Mycoplasma hyopneumoniae evades complement activation by binding to factor H via elongation factor thermo unstable (EF-Tu).

abstract：:Acinetobacter nosocomialis is an important nosocomial pathogen that causes a variety of human infections. However, the specific virulence factors of this microorganism have not yet been determined. We investigated the role of outer membrane protein A (OmpA) in the pathogenesis of A. nosocomialis. A ΔompA mutant of the...

journal_title：Virulence

authors： Kim SW,Oh MH,Jun SH,Jeon H,Kim SI,Kim K,Lee YC,Lee JC

更新日期：2016-05-18 00:00:00

abstract：:Particle size dictates where aerosolized pathogens deposit in the respiratory tract, thereafter the pathogens potential to cause disease is influenced by tissue tropism, clearance kinetics and the host immunological response. This interplay brings pathogens into contact with a range of tissues spanning the respiratory...

journal_title：Virulence

authors： Thomas RJ

更新日期：2013-11-15 00:00:00

abstract：:Novel approaches to treat carbapenem-resistant Acinetobacter baumannii (CRAB) infections are urgently needed and anti-virulence drugs represent promising alternatives, but our knowledge on potential targets is scarce. We searched for potential A. baumannii virulence factors by whole-genome sequencing-based comparisons...

journal_title：Virulence

authors： Labrador-Herrera G,Pérez-Pulido AJ,Álvarez-Marín R,Casimiro-Soriguer CS,Cebrero-Cangueiro T,Morán-Barrio J,Pachón J,Viale AM,Pachón-Ibáñez ME

更新日期：2020-12-01 00:00:00

abstract：:Legionella pneumophila, the causative agent of Legionnaires' disease, is widely distributed throughout natural and artificial water systems and can replicate in macrophages and amoebae. Amoebae are the natural hosts of L. pneumophila, whereas macrophages are incidentally infected. The life cycle of L. pneumophila comp...

journal_title：Virulence

authors： Mou Q,Leung PHM

更新日期：2018-01-01 00:00:00

abstract：:Quorum-sensing (QS), the regulation of bacterial gene expression in response to changes in cell density, involves pathways that synthesize signaling molecules (auto-inducers). The luxS/AI-2-mediated QS system has been identified in both gram-positive and gram-negative bacteria. Bacillus anthracis, the etiological agen...

journal_title：Virulence

authors： Jones MB,Peterson SN,Benn R,Braisted JC,Jarrahi B,Shatzkes K,Ren D,Wood TK,Blaser MJ

更新日期：2010-03-01 00:00:00

abstract：:Highly pathogenic (HP) avian influenza viruses (AIV) evolve from low pathogenic (LP) precursors after circulation in poultry by reassortment and/or single mutations in different gene segments including that encoding NS1. The carboxyl terminal end (CTE) of NS1 exhibits deletions between amino acid 202 and 230 with stil...

journal_title：Virulence

authors： Abdelwhab el-SM,Veits J,Breithaupt A,Gohrbandt S,Ziller M,Teifke JP,Stech J,Mettenleiter TC

更新日期：2016-07-03 00:00:00

abstract：:Sepsis remains a common, serious, and heterogeneous clinical entity that is difficult to define adequately. Despite its importance as a public health problem, efforts to develop and gain regulatory approval for a specific therapeutic agent for the adjuvant treatment of sepsis have been remarkably unsuccessful. One ste...

journal_title：Virulence

authors： Fink MP

更新日期：2014-01-01 00:00:00

abstract：:Human herpesviruses have latency and lytic replication phases in their lifecycle. Proper regulation of herpesviral lifecycle is essential for the evasion of host immune surveillance and development of their related diseases. Recent advancements indicate a role of a novel class of viral non-coding RNAs, microRNA (miRNA...

journal_title：Virulence

authors： Lei X,Bai Z,Ye F,Huang Y,Gao SJ

更新日期：2010-09-01 00:00:00

abstract：:In immune-competent hosts, adenoviruses (Ads) are mild pathogens that cause mainly infections of the respiratory and ocular tracks. The advent of Ad-based gene transfer vectors made the understanding of their interaction with the host cellular machinery an intensive field of research over the last decade. As studies f...

journal_title：Virulence

authors： Henaff D,Salinas S

更新日期：2010-05-01 00:00:00

abstract：:Bacterial pathogens release a number of toxins that are able to form pores in target host cells, which can result in their destruction. Due to this property of this subgroup of toxins, they are considered virulence factors. A lesser known ability of these toxins when present at lower concentrations that are insufficie...

journal_title：Virulence

authors： Yoong P

更新日期：2010-09-01 00:00:00

abstract：:Staphylococcus aureus infections are becoming a major global health issue due to the rapid emergence of multidrug-resistant strains. Therefore, there is an urgent need to develop an effective vaccine to prevent and control these infections. In order to develop a universal immunization strategy, we constructed a mutant...

journal_title：Virulence

authors： Moscoso M,García P,Cabral MP,Rumbo C,Bou G

更新日期：2018-01-01 00:00:00

abstract：:The hemagglutinin (HA) proteins derived from avian influenza viruses bind specifically to the α2-3 sialoglycan (Sia glycan), whereas human-adapted influenza viruses prefer to bind to the α2-6 Sia glycan. A switch of glycan specificity from α2-3 Sia glycan to α2-6 Sia glycan appears to be critical for a virus to become...

journal_title：Virulence

authors： Suenaga E,Mizuno H,Kumar PK

更新日期：2012-08-15 00:00:00

abstract：:Viral infections of the respiratory tract can be complicated by bacterial superinfection, resulting in a significantly longer duration of illness and even a fatal outcome. In this review, we focused on interactions between S. aureus and non-influenza viruses. Clinical data evidenced that rhinovirus infection may incre...

journal_title：Virulence

authors： Morgene MF,Botelho-Nevers E,Grattard F,Pillet S,Berthelot P,Pozzetto B,Verhoeven PO

更新日期：2018-01-01 00:00:00

abstract：:A new hypervirulent (hypermucoviscous) variant of Klebsiella pneumoniae has emerged. First described in the Asian Pacific Rim, it now increasingly recognized in Western countries. Defining clinical features are the ability to cause serious, life-threatening community-acquired infection in younger healthy hosts, includ...

journal_title：Virulence

authors： Shon AS,Bajwa RP,Russo TA

更新日期：2013-02-15 00:00:00

abstract：:Pathogens frequently exist in an immunological balancing act with their host. Pathogens must not only replicate within a host but also transmit effectively between hosts to perpetuate their species. On the other hand, the host seeks to maintain homeostasis by clearing pathogens. The inflammasome is a multi-protein com...

journal_title：Virulence

authors： Lupfer CR,Kanneganti TD

更新日期：2012-05-01 00:00:00

abstract：:Many studies have found that abnormalities in the proportion and differentiation of CD4+ T cells (Th cells) are closely related to the pathogenesis of viral myocarditis (VMC). Our previous research indicates that the cholinergic anti-inflammatory pathway (CAP) attenuates the inflammatory response of VMC and downregula...

journal_title：Virulence

authors： De-Pu Z,Li-Sha G,Guang-Yi C,Xiaohong G,Chao X,Cheng Z,Wen-Wu Z,Jia L,Jia-Feng L,Maoping C,Yue-Chun L

更新日期：2018-01-01 00:00:00

abstract：:In this issue of Virulence, Ban E et al. described the complete sequence of the pEntYN10 plasmid of Escherichia coli O169:H41. The plasmid has 182 coding sequences (CDs); among the identified CDs, some were identified as colonization factors (CFs), one was an enterotoxin and others were insertion sequences (IS). In th...

journal_title：Virulence

authors： Navarro A

更新日期：2015-01-01 00:00:00

abstract：:Non-invasive imaging techniques in microbial disease models have delivered valuable insights in the intimate pathogen-host interplay during infection. Here we describe evaluation and validation of a transgenic bioluminescence reporter strain of the human-pathogenic mold Aspergillus fumigatus, one of the main fungal pa...

journal_title：Virulence

authors： Donat S,Hasenberg M,Schäfer T,Ohlsen K,Gunzer M,Einsele H,Löffler J,Beilhack A,Krappmann S

更新日期：2012-01-01 00:00:00

abstract：:Chloroquine (CQ) was the best and most heavily used drug in the fight against malaria. However, the effectiveness of CQ has declined with the emergence and spread of CQ-resistant (CQR) Plasmodium falciparum parasites. The primary determinant of CQ resistance in P. falciparum is mutations in the parasite's 'chloroquine...

journal_title：Virulence

authors： Summers RL,Martin RE

更新日期：2010-07-01 00:00:00

abstract：:Bacterial eukaryotic-like serine threonine kinases (eSTKs) and serine threonine phosphatases (eSTPs) have emerged as important signaling elements that are indispensable for pathogenesis. Differing considerably from their histidine kinase counterparts, few eSTK genes are encoded within the average bacterial genome, and...

journal_title：Virulence

authors： Wright DP,Ulijasz AT

更新日期：2014-01-01 00:00:00

abstract：:Aeromonas hydrophila (A. hydrophila) can cause a number of diseases in both human and animals. A. hydrophila-related infections in aquaculture cause severe economic losses every year throughout the world. The emergence of antibiotic resistance that is due to the abuse of antibiotics has limited the application of anti...

journal_title：Virulence

authors： Dong J,Zhang L,Liu Y,Xu N,Zhou S,Yang Y,Yang Q,Ai X

更新日期：2021-12-01 00:00:00

abstract：:We recently developed a method that allows fast differentiation between Streptococcus pyogenes (GAS) strains. The method named phage profiling (PP) is based on a simple assumption that a regular PCR reaction with Taq polymerase and relatively short elongation time is not able to yield long DNA fragment, such as ~40-50...

journal_title：Virulence

authors： Borek AL,Obszańska K,Hryniewicz W,Sitkiewicz I

更新日期：2012-10-01 00:00:00

abstract：:Periodontitis is an infectious inflammatory disease that destroys the tooth-supporting tissues. It is caused by the formation of subgingival biofilms on the surface of the tooth. Characteristic bacteria associated with subgingival biofilms are the Gram-negative anaerobes Porphyromonas gingivalis, Tannerella forsythia ...

journal_title：Virulence

authors： Belibasakis GN,Kast JI,Thurnheer T,Akdis CA,Bostanci N

更新日期：2015-01-01 00:00:00

abstract：:The recent finding that the formation of staphylococcal enterotoxins in food is very different from that in cultures of pure Staphylococcus aureus sheds new light on, and brings into question, traditional microbial risk assessment methods based on planktonic liquid cultures. In fact, most bacteria in food appear to be...

journal_title：Virulence

authors： Schelin J,Wallin-Carlquist N,Cohn MT,Lindqvist R,Barker GC,Rådström P

更新日期：2011-11-01 00:00:00

abstract：:Until recently, epithelial cells have been a largely ignored component of host responses to microbes. However, this has been largely overturned over the last decade as an ever increasing number of studies have highlighted the key role that these cells play in many of our interactions with our microbiota and pathogens....

journal_title：Virulence

authors： Moyes DL,Richardson JP,Naglik JR

更新日期：2015-01-01 00:00:00

abstract：:The interaction between pathogens and their host plants is a ubiquitous process. Some plant fungal pathogens can form a specific infection structure, such as an appressorium, which is formed by the accumulation of a large amount of glycerin and thereby the creation of an extremely high intracellular turgor pressure, w...

journal_title：Virulence

authors： Zhu XM,Li L,Wu M,Liang S,Shi HB,Liu XH,Lin FC

更新日期：2019-12-01 00:00:00

abstract：:Many of the alterations that affect innate and adaptive immune cell compartments in HIV-infected patients are reminiscent of the process of immune aging, characteristic of old age. These alterations define the immunological age of individuals and are likely to participate to the decline of immune competence with HIV d...

journal_title：Virulence

authors： Appay V,Sauce D

更新日期：2017-07-04 00:00:00

abstract：:Biofilm-degrading enzymes could be used for the gentle cleaning of industrial and medical devices and the manufacture of biofilm-resistant materials. We therefore investigated 20 species and strains of the bacterial genus Lysobacter for their ability to degrade experimental biofilms formed by Staphylococcus epidermidi...

journal_title：Virulence

authors： Gökçen A,Vilcinskas A,Wiesner J

更新日期：2014-04-01 00:00:00

abstract：:Neurodegenerative human CJD and sheep scrapie are diseases caused by several different transmissible encephalopathy (TSE) agents. These infectious agents provoke innate immune responses in the brain, including late-onset abnormal prion protein (PrP-res) amyloid. Agent particles that lack detectable PrP sequences by de...

journal_title：Virulence

authors： Botsios S,Tittman S,Manuelidis L

更新日期：2015-01-01 00:00:00

abstract：:Bloodstream infections (BSI) carry a heavy burden of morbidity and mortality in modern internal medicine wards (IMW). These wards are often filled with elderly subjects with several risk factors for BSI, such as multiple comorbidities, polypharmacy, immunosuppression, and indwelling devices. Diagnosing BSI in such a s...

journal_title：Virulence

authors： Del Bono V,Giacobbe DR

更新日期：2016-04-02 00:00:00