Abstract:
:Carbapenem-Resistant Enterobacteriaceae (CRE) are an emerging healthcare crisis. Infections due to CRE are associated with high morbidity and mortality, especially in critically ill patients. Due to the multi-drug resistant nature of these infections only limited treatment options are available. Antimicrobials that have been described for the treatment of CRE infections include carbapenems, polymyxins, fosfomycin, tigecycline, aminoglycosides, and ceftazidime-avibactam. Given the limited treatment options it is imperative the pharmacokinetic and pharmacodynamics (PK-PD) characteristics of these agents are considered to optimize treatment regimens. This review will focus on the PK-PD challenges of the current treatment options for CRE infections.
journal_name
Virulencejournal_title
Virulenceauthors
Neuner EA,Gallagher JCdoi
10.1080/21505594.2016.1221021subject
Has Abstractpub_date
2017-05-19 00:00:00pages
440-452issue
4eissn
2150-5594issn
2150-5608journal_volume
8pub_type
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