Regulation of herpesvirus lifecycle by viral microRNAs.

abstract：:Cryptococcus neoformans: (H99W) was serially passaged in the invertebrate wax moth Galleria mellonella fifteen times to study how fungal virulence evolves under selection and whether those adaptations affect virulence. The G. mellonella passaged strain (P15) and the pre-passage H99W strains were used to infect three d...

journal_title：Virulence

authors： Merryman M,Crigler J,Seipelt-Thiemann R,McClelland E

更新日期：2020-12-01 00:00:00

abstract：:Quorum-sensing (QS), the regulation of bacterial gene expression in response to changes in cell density, involves pathways that synthesize signaling molecules (auto-inducers). The luxS/AI-2-mediated QS system has been identified in both gram-positive and gram-negative bacteria. Bacillus anthracis, the etiological agen...

journal_title：Virulence

authors： Jones MB,Peterson SN,Benn R,Braisted JC,Jarrahi B,Shatzkes K,Ren D,Wood TK,Blaser MJ

更新日期：2010-03-01 00:00:00

abstract：:Multi-antibiotic drug-resistant (MDR) gram-negative bacilli are becoming a major threat to the standard care of septic patients. Empiric antimicrobial drug regimens to cover likely bacterial pathogens have to be altered in keeping with the spread of MDR pathogens in the health care setting and in the community. Reliab...

journal_title：Virulence

authors： Pop-Vicas A,Opal SM

更新日期：2014-01-01 00:00:00

abstract：:A greater ethical conscience, new global rules and a modified perception of ethical consciousness entail a more rigorous control on utilizations of vertebrates for in vivo studies. To cope with this new scenario, numerous alternatives to rodents have been proposed. Among these, the greater wax moth Galleria mellonella...

journal_title：Virulence

authors： Cutuli MA,Petronio Petronio G,Vergalito F,Magnifico I,Pietrangelo L,Venditti N,Di Marco R

更新日期：2019-12-01 00:00:00

abstract：:The lipopolysaccharide (LPS) is a major virulence factor of Brucella, a facultative intracellular pathogenic Gram-negative bacterium. Brucella LPS exhibits a low toxicity and its atypical structure was postulated to delay the host immune response, favouring the establishment of chronic disease. Here we carried out an ...

journal_title：Virulence

authors： Zhao Y,Hanniffy S,Arce-Gorvel V,Conde-Alvarez R,Oh S,Moriyón I,Mémet S,Gorvel JP

更新日期：2018-01-01 00:00:00

abstract：:Pathogenic bacteria produce virulence factors called effectors, which are important components of the infection process. Effectors aid in pathogenesis by facilitating bacterial attachment, pathogen entry into or exit from the host cell, immunoevasion, and immunosuppression. Effectors also have the ability to subvert h...

journal_title：Virulence

authors： Rajamuthiah R,Mylonakis E

更新日期：2014-01-01 00:00:00

abstract：:Novel approaches to treat carbapenem-resistant Acinetobacter baumannii (CRAB) infections are urgently needed and anti-virulence drugs represent promising alternatives, but our knowledge on potential targets is scarce. We searched for potential A. baumannii virulence factors by whole-genome sequencing-based comparisons...

journal_title：Virulence

authors： Labrador-Herrera G,Pérez-Pulido AJ,Álvarez-Marín R,Casimiro-Soriguer CS,Cebrero-Cangueiro T,Morán-Barrio J,Pachón J,Viale AM,Pachón-Ibáñez ME

更新日期：2020-12-01 00:00:00

abstract：:The Campylobacter jejuni N-linked protein glycosylation pathway produces a heptasaccharide that is added to >65 periplasmic and membrane proteins and is also released into the periplasm as the free oligosaccharide (fOS). The fOS is a novel soluble component of the C. jejuni periplasmic space that exists in 10-fold gre...

journal_title：Virulence

authors： Nothaft H,Liu X,Li J,Szymanski CM

更新日期：2010-11-01 00:00:00

abstract：:Bacterial pathogens release a number of toxins that are able to form pores in target host cells, which can result in their destruction. Due to this property of this subgroup of toxins, they are considered virulence factors. A lesser known ability of these toxins when present at lower concentrations that are insufficie...

journal_title：Virulence

authors： Yoong P

更新日期：2010-09-01 00:00:00

abstract：:Legionella pneumophila is the primary respiratory pathogen and mostly transmitted to human through water cooling systems and cause mild to severe pneumonia with high mortality rate especially in elderly both in hospitals and community. However, current Legionella risk assessments may be compromised by uncertainties in...

journal_title：Virulence

authors： Ahmadrajabi R,Shakibaie MR,Iranmanesh Z,Mollaei HR,Sobhanipoor MH

更新日期：2016-07-03 00:00:00

abstract：:In all eukaryotic cells, the ER stress response is pivotal to survival and adaptation under stress conditions. During temperature adaptation in the human fungal pathogen Cryptococcus neoformans, ER stress is engaged transiently. Studies of this response have demonstrated that both the engagement (turning on the respon...

journal_title：Virulence

authors： Glazier VE,Panepinto JC

更新日期：2014-02-15 00:00:00

abstract：:Retrotransposons constitute a major part of the genome in a number of eukaryotes. Long-terminal repeat (LTR) retrotransposons are one type of the retrotransposons. Candida albicans have 34 distinct LTR-retrotransposon families. They respectively belong to the Ty1/copia and Ty3/gypsy groups which have been extensively ...

journal_title：Virulence

authors： Zhang L,Yan L,Jiang J,Wang Y,Jiang Y,Yan T,Cao Y

更新日期：2014-08-15 00:00:00

abstract：:Pathogens frequently exist in an immunological balancing act with their host. Pathogens must not only replicate within a host but also transmit effectively between hosts to perpetuate their species. On the other hand, the host seeks to maintain homeostasis by clearing pathogens. The inflammasome is a multi-protein com...

journal_title：Virulence

authors： Lupfer CR,Kanneganti TD

更新日期：2012-05-01 00:00:00

abstract：:The emergence of multiresistant Gram-negative bacteria requires new therapies for combating bacterial infections. Targeting the biogenesis of virulence factors could be an alternative strategy instead of killing bacteria with antibiotics. The outer membrane (OM) of Gram-negative bacteria acts as a physical barrier. At...

journal_title：Virulence

authors： Weirich J,Bräutigam C,Mühlenkamp M,Franz-Wachtel M,Macek B,Meuskens I,Skurnik M,Leskinen K,Bohn E,Autenrieth I,Schütz M

更新日期：2017-10-03 00:00:00

abstract：:Patients undergoing haematopoietic stem cell transplantation (HSCT) are highly exposed to infectious agents. However, it is not known why certain HSCT recipients rapidly develop severe infections while other, despite similar immunosuppressive conditions, do not. Increasing evidence suggests that such differences may b...

journal_title：Virulence

authors： Wójtowicz A,Bochud PY

更新日期：2016-11-16 00:00:00

abstract：:Staphylococcus aureus infections are becoming a major global health issue due to the rapid emergence of multidrug-resistant strains. Therefore, there is an urgent need to develop an effective vaccine to prevent and control these infections. In order to develop a universal immunization strategy, we constructed a mutant...

journal_title：Virulence

authors： Moscoso M,García P,Cabral MP,Rumbo C,Bou G

更新日期：2018-01-01 00:00:00

abstract：:Acinetobacter nosocomialis is an important nosocomial pathogen that causes a variety of human infections. However, the specific virulence factors of this microorganism have not yet been determined. We investigated the role of outer membrane protein A (OmpA) in the pathogenesis of A. nosocomialis. A ΔompA mutant of the...

journal_title：Virulence

authors： Kim SW,Oh MH,Jun SH,Jeon H,Kim SI,Kim K,Lee YC,Lee JC

更新日期：2016-05-18 00:00:00

abstract：:Sepsis remains a common, serious, and heterogeneous clinical entity that is difficult to define adequately. Despite its importance as a public health problem, efforts to develop and gain regulatory approval for a specific therapeutic agent for the adjuvant treatment of sepsis have been remarkably unsuccessful. One ste...

journal_title：Virulence

authors： Fink MP

更新日期：2014-01-01 00:00:00

abstract：:Periodontitis is an infectious inflammatory disease that destroys the tooth-supporting tissues. It is caused by the formation of subgingival biofilms on the surface of the tooth. Characteristic bacteria associated with subgingival biofilms are the Gram-negative anaerobes Porphyromonas gingivalis, Tannerella forsythia ...

journal_title：Virulence

authors： Belibasakis GN,Kast JI,Thurnheer T,Akdis CA,Bostanci N

更新日期：2015-01-01 00:00:00

abstract：:Until recently, epithelial cells have been a largely ignored component of host responses to microbes. However, this has been largely overturned over the last decade as an ever increasing number of studies have highlighted the key role that these cells play in many of our interactions with our microbiota and pathogens....

journal_title：Virulence

authors： Moyes DL,Richardson JP,Naglik JR

更新日期：2015-01-01 00:00:00

abstract：:Neurodegenerative human CJD and sheep scrapie are diseases caused by several different transmissible encephalopathy (TSE) agents. These infectious agents provoke innate immune responses in the brain, including late-onset abnormal prion protein (PrP-res) amyloid. Agent particles that lack detectable PrP sequences by de...

journal_title：Virulence

authors： Botsios S,Tittman S,Manuelidis L

更新日期：2015-01-01 00:00:00

abstract：:Anthrax toxins and capsule are the major virulence factors of Bacillus anthracis. They are encoded by genes located on the plasmids pXO1 and pXO2, respectively. The vaccine strain Pasteur II was produced from high temperature subcultures of B. anthracis, which resulted in virulence attenuation through the loss of the ...

journal_title：Virulence

authors： Liang X,Zhang H,Zhang E,Wei J,Li W,Wang B,Dong S,Zhu J

更新日期：2016-07-03 00:00:00

abstract：:Ebola virus (EBOV) is a member of the filoviridae family that causes severe hemorrhagic fever during sporadic outbreaks, and no approved treatments are currently available. The multifunctional EBOV VP35 protein facilitates immune evasion by antagonizing antiviral signaling pathways and is important for viral RNA synth...

journal_title：Virulence

authors： Leung DW,Prins KC,Basler CF,Amarasinghe GK

更新日期：2010-11-01 00:00:00

abstract：:Many studies have found that abnormalities in the proportion and differentiation of CD4+ T cells (Th cells) are closely related to the pathogenesis of viral myocarditis (VMC). Our previous research indicates that the cholinergic anti-inflammatory pathway (CAP) attenuates the inflammatory response of VMC and downregula...

journal_title：Virulence

authors： De-Pu Z,Li-Sha G,Guang-Yi C,Xiaohong G,Chao X,Cheng Z,Wen-Wu Z,Jia L,Jia-Feng L,Maoping C,Yue-Chun L

更新日期：2018-01-01 00:00:00

abstract：:In previous studies we demonstrated that the staphylococcal α-toxin inhibits adhesion and invasion of S. aureus by epithelial cells through binding to α5β1 integrin, a receptor of fibronectin. Moreover, we revealed that a H35A mutation abolishes the cytotoxicity of α-toxin completely. These findings led us to hypothes...

journal_title：Virulence

authors： Yang J,Liang X,Ji Y

更新日期：2013-01-01 00:00:00

abstract：:We recently developed a method that allows fast differentiation between Streptococcus pyogenes (GAS) strains. The method named phage profiling (PP) is based on a simple assumption that a regular PCR reaction with Taq polymerase and relatively short elongation time is not able to yield long DNA fragment, such as ~40-50...

journal_title：Virulence

authors： Borek AL,Obszańska K,Hryniewicz W,Sitkiewicz I

更新日期：2012-10-01 00:00:00

abstract：:The recent finding that the formation of staphylococcal enterotoxins in food is very different from that in cultures of pure Staphylococcus aureus sheds new light on, and brings into question, traditional microbial risk assessment methods based on planktonic liquid cultures. In fact, most bacteria in food appear to be...

journal_title：Virulence

authors： Schelin J,Wallin-Carlquist N,Cohn MT,Lindqvist R,Barker GC,Rådström P

更新日期：2011-11-01 00:00:00

abstract：:The aim of this study was to investigate if the alternative in vivo model Galleria mellonella can be used (i) to determine differences in pathogenicity of amphotericin B (AMB) resistant and susceptible A. terreus isolates, (ii) to evaluate AMB efficacy in vivo (iii) and to correlate outcome to in vitro susceptibility ...

journal_title：Virulence

authors： Maurer E,Browne N,Surlis C,Jukic E,Moser P,Kavanagh K,Lass-Flörl C,Binder U

更新日期：2015-01-01 00:00:00

abstract：:Mycoplasmas persist in the host for a long time, suggesting that they possess mechanisms for immune evasion. Factor H is a negative regulator of the complement system, which binds to host cells to avoid unexpected complement activation. In this study, we revealed that many mycoplasmas, such as Mycoplasma hyopneumoniae...

journal_title：Virulence

authors： Yu Y,Wang J,Han R,Wang L,Zhang L,Zhang AY,Xin J,Li S,Zeng Y,Shao G,Feng Z,Xiong Q

更新日期：2020-12-01 00:00:00

abstract：:Carbapenem-Resistant Enterobacteriaceae (CRE) are an emerging healthcare crisis. Infections due to CRE are associated with high morbidity and mortality, especially in critically ill patients. Due to the multi-drug resistant nature of these infections only limited treatment options are available. Antimicrobials that ha...

journal_title：Virulence

authors： Neuner EA,Gallagher JC

更新日期：2017-05-19 00:00:00