解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Aeromonas hydrophila (A. hydrophila) can cause a number of diseases in both human and animals. A. hydrophila-related infections in aquaculture cause severe economic losses every year throughout the world. The emergence of antibiotic resistance that is due to the abuse of antibiotics has limited the application of anti...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2020.1867455
更新日期:2021-12-01 00:00:00
abstract::The emergence of resistance requires alternative methods to treat Candida albicans infections. We evaluated efficacy of the efflux pump inhibitor (EPI) verapamil (VER) with fluconazole (FLC) against FLC-resistant (CaR) and -susceptible C. albicans (CaS). The susceptibility of both strains to VER and FLC was determined...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2020.1868814
更新日期:2021-12-01 00:00:00
abstract::Novel approaches to treat carbapenem-resistant Acinetobacter baumannii (CRAB) infections are urgently needed and anti-virulence drugs represent promising alternatives, but our knowledge on potential targets is scarce. We searched for potential A. baumannii virulence factors by whole-genome sequencing-based comparisons...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2020.1855912
更新日期:2020-12-01 00:00:00
abstract::The virulence behaviors of many Gram-negative bacterial pathogens are governed by quorum-sensing (QS), a hierarchical system of gene regulation that relies on population density by producing and detecting extracellular signaling molecules. Although extensively studied under in vitro conditions, adaptation of QS system...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2020.1809327
更新日期:2020-12-01 00:00:00
abstract::The twin-arginine translocation (Tat) system is involved in a variety of important bacterial physiological processes. Conserved among bacteria and crucial for virulence, the Tat system is deemed as a promising anti-microbial drug target. However, the mechanism of how the Tat system functions in bacterial pathogenesis ...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2020.1817709
更新日期:2020-12-01 00:00:00
abstract::Invasive pulmonary aspergillosis (IPA) is a severe infection that is difficult to diagnose due to the ubiquitous presence of fungal spores, the underlying diseases of risk patients, and limitations of currently available markers. In this study, we performed a comprehensive liquid chromatography tandem mass spectrometr...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2020.1824960
更新日期:2020-12-01 00:00:00
abstract::Cryptococcus neoformans: (H99W) was serially passaged in the invertebrate wax moth Galleria mellonella fifteen times to study how fungal virulence evolves under selection and whether those adaptations affect virulence. The G. mellonella passaged strain (P15) and the pre-passage H99W strains were used to infect three d...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2020.1831332
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVES:Hypervirulent Klebsiella pneumoniae(hvKp) is an increasingly important pathogen. Tracking its epidemiology and evolving antimicrobial resistance will facilitate care. METHODS:A retrospective study was conducted in two hospitals. We collected the clinical data. Antimicrobial and virulence-associated phenotyp...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2020.1809322
更新日期:2020-12-01 00:00:00
abstract::Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) have been reported in recent years across Asian countries and pose a serious threat to public health. Neutrophils represent the first line of defense against numerous infectious pathogens, such as CR-hvKP. Neutrophil extracellular traps (NETs) constitu...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2020.1809325
更新日期:2020-12-01 00:00:00
abstract::Mycoplasmas persist in the host for a long time, suggesting that they possess mechanisms for immune evasion. Factor H is a negative regulator of the complement system, which binds to host cells to avoid unexpected complement activation. In this study, we revealed that many mycoplasmas, such as Mycoplasma hyopneumoniae...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2020.1806664
更新日期:2020-12-01 00:00:00
abstract::Novel coronavirus disease 2019 (COVID-19), caused by novel coronavirus SARS-CoV-2, has spread globally since the end of 2019. Asymptomatic carriers are of great concern as they can undermine the interventions to stop the pandemic. However, there is limited information about the characteristics and outcomes of the asym...
journal_title:Virulence
pub_type: 杂志文章,多中心研究
doi:10.1080/21505594.2020.1802194
更新日期:2020-12-01 00:00:00
abstract::Burkholderia pseudomallei: is the etiological agent of the disease melioidosis and is a Tier 1 select agent. It survives and replicates inside phagocytic cells by escaping from the endocytic vacuole, replicating in the cytosol, spreading to other cells via actin polymerization and promoting the fusion of infected and ...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2020.1806675
更新日期:2020-12-01 00:00:00
abstract::The Gram-negative enteropathogen Yersinia pseudotuberculosis possesses a number of regulatory systems that detect cell envelope damage caused by noxious extracytoplasmic stresses. The CpxA sensor kinase and CpxR response regulator two-component regulatory system is one such pathway. Active Cpx signalling upregulates v...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2018.1556151
更新日期:2019-12-01 00:00:00
abstract::The interaction between pathogens and their host plants is a ubiquitous process. Some plant fungal pathogens can form a specific infection structure, such as an appressorium, which is formed by the accumulation of a large amount of glycerin and thereby the creation of an extremely high intracellular turgor pressure, w...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.1080/21505594.2018.1551011
更新日期:2019-12-01 00:00:00
abstract::Streptococcus agalactiae, or group B Streptococcus (GBS), infects diverse hosts including humans and economically important species such as cattle and fishes. In the context of human health, GBS is a major cause of neonatal infections and an emerging cause of invasive disease in adults and of foodborne disease in Sout...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2019.1631660
更新日期:2019-12-01 00:00:00
abstract::A greater ethical conscience, new global rules and a modified perception of ethical consciousness entail a more rigorous control on utilizations of vertebrates for in vivo studies. To cope with this new scenario, numerous alternatives to rodents have been proposed. Among these, the greater wax moth Galleria mellonella...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.1080/21505594.2019.1621649
更新日期:2019-12-01 00:00:00
abstract::Citrobacter rodentium is an attaching and effacing intestinal murine pathogen which shares similar virulence strategies with the human pathogens enteropathogenic- and enterohemorrhagic Escherichia coli to infect their host. C. rodentium is spontaneously cleared by healthy wild-type (WT) mice whereas mice lacking Muc2 ...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2019.1635417
更新日期:2019-12-01 00:00:00
abstract::Current treatment for combatting Chagas disease, a life-threatening illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi is inadequate, and thus the discovery of new antiparasitic compounds is of prime importance. Previous studies identified the indirubins, a class of ATP kinase inhibitors, as pote...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2018.1532242
更新日期:2018-01-01 00:00:00
abstract::Many studies have found that abnormalities in the proportion and differentiation of CD4+ T cells (Th cells) are closely related to the pathogenesis of viral myocarditis (VMC). Our previous research indicates that the cholinergic anti-inflammatory pathway (CAP) attenuates the inflammatory response of VMC and downregula...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2018.1482179
更新日期:2018-01-01 00:00:00
abstract::Staphylococcus aureus infections are becoming a major global health issue due to the rapid emergence of multidrug-resistant strains. Therefore, there is an urgent need to develop an effective vaccine to prevent and control these infections. In order to develop a universal immunization strategy, we constructed a mutant...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2017.1417723
更新日期:2018-01-01 00:00:00
abstract::The lipopolysaccharide (LPS) is a major virulence factor of Brucella, a facultative intracellular pathogenic Gram-negative bacterium. Brucella LPS exhibits a low toxicity and its atypical structure was postulated to delay the host immune response, favouring the establishment of chronic disease. Here we carried out an ...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2017.1386831
更新日期:2018-01-01 00:00:00
abstract::Lipid mediators, derived from arachidonic acid metabolism, play an important role in immune regulation. The functions of bioactive eicosanoids range from modulating cytokine signaling and inflammasome formation to anti-inflammatory and pro-resolving activities. Human pathogenic fungi such as Candida albicans, Candida ...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2018.1475797
更新日期:2018-01-01 00:00:00
abstract::Bacteria interact with their host through protein secretion systems and surface structures. Pathogenic bacteria encode protein secretion systems that promote the invasion of the host's tissue, the evasion of the host's immune response, the thwarting microbial competitors, and ultimately survival within the host. For m...
journal_title:Virulence
pub_type: 评论,社论
doi:10.1080/21505594.2017.1421829
更新日期:2018-01-01 00:00:00
abstract::Viral infections of the respiratory tract can be complicated by bacterial superinfection, resulting in a significantly longer duration of illness and even a fatal outcome. In this review, we focused on interactions between S. aureus and non-influenza viruses. Clinical data evidenced that rhinovirus infection may incre...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.1080/21505594.2018.1504561
更新日期:2018-01-01 00:00:00
abstract::Legionella pneumophila, the causative agent of Legionnaires' disease, is widely distributed throughout natural and artificial water systems and can replicate in macrophages and amoebae. Amoebae are the natural hosts of L. pneumophila, whereas macrophages are incidentally infected. The life cycle of L. pneumophila comp...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2017.1373925
更新日期:2018-01-01 00:00:00
abstract::Entomopathogenic fungi are potential biological control agents of mosquitoes. Our group observed that not all mosquitoes were equally susceptible to fungal infection and observed significant differences in virulence of different spore types. Conidiospores and blastospores were tested against Culex quinquefasciatus lar...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2018.1509665
更新日期:2018-01-01 00:00:00
abstract::Helicobacter pylori infection can result in non-ulcer dyspepsia (NUD), peptic ulcer disease (PUD), adenocarcinoma, and gastric lymphoma. H. pylori reside within the gastric mucus layer, mainly composed of mucins carrying an array of glycan structures that can serve as bacterial adhesion epitopes. The aim of the presen...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2018.1532243
更新日期:2018-01-01 00:00:00
abstract::Several human pathogens bind and respond to host cytokines, which can be considered a virulence mechanism that communicates defensive actions of the host to the pathogen. This review summarizes the current knowledge of bacterial cytokine-binding proteins, with a particular focus on their functional and structural char...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.1080/21505594.2017.1363140
更新日期:2017-11-17 00:00:00
abstract::Maternal antibodies induced by vaccination during pregnancy cross the placental barrier and can close the susceptibility gap to pertussis in young infants up to the start of primary immunization. As not only the quantity but also the quality of circulating antibodies is important for protection, we assessed whether ma...
journal_title:Virulence
pub_type: 临床试验,杂志文章
doi:10.1080/21505594.2017.1296998
更新日期:2017-10-03 00:00:00
abstract::The emergence of multiresistant Gram-negative bacteria requires new therapies for combating bacterial infections. Targeting the biogenesis of virulence factors could be an alternative strategy instead of killing bacteria with antibiotics. The outer membrane (OM) of Gram-negative bacteria acts as a physical barrier. At...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2016.1278333
更新日期:2017-10-03 00:00:00
abstract::Drugs such as linezolid that inhibit bacterial protein synthesis may be beneficial in treating infections caused by toxigenic Staphylococcus aureus. As protein synthesis inhibitors have no effect on preformed toxins, neutralization of pathogenic exotoxins with anti-toxin antibodies may be beneficial in conjunction wit...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2016.1267894
更新日期:2017-10-03 00:00:00
abstract::Bacterial pathogenicity deeply depends on the ability to secrete virulence factors that bind specific targets on host cells and manipulate host responses. The Gram-positive bacterium Listeria monocytogenes is a human foodborne pathogen that remains a serious public health concern. To transport proteins across its cell...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2016.1244589
更新日期:2017-08-18 00:00:00
abstract::Many of the alterations that affect innate and adaptive immune cell compartments in HIV-infected patients are reminiscent of the process of immune aging, characteristic of old age. These alterations define the immunological age of individuals and are likely to participate to the decline of immune competence with HIV d...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.1080/21505594.2016.1195536
更新日期:2017-07-04 00:00:00
abstract::Carbapenem-Resistant Enterobacteriaceae (CRE) are an emerging healthcare crisis. Infections due to CRE are associated with high morbidity and mortality, especially in critically ill patients. Due to the multi-drug resistant nature of these infections only limited treatment options are available. Antimicrobials that ha...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.1080/21505594.2016.1221021
更新日期:2017-05-19 00:00:00
abstract::Candida albicans remains the main etiological agent of candidiasis, as this otherwise normal commensal of humans is capable of causing active infection in immune- and medically-compromised patients. The high morbidity and mortality rates associated with candidiasis, coupled with the emergence of drug resistance demand...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.1080/21505594.2016.1197444
更新日期:2017-02-17 00:00:00
abstract::Intrinsically disordered proteins (IDPs) do not have a well-defined and stable 3-dimensional fold. Some IDPs can function as either transient or permanent binders of other proteins and may interact with an array of ligands by adopting different conformations. A novel outer membrane lipoprotein, bacterial interleukin r...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2016.1216294
更新日期:2017-02-17 00:00:00
abstract::Trehalose is a disaccharide formed from two glucose molecules. This sugar molecule can be isolated from a range of organisms including bacteria, fungi, plants and invertebrates. Trehalose has a variety of functions including a role as an energy storage molecule, a structural component of glycolipids and plays a role i...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2016.1199316
更新日期:2017-01-02 00:00:00
abstract::Rift Valley fever is a mosquito-borne zoonotic disease affecting ruminants and humans. Rift Valley fever virus (RVFV: family Bunyaviridae, genus Phlebovirus) causes abortions and fetal malformations in ruminants, and hemorrhagic fever, encephalitis, or retinitis in humans. The live-attenuated MP-12 vaccine is conditio...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2016.1195528
更新日期:2016-11-16 00:00:00
abstract::Patients undergoing haematopoietic stem cell transplantation (HSCT) are highly exposed to infectious agents. However, it is not known why certain HSCT recipients rapidly develop severe infections while other, despite similar immunosuppressive conditions, do not. Increasing evidence suggests that such differences may b...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.1080/21505594.2016.1234566
更新日期:2016-11-16 00:00:00
abstract::Rat bite fever (RBF), a worldwide occurring and most likely under-diagnosed zoonosis caused by Streptobacillus moniliformis, represents the most prominent disease of Streptobacillus infections. Recently, novel members have been described, from which a reservoir in rats and other animal species and a zoonotic potential...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.1080/21505594.2016.1177694
更新日期:2016-08-17 00:00:00