Effector triggered immunity.

Abstract:

:Pathogenic bacteria produce virulence factors called effectors, which are important components of the infection process. Effectors aid in pathogenesis by facilitating bacterial attachment, pathogen entry into or exit from the host cell, immunoevasion, and immunosuppression. Effectors also have the ability to subvert host cellular processes, such as hijacking cytoskeletal machinery or blocking protein translation. However, host cells possess an evolutionarily conserved innate immune response that can sense the pathogen through the activity of its effectors and mount a robust immune response. This "effector triggered immunity" (ETI) was first discovered in plants but recent evidence suggest that the process is also well conserved in metazoans. We will discuss salient points of the mechanism of ETI in metazoans from recent studies done in mammalian cells and invertebrate model hosts.

journal_name

Virulence

journal_title

Virulence

authors

Rajamuthiah R,Mylonakis E

doi

10.4161/viru.29091

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

697-702

issue

7

eissn

2150-5594

issn

2150-5608

journal_volume

5

pub_type

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