The cleavage specificity of an IgA1 protease from Haemophilus influenzae.

abstract：:Development of new therapeutics against Select Agents such as Francisella is critical preparation in the event of bioterrorism. Testing FDA-approved drugs for this purpose may yield new activities unrelated to their intended purpose and may hasten the discovery of new therapeutics. A library of 420 FDA-approved drugs ...

journal_title：Virulence

authors： Dean SN,van Hoek ML

更新日期：2015-01-01 00:00:00

abstract：:Streptococcus agalactiae, or group B Streptococcus (GBS), infects diverse hosts including humans and economically important species such as cattle and fishes. In the context of human health, GBS is a major cause of neonatal infections and an emerging cause of invasive disease in adults and of foodborne disease in Sout...

journal_title：Virulence

authors： Six A,Krajangwong S,Crumlish M,Zadoks RN,Walker D

更新日期：2019-12-01 00:00:00

abstract：:Legionella pneumophila is the primary respiratory pathogen and mostly transmitted to human through water cooling systems and cause mild to severe pneumonia with high mortality rate especially in elderly both in hospitals and community. However, current Legionella risk assessments may be compromised by uncertainties in...

journal_title：Virulence

authors： Ahmadrajabi R,Shakibaie MR,Iranmanesh Z,Mollaei HR,Sobhanipoor MH

更新日期：2016-07-03 00:00:00

abstract：:Pathogens frequently exist in an immunological balancing act with their host. Pathogens must not only replicate within a host but also transmit effectively between hosts to perpetuate their species. On the other hand, the host seeks to maintain homeostasis by clearing pathogens. The inflammasome is a multi-protein com...

journal_title：Virulence

authors： Lupfer CR,Kanneganti TD

更新日期：2012-05-01 00:00:00

abstract：:Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) have been reported in recent years across Asian countries and pose a serious threat to public health. Neutrophils represent the first line of defense against numerous infectious pathogens, such as CR-hvKP. Neutrophil extracellular traps (NETs) constitu...

journal_title：Virulence

authors： Jin L,Liu Y,Jing C,Wang R,Wang Q,Wang H

更新日期：2020-12-01 00:00:00

abstract：:The interaction between the fungal pathogen Paracoccidioides brasiliensis and host cells is usually mediated by specific binding events between adhesins on the fungal surface and receptors on the host extracellular matrix or cell surface. One molecule implicated in the P. brasiliensis-host interaction is the 14-3-3 pr...

journal_title：Virulence

authors： Marcos CM,Silva Jde F,Oliveira HC,Assato PA,Singulani Jde L,Lopez AM,Tamayo DP,Hernandez-Ruiz O,McEwen JG,Mendes-Giannini MJ,Fusco-Almeida AM

更新日期：2016-01-01 00:00:00

abstract：:Maternal antibodies induced by vaccination during pregnancy cross the placental barrier and can close the susceptibility gap to pertussis in young infants up to the start of primary immunization. As not only the quantity but also the quality of circulating antibodies is important for protection, we assessed whether ma...

journal_title：Virulence

authors： Caboré RN,Maertens K,Dobly A,Leuridan E,Van Damme P,Huygen K

更新日期：2017-10-03 00:00:00

abstract：:Entomopathogenic fungi are potential biological control agents of mosquitoes. Our group observed that not all mosquitoes were equally susceptible to fungal infection and observed significant differences in virulence of different spore types. Conidiospores and blastospores were tested against Culex quinquefasciatus lar...

journal_title：Virulence

authors： Alkhaibari AM,Lord AM,Maffeis T,Bull JC,Olivares FL,Samuels RI,Butt TM

更新日期：2018-01-01 00:00:00

abstract：:The Campylobacter jejuni N-linked protein glycosylation pathway produces a heptasaccharide that is added to >65 periplasmic and membrane proteins and is also released into the periplasm as the free oligosaccharide (fOS). The fOS is a novel soluble component of the C. jejuni periplasmic space that exists in 10-fold gre...

journal_title：Virulence

authors： Nothaft H,Liu X,Li J,Szymanski CM

更新日期：2010-11-01 00:00:00

abstract：:Th1-polarized host response, mediated by IFN-γ, has been associated with increased severity of periodontal disease as well as control of periodontal infection. The functional polymorphism TBX21-1993T/C (rs4794067) increases the transcriptional activity of the TBX21 gene (essential for Th1 polarization) resulting in a ...

journal_title：Virulence

authors： Cavalla F,Biguetti CC,Colavite PM,Silveira EV,Martins W Jr,Letra A,Trombone AP,Silva RM,Garlet GP

更新日期：2015-01-01 00:00:00

abstract：:A number of abundant mobile genetic elements called retrotransposons reverse transcribe RNA to generate DNA for insertion into eukaryotic genomes. Non-long-terminal repeat (non-LTR) retrotransposons represent a major class of retrotransposons, and transposons that move by target-primed reverse transcription lack LTRs ...

journal_title：Virulence

authors： Jiang J,Zhao L,Yan L,Zhang L,Cao Y,Wang Y,Jiang Y,Yan T,Cao Y

更新日期：2014-02-15 00:00:00

abstract：:Galleria mellonella (greater wax moth or honeycomb moth) has been introduced as an alternative model to study microbial infections. G. mellonella larvae can be easily and inexpensively obtained in large numbers and are simple to use as they don't require special lab equipment. There are no ethical constraints and thei...

journal_title：Virulence

authors： Tsai CJ,Loh JM,Proft T

更新日期：2016-04-02 00:00:00

abstract：:Many studies have found that abnormalities in the proportion and differentiation of CD4+ T cells (Th cells) are closely related to the pathogenesis of viral myocarditis (VMC). Our previous research indicates that the cholinergic anti-inflammatory pathway (CAP) attenuates the inflammatory response of VMC and downregula...

journal_title：Virulence

authors： De-Pu Z,Li-Sha G,Guang-Yi C,Xiaohong G,Chao X,Cheng Z,Wen-Wu Z,Jia L,Jia-Feng L,Maoping C,Yue-Chun L

更新日期：2018-01-01 00:00:00

abstract：:The interaction between pathogens and their host plants is a ubiquitous process. Some plant fungal pathogens can form a specific infection structure, such as an appressorium, which is formed by the accumulation of a large amount of glycerin and thereby the creation of an extremely high intracellular turgor pressure, w...

journal_title：Virulence

authors： Zhu XM,Li L,Wu M,Liang S,Shi HB,Liu XH,Lin FC

更新日期：2019-12-01 00:00:00

abstract：:Francisella tularensis is a highly virulent bacterial pathogen that is easily aerosolized and has a low infectious dose. As an intracellular pathogen, entry of Francisella into host cells is critical for its survival and virulence. However, the initial steps of attachment and internalization of Francisella into host c...

journal_title：Virulence

authors： Moreau GB,Mann BJ

更新日期：2013-11-15 00:00:00

abstract：:Quorum-sensing (QS), the regulation of bacterial gene expression in response to changes in cell density, involves pathways that synthesize signaling molecules (auto-inducers). The luxS/AI-2-mediated QS system has been identified in both gram-positive and gram-negative bacteria. Bacillus anthracis, the etiological agen...

journal_title：Virulence

authors： Jones MB,Peterson SN,Benn R,Braisted JC,Jarrahi B,Shatzkes K,Ren D,Wood TK,Blaser MJ

更新日期：2010-03-01 00:00:00

abstract：:In this issue of Virulence, Ban E et al. described the complete sequence of the pEntYN10 plasmid of Escherichia coli O169:H41. The plasmid has 182 coding sequences (CDs); among the identified CDs, some were identified as colonization factors (CFs), one was an enterotoxin and others were insertion sequences (IS). In th...

journal_title：Virulence

authors： Navarro A

更新日期：2015-01-01 00:00:00

abstract：:In the present study, we examined prolonged infection after antigenic co-stimulation by inoculation of the fungus Fonsecaea pedrosoi at two different sites in three mouse strains (BALB/c, Swiss, and C57BL/6). Using this murine model of infection, we showed that antigen induction of infection at more than one site led ...

journal_title：Virulence

authors： Machado AP,Silva MR,Fischman O

更新日期：2010-01-01 00:00:00

abstract：:The virulence behaviors of many Gram-negative bacterial pathogens are governed by quorum-sensing (QS), a hierarchical system of gene regulation that relies on population density by producing and detecting extracellular signaling molecules. Although extensively studied under in vitro conditions, adaptation of QS system...

journal_title：Virulence

authors： Kuang Z,Bennett RC,Lin J,Hao Y,Zhu L,Akinbi HT,Lau GW

更新日期：2020-12-01 00:00:00

abstract：:Anthrax toxins and capsule are the major virulence factors of Bacillus anthracis. They are encoded by genes located on the plasmids pXO1 and pXO2, respectively. The vaccine strain Pasteur II was produced from high temperature subcultures of B. anthracis, which resulted in virulence attenuation through the loss of the ...

journal_title：Virulence

authors： Liang X,Zhang H,Zhang E,Wei J,Li W,Wang B,Dong S,Zhu J

更新日期：2016-07-03 00:00:00

abstract：:Bacterial eukaryotic-like serine threonine kinases (eSTKs) and serine threonine phosphatases (eSTPs) have emerged as important signaling elements that are indispensable for pathogenesis. Differing considerably from their histidine kinase counterparts, few eSTK genes are encoded within the average bacterial genome, and...

journal_title：Virulence

authors： Wright DP,Ulijasz AT

更新日期：2014-01-01 00:00:00

abstract：:Intrinsically disordered proteins (IDPs) do not have a well-defined and stable 3-dimensional fold. Some IDPs can function as either transient or permanent binders of other proteins and may interact with an array of ligands by adopting different conformations. A novel outer membrane lipoprotein, bacterial interleukin r...

journal_title：Virulence

authors： Ahlstrand T,Tuominen H,Beklen A,Torittu A,Oscarsson J,Sormunen R,Pöllänen MT,Permi P,Ihalin R

更新日期：2017-02-17 00:00:00

abstract：:Sepsis remains a common, serious, and heterogeneous clinical entity that is difficult to define adequately. Despite its importance as a public health problem, efforts to develop and gain regulatory approval for a specific therapeutic agent for the adjuvant treatment of sepsis have been remarkably unsuccessful. One ste...

journal_title：Virulence

authors： Fink MP

更新日期：2014-01-01 00:00:00

abstract：:Multi-antibiotic drug-resistant (MDR) gram-negative bacilli are becoming a major threat to the standard care of septic patients. Empiric antimicrobial drug regimens to cover likely bacterial pathogens have to be altered in keeping with the spread of MDR pathogens in the health care setting and in the community. Reliab...

journal_title：Virulence

authors： Pop-Vicas A,Opal SM

更新日期：2014-01-01 00:00:00

abstract：:Novel coronavirus disease 2019 (COVID-19), caused by novel coronavirus SARS-CoV-2, has spread globally since the end of 2019. Asymptomatic carriers are of great concern as they can undermine the interventions to stop the pandemic. However, there is limited information about the characteristics and outcomes of the asym...

journal_title：Virulence

authors： Yu C,Zhou M,Liu Y,Guo T,Ou C,Yang L,Li Y,Li D,Hu X,Shuai L,Wang B,Zou Z

更新日期：2020-12-01 00:00:00

abstract：:Golden hamsters were inoculated with Schistosoma haematobium cercariae to examine histological lesions at different time points over an 18 month period of infection. Hamsters were sacrificed 26 weeks and 82 weeks after inoculation. The parasite was found in the blood and in the liver of infected animals as was expecte...

journal_title：Virulence

authors： Botelho MC,Oliveira PA,Vieira P,Delgado Mde L,Lourenço L,Lopes C,Machado JC,da Costa JM

更新日期：2010-05-01 00:00:00

abstract：:Burkholderia pseudomallei: is the etiological agent of the disease melioidosis and is a Tier 1 select agent. It survives and replicates inside phagocytic cells by escaping from the endocytic vacuole, replicating in the cytosol, spreading to other cells via actin polymerization and promoting the fusion of infected and ...

journal_title：Virulence

authors： Welkos S,Blanco I,Okaro U,Chua J,DeShazer D

更新日期：2020-12-01 00:00:00

abstract：:Bacillus anthracis, the causative agent of anthrax, is a zoonotic pathogen that is relatively common throughout the world and may cause life threatening diseases in animals and humans. There are many PCR-based assays in use for the detection of B. anthracis. While most of the developed assays rely on unique markers pr...

journal_title：Virulence

authors： Ågren J,Hamidjaja RA,Hansen T,Ruuls R,Thierry S,Vigre H,Janse I,Sundström A,Segerman B,Koene M,Löfström C,Van Rotterdam B,Derzelle S

更新日期：2013-11-15 00:00:00

abstract：:We recently developed a method that allows fast differentiation between Streptococcus pyogenes (GAS) strains. The method named phage profiling (PP) is based on a simple assumption that a regular PCR reaction with Taq polymerase and relatively short elongation time is not able to yield long DNA fragment, such as ~40-50...

journal_title：Virulence

authors： Borek AL,Obszańska K,Hryniewicz W,Sitkiewicz I

更新日期：2012-10-01 00:00:00

abstract：:Ebola virus (EBOV) is a member of the filoviridae family that causes severe hemorrhagic fever during sporadic outbreaks, and no approved treatments are currently available. The multifunctional EBOV VP35 protein facilitates immune evasion by antagonizing antiviral signaling pathways and is important for viral RNA synth...

journal_title：Virulence

authors： Leung DW,Prins KC,Basler CF,Amarasinghe GK

更新日期：2010-11-01 00:00:00