The ER stress response and host temperature adaptation in the human fungal pathogen Cryptococcus neoformans.

Abstract:

:In all eukaryotic cells, the ER stress response is pivotal to survival and adaptation under stress conditions. During temperature adaptation in the human fungal pathogen Cryptococcus neoformans, ER stress is engaged transiently. Studies of this response have demonstrated that both the engagement (turning on the response), as well as the resolution (turning off the response) are required for temperature adaptation and, therefore, pathogenesis. In this review, we synthesize our current understanding of ER stress response engagement and resolution in C. neoformans during host temperature adaptation with a focus on the posttranscriptional events that regulate it. Identification of fungal-specific and Cryptococcus-specific elements of the evolutionarily conserved ER stress response pathway could lead to identification of anti-fungal targets in this fundamental stress response.

journal_name

Virulence

journal_title

Virulence

authors

Glazier VE,Panepinto JC

doi

10.4161/viru.27187

subject

Has Abstract

pub_date

2014-02-15 00:00:00

pages

351-6

issue

2

eissn

2150-5594

issn

2150-5608

pii

27187

journal_volume

5

pub_type

杂志文章,评审
  • Regulation of transcription by eukaryotic-like serine-threonine kinases and phosphatases in Gram-positive bacterial pathogens.

    abstract::Bacterial eukaryotic-like serine threonine kinases (eSTKs) and serine threonine phosphatases (eSTPs) have emerged as important signaling elements that are indispensable for pathogenesis. Differing considerably from their histidine kinase counterparts, few eSTK genes are encoded within the average bacterial genome, and...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.4161/21505594.2014.983404

    authors: Wright DP,Ulijasz AT

    更新日期:2014-01-01 00:00:00

  • A D-Alanine auxotrophic live vaccine is effective against lethal infection caused by Staphylococcus aureus.

    abstract::Staphylococcus aureus infections are becoming a major global health issue due to the rapid emergence of multidrug-resistant strains. Therefore, there is an urgent need to develop an effective vaccine to prevent and control these infections. In order to develop a universal immunization strategy, we constructed a mutant...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2017.1417723

    authors: Moscoso M,García P,Cabral MP,Rumbo C,Bou G

    更新日期:2018-01-01 00:00:00

  • Screen of FDA-approved drug library identifies maprotiline, an antibiofilm and antivirulence compound with QseC sensor-kinase dependent activity in Francisella novicida.

    abstract::Development of new therapeutics against Select Agents such as Francisella is critical preparation in the event of bioterrorism. Testing FDA-approved drugs for this purpose may yield new activities unrelated to their intended purpose and may hasten the discovery of new therapeutics. A library of 420 FDA-approved drugs ...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2015.1046029

    authors: Dean SN,van Hoek ML

    更新日期:2015-01-01 00:00:00

  • Listeria monocytogenes encodes a functional ESX-1 secretion system whose expression is detrimental to in vivo infection.

    abstract::Bacterial pathogenicity deeply depends on the ability to secrete virulence factors that bind specific targets on host cells and manipulate host responses. The Gram-positive bacterium Listeria monocytogenes is a human foodborne pathogen that remains a serious public health concern. To transport proteins across its cell...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2016.1244589

    authors: Pinheiro J,Reis O,Vieira A,Moura IM,Zanolli Moreno L,Carvalho F,Pucciarelli MG,García-Del Portillo F,Sousa S,Cabanes D

    更新日期:2017-08-18 00:00:00

  • Adherence and uptake of Francisella into host cells.

    abstract::Francisella tularensis is a highly virulent bacterial pathogen that is easily aerosolized and has a low infectious dose. As an intracellular pathogen, entry of Francisella into host cells is critical for its survival and virulence. However, the initial steps of attachment and internalization of Francisella into host c...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.4161/viru.25629

    authors: Moreau GB,Mann BJ

    更新日期:2013-11-15 00:00:00

  • A DUF4148 family protein produced inside RAW264.7 cells is a critical Burkholderia pseudomallei virulence factor.

    abstract::Burkholderia pseudomallei: is the etiological agent of the disease melioidosis and is a Tier 1 select agent. It survives and replicates inside phagocytic cells by escaping from the endocytic vacuole, replicating in the cytosol, spreading to other cells via actin polymerization and promoting the fusion of infected and ...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2020.1806675

    authors: Welkos S,Blanco I,Okaro U,Chua J,DeShazer D

    更新日期:2020-12-01 00:00:00

  • The role of inflammasome modulation in virulence.

    abstract::Pathogens frequently exist in an immunological balancing act with their host. Pathogens must not only replicate within a host but also transmit effectively between hosts to perpetuate their species. On the other hand, the host seeks to maintain homeostasis by clearing pathogens. The inflammasome is a multi-protein com...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.4161/viru.20266

    authors: Lupfer CR,Kanneganti TD

    更新日期:2012-05-01 00:00:00

  • The girl with the iron tattoo.

    abstract::We describe a young woman with profound anemia whose serum iron studies were incongruous with what we expected from iron deficiency anemia. Her high serum iron was not fully explainable until we examined the patient and noticed a large black tattoo on her left flank area. Apparently iron oxide in the ink used for the ...

    journal_title:Virulence

    pub_type: 信件

    doi:10.4161/viru.22122

    authors: Fircanis S,Shields R,Castillo J,Mega A,Schiffman F

    更新日期:2012-11-15 00:00:00

  • The Tat system and its dependent cell division proteins are critical for virulence of extra-intestinal pathogenic Escherichia coli.

    abstract::The twin-arginine translocation (Tat) system is involved in a variety of important bacterial physiological processes. Conserved among bacteria and crucial for virulence, the Tat system is deemed as a promising anti-microbial drug target. However, the mechanism of how the Tat system functions in bacterial pathogenesis ...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2020.1817709

    authors: Liu J,Yin F,Liu T,Li S,Tan C,Li L,Zhou R,Huang Q

    更新日期:2020-12-01 00:00:00

  • Surfactant phospholipids act as molecular switches for premature induction of quorum sensing-dependent virulence in Pseudomonas aeruginosa.

    abstract::The virulence behaviors of many Gram-negative bacterial pathogens are governed by quorum-sensing (QS), a hierarchical system of gene regulation that relies on population density by producing and detecting extracellular signaling molecules. Although extensively studied under in vitro conditions, adaptation of QS system...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2020.1809327

    authors: Kuang Z,Bennett RC,Lin J,Hao Y,Zhu L,Akinbi HT,Lau GW

    更新日期:2020-12-01 00:00:00

  • Galleria mellonella as a host model to study Aspergillus terreus virulence and amphotericin B resistance.

    abstract::The aim of this study was to investigate if the alternative in vivo model Galleria mellonella can be used (i) to determine differences in pathogenicity of amphotericin B (AMB) resistant and susceptible A. terreus isolates, (ii) to evaluate AMB efficacy in vivo (iii) and to correlate outcome to in vitro susceptibility ...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2015.1045183

    authors: Maurer E,Browne N,Surlis C,Jukic E,Moser P,Kavanagh K,Lass-Flörl C,Binder U

    更新日期:2015-01-01 00:00:00

  • Campylobacter jejuni free oligosaccharides: function and fate.

    abstract::The Campylobacter jejuni N-linked protein glycosylation pathway produces a heptasaccharide that is added to >65 periplasmic and membrane proteins and is also released into the periplasm as the free oligosaccharide (fOS). The fOS is a novel soluble component of the C. jejuni periplasmic space that exists in 10-fold gre...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.4161/viru.1.6.13801

    authors: Nothaft H,Liu X,Li J,Szymanski CM

    更新日期:2010-11-01 00:00:00

  • The structure and retrotransposition mechanism of LTR-retrotransposons in the asexual yeast Candida albicans.

    abstract::Retrotransposons constitute a major part of the genome in a number of eukaryotes. Long-terminal repeat (LTR) retrotransposons are one type of the retrotransposons. Candida albicans have 34 distinct LTR-retrotransposon families. They respectively belong to the Ty1/copia and Ty3/gypsy groups which have been extensively ...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.4161/viru.32180

    authors: Zhang L,Yan L,Jiang J,Wang Y,Jiang Y,Yan T,Cao Y

    更新日期:2014-08-15 00:00:00

  • Voriconazole pre-exposure selects for breakthrough mucormycosis in a mixed model of Aspergillus fumigatus-Rhizopus oryzae pulmonary infection.

    abstract::Mucormycosis is an uncommon fungal infection that has been increasingly reported in severely immunocompromised patients receiving Aspergillus-active antifungals. Although clinical studies and pre-clinical animal models have suggested a unique predisposition for breakthrough mucormycoses in patients receiving voriconaz...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.4161/viru.2.4.17074

    authors: Lewis RE,Liao G,Wang W,Prince RA,Kontoyiannis DP

    更新日期:2011-07-01 00:00:00

  • The mutated staphylococcal H35A α-toxin inhibits adhesion and invasion of Staphylococcus aureus and group A streptococci.

    abstract::In previous studies we demonstrated that the staphylococcal α-toxin inhibits adhesion and invasion of S. aureus by epithelial cells through binding to α5β1 integrin, a receptor of fibronectin. Moreover, we revealed that a H35A mutation abolishes the cytotoxicity of α-toxin completely. These findings led us to hypothes...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.4161/viru.22719

    authors: Yang J,Liang X,Ji Y

    更新日期:2013-01-01 00:00:00

  • Outer membrane Protein A plays a role in pathogenesis of Acinetobacter nosocomialis.

    abstract::Acinetobacter nosocomialis is an important nosocomial pathogen that causes a variety of human infections. However, the specific virulence factors of this microorganism have not yet been determined. We investigated the role of outer membrane protein A (OmpA) in the pathogenesis of A. nosocomialis. A ΔompA mutant of the...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2016.1140298

    authors: Kim SW,Oh MH,Jun SH,Jeon H,Kim SI,Kim K,Lee YC,Lee JC

    更新日期:2016-05-18 00:00:00

  • Prevalence of the C-terminal truncations of NS1 in avian influenza A viruses and effect on virulence and replication of a highly pathogenic H7N1 virus in chickens.

    abstract::Highly pathogenic (HP) avian influenza viruses (AIV) evolve from low pathogenic (LP) precursors after circulation in poultry by reassortment and/or single mutations in different gene segments including that encoding NS1. The carboxyl terminal end (CTE) of NS1 exhibits deletions between amino acid 202 and 230 with stil...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2016.1159367

    authors: Abdelwhab el-SM,Veits J,Breithaupt A,Gohrbandt S,Ziller M,Teifke JP,Stech J,Mettenleiter TC

    更新日期:2016-07-03 00:00:00

  • Trehalase plays a role in macrophage colonization and virulence of Burkholderia pseudomallei in insect and mammalian hosts.

    abstract::Trehalose is a disaccharide formed from two glucose molecules. This sugar molecule can be isolated from a range of organisms including bacteria, fungi, plants and invertebrates. Trehalose has a variety of functions including a role as an energy storage molecule, a structural component of glycolipids and plays a role i...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2016.1199316

    authors: Vanaporn M,Sarkar-Tyson M,Kovacs-Simon A,Ireland PM,Pumirat P,Korbsrisate S,Titball RW,Butt A

    更新日期:2017-01-02 00:00:00

  • Structural features and mechanism of translocation of non-LTR retrotransposons in Candida albicans.

    abstract::A number of abundant mobile genetic elements called retrotransposons reverse transcribe RNA to generate DNA for insertion into eukaryotic genomes. Non-long-terminal repeat (non-LTR) retrotransposons represent a major class of retrotransposons, and transposons that move by target-primed reverse transcription lack LTRs ...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.4161/viru.27278

    authors: Jiang J,Zhao L,Yan L,Zhang L,Cao Y,Wang Y,Jiang Y,Yan T,Cao Y

    更新日期:2014-02-15 00:00:00

  • In silico and in vitro evaluation of PCR-based assays for the detection of Bacillus anthracis chromosomal signature sequences.

    abstract::Bacillus anthracis, the causative agent of anthrax, is a zoonotic pathogen that is relatively common throughout the world and may cause life threatening diseases in animals and humans. There are many PCR-based assays in use for the detection of B. anthracis. While most of the developed assays rely on unique markers pr...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.4161/viru.26288

    authors: Ågren J,Hamidjaja RA,Hansen T,Ruuls R,Thierry S,Vigre H,Janse I,Sundström A,Segerman B,Koene M,Löfström C,Van Rotterdam B,Derzelle S

    更新日期:2013-11-15 00:00:00

  • Passive therapy with humanized anti-staphylococcal enterotoxin B antibodies attenuates systemic inflammatory response and protects from lethal pneumonia caused by staphylococcal enterotoxin B-producing Staphylococcus aureus.

    abstract::Drugs such as linezolid that inhibit bacterial protein synthesis may be beneficial in treating infections caused by toxigenic Staphylococcus aureus. As protein synthesis inhibitors have no effect on preformed toxins, neutralization of pathogenic exotoxins with anti-toxin antibodies may be beneficial in conjunction wit...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2016.1267894

    authors: Karau MJ,Tilahun ME,Krogman A,Osborne BA,Goldsby RA,David CS,Mandrekar JN,Patel R,Rajagopalan G

    更新日期:2017-10-03 00:00:00

  • BabA-mediated adherence of pediatric ulcerogenic H. pylori strains to gastric mucins at neutral and acidic pH.

    abstract::Helicobacter pylori infection can result in non-ulcer dyspepsia (NUD), peptic ulcer disease (PUD), adenocarcinoma, and gastric lymphoma. H. pylori reside within the gastric mucus layer, mainly composed of mucins carrying an array of glycan structures that can serve as bacterial adhesion epitopes. The aim of the presen...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2018.1532243

    authors: Quintana-Hayashi MP,Rocha R,Padra M,Thorell A,Jin C,Karlsson NG,Roxo-Rosa M,Oleastro M,Lindén SK

    更新日期:2018-01-01 00:00:00

  • Indirubin derivatives are potent and selective anti-Trypanosoma cruzi agents.

    abstract::Current treatment for combatting Chagas disease, a life-threatening illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi is inadequate, and thus the discovery of new antiparasitic compounds is of prime importance. Previous studies identified the indirubins, a class of ATP kinase inhibitors, as pote...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2018.1532242

    authors: Efstathiou A,Meira CS,Gaboriaud-Kolar N,Bastos TM,Rocha VPC,Vougogiannopoulou K,Skaltsounis AL,Smirlis D,Soares MBP

    更新日期:2018-01-01 00:00:00

  • Influence of maternal vaccination against diphtheria, tetanus, and pertussis on the avidity of infant antibody responses to a pertussis containing vaccine in Belgium.

    abstract::Maternal antibodies induced by vaccination during pregnancy cross the placental barrier and can close the susceptibility gap to pertussis in young infants up to the start of primary immunization. As not only the quantity but also the quality of circulating antibodies is important for protection, we assessed whether ma...

    journal_title:Virulence

    pub_type: 临床试验,杂志文章

    doi:10.1080/21505594.2017.1296998

    authors: Caboré RN,Maertens K,Dobly A,Leuridan E,Van Damme P,Huygen K

    更新日期:2017-10-03 00:00:00

  • Role of luxS in Bacillus anthracis growth and virulence factor expression.

    abstract::Quorum-sensing (QS), the regulation of bacterial gene expression in response to changes in cell density, involves pathways that synthesize signaling molecules (auto-inducers). The luxS/AI-2-mediated QS system has been identified in both gram-positive and gram-negative bacteria. Bacillus anthracis, the etiological agen...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.4161/viru.1.2.10752

    authors: Jones MB,Peterson SN,Benn R,Braisted JC,Jarrahi B,Shatzkes K,Ren D,Wood TK,Blaser MJ

    更新日期:2010-03-01 00:00:00

  • Prevalence of mip virulence gene and PCR-base sequence typing of Legionella pneumophila from cooling water systems of two cities in Iran.

    abstract::Legionella pneumophila is the primary respiratory pathogen and mostly transmitted to human through water cooling systems and cause mild to severe pneumonia with high mortality rate especially in elderly both in hospitals and community. However, current Legionella risk assessments may be compromised by uncertainties in...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2016.1170944

    authors: Ahmadrajabi R,Shakibaie MR,Iranmanesh Z,Mollaei HR,Sobhanipoor MH

    更新日期:2016-07-03 00:00:00

  • Functional and structural characteristics of bacterial proteins that bind host cytokines.

    abstract::Several human pathogens bind and respond to host cytokines, which can be considered a virulence mechanism that communicates defensive actions of the host to the pathogen. This review summarizes the current knowledge of bacterial cytokine-binding proteins, with a particular focus on their functional and structural char...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.1080/21505594.2017.1363140

    authors: Högbom M,Ihalin R

    更新日期:2017-11-17 00:00:00

  • Candida albicans-epithelial interactions and pathogenicity mechanisms: scratching the surface.

    abstract::Until recently, epithelial cells have been a largely ignored component of host responses to microbes. However, this has been largely overturned over the last decade as an ever increasing number of studies have highlighted the key role that these cells play in many of our interactions with our microbiota and pathogens....

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.1080/21505594.2015.1012981

    authors: Moyes DL,Richardson JP,Naglik JR

    更新日期:2015-01-01 00:00:00

  • Risk stratification and immunogenetic risk for infections following stem cell transplantation.

    abstract::Patients undergoing haematopoietic stem cell transplantation (HSCT) are highly exposed to infectious agents. However, it is not known why certain HSCT recipients rapidly develop severe infections while other, despite similar immunosuppressive conditions, do not. Increasing evidence suggests that such differences may b...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.1080/21505594.2016.1234566

    authors: Wójtowicz A,Bochud PY

    更新日期:2016-11-16 00:00:00

  • Particle size and pathogenicity in the respiratory tract.

    abstract::Particle size dictates where aerosolized pathogens deposit in the respiratory tract, thereafter the pathogens potential to cause disease is influenced by tissue tropism, clearance kinetics and the host immunological response. This interplay brings pathogens into contact with a range of tissues spanning the respiratory...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.4161/viru.27172

    authors: Thomas RJ

    更新日期:2013-11-15 00:00:00