Abstract：
:How should a protein be designed to serve in processes as diverse as chromosome condensation, sister chromatid cohesion, DNA recombination, gene dosage regulation, and perhaps even gene silencing or transcriptional regulation--which occur in both mitosis and meiosis? Such a protein or protein complex needs to bear DNA interaction domains, it needs the capacity to use energy to move DNA, it needs to enter into highly specific protein interactions, it needs to be large enough to link two DNA molecules, it needs to be of sufficient flexibility to cope with different types of chromatin structure, yet it also needs to be rigid enough to pull, push or enclose DNA. SMC proteins fulfill these requirements and form the core units of high molecular weight complexes that act in all those processes, and are essential for some of them. SMC stands for 'Structural Maintenance of Chromosomes', although SMC proteins are not static scaffold proteins merely providing support for a particular chromosome structure. SMC proteins are rather highly dynamic actors, that generate and modulate chromosome structures, affecting a plethora of biological processes.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Jessberger Rdoi
10.1080/15216540310001639661keywords:
subject
Has Abstractpub_date
2003-12-01 00:00:00pages
643-52issue
12eissn
1521-6543issn
1521-6551journal_volume
55pub_type
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