Abstract:
:Bacterial pathogenicity deeply depends on the ability to secrete virulence factors that bind specific targets on host cells and manipulate host responses. The Gram-positive bacterium Listeria monocytogenes is a human foodborne pathogen that remains a serious public health concern. To transport proteins across its cell envelope, this facultative intracellular pathogen engages a set of specialized secretion systems. Here we show that L. monocytogenes EGDe uses a specialized secretion system, named ESX-1, to secrete EsxA, a homolog of the virulence determinants ESAT-6 and EsxA of Mycobacterium tuberculosis and Staphylococcus aureus, respectively. Our data show that the L. monocytogenes ESX-1 secretion system and its substrates are dispensable for bacterial invasion and intracellular multiplication in eukaryotic cell lines. Surprisingly, we found that the EssC-dependent secretion of EsxA has a detrimental effect on L. monocytogenes in vivo infection.
journal_name
Virulencejournal_title
Virulenceauthors
Pinheiro J,Reis O,Vieira A,Moura IM,Zanolli Moreno L,Carvalho F,Pucciarelli MG,García-Del Portillo F,Sousa S,Cabanes Ddoi
10.1080/21505594.2016.1244589subject
Has Abstractpub_date
2017-08-18 00:00:00pages
993-1004issue
6eissn
2150-5594issn
2150-5608journal_volume
8pub_type
杂志文章相关文献
Virulence文献大全abstract::The Gram-negative enteropathogen Yersinia pseudotuberculosis possesses a number of regulatory systems that detect cell envelope damage caused by noxious extracytoplasmic stresses. The CpxA sensor kinase and CpxR response regulator two-component regulatory system is one such pathway. Active Cpx signalling upregulates v...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2018.1556151
更新日期:2019-12-01 00:00:00
abstract::Acinetobacter nosocomialis is an important nosocomial pathogen that causes a variety of human infections. However, the specific virulence factors of this microorganism have not yet been determined. We investigated the role of outer membrane protein A (OmpA) in the pathogenesis of A. nosocomialis. A ΔompA mutant of the...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2016.1140298
更新日期:2016-05-18 00:00:00
abstract::Bloodstream infections (BSI) carry a heavy burden of morbidity and mortality in modern internal medicine wards (IMW). These wards are often filled with elderly subjects with several risk factors for BSI, such as multiple comorbidities, polypharmacy, immunosuppression, and indwelling devices. Diagnosing BSI in such a s...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.1080/21505594.2016.1140296
更新日期:2016-04-02 00:00:00
abstract::Drugs such as linezolid that inhibit bacterial protein synthesis may be beneficial in treating infections caused by toxigenic Staphylococcus aureus. As protein synthesis inhibitors have no effect on preformed toxins, neutralization of pathogenic exotoxins with anti-toxin antibodies may be beneficial in conjunction wit...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2016.1267894
更新日期:2017-10-03 00:00:00
abstract::Lipid mediators, derived from arachidonic acid metabolism, play an important role in immune regulation. The functions of bioactive eicosanoids range from modulating cytokine signaling and inflammasome formation to anti-inflammatory and pro-resolving activities. Human pathogenic fungi such as Candida albicans, Candida ...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2018.1475797
更新日期:2018-01-01 00:00:00
abstract::The emergence of resistance requires alternative methods to treat Candida albicans infections. We evaluated efficacy of the efflux pump inhibitor (EPI) verapamil (VER) with fluconazole (FLC) against FLC-resistant (CaR) and -susceptible C. albicans (CaS). The susceptibility of both strains to VER and FLC was determined...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2020.1868814
更新日期:2021-12-01 00:00:00
abstract::Novel coronavirus disease 2019 (COVID-19), caused by novel coronavirus SARS-CoV-2, has spread globally since the end of 2019. Asymptomatic carriers are of great concern as they can undermine the interventions to stop the pandemic. However, there is limited information about the characteristics and outcomes of the asym...
journal_title:Virulence
pub_type: 杂志文章,多中心研究
doi:10.1080/21505594.2020.1802194
更新日期:2020-12-01 00:00:00
abstract::Trehalose is a disaccharide formed from two glucose molecules. This sugar molecule can be isolated from a range of organisms including bacteria, fungi, plants and invertebrates. Trehalose has a variety of functions including a role as an energy storage molecule, a structural component of glycolipids and plays a role i...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2016.1199316
更新日期:2017-01-02 00:00:00
abstract::Until recently, epithelial cells have been a largely ignored component of host responses to microbes. However, this has been largely overturned over the last decade as an ever increasing number of studies have highlighted the key role that these cells play in many of our interactions with our microbiota and pathogens....
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.1080/21505594.2015.1012981
更新日期:2015-01-01 00:00:00
abstract::Biofilm-degrading enzymes could be used for the gentle cleaning of industrial and medical devices and the manufacture of biofilm-resistant materials. We therefore investigated 20 species and strains of the bacterial genus Lysobacter for their ability to degrade experimental biofilms formed by Staphylococcus epidermidi...
journal_title:Virulence
pub_type: 杂志文章
doi:10.4161/viru.27919
更新日期:2014-04-01 00:00:00
abstract::The twin-arginine translocation (Tat) system is involved in a variety of important bacterial physiological processes. Conserved among bacteria and crucial for virulence, the Tat system is deemed as a promising anti-microbial drug target. However, the mechanism of how the Tat system functions in bacterial pathogenesis ...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2020.1817709
更新日期:2020-12-01 00:00:00
abstract::We described an association between a strain of the nematode Caenorhabditis briggsae, i.e. KT0001, and the bacteria Serratia sp. SCBI (South African Caenorhabditis briggsae isolate), which was able to kill the insect Galleria. Here we show that the Serratia sp. SCBI lines the gut of the nematode, similar to the Hetero...
journal_title:Virulence
pub_type: 杂志文章
doi:10.4161/viru.2.2.15337
更新日期:2011-03-01 00:00:00
abstract::The virulence behaviors of many Gram-negative bacterial pathogens are governed by quorum-sensing (QS), a hierarchical system of gene regulation that relies on population density by producing and detecting extracellular signaling molecules. Although extensively studied under in vitro conditions, adaptation of QS system...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2020.1809327
更新日期:2020-12-01 00:00:00
abstract::Bacteria interact with their host through protein secretion systems and surface structures. Pathogenic bacteria encode protein secretion systems that promote the invasion of the host's tissue, the evasion of the host's immune response, the thwarting microbial competitors, and ultimately survival within the host. For m...
journal_title:Virulence
pub_type: 评论,社论
doi:10.1080/21505594.2017.1421829
更新日期:2018-01-01 00:00:00
abstract::Highly pathogenic (HP) avian influenza viruses (AIV) evolve from low pathogenic (LP) precursors after circulation in poultry by reassortment and/or single mutations in different gene segments including that encoding NS1. The carboxyl terminal end (CTE) of NS1 exhibits deletions between amino acid 202 and 230 with stil...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2016.1159367
更新日期:2016-07-03 00:00:00
abstract::A number of abundant mobile genetic elements called retrotransposons reverse transcribe RNA to generate DNA for insertion into eukaryotic genomes. Non-long-terminal repeat (non-LTR) retrotransposons represent a major class of retrotransposons, and transposons that move by target-primed reverse transcription lack LTRs ...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.4161/viru.27278
更新日期:2014-02-15 00:00:00
abstract::Legionella pneumophila, the causative agent of Legionnaires' disease, is widely distributed throughout natural and artificial water systems and can replicate in macrophages and amoebae. Amoebae are the natural hosts of L. pneumophila, whereas macrophages are incidentally infected. The life cycle of L. pneumophila comp...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2017.1373925
更新日期:2018-01-01 00:00:00
abstract::The aim of this study was to investigate if the alternative in vivo model Galleria mellonella can be used (i) to determine differences in pathogenicity of amphotericin B (AMB) resistant and susceptible A. terreus isolates, (ii) to evaluate AMB efficacy in vivo (iii) and to correlate outcome to in vitro susceptibility ...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2015.1045183
更新日期:2015-01-01 00:00:00
abstract::Neurodegenerative human CJD and sheep scrapie are diseases caused by several different transmissible encephalopathy (TSE) agents. These infectious agents provoke innate immune responses in the brain, including late-onset abnormal prion protein (PrP-res) amyloid. Agent particles that lack detectable PrP sequences by de...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2015.1098804
更新日期:2015-01-01 00:00:00
abstract::Development of new therapeutics against Select Agents such as Francisella is critical preparation in the event of bioterrorism. Testing FDA-approved drugs for this purpose may yield new activities unrelated to their intended purpose and may hasten the discovery of new therapeutics. A library of 420 FDA-approved drugs ...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2015.1046029
更新日期:2015-01-01 00:00:00
abstract::Carbapenem-Resistant Enterobacteriaceae (CRE) are an emerging healthcare crisis. Infections due to CRE are associated with high morbidity and mortality, especially in critically ill patients. Due to the multi-drug resistant nature of these infections only limited treatment options are available. Antimicrobials that ha...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.1080/21505594.2016.1221021
更新日期:2017-05-19 00:00:00
abstract::Cryptococcus neoformans: (H99W) was serially passaged in the invertebrate wax moth Galleria mellonella fifteen times to study how fungal virulence evolves under selection and whether those adaptations affect virulence. The G. mellonella passaged strain (P15) and the pre-passage H99W strains were used to infect three d...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2020.1831332
更新日期:2020-12-01 00:00:00
abstract::Rat bite fever (RBF), a worldwide occurring and most likely under-diagnosed zoonosis caused by Streptobacillus moniliformis, represents the most prominent disease of Streptobacillus infections. Recently, novel members have been described, from which a reservoir in rats and other animal species and a zoonotic potential...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.1080/21505594.2016.1177694
更新日期:2016-08-17 00:00:00
abstract::In immune-competent hosts, adenoviruses (Ads) are mild pathogens that cause mainly infections of the respiratory and ocular tracks. The advent of Ad-based gene transfer vectors made the understanding of their interaction with the host cellular machinery an intensive field of research over the last decade. As studies f...
journal_title:Virulence
pub_type: 杂志文章
doi:10.4161/viru.1.3.11379
更新日期:2010-05-01 00:00:00
abstract::Staphylococcus aureus infections are becoming a major global health issue due to the rapid emergence of multidrug-resistant strains. Therefore, there is an urgent need to develop an effective vaccine to prevent and control these infections. In order to develop a universal immunization strategy, we constructed a mutant...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2017.1417723
更新日期:2018-01-01 00:00:00
abstract::Mucormycosis is an uncommon fungal infection that has been increasingly reported in severely immunocompromised patients receiving Aspergillus-active antifungals. Although clinical studies and pre-clinical animal models have suggested a unique predisposition for breakthrough mucormycoses in patients receiving voriconaz...
journal_title:Virulence
pub_type: 杂志文章
doi:10.4161/viru.2.4.17074
更新日期:2011-07-01 00:00:00
abstract:BACKGROUND:Reports show that more than 20 million infants world-wide are born prematurely with 95% of all pre-term births occurring in developing countries. Oral colonization of gram-negative anaerobes has been implicated as a risk factor for preterm delivery of low birth weight infants. MATERIALS AND METHODS:This stu...
journal_title:Virulence
pub_type: 杂志文章
doi:10.4161/viru.1.4.12004
更新日期:2010-07-01 00:00:00
abstract::Golden hamsters were inoculated with Schistosoma haematobium cercariae to examine histological lesions at different time points over an 18 month period of infection. Hamsters were sacrificed 26 weeks and 82 weeks after inoculation. The parasite was found in the blood and in the liver of infected animals as was expecte...
journal_title:Virulence
pub_type: 杂志文章
doi:10.4161/viru.1.3.11348
更新日期:2010-05-01 00:00:00
abstract::Bacterial eukaryotic-like serine threonine kinases (eSTKs) and serine threonine phosphatases (eSTPs) have emerged as important signaling elements that are indispensable for pathogenesis. Differing considerably from their histidine kinase counterparts, few eSTK genes are encoded within the average bacterial genome, and...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.4161/21505594.2014.983404
更新日期:2014-01-01 00:00:00
abstract::Sepsis remains a common, serious, and heterogeneous clinical entity that is difficult to define adequately. Despite its importance as a public health problem, efforts to develop and gain regulatory approval for a specific therapeutic agent for the adjuvant treatment of sepsis have been remarkably unsuccessful. One ste...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.4161/viru.26083
更新日期:2014-01-01 00:00:00