Abstract:
:Pathogenic bacteria produce virulence factors called effectors, which are important components of the infection process. Effectors aid in pathogenesis by facilitating bacterial attachment, pathogen entry into or exit from the host cell, immunoevasion, and immunosuppression. Effectors also have the ability to subvert host cellular processes, such as hijacking cytoskeletal machinery or blocking protein translation. However, host cells possess an evolutionarily conserved innate immune response that can sense the pathogen through the activity of its effectors and mount a robust immune response. This "effector triggered immunity" (ETI) was first discovered in plants but recent evidence suggest that the process is also well conserved in metazoans. We will discuss salient points of the mechanism of ETI in metazoans from recent studies done in mammalian cells and invertebrate model hosts.
journal_name
Virulencejournal_title
Virulenceauthors
Rajamuthiah R,Mylonakis Edoi
10.4161/viru.29091subject
Has Abstractpub_date
2014-01-01 00:00:00pages
697-702issue
7eissn
2150-5594issn
2150-5608journal_volume
5pub_type
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