Leishmania species-dependent functional duality of toll-like receptor 2.

abstract：:Synucleinopathies are neurodegenerative diseases characterized by the accumulation of either neuronal/axonal or glial insoluble proteinaceous aggregates mainly composed of α-synuclein (α-syn). Among them, the most common disorders are Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and some fo...

journal_title：IUBMB life

authors： Longhena F,Faustini G,Brembati V,Pizzi M,Bellucci A

更新日期：2020-04-01 00:00:00

abstract：:Heart disease is the most common cause of morbidity and mortality in Western society and the incidence is projected to increase significantly over the next few decades as our population ages. Heart failure occurs when the heart is unable to pump blood at a rate to commensurate with tissue metabolic requirements and re...

journal_title：IUBMB life

authors： Graham RM,Bishopric NH,Webster KA

更新日期：2002-08-01 00:00:00

abstract：:Peroxynitrite is an inorganic toxin of physiological interest, formed from the diffusion-controlled reaction of superoxide and nitrogen monoxide with a rate constant of (1.6 +/- 0.3) x 10(10) M(-1) s(-1). On the basis of three experiments we conclude that homolysis of the O-O bond in peroxynitrous acid is unlikely: (1...

journal_title：IUBMB life

authors： Kissner R,Nauser T,Kurz C,Koppenol WH

更新日期：2003-10-01 00:00:00

abstract：:Immune infiltration of tumors has been increasingly accepted as a prognostic factor in colon cancer. Here, we aim to develop a novel immune signature, based on estimated immune landscape from tumor transcriptomes, to predict the overall survival of patients with colon cancer. The compositions of 22 immune cell subtype...

journal_title：IUBMB life

authors： Peng D,Wang L,Li H,Cai C,Tan Y,Xu B,Le H

更新日期：2019-11-01 00:00:00

abstract：:The disappointing results from large clinical studies of α-tocopherol (αT), the major form of vitamin E in tissues, for prevention of chronic diseases including cancer have cast doubt on not only αT but also other forms of vitamin E regarding their role in preventing carcinogenesis. However, basic research has shown t...

journal_title：IUBMB life

authors： Jiang Q

更新日期：2019-04-01 00:00:00

abstract：:Apolipoprotein E (apoE) is a major constituent of lipoproteins mediating peripheral uptake of lipids including the lipid-soluble vitamin alpha-tocopherol (alpha-toc). In a recent study, we observed significant lower alpha-toc concentrations in the lung of apoE4 compared with apoE3 transgenic mice. In this study, we de...

journal_title：IUBMB life

authors： Huebbe P,Jofre-Monseny L,Rimbach G

更新日期：2009-04-01 00:00:00

abstract：:From a liver cDNA library prepared from a nonvenomous striated snake, Elaphe quadrivirgata, we isolated a cDNA encoding a novel protein, PLIalpha-like protein (PLIalpha-LP), having approximately 70% sequence identities with the alpha-type phospholipase A2 (PLA2) inhibitors (PLIalpha(s)) previously purified from the ve...

journal_title：IUBMB life

authors： Okumura K,Inoue S,Ikeda K,Hayashi K

更新日期：2003-09-01 00:00:00

abstract：:The rat organic anion transporter 3 (rOAT3) has recently been identified as the third isoform of the OAT family. The mechanisms that regulate rOAT3's functions remain to be elucidated. rOAT3 contributes for moving a number of negatively charged organic compounds between cells and their extracellular milieu. Caveolin (...

journal_title：IUBMB life

authors： Kwak JO,Kim HW,Song JH,Kim MJ,Park HS,Hyun DK,Kim DS,Cha SH

更新日期：2005-02-01 00:00:00

abstract：:Vibrio cholerae is the causative agent of the diarrheal disease cholera, for which biofilm communities are considered to be environmental reservoirs. In endemic regions, and after algal blooms, which may result from phosphate enrichment following agricultural runoff, the bacterium is released from biofilms resulting i...

journal_title：IUBMB life

authors： Maestre-Reyna M,Huang WC,Wu WJ,Singh PK,Hartmann R,Wang PH,Lee CC,Hikima T,Yamamoto M,Bessho Y,Drescher K,Tsai MD,Wang AH

更新日期：2021-02-01 00:00:00

abstract：:Stem cells from human exfoliated deciduous teeth (SHEDs) are highly proliferative, clonogenic, and multipotent stem cells with a neural crest cell origin. This property could be a desirable option for potential therapeutic applications. In this study, we focus on the effects of Rho kinase inhibitors Y-27632 and Noggin...

journal_title：IUBMB life

authors： Yang S,Xin C,Zhang B,Zhang H,Hao Y

更新日期：2020-04-01 00:00:00

abstract：:Mitochondria play a key role in death signaling. The intermembrane space of these organelles contains a number of proteins which promote cell death once they are redistributed to the cytosol. The formation of pores in the outer membrane of mitochondria defines a gateway through which the apoptogenic proteins pass duri...

journal_title：IUBMB life

authors： Smith DJ,Ng H,Kluck RM,Nagley P

更新日期：2008-06-01 00:00:00

abstract：:Anthracyclines are a class of antitumor drugs widely used for the treatment of a variety of malignancy, including leukemias, lymphomas, sarcomas, and carcinomas. Different mechanisms have been proposed for anthracycline antitumor effects including free-radical generation, DNA intercalation/binding, activation of signa...

journal_title：IUBMB life

authors： Mordente A,Meucci E,Martorana GE,Giardina B,Minotti G

更新日期：2001-07-01 00:00:00

abstract：:Cyclic AMP metabolism is essential for the survival of the social amoebae Dictyostelium discoideum. Three distinct adenylyl cyclases are expressed and required for the normal development of this simple eukaryote. The adenylyl cyclase expressed during aggregation, ACA, is related to the mammalian and Drosophila G prote...

journal_title：IUBMB life

authors： Kriebel PW,Parent CA

更新日期：2004-09-01 00:00:00

abstract：:The formation, maturation, and dissolution of focal adhesions are basic prerequisites of cell migration and rely on the recruitment, signalling, and endocytosis of integrins. In many instances, extracellular matrix molecules are recognised by a number of integrins, and it is the sequential involvement of different int...

journal_title：IUBMB life

authors： Morgan MR,Byron A,Humphries MJ,Bass MD

更新日期：2009-07-01 00:00:00

abstract：:Methionine (Met) is a neutral, sulfur-containing, essential amino acid with biological functions in the initiation and prolongation step of protein synthesis, transmethylation reactions, the synthesis of cysteine and cystine, and as a component of antioxidant systems. Its key importance is reflected by the fact that i...

journal_title：IUBMB life

authors： Mastrototaro L,Sponder G,Saremi B,Aschenbach JR

更新日期：2016-12-01 00:00:00

abstract：:In this study, the impact of pancreatic cancer cell interaction with macrophages on the differentiation and function of macrophages and the behaviors of pancreatic cancer cells in vitro is evaluated. The expression of immunocompetent cell-associated markers in 22 pancreatic cancer specimens was characterized by immuno...

journal_title：IUBMB life

authors： Meng F,Li C,Li W,Gao Z,Guo K,Song S

更新日期：2014-12-01 00:00:00

abstract：:Xanthomonas campestris pv. campestris, a plant-associated pathogenic bacterium, is the causal agent of foliar spots and blights in crucifers. The major outer membrane protein, Omp37, of 37 kDa, has been identified, purified to homogeneity, and its characterization has also been carried out. Native Omp37 behaved as a t...

journal_title：IUBMB life

authors： Wang L,Zheng Y,Zhang X

更新日期：2002-07-01 00:00:00

abstract：:Red blood cells of yellow-spotted river turtles (Podocnemis unifilis, Pleurodira, Chelonia, REPTILIA) have two hemoglobin (Hb) components, Hb A and Hb D. We purified the hemoglobin component homologous to amniote (reptiles, birds, and mammals) adult Hb A which comprises two identical α(A) -globin polypeptides and two ...

journal_title：IUBMB life

authors： Hasegawa T,Shishikura F,Kuwada T

更新日期：2011-03-01 00:00:00

abstract：:Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with impairments in social communication, restricted, repetitive and stereotyped behaviors. Both genetic and environmental factors are known to contribute toward pathophysiology of Autism. Environmental influences on gene expression can be mediate...

journal_title：IUBMB life

authors： Alex AM,Saradalekshmi KR,Shilen N,Suresh PA,Banerjee M

更新日期：2019-07-01 00:00:00

abstract：:To establish possible cancerous aggressiveness between the metabolism of variously labeled [14C]glucose in the human breast invasive ductal carcinoma (IDC) tissues, we measured the rates of 14CO2 production from those tissues by using radiorespirometry, expressing the results as initial velocity (V) in nanomoles of 14...

journal_title：IUBMB life

authors： Yan SH,Wallon J,Mayaudon J

更新日期：1999-10-01 00:00:00

abstract：:In this study, we intended to determine the detailed function and mechanism of long noncoding RNA (lncRNA) colorectal neoplasia differentially expressed (CRNDE) in liver injury induced by sepsis. Cecal ligation and perforation (CLP) models were adopted to induce sepsis in vivo with rats, and hepatic epithelial cells L...

journal_title：IUBMB life

authors： Li Y,Song J,Xie Z,Liu M,Sun K

更新日期：2020-03-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D3 [1,25(OH)2 D3 ] has recently been shown to have immunomodulatory property. This study aimed to investigate the expression and potential role of 1,25(OH)2 D3 in the pathogenesis of diabetic retinopathy (DR) in the Uygur population. Blood samples were obtained from 22 patients with proliferative...

journal_title：IUBMB life

authors： Yi X,Sun J,Li L,Wei Q,Qian Y,Chen X,Ma L

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:Heart diseases are common in the offspring of gestational diabetic mother (ODM). Defects in mitochondrial metabolism and autophagy may, in part, be responsible for the adverse structural and functional alterations in the heart. The principal objective of this study was to investigate cardiac mitochondrial res...

journal_title：IUBMB life

authors： Rajendran RS,Jayakumari NR,Sivasailam A,Reghuvaran AC,Pillai VV,Karunakaran J,Sreelatha HV,Manjunatha S,Gopala S

更新日期：2021-01-22 00:00:00

abstract：:Ten-eleven translocation (TET) family enzymes convert 5-methylcytosine to 5-hydroxymethylcytosine in DNA. However, the role of TET enzymes in human gastric cancer remains unknown. Here, we show that TET2 mRNA and protein levels are downregulated in human gastric cancer tissues when compared with normal gastric mucosa....

journal_title：IUBMB life

authors： Deng W,Wang J,Zhang J,Cai J,Bai Z,Zhang Z

更新日期：2016-05-01 00:00:00

abstract：:A large amount of evidence suggests a pathogenic link between cholesterol homeostasis dysregulation and Alzheimer's disease (AD). In cell culture systems, the production of amyloid-β (Aβ) is modulated by cholesterol, and studies on animal models have consistently demonstrated that hypercholesterolemia is associated wi...

journal_title：IUBMB life

authors： Ricciarelli R,Canepa E,Marengo B,Marinari UM,Poli G,Pronzato MA,Domenicotti C

更新日期：2012-12-01 00:00:00

abstract：:In this study, two different epitope tags (HA, c-myc) were introduced near the N terminus of the yeast PMA1 H(+)-ATPase. The resulting proteins were indistinguishable from the wild-type ATPase in their ability to travel through the secretory pathway, as judged by quantitative immunoblotting of isolated secretory vesic...

journal_title：IUBMB life

authors： dos Santos CF,DeWitt ND,Gupta SS,Allen KE,Slayman CW

更新日期：2000-02-01 00:00:00

abstract：:The best known NADPH oxidase is that of phagocytes-neutrophils and monocytes. In these cells, the enzyme manufactures large quantities of O2- and other reactive oxidants that are used for the purpose of killing invading microorganisms. Recent studies, however, have suggested that a number of other tissues contain NADP...

journal_title：IUBMB life

authors： Babior BM

更新日期：2000-10-01 00:00:00

abstract：:Cancer related inflammation (CRI) is now recognized as the seventh hallmark in the pathogenesis of many types of malignancies. Paeonol, a natural phenolic component isolated from the root bark of Paeonia moutan, has significant anti-inflammatory activity. Recently, accumulating body of research has revealed potent ant...

journal_title：IUBMB life

authors： Zhang L,Tao L,Shi T,Zhang F,Sheng X,Cao Y,Zheng S,Wang A,Qian W,Jiang L,Lu Y

更新日期：2015-10-01 00:00:00

abstract：:The existence of a genetic component in mycobacterial disease susceptibility is no longer in doubt and the investigations now being conducted aim to determine which genes are involved, to what extent, and in which disease phenotype they are relevant. In certain rare instances of susceptibility to poorly pathogenic myc...

journal_title：IUBMB life

authors： Hoal EG

更新日期：2002-04-01 00:00:00

abstract：:Renal ischemia/reperfusion (I/R) is an alternation of renal hemodynamics, which results in diverse postischemic responses and eventually acute kidney injury. Although renal ischemic preconditioning (IPC) is known to protect the kidney from I/R injury, the precise renoprotective mechanisms are not completely understood...

journal_title：IUBMB life

authors： Li JR,Ou YC,Wu CC,Wang JD,Lin SY,Wang YY,Chen WY,Chen CJ

更新日期：2019-03-01 00:00:00