Abstract:
:Invasive pulmonary aspergillosis (IPA) is a severe infection that is difficult to diagnose due to the ubiquitous presence of fungal spores, the underlying diseases of risk patients, and limitations of currently available markers. In this study, we performed a comprehensive liquid chromatography tandem mass spectrometry (LC-MS/MS)-based identification of host and fungal proteins expressed during IPA in mice and humans. The proteomic analysis of bronchoalveolar lavage samples of individual IPA and control cases allowed the description of common host factors that had significantly increased abundance in both infected animals and IPA patients compared to their controls. Although increased levels of these individual host proteins might not be sufficient to distinguish bacterial from fungal infection, a combination of these markers might be beneficial to improve diagnosis. We also identified 16 fungal proteins that were specifically detected during infection and may be valuable candidates for biomarker evaluation.
journal_name
Virulencejournal_title
Virulenceauthors
Machata S,Müller MM,Lehmann R,Sieber P,Panagiotou G,Carvalho A,Cunha C,Lagrou K,Maertens J,Slevogt H,Jacobsen IDdoi
10.1080/21505594.2020.1824960subject
Has Abstractpub_date
2020-12-01 00:00:00pages
1337-1351issue
1eissn
2150-5594issn
2150-5608journal_volume
11pub_type
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