Effect of streptozotocin-induced diabetes on activities of cholinesterases in the rat retina.

abstract：:Tumstatin is a candidate tumor suppressor that plays an important role in tumor growth and angiogenesis. The purpose of this study was to evaluate the correlation between tumstatin-mRNA expression and the clinicopathologic characteristics, tumor angiogenesis, outcome of patients with non-small cell lung cancer (NSCLC)...

journal_title：IUBMB life

authors： Luo YQ,Ming Z,Zhao L,Yao LJ,Dong H,Du JP,Wu SZ,Hu W

更新日期：2012-05-01 00:00:00

abstract：:Transfected human apoptosis signal-regulating kinase 1 (ASK1) produces a 150 kDa protein. However, we have detected endogenous ASK1 predominantly as 39 and 50 kDa C-terminal and 75 and 110 kDa N-terminal fragments in a panel of nontransfected cancer cell lines and HUVEC endothelial cells. This suggests that in nonapop...

journal_title：IUBMB life

authors： Stordal B,Davey R

更新日期：2008-03-01 00:00:00

abstract：:The ATP-sensitive potassium (K(ATP)) channel is expressed in most excitable tissues and plays a critical role in numerous physiological processes by coupling intracellular energetics to electrical activity. The channel is comprised of four Kir6.x subunits associated with four regulatory sulfonylurea receptors (SUR). I...

journal_title：IUBMB life

authors： Akrouh A,Halcomb SE,Nichols CG,Sala-Rabanal M

更新日期：2009-10-01 00:00:00

abstract：:Interplay between the apoptosis, DNA damage, and oxidative stress as a host response to dengue viral infections remains unclear. Peripheral blood mononuclear cells (PBMCs) were isolated from 60 dengue infected patients, 20 patients with febrile illness other than dengue (OFI) and 10 non-febrile illness (NFI) patients....

journal_title：IUBMB life

authors： Cherupanakkal C,Samadanam DM,Muthuraman KR,Ramesh S,Venkatesan A,Balakrishna Pillai AK,Rajendiran S

更新日期：2018-11-01 00:00:00

abstract：:A pool of Plasmodium falciparum casein kinase 1 (PfCK1) has been shown to localize to the host red blood cell (RBC) membrane and be secreted to the extracellular medium during trophozoite stage of development. We attempted to identify mechanisms for secretion of PfCK1 and its appearance on the RBC membrane. We found t...

journal_title：IUBMB life

authors： Batty MB,Schittenhelm RB,Dorin-Semblat D,Doerig C,Garcia-Bustos JF

更新日期：2020-06-01 00:00:00

abstract：:Kaposi's sarcoma-associated herpesvirus (KSHV or HHV-8) is linked to the etiopathogenesis of Kaposi's sarcoma, a plasma-blastic variant of Castleman's disease and primary effusion lymphoma. KSHV is related to a number of non-human primate viruses. Only a limited number of KSHV proteins are expressed in tumor cells. He...

journal_title：IUBMB life

authors： Sharp TV,Boshoff C

更新日期：2000-02-01 00:00:00

abstract：:The 10th jubilee conference (IPK2019) took place on September 15-19, 2019 in Warsaw, on the Ochota campus as the IUBMB Focused Meeting entitled "Inhibitors of Protein Kinases. Kinase inhibitors in target biology and disease". ...

journal_title：IUBMB life

authors： Poznanski J,Fabbro D

更新日期：2020-06-01 00:00:00

abstract：:Transketolase (TK, EC 2.2.1.1), the key enzyme of the non-oxidative branch of pentose phosphate pathway of hydrocarbon transformation, plays an important role in a system of substrate rearrangement between pentose shunt and glycolysis, acting as a reversible link between the two metabolic pathways. In addition, it sup...

journal_title：IUBMB life

authors： Kochetov GA,Sevostyanova IA

更新日期：2010-11-01 00:00:00

abstract：:Induction of apoptosis is the target of choice for modern chemotherapeutic treatment of cancer, where lack of potent "target-specific" drugs has led to extensive research on anticancer compounds from natural sources. In our study, we have used astrakurkurone, a triterpene isolated from wild edible mushroom, Astraeus h...

journal_title：IUBMB life

authors： Dasgupta A,Dey D,Ghosh D,Lai TK,Bhuvanesh N,Dolui S,Velayutham R,Acharya K

更新日期：2019-07-01 00:00:00

abstract：:In vivo site-directed mutagenesis by single-stranded deoxyribonucleic acid recombineering is a facile method to change the color of fluorescent proteins (FPs) without cloning. Two different starting alleles of GFP were targeted for mutagenesis: gfpmut3* residing in the Escherichia coli genome and egfp carried by a bac...

journal_title：IUBMB life

authors： Valledor M,Hu Q,Schiller P,Myers RS

更新日期：2012-08-01 00:00:00

abstract：:The mammalian antizyme (AZ) promotes ubiqutin-independent degradation of ornithine decarboxylase, a key enzyme in polyamine biosynthesis. This study shows that AZ suppression in human lung carcinoma A549 cells caused growth defects and death, but made the cells resistant to DNA damaging agents such as gamma-radiation ...

journal_title：IUBMB life

authors： Kim JS,Kim TL,Cho EW,Paik SG,Chung HW,Kim IG

更新日期：2008-06-01 00:00:00

abstract：:In this article, the experiments used to construct the ambient pH-signaling network involved in the secretion of enzymes by filamentous fungi have been reviewed, focusing on the phosphate-repressible phosphatases in Aspergillus nidulans. Classic and molecular genetics have been used to demonstrate that proteolysis of ...

journal_title：IUBMB life

authors： Rossi A,Cruz AH,Santos RS,Silva PM,Silva EM,Mendes NS,Martinez-Rossi NM

更新日期：2013-11-01 00:00:00

abstract：:Insulin-like growth factor-1 (IGF-1) signaling is a key pathway in the control of cell growth and survival. Three critical nodes in the IGF-1 signaling pathway have been described in cardiomyocytes: protein kinase Akt/mammalian target of rapamycin (mTOR), Ras/Raf/extracellular signal-regulated kinase (ERK), and phosph...

journal_title：IUBMB life

authors： Troncoso R,Díaz-Elizondo J,Espinoza SP,Navarro-Marquez MF,Oyarzún AP,Riquelme JA,Garcia-Carvajal I,Díaz-Araya G,García L,Hill JA,Lavandero S

更新日期：2013-07-01 00:00:00

abstract：:It is known that that human serum albumin (HSA) and alpha-lactalbumin (LA) possess DNA-binding sites. Electrophoretically homogeneous HSA and LA containing no canonical enzymes were isolated from human sera and milk. Here we have analyzed for the first time the possibility of DNA hydrolysis by these proteins. It was s...

journal_title：IUBMB life

authors： Soboleva SE,Guschina TA,Nevinsky GA

更新日期：2018-06-01 00:00:00

abstract：:Fascin actin-bundling protein 1 (FSCN1) is an evolutionarily conserved actin-bundling protein that plays a critical role in cell migration, motility, adhesion, and cellular interactions. Although multiple clinical studies have implicated the expression of FSCN1 in laryngeal squamous cell carcinoma (LSCC) progression, ...

journal_title：IUBMB life

authors： Liu H,Cui J,Zhang Y,Niu M,Xue X,Yin H,Tang Y,Dai L,Dai F,Guo Y,Wu Y,Gao W

更新日期：2019-11-01 00:00:00

abstract：:Nasal-type natural killer/T-cell lymphoma (NKTCL) is an aggressive malignancy with poor survival outcomes that is relatively resistant to chemotherapy. N6-Methyladenosine (m6A) modification, the most prevalent modification of eukaryotic messenger RNA, is involved in the progression of various tumors. However, it is un...

journal_title：IUBMB life

authors： Ma H,Shen L,Yang H,Gong H,Du X,Li J

更新日期：2020-11-17 00:00:00

abstract：:Lead (Pb) is a toxic heavy metal that is harmful to humans, especially male reproductive organs. Luteolin (LUT) is a naturally occurring flavonoid with numerous biological activities. Our aim was to investigate the possible reproprotective effect of LUT against testicular deficits induced by Pb intoxication. In the pr...

journal_title：IUBMB life

authors： Al-Megrin WA,Alomar S,Alkhuriji AF,Metwally DM,Mohamed SK,Kassab RB,Abdel Moneim AE,El-Khadragy MF

更新日期：2020-08-01 00:00:00

abstract：:Studies have shown that despite the decreasing mortality rates of kidney cancer patients, its incidence is increasing. Therefore, a comprehensive re-evaluation of treatment options is necessary to provide appropriate treatments for the increasing number of patients. Moreover, the side effects caused by surgery, which ...

journal_title：IUBMB life

authors： Maleki Dana P,Reiter RJ,Hallajzadeh J,Asemi Z,Mansournia MA,Yousefi B

更新日期：2020-11-01 00:00:00

abstract：:The sodA gene coding for manganese superoxide dismutase (Mn-SOD) from the marine microorganism Vibrio parahaemolyticus was cloned, sequenced, and overexpressed in Escherichia coli by use of the pET20b (+) expression vector. The full-length gene consisted of a 588-bp open reading frame and encoded a polypeptide of 196 ...

journal_title：IUBMB life

authors： Shyu YC,Lin FP

更新日期：1999-09-01 00:00:00

abstract：:Malaria remains a worldwide health concern with an estimated quarter of a billion people infected and nearly half a million deaths annually. Malaria is caused by a parasite infection from Plasmodium strains which are transmitted from mosquitoes into the human host. Although several small molecule inhibitors have been ...

journal_title：IUBMB life

authors： Helton LG,Kennedy EJ

更新日期：2020-06-01 00:00:00

abstract：:To explore the oxygen response regulators involved in thiol peroxidase gene (tpx) expression in Escherichia coli, we constructed a single-copy tpx-lacZ operon fusion and monitored tpx-lacZ expression in various genetic backgrounds. Expression of the tpx-lacZ fusion was increased 4-fold by aerobic growth. Anaerobic exp...

journal_title：IUBMB life

authors： Kim SJ,Han YH,Kim IH,Kim HK

更新日期：1999-08-01 00:00:00

abstract：:Transfer RNAs require essential maturation steps to become functional. Among them, RNase P removes 5' leader sequences of pre-tRNAs. Although RNase P was long thought to occur universally as ribonucleoproteins, different types of protein-only RNase P enzymes were discovered in both eukaryotes and prokaryotes. Interest...

journal_title：IUBMB life

authors： Gobert A,Bruggeman M,Giegé P

更新日期：2019-08-01 00:00:00

abstract：:Polycystic ovary syndrome (PCOS) is one of the most common endocrine-metabolic disorders; however, its pathophysiology is still unclear. Certain polymorphisms of luteinizing hormone beta-subunit (LHβ) and LH/choriogonadotrophin receptor (LHCGR) genes may lead to changes in the bioactivity of this hormone. We aimed to ...

journal_title：IUBMB life

authors： El-Shal AS,Zidan HE,Rashad NM,Abdelaziz AM,Harira MM

更新日期：2016-01-01 00:00:00

abstract：:Recent structural studies of proteins mediating membrane fusion reveal intriguing similarities between diverse viral and mammalian systems. Particularly striking is the close similarity between the transmembrane envelope glycoproteins from the retrovirus HTLV-1 and the filovirus Ebola. These similarities suggest simil...

journal_title：IUBMB life

authors： Poumbourios P,Center RJ,Wilson KA,Kemp BE,Kobe B

更新日期：1999-08-01 00:00:00

abstract：:How cells regulate Gq efficacy (initiation and termination of Gq signaling) to effect response remains a central question in pharmacology and drug discovery. Phospholipase C-β1 (PLC-β1) is an effector and a GTPase activating protein (GAP) specific to Gαq. The physiological function of PLC-β1 GAP remains unclear and co...

journal_title：IUBMB life

authors： Litosch I

更新日期：2013-11-01 00:00:00

abstract：:The functional effect of the interaction of E2F1 and hepatitis B virus X protein (HBx) on the promoter of human p53 gene was studied using chloramphenicol acetyl transferase (CAT) assay. E2F1 activated the p53 promoter through E2F1 binding site. As previously reported, HBx repressed the p53 promoter through E-box. Whe...

journal_title：IUBMB life

authors： Choi M,Lee H,Rho HM

更新日期：2002-06-01 00:00:00

abstract：:Alzheimer's disease (AD) is a devastating neurodegenerative disorder that results in loss of memory and cognitive function, eventually leading to dementia. A key neuropathological event in AD is the cerebral accumulation of senile plaques formed by aggregates of amyloid-β-peptides (Aβ). Aβ results from two sequential ...

journal_title：IUBMB life

authors： Tamagno E,Guglielmotto M,Monteleone D,Vercelli A,Tabaton M

更新日期：2012-12-01 00:00:00

abstract：:Hydrogen peroxide is a major regulator of plant programmed cell death (PCD) but little is known about the downstream genes from the H(2)O(2)-signaling network that mediate the cell death. To address this question, a novel system for studying H(2)O(2)-induced programmed cell death in Arabidopsis thaliana was used. The ...

journal_title：IUBMB life

authors： Gechev TS,Minkov IN,Hille J

更新日期：2005-03-01 00:00:00

abstract：:The mitochondrial ATP-Mg/Pi carrier is responsible for the calcium-dependent regulation of adenosine nucleotide concentrations in the mitochondrial matrix, which allows mitochondria to respond to changing energy requirements of the cell. The carrier is expressed in mitochondria of fungi, plants and animals and belongs...

journal_title：IUBMB life

authors： Harborne SPD,Kunji ERS

更新日期：2018-12-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common malignancies with poor prognosis. Oxaliplatin-based chemotherapy is an important treatment for CRC; however, the cells develop resistance to therapy. The mechanisms underlying oxaliplatin resistance are complex and unclear. There is increasing evidence that microRNAs (...

journal_title：IUBMB life

authors： Moradi Marjaneh R,Khazaei M,Ferns GA,Avan A,Aghaee-Bakhtiari SH

更新日期：2019-10-01 00:00:00