Abstract:
:Pathogens frequently exist in an immunological balancing act with their host. Pathogens must not only replicate within a host but also transmit effectively between hosts to perpetuate their species. On the other hand, the host seeks to maintain homeostasis by clearing pathogens. The inflammasome is a multi-protein complex that can induce cell death and processes IL-1β and additional proinflammatory substrates. In this review we discuss the pathogen specific modulation of inflammasome activation and the role this plays in virulence and disease pathology.
journal_name
Virulencejournal_title
Virulenceauthors
Lupfer CR,Kanneganti TDdoi
10.4161/viru.20266subject
Has Abstractpub_date
2012-05-01 00:00:00pages
262-70issue
3eissn
2150-5594issn
2150-5608pii
20266journal_volume
3pub_type
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