Abstract:
:In immune-competent hosts, adenoviruses (Ads) are mild pathogens that cause mainly infections of the respiratory and ocular tracks. The advent of Ad-based gene transfer vectors made the understanding of their interaction with the host cellular machinery an intensive field of research over the last decade. As studies focused primarily on epithelial-like cells, the mechanism of neuronal uptake of Ads was still missing. Using a combination of biochemical and cell biology approaches, we characterized the axonal trafficking pathway used by the canine adenovirus serotype 2 (CAV-2) to reach the neuronal soma. We showed that CAV-2 and CAR (coxsackievirus and adenovirus receptor) are entering a vesicular pathway coupled to the axonal transport machinery. The lumen of the multivalent Rab7 (+) vesicles that transport CAV-2 and CAR is, surprisingly, pH neutral. Among other issues, our study opens numerous questions concerning the neuronal function of CAR.
journal_name
Virulencejournal_title
Virulenceauthors
Henaff D,Salinas Sdoi
10.4161/viru.1.3.11379subject
Has Abstractpub_date
2010-05-01 00:00:00pages
188-91issue
3eissn
2150-5594issn
2150-5608pii
11379journal_volume
1pub_type
杂志文章相关文献
Virulence文献大全abstract::The recent finding that the formation of staphylococcal enterotoxins in food is very different from that in cultures of pure Staphylococcus aureus sheds new light on, and brings into question, traditional microbial risk assessment methods based on planktonic liquid cultures. In fact, most bacteria in food appear to be...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.4161/viru.2.6.18122
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Reports show that more than 20 million infants world-wide are born prematurely with 95% of all pre-term births occurring in developing countries. Oral colonization of gram-negative anaerobes has been implicated as a risk factor for preterm delivery of low birth weight infants. MATERIALS AND METHODS:This stu...
journal_title:Virulence
pub_type: 杂志文章
doi:10.4161/viru.1.4.12004
更新日期:2010-07-01 00:00:00
abstract::The exploration of epidemic dynamics on dynamically evolving ("adaptive") networks poses nontrivial challenges to the modeler, such as the determination of a small number of informative statistics of the detailed network state (that is, a few "good observables") that usefully summarize the overall (macroscopic, system...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2015.1121357
更新日期:2016-01-01 00:00:00
abstract::Intrinsically disordered proteins (IDPs) do not have a well-defined and stable 3-dimensional fold. Some IDPs can function as either transient or permanent binders of other proteins and may interact with an array of ligands by adopting different conformations. A novel outer membrane lipoprotein, bacterial interleukin r...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2016.1216294
更新日期:2017-02-17 00:00:00
abstract::Multi-antibiotic drug-resistant (MDR) gram-negative bacilli are becoming a major threat to the standard care of septic patients. Empiric antimicrobial drug regimens to cover likely bacterial pathogens have to be altered in keeping with the spread of MDR pathogens in the health care setting and in the community. Reliab...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.4161/viru.26210
更新日期:2014-01-01 00:00:00
abstract::Lipid mediators, derived from arachidonic acid metabolism, play an important role in immune regulation. The functions of bioactive eicosanoids range from modulating cytokine signaling and inflammasome formation to anti-inflammatory and pro-resolving activities. Human pathogenic fungi such as Candida albicans, Candida ...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2018.1475797
更新日期:2018-01-01 00:00:00
abstract::Chloroquine (CQ) was the best and most heavily used drug in the fight against malaria. However, the effectiveness of CQ has declined with the emergence and spread of CQ-resistant (CQR) Plasmodium falciparum parasites. The primary determinant of CQ resistance in P. falciparum is mutations in the parasite's 'chloroquine...
journal_title:Virulence
pub_type: 杂志文章
doi:10.4161/viru.1.4.12012
更新日期:2010-07-01 00:00:00
abstract::Bacterial IgA1 proteases are thought to be important virulence factors in respiratory tract infections. These proteolytic enzymes specifically cleave one of several post-proline peptide bonds within the hinge region of human immunoglobulin A1 (IgA1). Human IgA1 was cleaved with an IgA1 protease purified from an isolat...
journal_title:Virulence
pub_type: 杂志文章
doi:10.4161/viru.2.2.15401
更新日期:2011-03-01 00:00:00
abstract::Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) have been reported in recent years across Asian countries and pose a serious threat to public health. Neutrophils represent the first line of defense against numerous infectious pathogens, such as CR-hvKP. Neutrophil extracellular traps (NETs) constitu...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2020.1809325
更新日期:2020-12-01 00:00:00
abstract::Pathogens frequently exist in an immunological balancing act with their host. Pathogens must not only replicate within a host but also transmit effectively between hosts to perpetuate their species. On the other hand, the host seeks to maintain homeostasis by clearing pathogens. The inflammasome is a multi-protein com...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.4161/viru.20266
更新日期:2012-05-01 00:00:00
abstract::Bloodstream infections (BSI) carry a heavy burden of morbidity and mortality in modern internal medicine wards (IMW). These wards are often filled with elderly subjects with several risk factors for BSI, such as multiple comorbidities, polypharmacy, immunosuppression, and indwelling devices. Diagnosing BSI in such a s...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.1080/21505594.2016.1140296
更新日期:2016-04-02 00:00:00
abstract::The innate immune system plays a critical role in host defense against mucosal bacteria. Campylobacter jejuni is a major cause of human gastroenteritis that usually resolves spontaneously within several days, suggesting that innate mechanisms are important to control the infection. However, the specific means by which...
journal_title:Virulence
pub_type: 杂志文章
doi:10.4161/viru.2.1.14752
更新日期:2011-01-01 00:00:00
abstract::Novel coronavirus disease 2019 (COVID-19), caused by novel coronavirus SARS-CoV-2, has spread globally since the end of 2019. Asymptomatic carriers are of great concern as they can undermine the interventions to stop the pandemic. However, there is limited information about the characteristics and outcomes of the asym...
journal_title:Virulence
pub_type: 杂志文章,多中心研究
doi:10.1080/21505594.2020.1802194
更新日期:2020-12-01 00:00:00
abstract::Bacterial pathogens release a number of toxins that are able to form pores in target host cells, which can result in their destruction. Due to this property of this subgroup of toxins, they are considered virulence factors. A lesser known ability of these toxins when present at lower concentrations that are insufficie...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.4161/viru.1.5.12705
更新日期:2010-09-01 00:00:00
abstract::The interaction between the fungal pathogen Paracoccidioides brasiliensis and host cells is usually mediated by specific binding events between adhesins on the fungal surface and receptors on the host extracellular matrix or cell surface. One molecule implicated in the P. brasiliensis-host interaction is the 14-3-3 pr...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2015.1122166
更新日期:2016-01-01 00:00:00
abstract::A greater ethical conscience, new global rules and a modified perception of ethical consciousness entail a more rigorous control on utilizations of vertebrates for in vivo studies. To cope with this new scenario, numerous alternatives to rodents have been proposed. Among these, the greater wax moth Galleria mellonella...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.1080/21505594.2019.1621649
更新日期:2019-12-01 00:00:00
abstract::Novel approaches to treat carbapenem-resistant Acinetobacter baumannii (CRAB) infections are urgently needed and anti-virulence drugs represent promising alternatives, but our knowledge on potential targets is scarce. We searched for potential A. baumannii virulence factors by whole-genome sequencing-based comparisons...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2020.1855912
更新日期:2020-12-01 00:00:00
abstract::The twin-arginine translocation (Tat) system is involved in a variety of important bacterial physiological processes. Conserved among bacteria and crucial for virulence, the Tat system is deemed as a promising anti-microbial drug target. However, the mechanism of how the Tat system functions in bacterial pathogenesis ...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2020.1817709
更新日期:2020-12-01 00:00:00
abstract::Until recently, epithelial cells have been a largely ignored component of host responses to microbes. However, this has been largely overturned over the last decade as an ever increasing number of studies have highlighted the key role that these cells play in many of our interactions with our microbiota and pathogens....
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.1080/21505594.2015.1012981
更新日期:2015-01-01 00:00:00
abstract::Non-invasive imaging techniques in microbial disease models have delivered valuable insights in the intimate pathogen-host interplay during infection. Here we describe evaluation and validation of a transgenic bioluminescence reporter strain of the human-pathogenic mold Aspergillus fumigatus, one of the main fungal pa...
journal_title:Virulence
pub_type: 杂志文章
doi:10.4161/viru.3.1.18799
更新日期:2012-01-01 00:00:00
abstract::Current treatment for combatting Chagas disease, a life-threatening illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi is inadequate, and thus the discovery of new antiparasitic compounds is of prime importance. Previous studies identified the indirubins, a class of ATP kinase inhibitors, as pote...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2018.1532242
更新日期:2018-01-01 00:00:00
abstract::Anthrax toxins and capsule are the major virulence factors of Bacillus anthracis. They are encoded by genes located on the plasmids pXO1 and pXO2, respectively. The vaccine strain Pasteur II was produced from high temperature subcultures of B. anthracis, which resulted in virulence attenuation through the loss of the ...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2016.1164366
更新日期:2016-07-03 00:00:00
abstract::Streptococcus agalactiae, or group B Streptococcus (GBS), infects diverse hosts including humans and economically important species such as cattle and fishes. In the context of human health, GBS is a major cause of neonatal infections and an emerging cause of invasive disease in adults and of foodborne disease in Sout...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2019.1631660
更新日期:2019-12-01 00:00:00
abstract::Biofilm-degrading enzymes could be used for the gentle cleaning of industrial and medical devices and the manufacture of biofilm-resistant materials. We therefore investigated 20 species and strains of the bacterial genus Lysobacter for their ability to degrade experimental biofilms formed by Staphylococcus epidermidi...
journal_title:Virulence
pub_type: 杂志文章
doi:10.4161/viru.27919
更新日期:2014-04-01 00:00:00
abstract::Bacteria interact with their host through protein secretion systems and surface structures. Pathogenic bacteria encode protein secretion systems that promote the invasion of the host's tissue, the evasion of the host's immune response, the thwarting microbial competitors, and ultimately survival within the host. For m...
journal_title:Virulence
pub_type: 评论,社论
doi:10.1080/21505594.2017.1421829
更新日期:2018-01-01 00:00:00
abstract::Viral infections of the respiratory tract can be complicated by bacterial superinfection, resulting in a significantly longer duration of illness and even a fatal outcome. In this review, we focused on interactions between S. aureus and non-influenza viruses. Clinical data evidenced that rhinovirus infection may incre...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.1080/21505594.2018.1504561
更新日期:2018-01-01 00:00:00
abstract::Burkholderia pseudomallei: is the etiological agent of the disease melioidosis and is a Tier 1 select agent. It survives and replicates inside phagocytic cells by escaping from the endocytic vacuole, replicating in the cytosol, spreading to other cells via actin polymerization and promoting the fusion of infected and ...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2020.1806675
更新日期:2020-12-01 00:00:00
abstract::We describe a young woman with profound anemia whose serum iron studies were incongruous with what we expected from iron deficiency anemia. Her high serum iron was not fully explainable until we examined the patient and noticed a large black tattoo on her left flank area. Apparently iron oxide in the ink used for the ...
journal_title:Virulence
pub_type: 信件
doi:10.4161/viru.22122
更新日期:2012-11-15 00:00:00
abstract::Mycoplasmas persist in the host for a long time, suggesting that they possess mechanisms for immune evasion. Factor H is a negative regulator of the complement system, which binds to host cells to avoid unexpected complement activation. In this study, we revealed that many mycoplasmas, such as Mycoplasma hyopneumoniae...
journal_title:Virulence
pub_type: 杂志文章
doi:10.1080/21505594.2020.1806664
更新日期:2020-12-01 00:00:00
abstract::Human herpesviruses have latency and lytic replication phases in their lifecycle. Proper regulation of herpesviral lifecycle is essential for the evasion of host immune surveillance and development of their related diseases. Recent advancements indicate a role of a novel class of viral non-coding RNAs, microRNA (miRNA...
journal_title:Virulence
pub_type: 杂志文章,评审
doi:10.4161/viru.1.5.12966
更新日期:2010-09-01 00:00:00