A role for human neuroglobin in apoptosis.

abstract：:During the hand plate development, the processes of cell differentiation and control of cell death are relevant to ensure a correct shape of the limb. The progenitor cell pool that later will differentiate into cartilage to form the digits arises from undifferentiated mesenchymal cells beneath the apical ectodermal ri...

journal_title：IUBMB life

authors： Chimal-Monroy J,Abarca-Buis RF,Cuervo R,Díaz-Hernández M,Bustamante M,Rios-Flores JA,Romero-Suárez S,Farrera-Hernández A

更新日期：2011-10-01 00:00:00

abstract：:Studies have shown that despite the decreasing mortality rates of kidney cancer patients, its incidence is increasing. Therefore, a comprehensive re-evaluation of treatment options is necessary to provide appropriate treatments for the increasing number of patients. Moreover, the side effects caused by surgery, which ...

journal_title：IUBMB life

authors： Maleki Dana P,Reiter RJ,Hallajzadeh J,Asemi Z,Mansournia MA,Yousefi B

更新日期：2020-11-01 00:00:00

abstract：:In the Antarctic, fishes of dominant suborder Notothenioidei have evolved in a unique thermal scenario. Phylogenetically related taxa of the suborder live in a wide range of latitudes, in Antarctic, sub-Antarctic and temperate oceans. Consequently, they offer a remarkable opportunity to study the physiological and bio...

journal_title：IUBMB life

authors： Verde C,Giordano D,di Prisco G

更新日期：2008-01-01 00:00:00

abstract：:The aggressive biological behavior of invasive and metastatic cancer is considered to be the most insidious and life-threatening aspect for breast cancer patients. It is mostly the result of changes in many molecular characteristics of tumor cells, including alterations in gene expression and the balance of proteolyti...

journal_title：IUBMB life

authors： Swellam M,Arab LR,Bushnak HA

更新日期：2007-06-01 00:00:00

abstract：:Hepatocyte mitochondrial aquaporin-8 (mtAQP8) works as a multifunctional membrane channel protein that facilitates the uptake of ammonia for its detoxification to urea as well as the mitochondrial release of hydrogen peroxide. Since early oligonucleotide microarray studies in liver of cholesterol-fed mice showed an AQ...

journal_title：IUBMB life

authors： Danielli M,Capiglioni AM,Marrone J,Calamita G,Marinelli RA

更新日期：2017-05-01 00:00:00

abstract：:Acid fibroblast growth factor (aFGF) binds to its cell-surface receptors in a heparin-dependent manner. In an attempt to define the aFGF recognition site on fibroblast growth factor receptor 1 (FGFR1), we developed a screening strategy for identifying FGF ligands that bind to the receptor-binding region of FGF. To ret...

journal_title：IUBMB life

authors： Fan H,Liu Y,Zhou H,Wang L,Li W,Guo L,Roeske RW

更新日期：2000-06-01 00:00:00

abstract：:The human nuclear estrogen receptors (i.e., ERalpha and ERbeta), as other transcriptional factors, regulate cellular processes inducing genomic events. In addition, the binding of 17beta-estradiol to ERs induces different membrane initiating non-genomic signaling. The non-genomic effects of ER are independent of trans...

journal_title：IUBMB life

authors： Acconcia F,Bocedi A,Ascenzi P,Marino M

更新日期：2003-01-01 00:00:00

abstract：:Calcineurin (CN) is the only serine/threonine specific protein phosphatase regulated by Ca(2+) /calmodulin (CaM), which is composed of catalytic A subunit (CNA) and regulatory B subunit (CNB). Tumor necrosis factor (TNF) receptor associated factor 3 (TRAF3) is an essential component in the Toll like receptors and TNF ...

journal_title：IUBMB life

authors： Wang X,Huang Y,Li L,Wei Q

更新日期：2012-09-01 00:00:00

abstract：:Toll-like receptors (TLRs) are a subset of pattern recognition receptors (PRR) in innate immunity and act as a connecting link between innate and adaptive immune systems. During Leishmania infection, the activation of TLRs influences the pathogen-specific immune responses, which may play a decisive role in determining...

journal_title：IUBMB life

authors： Jafarzadeh A,Nemati M,Sharifi I,Nair A,Shukla D,Chauhan P,Khorramdelazad H,Sarkar A,Saha B

更新日期：2019-11-01 00:00:00

abstract：:How cells regulate Gq efficacy (initiation and termination of Gq signaling) to effect response remains a central question in pharmacology and drug discovery. Phospholipase C-β1 (PLC-β1) is an effector and a GTPase activating protein (GAP) specific to Gαq. The physiological function of PLC-β1 GAP remains unclear and co...

journal_title：IUBMB life

authors： Litosch I

更新日期：2013-11-01 00:00:00

abstract：:Cocaine is a powerful central nervous stimulant and among the most abused of drugs. Despite decades of efforts, however, no effective pharmacological treatments are available against cocaine addiction or toxic effects. Classical receptor-antagonist therapeutic approaches have not yielded significant effects, although ...

journal_title：IUBMB life

authors： Ascenzi P,Clementi E,Polticelli F

更新日期：2003-07-01 00:00:00

abstract：:Sirolimus(SRL, Rapamune(â), rapamycin) is a highly specific inhibitor of mammalian target of rapamycin (mTOR). Sirolimus exerts its biological activity by inhibiting the serine-threonine kinase mammalian target of rapamycin (mTOR), which regulates important cellular processes such as control of cell cycle, cell size, ...

journal_title：IUBMB life

authors： Wang Y,Zhao Q,Ma S,Yang F,Gong Y,Ke C

更新日期：2007-11-01 00:00:00

abstract：:Carbon monoxide (CO) is a gaseous transmitter that is known to be involved in several physiological processes, but surprisingly it is also becoming a promising molecule to treat several pathologies including stroke and cancer. CO can cross the plasma membrane and activate guanylate cyclase, increasing the cGMP concent...

journal_title：IUBMB life

authors： Retamal MA,León-Paravic CG,Ezquer M,Ezquer F,Del Rio R,Pupo A,Martínez AD,González C

更新日期：2015-06-01 00:00:00

abstract：:Ovarian cancer (OC) is one of the most lethal gynaecological cancers, which usually has a poor prognosis due to late diagnosis. A large percentage of the OC cell population is in a nonproliferating and quiescent stage, which poses a barrier to success when using most chemotherapeutic agents. Recent studies have shown ...

journal_title：IUBMB life

authors： Duncan K,Uwimpuhwe H,Czibere A,Sarkar D,Libermann TA,Fisher PB,Zerbini LF

更新日期：2012-07-01 00:00:00

abstract：:Pilins or fimbrilins are a class of proteins found in bacterial surface pilus, a hair-like surface appendage. Both the Gram-negative and -positive bacteria produce pilins to assemble pili on their cell-surface for different purposes including adherence, twitching motility, conjugation, immunomodulation, biofilm format...

journal_title：IUBMB life

authors： Krishnan V

更新日期：2015-07-01 00:00:00

abstract：:Tilorone hydrochloride, a low-molecular-weight synthetic compound, induces interferon production and has been reported to have both antiviral and antitumor activities. Here, we have demonstrated the ability of tilorone to activate NK cells and specific subpopulations of cytotoxic CD4+ and CD8+ T lymphocytes that recog...

journal_title：IUBMB life

authors： Sharapova TN,Romanova EA,Sashchenko LP,Yashin DV

更新日期：2019-03-01 00:00:00

abstract：:The complex life cycle of intracellular parasitic protozoans entails multiple rounds of DNA replication and mitosis followed by cytokinesis to release daughter parasites. To gain insights into mitotic events it is imperative to identify the biomarkers that constitute the chromosome segregation machinery in the parasit...

journal_title：IUBMB life

authors： Verma G,Surolia N

更新日期：2018-08-01 00:00:00

abstract：:Lead (Pb) is a toxic heavy metal that is harmful to humans, especially male reproductive organs. Luteolin (LUT) is a naturally occurring flavonoid with numerous biological activities. Our aim was to investigate the possible reproprotective effect of LUT against testicular deficits induced by Pb intoxication. In the pr...

journal_title：IUBMB life

authors： Al-Megrin WA,Alomar S,Alkhuriji AF,Metwally DM,Mohamed SK,Kassab RB,Abdel Moneim AE,El-Khadragy MF

更新日期：2020-08-01 00:00:00

abstract：:The last 15 years of effort in understanding bacterial DNA replication and repair has identified that the donut shaped beta2 sliding clamp is harnessed by very functionally different DNA polymerases throughout the lifecycle of the bacterial cell. Remarkably, the sites of binding of these polymerases, in most cases, ap...

journal_title：IUBMB life

authors： Wijffels G,Dalrymple B,Kongsuwan K,Dixon NE

更新日期：2005-06-01 00:00:00

abstract：:Ten-eleven translocation (TET) family enzymes convert 5-methylcytosine to 5-hydroxymethylcytosine in DNA. However, the role of TET enzymes in human gastric cancer remains unknown. Here, we show that TET2 mRNA and protein levels are downregulated in human gastric cancer tissues when compared with normal gastric mucosa....

journal_title：IUBMB life

authors： Deng W,Wang J,Zhang J,Cai J,Bai Z,Zhang Z

更新日期：2016-05-01 00:00:00

abstract：:Alzheimer's disease (AD) is a devastating neurodegenerative disorder that results in loss of memory and cognitive function, eventually leading to dementia. A key neuropathological event in AD is the cerebral accumulation of senile plaques formed by aggregates of amyloid-β-peptides (Aβ). Aβ results from two sequential ...

journal_title：IUBMB life

authors： Tamagno E,Guglielmotto M,Monteleone D,Vercelli A,Tabaton M

更新日期：2012-12-01 00:00:00

abstract：:The existence of a genetic component in mycobacterial disease susceptibility is no longer in doubt and the investigations now being conducted aim to determine which genes are involved, to what extent, and in which disease phenotype they are relevant. In certain rare instances of susceptibility to poorly pathogenic myc...

journal_title：IUBMB life

authors： Hoal EG

更新日期：2002-04-01 00:00:00

abstract：:Xanthomonas campestris pv. campestris, a plant-associated pathogenic bacterium, is the causal agent of foliar spots and blights in crucifers. The major outer membrane protein, Omp37, of 37 kDa, has been identified, purified to homogeneity, and its characterization has also been carried out. Native Omp37 behaved as a t...

journal_title：IUBMB life

authors： Wang L,Zheng Y,Zhang X

更新日期：2002-07-01 00:00:00

abstract：:This study was expected to reveal the regulatory effects of lncRNA UCA1 on pancreatic cancer cell progression through targeting miR-96/FOXO3. Microarray analysis was carried out on 36 cases of pancreatic cancer tissues and 16 cases of adjacent tissues among them. Expression levels of lncRNA UCA1, miR-96, and FOXO3 in ...

journal_title：IUBMB life

authors： Zhou Y,Chen Y,Ding W,Hua Z,Wang L,Zhu Y,Qian H,Dai T

更新日期：2018-04-01 00:00:00

abstract：:For 8 years, it was not understood why certain genes of plant mitochondria contain CGG (arginine) codons at positions where tryptophan codons (UGG) are present in the corresponding genes of nonplant species. Identification and sequencing of a tRNA(Trp) gene showed that it is not able to decode the CGG codon. Analysis ...

journal_title：IUBMB life

authors： Grienenberger JM

更新日期：2009-12-01 00:00:00

abstract：:We have adapted the Java Molecular Viewer (JMV) to virtual reality display environments, through a number of extensions to the Java 3D code. Phylogenetic information derived from multiple alignments (temporal information) can be overlaid onto molecule structures (spatial information). The number of sequences included ...

journal_title：IUBMB life

authors： Quon GT,Gordon P,Sensen CW

更新日期：2003-04-01 00:00:00

abstract：:In this review we discuss the limited efficacy for current pharmacological agents used in prophylaxis and treatment of thrombosis and highlight targeted delivery of anti-thrombotic agents to fibrin, platelets, red blood cells and endothelium. ...

journal_title：IUBMB life

authors： Carnemolla R,Muzykantov VR

更新日期：2011-08-01 00:00:00

abstract：:Duchenne and Becker muscular dystrophy (DMD/BMD) are X-linked muscular dystrophies. The isolation of the defective gene in DMD/BMD has led to a better understanding of the disease process and has promoted studies regarding the application of molecular therapy. The purpose of this review is to present the progress made...

journal_title：IUBMB life

authors： Matsuo M

更新日期：2002-03-01 00:00:00

abstract：:Calcium-sensing receptor (CaSR) contributes to maintain homeostatic levels of extracellular calcium. In addition, CaSR controls other cellular activities such as proliferation and migration, particularly in cells not related to extracellular calcium homeostasis, potentially by cross-talking with parallel signaling pat...

journal_title：IUBMB life

authors： Organista-Juárez D,Carretero-Ortega J,Vicente-Fermín O,Vázquez-Victorio G,Sosa-Garrocho M,Vázquez-Prado J,Macías-Silva M,Reyes-Cruz G

更新日期：2013-12-01 00:00:00

abstract：:Cardiac hypoxia plays a significant role in various types of heart disease, and improper treatment of hypoxia often leads to myocardial cell damage or even death. Transcriptome profiling and open chromatin mapping have been used as powerful tools to understand the development of heart disease, but the interplay betwee...

journal_title：IUBMB life

authors： Wang J,Wang Y,Duan Z,Hu W

更新日期：2020-08-01 00:00:00