Abstract:
:Francisella tularensis is a highly virulent bacterial pathogen that is easily aerosolized and has a low infectious dose. As an intracellular pathogen, entry of Francisella into host cells is critical for its survival and virulence. However, the initial steps of attachment and internalization of Francisella into host cells are not well characterized, and little is known about bacterial factors that promote these processes. This review highlights our current understanding of Francisella attachment and internalization into host cells. In particular, we emphasize the host cell types Francisella has been shown to interact with, as well as specific receptors and signaling processes involved in the internalization process. This review will shed light on gaps in our current understanding and future areas of investigation.
journal_name
Virulencejournal_title
Virulenceauthors
Moreau GB,Mann BJdoi
10.4161/viru.25629subject
Has Abstractpub_date
2013-11-15 00:00:00pages
826-32issue
8eissn
2150-5594issn
2150-5608pii
25629journal_volume
4pub_type
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