Galleria mellonella as a consolidated in vivo model hosts: New developments in antibacterial strategies and novel drug testing.

abstract：:Staphylococcus aureus infections are becoming a major global health issue due to the rapid emergence of multidrug-resistant strains. Therefore, there is an urgent need to develop an effective vaccine to prevent and control these infections. In order to develop a universal immunization strategy, we constructed a mutant...

journal_title：Virulence

authors： Moscoso M,García P,Cabral MP,Rumbo C,Bou G

更新日期：2018-01-01 00:00:00

abstract：:In this issue of Virulence, Ban E et al. described the complete sequence of the pEntYN10 plasmid of Escherichia coli O169:H41. The plasmid has 182 coding sequences (CDs); among the identified CDs, some were identified as colonization factors (CFs), one was an enterotoxin and others were insertion sequences (IS). In th...

journal_title：Virulence

authors： Navarro A

更新日期：2015-01-01 00:00:00

abstract：:Cryptococcus neoformans undergoes phenotypical changes during host infection in order to promote persistence and survival. Studies have demonstrated that such adaptations require alterations in gene transcription networks by distinct mechanisms. Drugs such as the histone deacetylases inhibitors (HDACi) Sodium Butyrate...

journal_title：Virulence

authors： Brandão FA,Derengowski LS,Albuquerque P,Nicola AM,Silva-Pereira I,Poças-Fonseca MJ

更新日期：2015-01-01 00:00:00

abstract：:Mycoplasmas persist in the host for a long time, suggesting that they possess mechanisms for immune evasion. Factor H is a negative regulator of the complement system, which binds to host cells to avoid unexpected complement activation. In this study, we revealed that many mycoplasmas, such as Mycoplasma hyopneumoniae...

journal_title：Virulence

authors： Yu Y,Wang J,Han R,Wang L,Zhang L,Zhang AY,Xin J,Li S,Zeng Y,Shao G,Feng Z,Xiong Q

更新日期：2020-12-01 00:00:00

abstract：:Helicobacter pylori infection can result in non-ulcer dyspepsia (NUD), peptic ulcer disease (PUD), adenocarcinoma, and gastric lymphoma. H. pylori reside within the gastric mucus layer, mainly composed of mucins carrying an array of glycan structures that can serve as bacterial adhesion epitopes. The aim of the presen...

journal_title：Virulence

authors： Quintana-Hayashi MP,Rocha R,Padra M,Thorell A,Jin C,Karlsson NG,Roxo-Rosa M,Oleastro M,Lindén SK

更新日期：2018-01-01 00:00:00

abstract：:Bacteria interact with their host through protein secretion systems and surface structures. Pathogenic bacteria encode protein secretion systems that promote the invasion of the host's tissue, the evasion of the host's immune response, the thwarting microbial competitors, and ultimately survival within the host. For m...

journal_title：Virulence

authors： Troxell B

更新日期：2018-01-01 00:00:00

abstract：:Human herpesviruses have latency and lytic replication phases in their lifecycle. Proper regulation of herpesviral lifecycle is essential for the evasion of host immune surveillance and development of their related diseases. Recent advancements indicate a role of a novel class of viral non-coding RNAs, microRNA (miRNA...

journal_title：Virulence

authors： Lei X,Bai Z,Ye F,Huang Y,Gao SJ

更新日期：2010-09-01 00:00:00

abstract：:We recently developed a method that allows fast differentiation between Streptococcus pyogenes (GAS) strains. The method named phage profiling (PP) is based on a simple assumption that a regular PCR reaction with Taq polymerase and relatively short elongation time is not able to yield long DNA fragment, such as ~40-50...

journal_title：Virulence

authors： Borek AL,Obszańska K,Hryniewicz W,Sitkiewicz I

更新日期：2012-10-01 00:00:00

abstract：:In immune-competent hosts, adenoviruses (Ads) are mild pathogens that cause mainly infections of the respiratory and ocular tracks. The advent of Ad-based gene transfer vectors made the understanding of their interaction with the host cellular machinery an intensive field of research over the last decade. As studies f...

journal_title：Virulence

authors： Henaff D,Salinas S

更新日期：2010-05-01 00:00:00

abstract：:Patients undergoing haematopoietic stem cell transplantation (HSCT) are highly exposed to infectious agents. However, it is not known why certain HSCT recipients rapidly develop severe infections while other, despite similar immunosuppressive conditions, do not. Increasing evidence suggests that such differences may b...

journal_title：Virulence

authors： Wójtowicz A,Bochud PY

更新日期：2016-11-16 00:00:00

abstract：:Th1-polarized host response, mediated by IFN-γ, has been associated with increased severity of periodontal disease as well as control of periodontal infection. The functional polymorphism TBX21-1993T/C (rs4794067) increases the transcriptional activity of the TBX21 gene (essential for Th1 polarization) resulting in a ...

journal_title：Virulence

authors： Cavalla F,Biguetti CC,Colavite PM,Silveira EV,Martins W Jr,Letra A,Trombone AP,Silva RM,Garlet GP

更新日期：2015-01-01 00:00:00

abstract：:Novel coronavirus disease 2019 (COVID-19), caused by novel coronavirus SARS-CoV-2, has spread globally since the end of 2019. Asymptomatic carriers are of great concern as they can undermine the interventions to stop the pandemic. However, there is limited information about the characteristics and outcomes of the asym...

journal_title：Virulence

authors： Yu C,Zhou M,Liu Y,Guo T,Ou C,Yang L,Li Y,Li D,Hu X,Shuai L,Wang B,Zou Z

更新日期：2020-12-01 00:00:00

abstract：:Carbapenem-Resistant Enterobacteriaceae (CRE) are an emerging healthcare crisis. Infections due to CRE are associated with high morbidity and mortality, especially in critically ill patients. Due to the multi-drug resistant nature of these infections only limited treatment options are available. Antimicrobials that ha...

journal_title：Virulence

authors： Neuner EA,Gallagher JC

更新日期：2017-05-19 00:00:00

abstract：:Ebola virus (EBOV) is a member of the filoviridae family that causes severe hemorrhagic fever during sporadic outbreaks, and no approved treatments are currently available. The multifunctional EBOV VP35 protein facilitates immune evasion by antagonizing antiviral signaling pathways and is important for viral RNA synth...

journal_title：Virulence

authors： Leung DW,Prins KC,Basler CF,Amarasinghe GK

更新日期：2010-11-01 00:00:00

abstract：:Legionella pneumophila is the primary respiratory pathogen and mostly transmitted to human through water cooling systems and cause mild to severe pneumonia with high mortality rate especially in elderly both in hospitals and community. However, current Legionella risk assessments may be compromised by uncertainties in...

journal_title：Virulence

authors： Ahmadrajabi R,Shakibaie MR,Iranmanesh Z,Mollaei HR,Sobhanipoor MH

更新日期：2016-07-03 00:00:00

abstract：:Current treatment for combatting Chagas disease, a life-threatening illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi is inadequate, and thus the discovery of new antiparasitic compounds is of prime importance. Previous studies identified the indirubins, a class of ATP kinase inhibitors, as pote...

journal_title：Virulence

authors： Efstathiou A,Meira CS,Gaboriaud-Kolar N,Bastos TM,Rocha VPC,Vougogiannopoulou K,Skaltsounis AL,Smirlis D,Soares MBP

更新日期：2018-01-01 00:00:00

abstract：:Rift Valley fever is a mosquito-borne zoonotic disease affecting ruminants and humans. Rift Valley fever virus (RVFV: family Bunyaviridae, genus Phlebovirus) causes abortions and fetal malformations in ruminants, and hemorrhagic fever, encephalitis, or retinitis in humans. The live-attenuated MP-12 vaccine is conditio...

journal_title：Virulence

authors： Nishiyama S,Slack OA,Lokugamage N,Hill TE,Juelich TL,Zhang L,Smith JK,Perez D,Gong B,Freiberg AN,Ikegami T

更新日期：2016-11-16 00:00:00

abstract：:Neurodegenerative human CJD and sheep scrapie are diseases caused by several different transmissible encephalopathy (TSE) agents. These infectious agents provoke innate immune responses in the brain, including late-onset abnormal prion protein (PrP-res) amyloid. Agent particles that lack detectable PrP sequences by de...

journal_title：Virulence

authors： Botsios S,Tittman S,Manuelidis L

更新日期：2015-01-01 00:00:00

abstract：:Intrinsically disordered proteins (IDPs) do not have a well-defined and stable 3-dimensional fold. Some IDPs can function as either transient or permanent binders of other proteins and may interact with an array of ligands by adopting different conformations. A novel outer membrane lipoprotein, bacterial interleukin r...

journal_title：Virulence

authors： Ahlstrand T,Tuominen H,Beklen A,Torittu A,Oscarsson J,Sormunen R,Pöllänen MT,Permi P,Ihalin R

更新日期：2017-02-17 00:00:00

abstract：:Invasive pulmonary aspergillosis (IPA) is a severe infection that is difficult to diagnose due to the ubiquitous presence of fungal spores, the underlying diseases of risk patients, and limitations of currently available markers. In this study, we performed a comprehensive liquid chromatography tandem mass spectrometr...

journal_title：Virulence

authors： Machata S,Müller MM,Lehmann R,Sieber P,Panagiotou G,Carvalho A,Cunha C,Lagrou K,Maertens J,Slevogt H,Jacobsen ID

更新日期：2020-12-01 00:00:00

abstract：:Lipid mediators, derived from arachidonic acid metabolism, play an important role in immune regulation. The functions of bioactive eicosanoids range from modulating cytokine signaling and inflammasome formation to anti-inflammatory and pro-resolving activities. Human pathogenic fungi such as Candida albicans, Candida ...

journal_title：Virulence

authors： Chakraborty T,Thuer E,Heijink M,Tóth R,Bodai L,Vágvölgyi C,Giera M,Gabaldón T,Gácser A

更新日期：2018-01-01 00:00:00

abstract：:Bacterial pathogenicity deeply depends on the ability to secrete virulence factors that bind specific targets on host cells and manipulate host responses. The Gram-positive bacterium Listeria monocytogenes is a human foodborne pathogen that remains a serious public health concern. To transport proteins across its cell...

journal_title：Virulence

authors： Pinheiro J,Reis O,Vieira A,Moura IM,Zanolli Moreno L,Carvalho F,Pucciarelli MG,García-Del Portillo F,Sousa S,Cabanes D

更新日期：2017-08-18 00:00:00

abstract：:Golden hamsters were inoculated with Schistosoma haematobium cercariae to examine histological lesions at different time points over an 18 month period of infection. Hamsters were sacrificed 26 weeks and 82 weeks after inoculation. The parasite was found in the blood and in the liver of infected animals as was expecte...

journal_title：Virulence

authors： Botelho MC,Oliveira PA,Vieira P,Delgado Mde L,Lourenço L,Lopes C,Machado JC,da Costa JM

更新日期：2010-05-01 00:00:00

abstract：:Gram-negative bacterial (GNB) infections are a leading cause of serious infections both in hospitals and the community. The mortality remains high despite potent antimicrobials and modern supportive care. In the last decade invasive GNB have become increasingly resistant to commonly used antibiotics, and attempts to i...

journal_title：Virulence

authors： Cross AS

更新日期：2014-01-01 00:00:00

abstract：:Francisella tularensis is a highly virulent bacterial pathogen that is easily aerosolized and has a low infectious dose. As an intracellular pathogen, entry of Francisella into host cells is critical for its survival and virulence. However, the initial steps of attachment and internalization of Francisella into host c...

journal_title：Virulence

authors： Moreau GB,Mann BJ

更新日期：2013-11-15 00:00:00

abstract：:In the present study, we examined prolonged infection after antigenic co-stimulation by inoculation of the fungus Fonsecaea pedrosoi at two different sites in three mouse strains (BALB/c, Swiss, and C57BL/6). Using this murine model of infection, we showed that antigen induction of infection at more than one site led ...

journal_title：Virulence

authors： Machado AP,Silva MR,Fischman O

更新日期：2010-01-01 00:00:00

abstract：:Anthrax toxins and capsule are the major virulence factors of Bacillus anthracis. They are encoded by genes located on the plasmids pXO1 and pXO2, respectively. The vaccine strain Pasteur II was produced from high temperature subcultures of B. anthracis, which resulted in virulence attenuation through the loss of the ...

journal_title：Virulence

authors： Liang X,Zhang H,Zhang E,Wei J,Li W,Wang B,Dong S,Zhu J

更新日期：2016-07-03 00:00:00

abstract：:Pathogens frequently exist in an immunological balancing act with their host. Pathogens must not only replicate within a host but also transmit effectively between hosts to perpetuate their species. On the other hand, the host seeks to maintain homeostasis by clearing pathogens. The inflammasome is a multi-protein com...

journal_title：Virulence

authors： Lupfer CR,Kanneganti TD

更新日期：2012-05-01 00:00:00

abstract：:Periodontitis is an infectious inflammatory disease that destroys the tooth-supporting tissues. It is caused by the formation of subgingival biofilms on the surface of the tooth. Characteristic bacteria associated with subgingival biofilms are the Gram-negative anaerobes Porphyromonas gingivalis, Tannerella forsythia ...

journal_title：Virulence

authors： Belibasakis GN,Kast JI,Thurnheer T,Akdis CA,Bostanci N

更新日期：2015-01-01 00:00:00

abstract：:Bacterial IgA1 proteases are thought to be important virulence factors in respiratory tract infections. These proteolytic enzymes specifically cleave one of several post-proline peptide bonds within the hinge region of human immunoglobulin A1 (IgA1). Human IgA1 was cleaved with an IgA1 protease purified from an isolat...

journal_title：Virulence

authors： Mistry DV,Stockley RA

更新日期：2011-03-01 00:00:00