Microarray-based DNA profiling to study genomic aberrations.

abstract：:Nuclear receptors (NRs) comprise a large family of proteins essential to manipulate various aspects of human biology. The class III of the NR family includes steroid hormone receptors (SHRs) involved in embryonic development, maintenance of differentiated cellular phenotypes, metabolism, and cell death. Dysfunction of...

journal_title：IUBMB life

authors： Marino M,Ascenzi P

更新日期：2006-12-01 00:00:00

abstract：:Although proteins and nucleic acids consist of different chemical components, proteins can mimic structures and possibly also functions of nucleic acids. Recently, structural mimicry was observed between two elongation factors in bacterial protein biosynthesis leading to the introduction of the concept of macromolecul...

journal_title：IUBMB life

authors： Pedersen GN,Nyborg J,Clark BF

更新日期：1999-07-01 00:00:00

abstract：:Synucleinopathies are neurodegenerative diseases characterized by the accumulation of either neuronal/axonal or glial insoluble proteinaceous aggregates mainly composed of α-synuclein (α-syn). Among them, the most common disorders are Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and some fo...

journal_title：IUBMB life

authors： Longhena F,Faustini G,Brembati V,Pizzi M,Bellucci A

更新日期：2020-04-01 00:00:00

abstract：:Vibrio cholerae is the causative agent of the diarrheal disease cholera, for which biofilm communities are considered to be environmental reservoirs. In endemic regions, and after algal blooms, which may result from phosphate enrichment following agricultural runoff, the bacterium is released from biofilms resulting i...

journal_title：IUBMB life

authors： Maestre-Reyna M,Huang WC,Wu WJ,Singh PK,Hartmann R,Wang PH,Lee CC,Hikima T,Yamamoto M,Bessho Y,Drescher K,Tsai MD,Wang AH

更新日期：2021-02-01 00:00:00

abstract：:We previously found a novel glycosylphosphatidylinositol (GPI)-anchored glycoprotein designated GPI-80 that modulates complement receptor 3 integrin-dependent adhesion and in vitro transendothelial migration of neutrophils. In this study, we show that antibody-mediated cross-linking of GPI-80 led to rapid tyrosine pho...

journal_title：IUBMB life

authors： Yu Y,Araki Y,Sendo F

更新日期：2000-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is one of the most common malignancies with poor prognosis. Oxaliplatin-based chemotherapy is an important treatment for CRC; however, the cells develop resistance to therapy. The mechanisms underlying oxaliplatin resistance are complex and unclear. There is increasing evidence that microRNAs (...

journal_title：IUBMB life

authors： Moradi Marjaneh R,Khazaei M,Ferns GA,Avan A,Aghaee-Bakhtiari SH

更新日期：2019-10-01 00:00:00

abstract：:Peroxynitrite is an inorganic toxin of physiological interest, formed from the diffusion-controlled reaction of superoxide and nitrogen monoxide with a rate constant of (1.6 +/- 0.3) x 10(10) M(-1) s(-1). On the basis of three experiments we conclude that homolysis of the O-O bond in peroxynitrous acid is unlikely: (1...

journal_title：IUBMB life

authors： Kissner R,Nauser T,Kurz C,Koppenol WH

更新日期：2003-10-01 00:00:00

abstract：:Studies have shown that despite the decreasing mortality rates of kidney cancer patients, its incidence is increasing. Therefore, a comprehensive re-evaluation of treatment options is necessary to provide appropriate treatments for the increasing number of patients. Moreover, the side effects caused by surgery, which ...

journal_title：IUBMB life

authors： Maleki Dana P,Reiter RJ,Hallajzadeh J,Asemi Z,Mansournia MA,Yousefi B

更新日期：2020-11-01 00:00:00

abstract：:Extracellular matrix (ECM)-independent survival is an essential prerequisite for tumor metastasis, and a hallmark of epithelial cancer stem cells and epithelial-mesenchymal transition (EMT). Here, we found that loss of TP53I11 enhanced, and overexpression of TP53I11 suppressed the ECM-independent survival, EMT, and mi...

journal_title：IUBMB life

authors： Xiao T,Xu Z,Zhou Y,Zhang H,Geng J,Liang Y,Qiao H,Suo G

更新日期：2019-02-01 00:00:00

abstract：:Induction of apoptosis is the target of choice for modern chemotherapeutic treatment of cancer, where lack of potent "target-specific" drugs has led to extensive research on anticancer compounds from natural sources. In our study, we have used astrakurkurone, a triterpene isolated from wild edible mushroom, Astraeus h...

journal_title：IUBMB life

authors： Dasgupta A,Dey D,Ghosh D,Lai TK,Bhuvanesh N,Dolui S,Velayutham R,Acharya K

更新日期：2019-07-01 00:00:00

abstract：:Alkyl-dihydroxyacetonephosphate synthase (alkyl-DHAP synthase) is a peroxisomal enzyme that plays a key role in ether phospholipid biosynthesis. To determine the turnover of alkyl-DHAP synthase in several peroxisomal disorders, pulse-chase experiments were performed. In control fibroblasts, mature alkyl-DHAP synthase ...

journal_title：IUBMB life

authors： Biermann J,Gootjes J,Wanders RJ,van den Bosch H

更新日期：1999-12-01 00:00:00

abstract：:For more than a century, the metabolic role of lactate has intrigued physiologists and biochemists. Yet, for the first half of the last century lactate had been designated as a waste product, and assigned no additional significance besides its controversial role in muscle fatigue. The decline of the lactate hypothesis...

journal_title：IUBMB life

authors： Sola-Penna M

更新日期：2008-09-01 00:00:00

abstract：:Ovarian cancer (OC) is one of the most lethal gynaecological cancers, which usually has a poor prognosis due to late diagnosis. A large percentage of the OC cell population is in a nonproliferating and quiescent stage, which poses a barrier to success when using most chemotherapeutic agents. Recent studies have shown ...

journal_title：IUBMB life

authors： Duncan K,Uwimpuhwe H,Czibere A,Sarkar D,Libermann TA,Fisher PB,Zerbini LF

更新日期：2012-07-01 00:00:00

abstract：:We hypothesize that the various, previously reported, reactivities of neuroglobin with redox partners and oxygen provide for the establishment of a redox cycle within cells, such as neurons and retinal rod cells. Using native cell lysates, from cultured human cells of neuronal origin, we have estimated the rate of red...

journal_title：IUBMB life

authors： Brittain T,Skommer J

更新日期：2012-05-01 00:00:00

abstract：:The generation of free radicals and the resulting oxidative modification of cell structures are omnipresent in mammalian cells. This includes the permanent oxidation of proteins leading to the disruption of the protein structure and an impaired functionality. In consequence, these oxidized proteins have to be removed ...

journal_title：IUBMB life

authors： Jung T,Grune T

更新日期：2008-11-01 00:00:00

abstract：:Epidemiological evidence demonstrates that diets rich in fruit and vegetables promote health, and attenuate, or delay, the onset of various diseases, including cardiovascular disease, diabetes, certain cancers, and several other age-related degenerative disorders. The chemical components and the physiological and mole...

journal_title：IUBMB life

authors： Fraga CG

更新日期：2007-04-01 00:00:00

abstract：:The extensive post-transcriptional modification of U2 snRNA is required for spliceosome assembly and pre-mRNA splicing in vertebrates. However, the rare modification of U2 snRNA in yeast implies a different mechanism for regulating spliceosome biogenesis in single-celled eukaryotes. To understand the evolutionary patt...

journal_title：IUBMB life

authors： Huang ZP,Zhou H,Qu LH

更新日期：2005-10-01 00:00:00

abstract：:Cartilage engineering is one challenging issue in regenerative medicine. Low oxygen tension or hypoxia inducible factor-1 (HIF-1α) gene therapy are promising strategies in the field of cartilage repair. Previously, we showed that hypoxia and its mediator HIF-1 regulate matrix genes expression (collagens and aggrecan)....

journal_title：IUBMB life

authors： Duval E,Bouyoucef M,Leclercq S,Baugé C,Boumédiene K

更新日期：2016-09-01 00:00:00

abstract：:The mitochondrial ATP-Mg/Pi carrier is responsible for the calcium-dependent regulation of adenosine nucleotide concentrations in the mitochondrial matrix, which allows mitochondria to respond to changing energy requirements of the cell. The carrier is expressed in mitochondria of fungi, plants and animals and belongs...

journal_title：IUBMB life

authors： Harborne SPD,Kunji ERS

更新日期：2018-12-01 00:00:00

abstract：:Interferon regulatory factors (IRFs) were originally discovered in the context of type I interferon (IFN-alpha/beta) gene induction, and subsequent studies on these transcription factors have revealed their remarkable functional diversity in regulating immune systems. Indeed, the critical involvement of IRF members in...

journal_title：IUBMB life

authors： Honda K,Taniguchi T

更新日期：2006-05-01 00:00:00

abstract：:In tsRSV-infected NRK (tsNRK) cells, pp60(v-src) reactivation by temperature-shift from a nonpermissive temperature, 39 C, to a permissive one, 32 degrees C, induced the production of inositol phosphates (IPt) and phosphatidylethanol (PEt). This was accompanied by an increase in membrane-associated protein kinase C (P...

journal_title：IUBMB life

authors： Kim BY,Kim JH,Han YJ,Ahn SC,Kang DO,Oh WK,Ko HR,Lee HS,Mheen TI,Ahn JS

更新日期：1999-07-01 00:00:00

abstract：:Traumatic optic neuropathy is an important cause of severe vision loss. So, many attempts were performed to transplant stem cells systemically or locally to regenerate the injured retina. In this study, we investigated the effect of human umbilical cord blood mesenchymal stem cells (hUBMSCs) on histological structure,...

journal_title：IUBMB life

authors： Mohamed EM,Abdelrahman SA,Hussein S,Shalaby SM,Mosaad H,Awad AM

更新日期：2017-03-01 00:00:00

abstract：:Crude brazilin extract from Sappan wood has demonstrated strong anti tumor activity in the mouse model of human bladder carcinoma and clinical trial for intravesical therapy. Purified brazilin was confirmed the most active molecule in inhibition of bladder carcinoma T24 cells. Brazilin decreased proliferation and viab...

journal_title：IUBMB life

authors： Zhang T,Fan X,Song L,Ren L,Ma E,Zhang S,Ren L,Zheng Y,Zhang J

更新日期：2015-03-01 00:00:00

abstract：:The sodA gene coding for manganese superoxide dismutase (Mn-SOD) from the marine microorganism Vibrio parahaemolyticus was cloned, sequenced, and overexpressed in Escherichia coli by use of the pET20b (+) expression vector. The full-length gene consisted of a 588-bp open reading frame and encoded a polypeptide of 196 ...

journal_title：IUBMB life

authors： Shyu YC,Lin FP

更新日期：1999-09-01 00:00:00

abstract：:Nur77 is a member of nuclear receptor superfamily that acts as a transcription factor and regulates expression of multiple genes. Subcellular localization of Nur77 protein plays an important role in the survival and cell death. In this study, we have predicted and confirmed alternatively spliced two new transcripts of...

journal_title：IUBMB life

authors： Rehman SU,Sarwar T,Husain MA,Ishqi HM,Tabish M

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:Heart diseases are common in the offspring of gestational diabetic mother (ODM). Defects in mitochondrial metabolism and autophagy may, in part, be responsible for the adverse structural and functional alterations in the heart. The principal objective of this study was to investigate cardiac mitochondrial res...

journal_title：IUBMB life

authors： Rajendran RS,Jayakumari NR,Sivasailam A,Reghuvaran AC,Pillai VV,Karunakaran J,Sreelatha HV,Manjunatha S,Gopala S

更新日期：2021-01-22 00:00:00

abstract：:Red blood cells of yellow-spotted river turtles (Podocnemis unifilis, Pleurodira, Chelonia, REPTILIA) have two hemoglobin (Hb) components, Hb A and Hb D. We purified the hemoglobin component homologous to amniote (reptiles, birds, and mammals) adult Hb A which comprises two identical α(A) -globin polypeptides and two ...

journal_title：IUBMB life

authors： Hasegawa T,Shishikura F,Kuwada T

更新日期：2011-03-01 00:00:00

abstract：:The expression of the cytM gene, which encodes cytochrome cM in Synechocystis sp. PCC 6803, is induced under stress conditions such as low temperature. Results of spectrophotometric studies revealed that cytochrome cM was oxidized by light absorbed by photosystem I in cells that had acclimatized to a low temperature. ...

journal_title：IUBMB life

authors： Shuvalov VA,Allakhverdiev SI,Sakamoto A,Malakhov M,Murata N

更新日期：2001-02-01 00:00:00

abstract：:During the hand plate development, the processes of cell differentiation and control of cell death are relevant to ensure a correct shape of the limb. The progenitor cell pool that later will differentiate into cartilage to form the digits arises from undifferentiated mesenchymal cells beneath the apical ectodermal ri...

journal_title：IUBMB life

authors： Chimal-Monroy J,Abarca-Buis RF,Cuervo R,Díaz-Hernández M,Bustamante M,Rios-Flores JA,Romero-Suárez S,Farrera-Hernández A

更新日期：2011-10-01 00:00:00

abstract：:Stem cells from human exfoliated deciduous teeth (SHEDs) are highly proliferative, clonogenic, and multipotent stem cells with a neural crest cell origin. This property could be a desirable option for potential therapeutic applications. In this study, we focus on the effects of Rho kinase inhibitors Y-27632 and Noggin...

journal_title：IUBMB life

authors： Yang S,Xin C,Zhang B,Zhang H,Hao Y

更新日期：2020-04-01 00:00:00