Regulation of herpesvirus lifecycle by viral microRNAs.

Abstract:

:Human herpesviruses have latency and lytic replication phases in their lifecycle. Proper regulation of herpesviral lifecycle is essential for the evasion of host immune surveillance and development of their related diseases. Recent advancements indicate a role of a novel class of viral non-coding RNAs, microRNA (miRNA), in the fine-tuning of herpesviral lifecycle. So far, herpesviral miRNAs appear to promote viral latency by inhibiting viral lytic replication either through direct targeting of key viral replication genes or through manipulation of host pathways that regulate viral lifecycle. The oncogenic Kaposi sarcoma-associated herpesvirus (KSHV) has adapted both strategies to control viral latency. Our recent study has identified a KSHV miRNA that inhibits viral lytic replication by upregulating the NFκB pathway.

journal_name

Virulence

journal_title

Virulence

authors

Lei X,Bai Z,Ye F,Huang Y,Gao SJ

doi

10.4161/viru.1.5.12966

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

433-5

issue

5

eissn

2150-5594

issn

2150-5608

journal_volume

1

pub_type

杂志文章,评审
  • Adherence and uptake of Francisella into host cells.

    abstract::Francisella tularensis is a highly virulent bacterial pathogen that is easily aerosolized and has a low infectious dose. As an intracellular pathogen, entry of Francisella into host cells is critical for its survival and virulence. However, the initial steps of attachment and internalization of Francisella into host c...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.4161/viru.25629

    authors: Moreau GB,Mann BJ

    更新日期:2013-11-15 00:00:00

  • A novel intrinsically disordered outer membrane lipoprotein of Aggregatibacter actinomycetemcomitans binds various cytokines and plays a role in biofilm response to interleukin-1β and interleukin-8.

    abstract::Intrinsically disordered proteins (IDPs) do not have a well-defined and stable 3-dimensional fold. Some IDPs can function as either transient or permanent binders of other proteins and may interact with an array of ligands by adopting different conformations. A novel outer membrane lipoprotein, bacterial interleukin r...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2016.1216294

    authors: Ahlstrand T,Tuominen H,Beklen A,Torittu A,Oscarsson J,Sormunen R,Pöllänen MT,Permi P,Ihalin R

    更新日期:2017-02-17 00:00:00

  • Outer membrane Protein A plays a role in pathogenesis of Acinetobacter nosocomialis.

    abstract::Acinetobacter nosocomialis is an important nosocomial pathogen that causes a variety of human infections. However, the specific virulence factors of this microorganism have not yet been determined. We investigated the role of outer membrane protein A (OmpA) in the pathogenesis of A. nosocomialis. A ΔompA mutant of the...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2016.1140298

    authors: Kim SW,Oh MH,Jun SH,Jeon H,Kim SI,Kim K,Lee YC,Lee JC

    更新日期:2016-05-18 00:00:00

  • Campylobacter capsule and lipooligosaccharide confer resistance to serum and cationic antimicrobials.

    abstract::The innate immune system plays a critical role in host defense against mucosal bacteria. Campylobacter jejuni is a major cause of human gastroenteritis that usually resolves spontaneously within several days, suggesting that innate mechanisms are important to control the infection. However, the specific means by which...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.4161/viru.2.1.14752

    authors: Keo T,Collins J,Kunwar P,Blaser MJ,Iovine NM

    更新日期:2011-01-01 00:00:00

  • Luteolin decreases the pathogenicity of Aeromonas hydrophila via inhibiting the activity of aerolysin.

    abstract::Aeromonas hydrophila (A. hydrophila) can cause a number of diseases in both human and animals. A. hydrophila-related infections in aquaculture cause severe economic losses every year throughout the world. The emergence of antibiotic resistance that is due to the abuse of antibiotics has limited the application of anti...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2020.1867455

    authors: Dong J,Zhang L,Liu Y,Xu N,Zhou S,Yang Y,Yang Q,Ai X

    更新日期:2021-12-01 00:00:00

  • Highly specific host-pathogen interactions influence Metarhizium brunneum blastospore virulence against Culex quinquefasciatus larvae.

    abstract::Entomopathogenic fungi are potential biological control agents of mosquitoes. Our group observed that not all mosquitoes were equally susceptible to fungal infection and observed significant differences in virulence of different spore types. Conidiospores and blastospores were tested against Culex quinquefasciatus lar...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2018.1509665

    authors: Alkhaibari AM,Lord AM,Maffeis T,Bull JC,Olivares FL,Samuels RI,Butt TM

    更新日期:2018-01-01 00:00:00

  • Neutrophil extracellular traps (NETs)-mediated killing of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) are impaired in patients with diabetes mellitus.

    abstract::Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) have been reported in recent years across Asian countries and pose a serious threat to public health. Neutrophils represent the first line of defense against numerous infectious pathogens, such as CR-hvKP. Neutrophil extracellular traps (NETs) constitu...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2020.1809325

    authors: Jin L,Liu Y,Jing C,Wang R,Wang Q,Wang H

    更新日期:2020-12-01 00:00:00

  • Identifying components required for OMP biogenesis as novel targets for antiinfective drugs.

    abstract::The emergence of multiresistant Gram-negative bacteria requires new therapies for combating bacterial infections. Targeting the biogenesis of virulence factors could be an alternative strategy instead of killing bacteria with antibiotics. The outer membrane (OM) of Gram-negative bacteria acts as a physical barrier. At...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2016.1278333

    authors: Weirich J,Bräutigam C,Mühlenkamp M,Franz-Wachtel M,Macek B,Meuskens I,Skurnik M,Leskinen K,Bohn E,Autenrieth I,Schütz M

    更新日期:2017-10-03 00:00:00

  • Targeting Candida albicans filamentation for antifungal drug development.

    abstract::Candida albicans remains the main etiological agent of candidiasis, as this otherwise normal commensal of humans is capable of causing active infection in immune- and medically-compromised patients. The high morbidity and mortality rates associated with candidiasis, coupled with the emergence of drug resistance demand...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.1080/21505594.2016.1197444

    authors: Vila T,Romo JA,Pierce CG,McHardy SF,Saville SP,Lopez-Ribot JL

    更新日期:2017-02-17 00:00:00

  • Influenza virus surveillance using surface plasmon resonance.

    abstract::The hemagglutinin (HA) proteins derived from avian influenza viruses bind specifically to the α2-3 sialoglycan (Sia glycan), whereas human-adapted influenza viruses prefer to bind to the α2-6 Sia glycan. A switch of glycan specificity from α2-3 Sia glycan to α2-6 Sia glycan appears to be critical for a virus to become...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.4161/viru.21822

    authors: Suenaga E,Mizuno H,Kumar PK

    更新日期:2012-08-15 00:00:00

  • Virulence role of the outer membrane protein CarO in carbapenem-resistant Acinetobacter baumannii.

    abstract::Novel approaches to treat carbapenem-resistant Acinetobacter baumannii (CRAB) infections are urgently needed and anti-virulence drugs represent promising alternatives, but our knowledge on potential targets is scarce. We searched for potential A. baumannii virulence factors by whole-genome sequencing-based comparisons...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2020.1855912

    authors: Labrador-Herrera G,Pérez-Pulido AJ,Álvarez-Marín R,Casimiro-Soriguer CS,Cebrero-Cangueiro T,Morán-Barrio J,Pachón J,Viale AM,Pachón-Ibáñez ME

    更新日期:2020-12-01 00:00:00

  • Influence of maternal vaccination against diphtheria, tetanus, and pertussis on the avidity of infant antibody responses to a pertussis containing vaccine in Belgium.

    abstract::Maternal antibodies induced by vaccination during pregnancy cross the placental barrier and can close the susceptibility gap to pertussis in young infants up to the start of primary immunization. As not only the quantity but also the quality of circulating antibodies is important for protection, we assessed whether ma...

    journal_title:Virulence

    pub_type: 临床试验,杂志文章

    doi:10.1080/21505594.2017.1296998

    authors: Caboré RN,Maertens K,Dobly A,Leuridan E,Van Damme P,Huygen K

    更新日期:2017-10-03 00:00:00

  • Galleria mellonella as a host model to study Aspergillus terreus virulence and amphotericin B resistance.

    abstract::The aim of this study was to investigate if the alternative in vivo model Galleria mellonella can be used (i) to determine differences in pathogenicity of amphotericin B (AMB) resistant and susceptible A. terreus isolates, (ii) to evaluate AMB efficacy in vivo (iii) and to correlate outcome to in vitro susceptibility ...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2015.1045183

    authors: Maurer E,Browne N,Surlis C,Jukic E,Moser P,Kavanagh K,Lass-Flörl C,Binder U

    更新日期:2015-01-01 00:00:00

  • Modeling epidemics on adaptively evolving networks: A data-mining perspective.

    abstract::The exploration of epidemic dynamics on dynamically evolving ("adaptive") networks poses nontrivial challenges to the modeler, such as the determination of a small number of informative statistics of the detailed network state (that is, a few "good observables") that usefully summarize the overall (macroscopic, system...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2015.1121357

    authors: Kattis AA,Holiday A,Stoica AA,Kevrekidis IG

    更新日期:2016-01-01 00:00:00

  • Granulomatous-like immune reaction and hepatic fibrosis induced by Schistosoma haematobium immature worms.

    abstract::Golden hamsters were inoculated with Schistosoma haematobium cercariae to examine histological lesions at different time points over an 18 month period of infection. Hamsters were sacrificed 26 weeks and 82 weeks after inoculation. The parasite was found in the blood and in the liver of infected animals as was expecte...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.4161/viru.1.3.11348

    authors: Botelho MC,Oliveira PA,Vieira P,Delgado Mde L,Lourenço L,Lopes C,Machado JC,da Costa JM

    更新日期:2010-05-01 00:00:00

  • A mutation in C. neoformans mitochondrial NADH dehydrogenase results in increased virulence in mice.

    abstract::Cryptococcus neoformans: (H99W) was serially passaged in the invertebrate wax moth Galleria mellonella fifteen times to study how fungal virulence evolves under selection and whether those adaptations affect virulence. The G. mellonella passaged strain (P15) and the pre-passage H99W strains were used to infect three d...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2020.1831332

    authors: Merryman M,Crigler J,Seipelt-Thiemann R,McClelland E

    更新日期:2020-12-01 00:00:00

  • Staphylococcus aureus colonization and non-influenza respiratory viruses: Interactions and synergism mechanisms.

    abstract::Viral infections of the respiratory tract can be complicated by bacterial superinfection, resulting in a significantly longer duration of illness and even a fatal outcome. In this review, we focused on interactions between S. aureus and non-influenza viruses. Clinical data evidenced that rhinovirus infection may incre...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.1080/21505594.2018.1504561

    authors: Morgene MF,Botelho-Nevers E,Grattard F,Pillet S,Berthelot P,Pozzetto B,Verhoeven PO

    更新日期:2018-01-01 00:00:00

  • Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed.

    abstract::A new hypervirulent (hypermucoviscous) variant of Klebsiella pneumoniae has emerged. First described in the Asian Pacific Rim, it now increasingly recognized in Western countries. Defining clinical features are the ability to cause serious, life-threatening community-acquired infection in younger healthy hosts, includ...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.4161/viru.22718

    authors: Shon AS,Bajwa RP,Russo TA

    更新日期:2013-02-15 00:00:00

  • TBX21-1993T/C (rs4794067) polymorphism is associated with increased risk of chronic periodontitis and increased T-bet expression in periodontal lesions, but does not significantly impact the IFN-g transcriptional level or the pattern of periodontophatic b

    abstract::Th1-polarized host response, mediated by IFN-γ, has been associated with increased severity of periodontal disease as well as control of periodontal infection. The functional polymorphism TBX21-1993T/C (rs4794067) increases the transcriptional activity of the TBX21 gene (essential for Th1 polarization) resulting in a ...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2015.1029828

    authors: Cavalla F,Biguetti CC,Colavite PM,Silveira EV,Martins W Jr,Letra A,Trombone AP,Silva RM,Garlet GP

    更新日期:2015-01-01 00:00:00

  • Role of luxS in Bacillus anthracis growth and virulence factor expression.

    abstract::Quorum-sensing (QS), the regulation of bacterial gene expression in response to changes in cell density, involves pathways that synthesize signaling molecules (auto-inducers). The luxS/AI-2-mediated QS system has been identified in both gram-positive and gram-negative bacteria. Bacillus anthracis, the etiological agen...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.4161/viru.1.2.10752

    authors: Jones MB,Peterson SN,Benn R,Braisted JC,Jarrahi B,Shatzkes K,Ren D,Wood TK,Blaser MJ

    更新日期:2010-03-01 00:00:00

  • Mycoplasma hyopneumoniae evades complement activation by binding to factor H via elongation factor thermo unstable (EF-Tu).

    abstract::Mycoplasmas persist in the host for a long time, suggesting that they possess mechanisms for immune evasion. Factor H is a negative regulator of the complement system, which binds to host cells to avoid unexpected complement activation. In this study, we revealed that many mycoplasmas, such as Mycoplasma hyopneumoniae...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2020.1806664

    authors: Yu Y,Wang J,Han R,Wang L,Zhang L,Zhang AY,Xin J,Li S,Zeng Y,Shao G,Feng Z,Xiong Q

    更新日期:2020-12-01 00:00:00

  • Current opinions on autophagy in pathogenicity of fungi.

    abstract::The interaction between pathogens and their host plants is a ubiquitous process. Some plant fungal pathogens can form a specific infection structure, such as an appressorium, which is formed by the accumulation of a large amount of glycerin and thereby the creation of an extremely high intracellular turgor pressure, w...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.1080/21505594.2018.1551011

    authors: Zhu XM,Li L,Wu M,Liang S,Shi HB,Liu XH,Lin FC

    更新日期:2019-12-01 00:00:00

  • The girl with the iron tattoo.

    abstract::We describe a young woman with profound anemia whose serum iron studies were incongruous with what we expected from iron deficiency anemia. Her high serum iron was not fully explainable until we examined the patient and noticed a large black tattoo on her left flank area. Apparently iron oxide in the ink used for the ...

    journal_title:Virulence

    pub_type: 信件

    doi:10.4161/viru.22122

    authors: Fircanis S,Shields R,Castillo J,Mega A,Schiffman F

    更新日期:2012-11-15 00:00:00

  • The role of inflammasome modulation in virulence.

    abstract::Pathogens frequently exist in an immunological balancing act with their host. Pathogens must not only replicate within a host but also transmit effectively between hosts to perpetuate their species. On the other hand, the host seeks to maintain homeostasis by clearing pathogens. The inflammasome is a multi-protein com...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.4161/viru.20266

    authors: Lupfer CR,Kanneganti TD

    更新日期:2012-05-01 00:00:00

  • A DUF4148 family protein produced inside RAW264.7 cells is a critical Burkholderia pseudomallei virulence factor.

    abstract::Burkholderia pseudomallei: is the etiological agent of the disease melioidosis and is a Tier 1 select agent. It survives and replicates inside phagocytic cells by escaping from the endocytic vacuole, replicating in the cytosol, spreading to other cells via actin polymerization and promoting the fusion of infected and ...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2020.1806675

    authors: Welkos S,Blanco I,Okaro U,Chua J,DeShazer D

    更新日期:2020-12-01 00:00:00

  • The Yersinia pseudotuberculosis Cpx envelope stress system contributes to transcriptional activation of rovM.

    abstract::The Gram-negative enteropathogen Yersinia pseudotuberculosis possesses a number of regulatory systems that detect cell envelope damage caused by noxious extracytoplasmic stresses. The CpxA sensor kinase and CpxR response regulator two-component regulatory system is one such pathway. Active Cpx signalling upregulates v...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2018.1556151

    authors: Thanikkal EJ,Gahlot DK,Liu J,Fredriksson Sundbom M,Gurung JM,Ruuth K,Francis MK,Obi IR,Thompson KM,Chen S,Dersch P,Francis MS

    更新日期:2019-12-01 00:00:00

  • An endocytic CARriage tale: Adenoviruses internalization and trafficking in neurons.

    abstract::In immune-competent hosts, adenoviruses (Ads) are mild pathogens that cause mainly infections of the respiratory and ocular tracks. The advent of Ad-based gene transfer vectors made the understanding of their interaction with the host cellular machinery an intensive field of research over the last decade. As studies f...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.4161/viru.1.3.11379

    authors: Henaff D,Salinas S

    更新日期:2010-05-01 00:00:00

  • The mutated staphylococcal H35A α-toxin inhibits adhesion and invasion of Staphylococcus aureus and group A streptococci.

    abstract::In previous studies we demonstrated that the staphylococcal α-toxin inhibits adhesion and invasion of S. aureus by epithelial cells through binding to α5β1 integrin, a receptor of fibronectin. Moreover, we revealed that a H35A mutation abolishes the cytotoxicity of α-toxin completely. These findings led us to hypothes...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.4161/viru.22719

    authors: Yang J,Liang X,Ji Y

    更新日期:2013-01-01 00:00:00

  • Prolonged infection by Fonsecaea pedrosoi after antigenic co-stimulation at different sites in experimental murine chromoblastomycosis.

    abstract::In the present study, we examined prolonged infection after antigenic co-stimulation by inoculation of the fungus Fonsecaea pedrosoi at two different sites in three mouse strains (BALB/c, Swiss, and C57BL/6). Using this murine model of infection, we showed that antigen induction of infection at more than one site led ...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.4161/viru.1.1.9920

    authors: Machado AP,Silva MR,Fischman O

    更新日期:2010-01-01 00:00:00

  • Ebolavirus VP35 is a multifunctional virulence factor.

    abstract::Ebola virus (EBOV) is a member of the filoviridae family that causes severe hemorrhagic fever during sporadic outbreaks, and no approved treatments are currently available. The multifunctional EBOV VP35 protein facilitates immune evasion by antagonizing antiviral signaling pathways and is important for viral RNA synth...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.4161/viru.1.6.12984

    authors: Leung DW,Prins KC,Basler CF,Amarasinghe GK

    更新日期:2010-11-01 00:00:00