Abstract:
:The cancer microenvironment and the interactions between cancer and surrounding tissue cells are thought to play a pivotal role in tumor development and progression. Glycosaminoglycans (GAGs)/proteoglycans (PGs) are major constituents of the extracellular matrix, the composition of which may affect various cellular functions. In the present study, the effects of GAGs on the proliferation of HT29, SW1116, and HCT116 human colon cancer cell lines were examined using exogenously added GAGs, an inhibitor of endogenous GAG sulfation and specific glycosidase digestions. Our results demonstrate that colon cancer cell growth was exclusively stimulated by exogenously added heparin and insensitive to endogenous GAGs/PGs production, in a sulfation pattern-related manner. Treatment of the tested cell lines with the FGF-2 neutralizing antibody showed that the stimulatory effect of heparin on the cells' growth was not FGF-2-dependent. Responsiveness of colon cancer cell lines to exogenous heparin/heparan sulfate may play a role in their growth and metastasis.
journal_name
IUBMB Lifejournal_title
IUBMB lifeauthors
Chatzinikolaou G,Nikitovic D,Asimakopoulou A,Tsatsakis A,Karamanos NK,Tzanakakis GNdoi
10.1002/iub.70subject
Has Abstractpub_date
2008-05-01 00:00:00pages
333-40issue
5eissn
1521-6543issn
1521-6551journal_volume
60pub_type
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