The girl with the iron tattoo.

abstract：:Bacterial IgA1 proteases are thought to be important virulence factors in respiratory tract infections. These proteolytic enzymes specifically cleave one of several post-proline peptide bonds within the hinge region of human immunoglobulin A1 (IgA1). Human IgA1 was cleaved with an IgA1 protease purified from an isolat...

journal_title：Virulence

authors： Mistry DV,Stockley RA

更新日期：2011-03-01 00:00:00

abstract：:Patients undergoing haematopoietic stem cell transplantation (HSCT) are highly exposed to infectious agents. However, it is not known why certain HSCT recipients rapidly develop severe infections while other, despite similar immunosuppressive conditions, do not. Increasing evidence suggests that such differences may b...

journal_title：Virulence

authors： Wójtowicz A,Bochud PY

更新日期：2016-11-16 00:00:00

abstract：:Gram-negative bacterial (GNB) infections are a leading cause of serious infections both in hospitals and the community. The mortality remains high despite potent antimicrobials and modern supportive care. In the last decade invasive GNB have become increasingly resistant to commonly used antibiotics, and attempts to i...

journal_title：Virulence

authors： Cross AS

更新日期：2014-01-01 00:00:00

abstract：:Several human pathogens bind and respond to host cytokines, which can be considered a virulence mechanism that communicates defensive actions of the host to the pathogen. This review summarizes the current knowledge of bacterial cytokine-binding proteins, with a particular focus on their functional and structural char...

journal_title：Virulence

authors： Högbom M,Ihalin R

更新日期：2017-11-17 00:00:00

abstract：:Cryptococcus neoformans undergoes phenotypical changes during host infection in order to promote persistence and survival. Studies have demonstrated that such adaptations require alterations in gene transcription networks by distinct mechanisms. Drugs such as the histone deacetylases inhibitors (HDACi) Sodium Butyrate...

journal_title：Virulence

authors： Brandão FA,Derengowski LS,Albuquerque P,Nicola AM,Silva-Pereira I,Poças-Fonseca MJ

更新日期：2015-01-01 00:00:00

abstract：:Rat bite fever (RBF), a worldwide occurring and most likely under-diagnosed zoonosis caused by Streptobacillus moniliformis, represents the most prominent disease of Streptobacillus infections. Recently, novel members have been described, from which a reservoir in rats and other animal species and a zoonotic potential...

journal_title：Virulence

authors： Eisenberg T,Ewers C,Rau J,Akimkin V,Nicklas W

更新日期：2016-08-17 00:00:00

abstract：:The Campylobacter jejuni N-linked protein glycosylation pathway produces a heptasaccharide that is added to >65 periplasmic and membrane proteins and is also released into the periplasm as the free oligosaccharide (fOS). The fOS is a novel soluble component of the C. jejuni periplasmic space that exists in 10-fold gre...

journal_title：Virulence

authors： Nothaft H,Liu X,Li J,Szymanski CM

更新日期：2010-11-01 00:00:00

abstract：:The twin-arginine translocation (Tat) system is involved in a variety of important bacterial physiological processes. Conserved among bacteria and crucial for virulence, the Tat system is deemed as a promising anti-microbial drug target. However, the mechanism of how the Tat system functions in bacterial pathogenesis ...

journal_title：Virulence

authors： Liu J,Yin F,Liu T,Li S,Tan C,Li L,Zhou R,Huang Q

更新日期：2020-12-01 00:00:00

abstract：:Novel coronavirus disease 2019 (COVID-19), caused by novel coronavirus SARS-CoV-2, has spread globally since the end of 2019. Asymptomatic carriers are of great concern as they can undermine the interventions to stop the pandemic. However, there is limited information about the characteristics and outcomes of the asym...

journal_title：Virulence

authors： Yu C,Zhou M,Liu Y,Guo T,Ou C,Yang L,Li Y,Li D,Hu X,Shuai L,Wang B,Zou Z

更新日期：2020-12-01 00:00:00

abstract：:Burkholderia pseudomallei: is the etiological agent of the disease melioidosis and is a Tier 1 select agent. It survives and replicates inside phagocytic cells by escaping from the endocytic vacuole, replicating in the cytosol, spreading to other cells via actin polymerization and promoting the fusion of infected and ...

journal_title：Virulence

authors： Welkos S,Blanco I,Okaro U,Chua J,DeShazer D

更新日期：2020-12-01 00:00:00

abstract：:Development of new therapeutics against Select Agents such as Francisella is critical preparation in the event of bioterrorism. Testing FDA-approved drugs for this purpose may yield new activities unrelated to their intended purpose and may hasten the discovery of new therapeutics. A library of 420 FDA-approved drugs ...

journal_title：Virulence

authors： Dean SN,van Hoek ML

更新日期：2015-01-01 00:00:00

abstract：:Drugs such as linezolid that inhibit bacterial protein synthesis may be beneficial in treating infections caused by toxigenic Staphylococcus aureus. As protein synthesis inhibitors have no effect on preformed toxins, neutralization of pathogenic exotoxins with anti-toxin antibodies may be beneficial in conjunction wit...

journal_title：Virulence

authors： Karau MJ,Tilahun ME,Krogman A,Osborne BA,Goldsby RA,David CS,Mandrekar JN,Patel R,Rajagopalan G

更新日期：2017-10-03 00:00:00

abstract：:Helicobacter pylori infection can result in non-ulcer dyspepsia (NUD), peptic ulcer disease (PUD), adenocarcinoma, and gastric lymphoma. H. pylori reside within the gastric mucus layer, mainly composed of mucins carrying an array of glycan structures that can serve as bacterial adhesion epitopes. The aim of the presen...

journal_title：Virulence

authors： Quintana-Hayashi MP,Rocha R,Padra M,Thorell A,Jin C,Karlsson NG,Roxo-Rosa M,Oleastro M,Lindén SK

更新日期：2018-01-01 00:00:00

abstract：:A greater ethical conscience, new global rules and a modified perception of ethical consciousness entail a more rigorous control on utilizations of vertebrates for in vivo studies. To cope with this new scenario, numerous alternatives to rodents have been proposed. Among these, the greater wax moth Galleria mellonella...

journal_title：Virulence

authors： Cutuli MA,Petronio Petronio G,Vergalito F,Magnifico I,Pietrangelo L,Venditti N,Di Marco R

更新日期：2019-12-01 00:00:00

abstract：:Candida albicans remains the main etiological agent of candidiasis, as this otherwise normal commensal of humans is capable of causing active infection in immune- and medically-compromised patients. The high morbidity and mortality rates associated with candidiasis, coupled with the emergence of drug resistance demand...

journal_title：Virulence

authors： Vila T,Romo JA,Pierce CG,McHardy SF,Saville SP,Lopez-Ribot JL

更新日期：2017-02-17 00:00:00

abstract：:Current treatment for combatting Chagas disease, a life-threatening illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi is inadequate, and thus the discovery of new antiparasitic compounds is of prime importance. Previous studies identified the indirubins, a class of ATP kinase inhibitors, as pote...

journal_title：Virulence

authors： Efstathiou A,Meira CS,Gaboriaud-Kolar N,Bastos TM,Rocha VPC,Vougogiannopoulou K,Skaltsounis AL,Smirlis D,Soares MBP

更新日期：2018-01-01 00:00:00

abstract：:Intrinsically disordered proteins (IDPs) do not have a well-defined and stable 3-dimensional fold. Some IDPs can function as either transient or permanent binders of other proteins and may interact with an array of ligands by adopting different conformations. A novel outer membrane lipoprotein, bacterial interleukin r...

journal_title：Virulence

authors： Ahlstrand T,Tuominen H,Beklen A,Torittu A,Oscarsson J,Sormunen R,Pöllänen MT,Permi P,Ihalin R

更新日期：2017-02-17 00:00:00

abstract：:Ebola virus (EBOV) is a member of the filoviridae family that causes severe hemorrhagic fever during sporadic outbreaks, and no approved treatments are currently available. The multifunctional EBOV VP35 protein facilitates immune evasion by antagonizing antiviral signaling pathways and is important for viral RNA synth...

journal_title：Virulence

authors： Leung DW,Prins KC,Basler CF,Amarasinghe GK

更新日期：2010-11-01 00:00:00

abstract：:Chloroquine (CQ) was the best and most heavily used drug in the fight against malaria. However, the effectiveness of CQ has declined with the emergence and spread of CQ-resistant (CQR) Plasmodium falciparum parasites. The primary determinant of CQ resistance in P. falciparum is mutations in the parasite's 'chloroquine...

journal_title：Virulence

authors： Summers RL,Martin RE

更新日期：2010-07-01 00:00:00

abstract：:The virulence behaviors of many Gram-negative bacterial pathogens are governed by quorum-sensing (QS), a hierarchical system of gene regulation that relies on population density by producing and detecting extracellular signaling molecules. Although extensively studied under in vitro conditions, adaptation of QS system...

journal_title：Virulence

authors： Kuang Z,Bennett RC,Lin J,Hao Y,Zhu L,Akinbi HT,Lau GW

更新日期：2020-12-01 00:00:00

abstract：:In the present study, we examined prolonged infection after antigenic co-stimulation by inoculation of the fungus Fonsecaea pedrosoi at two different sites in three mouse strains (BALB/c, Swiss, and C57BL/6). Using this murine model of infection, we showed that antigen induction of infection at more than one site led ...

journal_title：Virulence

authors： Machado AP,Silva MR,Fischman O

更新日期：2010-01-01 00:00:00

abstract：:The interaction between the fungal pathogen Paracoccidioides brasiliensis and host cells is usually mediated by specific binding events between adhesins on the fungal surface and receptors on the host extracellular matrix or cell surface. One molecule implicated in the P. brasiliensis-host interaction is the 14-3-3 pr...

journal_title：Virulence

authors： Marcos CM,Silva Jde F,Oliveira HC,Assato PA,Singulani Jde L,Lopez AM,Tamayo DP,Hernandez-Ruiz O,McEwen JG,Mendes-Giannini MJ,Fusco-Almeida AM

更新日期：2016-01-01 00:00:00

abstract：:Particle size dictates where aerosolized pathogens deposit in the respiratory tract, thereafter the pathogens potential to cause disease is influenced by tissue tropism, clearance kinetics and the host immunological response. This interplay brings pathogens into contact with a range of tissues spanning the respiratory...

journal_title：Virulence

authors： Thomas RJ

更新日期：2013-11-15 00:00:00

abstract：:Acinetobacter nosocomialis is an important nosocomial pathogen that causes a variety of human infections. However, the specific virulence factors of this microorganism have not yet been determined. We investigated the role of outer membrane protein A (OmpA) in the pathogenesis of A. nosocomialis. A ΔompA mutant of the...

journal_title：Virulence

authors： Kim SW,Oh MH,Jun SH,Jeon H,Kim SI,Kim K,Lee YC,Lee JC

更新日期：2016-05-18 00:00:00

abstract：:Bacteria interact with their host through protein secretion systems and surface structures. Pathogenic bacteria encode protein secretion systems that promote the invasion of the host's tissue, the evasion of the host's immune response, the thwarting microbial competitors, and ultimately survival within the host. For m...

journal_title：Virulence

authors： Troxell B

更新日期：2018-01-01 00:00:00

abstract：:A number of abundant mobile genetic elements called retrotransposons reverse transcribe RNA to generate DNA for insertion into eukaryotic genomes. Non-long-terminal repeat (non-LTR) retrotransposons represent a major class of retrotransposons, and transposons that move by target-primed reverse transcription lack LTRs ...

journal_title：Virulence

authors： Jiang J,Zhao L,Yan L,Zhang L,Cao Y,Wang Y,Jiang Y,Yan T,Cao Y

更新日期：2014-02-15 00:00:00

abstract：:The emergence of multiresistant Gram-negative bacteria requires new therapies for combating bacterial infections. Targeting the biogenesis of virulence factors could be an alternative strategy instead of killing bacteria with antibiotics. The outer membrane (OM) of Gram-negative bacteria acts as a physical barrier. At...

journal_title：Virulence

authors： Weirich J,Bräutigam C,Mühlenkamp M,Franz-Wachtel M,Macek B,Meuskens I,Skurnik M,Leskinen K,Bohn E,Autenrieth I,Schütz M

更新日期：2017-10-03 00:00:00

abstract：:Invasive pulmonary aspergillosis (IPA) is a severe infection that is difficult to diagnose due to the ubiquitous presence of fungal spores, the underlying diseases of risk patients, and limitations of currently available markers. In this study, we performed a comprehensive liquid chromatography tandem mass spectrometr...

journal_title：Virulence

authors： Machata S,Müller MM,Lehmann R,Sieber P,Panagiotou G,Carvalho A,Cunha C,Lagrou K,Maertens J,Slevogt H,Jacobsen ID

更新日期：2020-12-01 00:00:00

abstract：:The recent finding that the formation of staphylococcal enterotoxins in food is very different from that in cultures of pure Staphylococcus aureus sheds new light on, and brings into question, traditional microbial risk assessment methods based on planktonic liquid cultures. In fact, most bacteria in food appear to be...

journal_title：Virulence

authors： Schelin J,Wallin-Carlquist N,Cohn MT,Lindqvist R,Barker GC,Rådström P

更新日期：2011-11-01 00:00:00

abstract：:Bacterial pathogens release a number of toxins that are able to form pores in target host cells, which can result in their destruction. Due to this property of this subgroup of toxins, they are considered virulence factors. A lesser known ability of these toxins when present at lower concentrations that are insufficie...

journal_title：Virulence

authors： Yoong P

更新日期：2010-09-01 00:00:00