The role of inflammasome modulation in virulence.

Abstract:

:Pathogens frequently exist in an immunological balancing act with their host. Pathogens must not only replicate within a host but also transmit effectively between hosts to perpetuate their species. On the other hand, the host seeks to maintain homeostasis by clearing pathogens. The inflammasome is a multi-protein complex that can induce cell death and processes IL-1β and additional proinflammatory substrates. In this review we discuss the pathogen specific modulation of inflammasome activation and the role this plays in virulence and disease pathology.

journal_name

Virulence

journal_title

Virulence

authors

Lupfer CR,Kanneganti TD

doi

10.4161/viru.20266

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

262-70

issue

3

eissn

2150-5594

issn

2150-5608

pii

20266

journal_volume

3

pub_type

杂志文章,评审
  • Trehalase plays a role in macrophage colonization and virulence of Burkholderia pseudomallei in insect and mammalian hosts.

    abstract::Trehalose is a disaccharide formed from two glucose molecules. This sugar molecule can be isolated from a range of organisms including bacteria, fungi, plants and invertebrates. Trehalose has a variety of functions including a role as an energy storage molecule, a structural component of glycolipids and plays a role i...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2016.1199316

    authors: Vanaporn M,Sarkar-Tyson M,Kovacs-Simon A,Ireland PM,Pumirat P,Korbsrisate S,Titball RW,Butt A

    更新日期:2017-01-02 00:00:00

  • The ER stress response and host temperature adaptation in the human fungal pathogen Cryptococcus neoformans.

    abstract::In all eukaryotic cells, the ER stress response is pivotal to survival and adaptation under stress conditions. During temperature adaptation in the human fungal pathogen Cryptococcus neoformans, ER stress is engaged transiently. Studies of this response have demonstrated that both the engagement (turning on the respon...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.4161/viru.27187

    authors: Glazier VE,Panepinto JC

    更新日期:2014-02-15 00:00:00

  • Assessing immune aging in HIV-infected patients.

    abstract::Many of the alterations that affect innate and adaptive immune cell compartments in HIV-infected patients are reminiscent of the process of immune aging, characteristic of old age. These alterations define the immunological age of individuals and are likely to participate to the decline of immune competence with HIV d...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.1080/21505594.2016.1195536

    authors: Appay V,Sauce D

    更新日期:2017-07-04 00:00:00

  • A mutation in C. neoformans mitochondrial NADH dehydrogenase results in increased virulence in mice.

    abstract::Cryptococcus neoformans: (H99W) was serially passaged in the invertebrate wax moth Galleria mellonella fifteen times to study how fungal virulence evolves under selection and whether those adaptations affect virulence. The G. mellonella passaged strain (P15) and the pre-passage H99W strains were used to infect three d...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2020.1831332

    authors: Merryman M,Crigler J,Seipelt-Thiemann R,McClelland E

    更新日期:2020-12-01 00:00:00

  • Effector triggered immunity.

    abstract::Pathogenic bacteria produce virulence factors called effectors, which are important components of the infection process. Effectors aid in pathogenesis by facilitating bacterial attachment, pathogen entry into or exit from the host cell, immunoevasion, and immunosuppression. Effectors also have the ability to subvert h...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.4161/viru.29091

    authors: Rajamuthiah R,Mylonakis E

    更新日期:2014-01-01 00:00:00

  • Functional and structural characteristics of bacterial proteins that bind host cytokines.

    abstract::Several human pathogens bind and respond to host cytokines, which can be considered a virulence mechanism that communicates defensive actions of the host to the pathogen. This review summarizes the current knowledge of bacterial cytokine-binding proteins, with a particular focus on their functional and structural char...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.1080/21505594.2017.1363140

    authors: Högbom M,Ihalin R

    更新日期:2017-11-17 00:00:00

  • Campylobacter capsule and lipooligosaccharide confer resistance to serum and cationic antimicrobials.

    abstract::The innate immune system plays a critical role in host defense against mucosal bacteria. Campylobacter jejuni is a major cause of human gastroenteritis that usually resolves spontaneously within several days, suggesting that innate mechanisms are important to control the infection. However, the specific means by which...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.4161/viru.2.1.14752

    authors: Keo T,Collins J,Kunwar P,Blaser MJ,Iovine NM

    更新日期:2011-01-01 00:00:00

  • Campylobacter jejuni free oligosaccharides: function and fate.

    abstract::The Campylobacter jejuni N-linked protein glycosylation pathway produces a heptasaccharide that is added to >65 periplasmic and membrane proteins and is also released into the periplasm as the free oligosaccharide (fOS). The fOS is a novel soluble component of the C. jejuni periplasmic space that exists in 10-fold gre...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.4161/viru.1.6.13801

    authors: Nothaft H,Liu X,Li J,Szymanski CM

    更新日期:2010-11-01 00:00:00

  • The formation of Staphylococcus aureus enterotoxin in food environments and advances in risk assessment.

    abstract::The recent finding that the formation of staphylococcal enterotoxins in food is very different from that in cultures of pure Staphylococcus aureus sheds new light on, and brings into question, traditional microbial risk assessment methods based on planktonic liquid cultures. In fact, most bacteria in food appear to be...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.4161/viru.2.6.18122

    authors: Schelin J,Wallin-Carlquist N,Cohn MT,Lindqvist R,Barker GC,Rådström P

    更新日期:2011-11-01 00:00:00

  • Luteolin decreases the pathogenicity of Aeromonas hydrophila via inhibiting the activity of aerolysin.

    abstract::Aeromonas hydrophila (A. hydrophila) can cause a number of diseases in both human and animals. A. hydrophila-related infections in aquaculture cause severe economic losses every year throughout the world. The emergence of antibiotic resistance that is due to the abuse of antibiotics has limited the application of anti...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2020.1867455

    authors: Dong J,Zhang L,Liu Y,Xu N,Zhou S,Yang Y,Yang Q,Ai X

    更新日期:2021-12-01 00:00:00

  • Ebolavirus VP35 is a multifunctional virulence factor.

    abstract::Ebola virus (EBOV) is a member of the filoviridae family that causes severe hemorrhagic fever during sporadic outbreaks, and no approved treatments are currently available. The multifunctional EBOV VP35 protein facilitates immune evasion by antagonizing antiviral signaling pathways and is important for viral RNA synth...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.4161/viru.1.6.12984

    authors: Leung DW,Prins KC,Basler CF,Amarasinghe GK

    更新日期:2010-11-01 00:00:00

  • An insect pathogenic symbiosis between a Caenorhabditis and Serratia.

    abstract::We described an association between a strain of the nematode Caenorhabditis briggsae, i.e. KT0001, and the bacteria Serratia sp. SCBI (South African Caenorhabditis briggsae isolate), which was able to kill the insect Galleria. Here we show that the Serratia sp. SCBI lines the gut of the nematode, similar to the Hetero...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.4161/viru.2.2.15337

    authors: Abebe E,Abebe-Akele F,Morrison J,Cooper V,Thomas WK

    更新日期:2011-03-01 00:00:00

  • Bloodstream infections in internal medicine.

    abstract::Bloodstream infections (BSI) carry a heavy burden of morbidity and mortality in modern internal medicine wards (IMW). These wards are often filled with elderly subjects with several risk factors for BSI, such as multiple comorbidities, polypharmacy, immunosuppression, and indwelling devices. Diagnosing BSI in such a s...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.1080/21505594.2016.1140296

    authors: Del Bono V,Giacobbe DR

    更新日期:2016-04-02 00:00:00

  • Hypervirulent Klebsiella pneumoniae is emerging as an increasingly prevalent K. pneumoniae pathotype responsible for nosocomial and healthcare-associated infections in Beijing, China.

    abstract:OBJECTIVES:Hypervirulent Klebsiella pneumoniae(hvKp) is an increasingly important pathogen. Tracking its epidemiology and evolving antimicrobial resistance will facilitate care. METHODS:A retrospective study was conducted in two hospitals. We collected the clinical data. Antimicrobial and virulence-associated phenotyp...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2020.1809322

    authors: Liu C,Du P,Xiao N,Ji F,Russo TA,Guo J

    更新日期:2020-12-01 00:00:00

  • Particle size and pathogenicity in the respiratory tract.

    abstract::Particle size dictates where aerosolized pathogens deposit in the respiratory tract, thereafter the pathogens potential to cause disease is influenced by tissue tropism, clearance kinetics and the host immunological response. This interplay brings pathogens into contact with a range of tissues spanning the respiratory...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.4161/viru.27172

    authors: Thomas RJ

    更新日期:2013-11-15 00:00:00

  • An endocytic CARriage tale: Adenoviruses internalization and trafficking in neurons.

    abstract::In immune-competent hosts, adenoviruses (Ads) are mild pathogens that cause mainly infections of the respiratory and ocular tracks. The advent of Ad-based gene transfer vectors made the understanding of their interaction with the host cellular machinery an intensive field of research over the last decade. As studies f...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.4161/viru.1.3.11379

    authors: Henaff D,Salinas S

    更新日期:2010-05-01 00:00:00

  • TBX21-1993T/C (rs4794067) polymorphism is associated with increased risk of chronic periodontitis and increased T-bet expression in periodontal lesions, but does not significantly impact the IFN-g transcriptional level or the pattern of periodontophatic b

    abstract::Th1-polarized host response, mediated by IFN-γ, has been associated with increased severity of periodontal disease as well as control of periodontal infection. The functional polymorphism TBX21-1993T/C (rs4794067) increases the transcriptional activity of the TBX21 gene (essential for Th1 polarization) resulting in a ...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2015.1029828

    authors: Cavalla F,Biguetti CC,Colavite PM,Silveira EV,Martins W Jr,Letra A,Trombone AP,Silva RM,Garlet GP

    更新日期:2015-01-01 00:00:00

  • Verapamil inhibits efflux pumps in Candida albicans, exhibits synergism with fluconazole, and increases survival of Galleria mellonella.

    abstract::The emergence of resistance requires alternative methods to treat Candida albicans infections. We evaluated efficacy of the efflux pump inhibitor (EPI) verapamil (VER) with fluconazole (FLC) against FLC-resistant (CaR) and -susceptible C. albicans (CaS). The susceptibility of both strains to VER and FLC was determined...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2020.1868814

    authors: Vega-Chacón Y,de Albuquerque MC,Pavarina AC,Goldman GH,Mima EGO

    更新日期:2021-12-01 00:00:00

  • Prevalence of the C-terminal truncations of NS1 in avian influenza A viruses and effect on virulence and replication of a highly pathogenic H7N1 virus in chickens.

    abstract::Highly pathogenic (HP) avian influenza viruses (AIV) evolve from low pathogenic (LP) precursors after circulation in poultry by reassortment and/or single mutations in different gene segments including that encoding NS1. The carboxyl terminal end (CTE) of NS1 exhibits deletions between amino acid 202 and 230 with stil...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2016.1159367

    authors: Abdelwhab el-SM,Veits J,Breithaupt A,Gohrbandt S,Ziller M,Teifke JP,Stech J,Mettenleiter TC

    更新日期:2016-07-03 00:00:00

  • The clinical impact of multidrug-resistant gram-negative bacilli in the management of septic shock.

    abstract::Multi-antibiotic drug-resistant (MDR) gram-negative bacilli are becoming a major threat to the standard care of septic patients. Empiric antimicrobial drug regimens to cover likely bacterial pathogens have to be altered in keeping with the spread of MDR pathogens in the health care setting and in the community. Reliab...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.4161/viru.26210

    authors: Pop-Vicas A,Opal SM

    更新日期:2014-01-01 00:00:00

  • Listeria monocytogenes encodes a functional ESX-1 secretion system whose expression is detrimental to in vivo infection.

    abstract::Bacterial pathogenicity deeply depends on the ability to secrete virulence factors that bind specific targets on host cells and manipulate host responses. The Gram-positive bacterium Listeria monocytogenes is a human foodborne pathogen that remains a serious public health concern. To transport proteins across its cell...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2016.1244589

    authors: Pinheiro J,Reis O,Vieira A,Moura IM,Zanolli Moreno L,Carvalho F,Pucciarelli MG,García-Del Portillo F,Sousa S,Cabanes D

    更新日期:2017-08-18 00:00:00

  • A D-Alanine auxotrophic live vaccine is effective against lethal infection caused by Staphylococcus aureus.

    abstract::Staphylococcus aureus infections are becoming a major global health issue due to the rapid emergence of multidrug-resistant strains. Therefore, there is an urgent need to develop an effective vaccine to prevent and control these infections. In order to develop a universal immunization strategy, we constructed a mutant...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2017.1417723

    authors: Moscoso M,García P,Cabral MP,Rumbo C,Bou G

    更新日期:2018-01-01 00:00:00

  • Highly specific host-pathogen interactions influence Metarhizium brunneum blastospore virulence against Culex quinquefasciatus larvae.

    abstract::Entomopathogenic fungi are potential biological control agents of mosquitoes. Our group observed that not all mosquitoes were equally susceptible to fungal infection and observed significant differences in virulence of different spore types. Conidiospores and blastospores were tested against Culex quinquefasciatus lar...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2018.1509665

    authors: Alkhaibari AM,Lord AM,Maffeis T,Bull JC,Olivares FL,Samuels RI,Butt TM

    更新日期:2018-01-01 00:00:00

  • Identifying components required for OMP biogenesis as novel targets for antiinfective drugs.

    abstract::The emergence of multiresistant Gram-negative bacteria requires new therapies for combating bacterial infections. Targeting the biogenesis of virulence factors could be an alternative strategy instead of killing bacteria with antibiotics. The outer membrane (OM) of Gram-negative bacteria acts as a physical barrier. At...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2016.1278333

    authors: Weirich J,Bräutigam C,Mühlenkamp M,Franz-Wachtel M,Macek B,Meuskens I,Skurnik M,Leskinen K,Bohn E,Autenrieth I,Schütz M

    更新日期:2017-10-03 00:00:00

  • Impact of daptomycin resistance on Staphylococcus aureus virulence.

    abstract::Daptomycin resistance (DAP(R)) in Staphylococcus aureus is associated with mutations in genes that are also implicated in staphylococcal pathogenesis. Using a laboratory-derived series of DAP exposed strains, we showed a relationship between increasing DAP MIC and reduced virulence in a Galleria mellonella infection m...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2015.1011532

    authors: Cameron DR,Mortin LI,Rubio A,Mylonakis E,Moellering RC Jr,Eliopoulos GM,Peleg AY

    更新日期:2015-01-01 00:00:00

  • The cholinergic anti-inflammatory pathway ameliorates acute viral myocarditis in mice by regulating CD4+ T cell differentiation.

    abstract::Many studies have found that abnormalities in the proportion and differentiation of CD4+ T cells (Th cells) are closely related to the pathogenesis of viral myocarditis (VMC). Our previous research indicates that the cholinergic anti-inflammatory pathway (CAP) attenuates the inflammatory response of VMC and downregula...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.1080/21505594.2018.1482179

    authors: De-Pu Z,Li-Sha G,Guang-Yi C,Xiaohong G,Chao X,Cheng Z,Wen-Wu Z,Jia L,Jia-Feng L,Maoping C,Yue-Chun L

    更新日期:2018-01-01 00:00:00

  • Regulation of transcription by eukaryotic-like serine-threonine kinases and phosphatases in Gram-positive bacterial pathogens.

    abstract::Bacterial eukaryotic-like serine threonine kinases (eSTKs) and serine threonine phosphatases (eSTPs) have emerged as important signaling elements that are indispensable for pathogenesis. Differing considerably from their histidine kinase counterparts, few eSTK genes are encoded within the average bacterial genome, and...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.4161/21505594.2014.983404

    authors: Wright DP,Ulijasz AT

    更新日期:2014-01-01 00:00:00

  • The cleavage specificity of an IgA1 protease from Haemophilus influenzae.

    abstract::Bacterial IgA1 proteases are thought to be important virulence factors in respiratory tract infections. These proteolytic enzymes specifically cleave one of several post-proline peptide bonds within the hinge region of human immunoglobulin A1 (IgA1). Human IgA1 was cleaved with an IgA1 protease purified from an isolat...

    journal_title:Virulence

    pub_type: 杂志文章

    doi:10.4161/viru.2.2.15401

    authors: Mistry DV,Stockley RA

    更新日期:2011-03-01 00:00:00

  • Animal models of sepsis.

    abstract::Sepsis remains a common, serious, and heterogeneous clinical entity that is difficult to define adequately. Despite its importance as a public health problem, efforts to develop and gain regulatory approval for a specific therapeutic agent for the adjuvant treatment of sepsis have been remarkably unsuccessful. One ste...

    journal_title:Virulence

    pub_type: 杂志文章,评审

    doi:10.4161/viru.26083

    authors: Fink MP

    更新日期:2014-01-01 00:00:00

  • The girl with the iron tattoo.

    abstract::We describe a young woman with profound anemia whose serum iron studies were incongruous with what we expected from iron deficiency anemia. Her high serum iron was not fully explainable until we examined the patient and noticed a large black tattoo on her left flank area. Apparently iron oxide in the ink used for the ...

    journal_title:Virulence

    pub_type: 信件

    doi:10.4161/viru.22122

    authors: Fircanis S,Shields R,Castillo J,Mega A,Schiffman F

    更新日期:2012-11-15 00:00:00