Anti-endotoxin vaccines: back to the future.

Abstract:

:Gram-negative bacterial (GNB) infections are a leading cause of serious infections both in hospitals and the community. The mortality remains high despite potent antimicrobials and modern supportive care. In the last decade invasive GNB have become increasingly resistant to commonly used antibiotics, and attempts to intervene with novel biological therapies have been unsuccessful. Earlier studies with antibodies directed against a highly conserved core region in the GNB lipopolysaccharide (LPS, or endotoxin) suggested that this approach may have therapeutic benefit, and led to the development of a subunit vaccine that has progressed to phase 1 clinical testing. Since only a few serogroups of GNB cause bacteremia, O-specific vaccines had been developed, but these were not deployed because of the availability of other therapeutic options at the time. Given the likelihood that new antibiotics will not be soon available, the development of vaccines and antibodies directed against endotoxin, both O and core antigens, deserves a "second look".

journal_name

Virulence

journal_title

Virulence

authors

Cross AS

doi

10.4161/viru.25965

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

219-25

issue

1

eissn

2150-5594

issn

2150-5608

pii

25965

journal_volume

5

pub_type

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