-01 00:00:00