The girl with the iron tattoo.

abstract：:The hemagglutinin (HA) proteins derived from avian influenza viruses bind specifically to the α2-3 sialoglycan (Sia glycan), whereas human-adapted influenza viruses prefer to bind to the α2-6 Sia glycan. A switch of glycan specificity from α2-3 Sia glycan to α2-6 Sia glycan appears to be critical for a virus to become...

journal_title：Virulence

authors： Suenaga E,Mizuno H,Kumar PK

更新日期：2012-08-15 00:00:00

abstract：:Gram-negative bacterial (GNB) infections are a leading cause of serious infections both in hospitals and the community. The mortality remains high despite potent antimicrobials and modern supportive care. In the last decade invasive GNB have become increasingly resistant to commonly used antibiotics, and attempts to i...

journal_title：Virulence

authors： Cross AS

更新日期：2014-01-01 00:00:00

abstract：:In previous studies we demonstrated that the staphylococcal α-toxin inhibits adhesion and invasion of S. aureus by epithelial cells through binding to α5β1 integrin, a receptor of fibronectin. Moreover, we revealed that a H35A mutation abolishes the cytotoxicity of α-toxin completely. These findings led us to hypothes...

journal_title：Virulence

authors： Yang J,Liang X,Ji Y

更新日期：2013-01-01 00:00:00

abstract：:Legionella pneumophila is the primary respiratory pathogen and mostly transmitted to human through water cooling systems and cause mild to severe pneumonia with high mortality rate especially in elderly both in hospitals and community. However, current Legionella risk assessments may be compromised by uncertainties in...

journal_title：Virulence

authors： Ahmadrajabi R,Shakibaie MR,Iranmanesh Z,Mollaei HR,Sobhanipoor MH

更新日期：2016-07-03 00:00:00

abstract：:Golden hamsters were inoculated with Schistosoma haematobium cercariae to examine histological lesions at different time points over an 18 month period of infection. Hamsters were sacrificed 26 weeks and 82 weeks after inoculation. The parasite was found in the blood and in the liver of infected animals as was expecte...

journal_title：Virulence

authors： Botelho MC,Oliveira PA,Vieira P,Delgado Mde L,Lourenço L,Lopes C,Machado JC,da Costa JM

更新日期：2010-05-01 00:00:00

abstract：:The recent finding that the formation of staphylococcal enterotoxins in food is very different from that in cultures of pure Staphylococcus aureus sheds new light on, and brings into question, traditional microbial risk assessment methods based on planktonic liquid cultures. In fact, most bacteria in food appear to be...

journal_title：Virulence

authors： Schelin J,Wallin-Carlquist N,Cohn MT,Lindqvist R,Barker GC,Rådström P

更新日期：2011-11-01 00:00:00

abstract：:Human herpesviruses have latency and lytic replication phases in their lifecycle. Proper regulation of herpesviral lifecycle is essential for the evasion of host immune surveillance and development of their related diseases. Recent advancements indicate a role of a novel class of viral non-coding RNAs, microRNA (miRNA...

journal_title：Virulence

authors： Lei X,Bai Z,Ye F,Huang Y,Gao SJ

更新日期：2010-09-01 00:00:00

abstract：:Candida albicans remains the main etiological agent of candidiasis, as this otherwise normal commensal of humans is capable of causing active infection in immune- and medically-compromised patients. The high morbidity and mortality rates associated with candidiasis, coupled with the emergence of drug resistance demand...

journal_title：Virulence

authors： Vila T,Romo JA,Pierce CG,McHardy SF,Saville SP,Lopez-Ribot JL

更新日期：2017-02-17 00:00:00

abstract：:In immune-competent hosts, adenoviruses (Ads) are mild pathogens that cause mainly infections of the respiratory and ocular tracks. The advent of Ad-based gene transfer vectors made the understanding of their interaction with the host cellular machinery an intensive field of research over the last decade. As studies f...

journal_title：Virulence

authors： Henaff D,Salinas S

更新日期：2010-05-01 00:00:00

abstract：:Periodontitis is an infectious inflammatory disease that destroys the tooth-supporting tissues. It is caused by the formation of subgingival biofilms on the surface of the tooth. Characteristic bacteria associated with subgingival biofilms are the Gram-negative anaerobes Porphyromonas gingivalis, Tannerella forsythia ...

journal_title：Virulence

authors： Belibasakis GN,Kast JI,Thurnheer T,Akdis CA,Bostanci N

更新日期：2015-01-01 00:00:00

abstract：:Lipid mediators, derived from arachidonic acid metabolism, play an important role in immune regulation. The functions of bioactive eicosanoids range from modulating cytokine signaling and inflammasome formation to anti-inflammatory and pro-resolving activities. Human pathogenic fungi such as Candida albicans, Candida ...

journal_title：Virulence

authors： Chakraborty T,Thuer E,Heijink M,Tóth R,Bodai L,Vágvölgyi C,Giera M,Gabaldón T,Gácser A

更新日期：2018-01-01 00:00:00

abstract：:Current treatment for combatting Chagas disease, a life-threatening illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi is inadequate, and thus the discovery of new antiparasitic compounds is of prime importance. Previous studies identified the indirubins, a class of ATP kinase inhibitors, as pote...

journal_title：Virulence

authors： Efstathiou A,Meira CS,Gaboriaud-Kolar N,Bastos TM,Rocha VPC,Vougogiannopoulou K,Skaltsounis AL,Smirlis D,Soares MBP

更新日期：2018-01-01 00:00:00

abstract：:Multi-antibiotic drug-resistant (MDR) gram-negative bacilli are becoming a major threat to the standard care of septic patients. Empiric antimicrobial drug regimens to cover likely bacterial pathogens have to be altered in keeping with the spread of MDR pathogens in the health care setting and in the community. Reliab...

journal_title：Virulence

authors： Pop-Vicas A,Opal SM

更新日期：2014-01-01 00:00:00

abstract：:The interaction between the fungal pathogen Paracoccidioides brasiliensis and host cells is usually mediated by specific binding events between adhesins on the fungal surface and receptors on the host extracellular matrix or cell surface. One molecule implicated in the P. brasiliensis-host interaction is the 14-3-3 pr...

journal_title：Virulence

authors： Marcos CM,Silva Jde F,Oliveira HC,Assato PA,Singulani Jde L,Lopez AM,Tamayo DP,Hernandez-Ruiz O,McEwen JG,Mendes-Giannini MJ,Fusco-Almeida AM

更新日期：2016-01-01 00:00:00

abstract：:Entomopathogenic fungi are potential biological control agents of mosquitoes. Our group observed that not all mosquitoes were equally susceptible to fungal infection and observed significant differences in virulence of different spore types. Conidiospores and blastospores were tested against Culex quinquefasciatus lar...

journal_title：Virulence

authors： Alkhaibari AM,Lord AM,Maffeis T,Bull JC,Olivares FL,Samuels RI,Butt TM

更新日期：2018-01-01 00:00:00

abstract：:Maternal antibodies induced by vaccination during pregnancy cross the placental barrier and can close the susceptibility gap to pertussis in young infants up to the start of primary immunization. As not only the quantity but also the quality of circulating antibodies is important for protection, we assessed whether ma...

journal_title：Virulence

authors： Caboré RN,Maertens K,Dobly A,Leuridan E,Van Damme P,Huygen K

更新日期：2017-10-03 00:00:00

abstract：:In the present study, we examined prolonged infection after antigenic co-stimulation by inoculation of the fungus Fonsecaea pedrosoi at two different sites in three mouse strains (BALB/c, Swiss, and C57BL/6). Using this murine model of infection, we showed that antigen induction of infection at more than one site led ...

journal_title：Virulence

authors： Machado AP,Silva MR,Fischman O

更新日期：2010-01-01 00:00:00

abstract：:Mucormycosis is an uncommon fungal infection that has been increasingly reported in severely immunocompromised patients receiving Aspergillus-active antifungals. Although clinical studies and pre-clinical animal models have suggested a unique predisposition for breakthrough mucormycoses in patients receiving voriconaz...

journal_title：Virulence

authors： Lewis RE,Liao G,Wang W,Prince RA,Kontoyiannis DP

更新日期：2011-07-01 00:00:00

abstract：:Mycoplasmas persist in the host for a long time, suggesting that they possess mechanisms for immune evasion. Factor H is a negative regulator of the complement system, which binds to host cells to avoid unexpected complement activation. In this study, we revealed that many mycoplasmas, such as Mycoplasma hyopneumoniae...

journal_title：Virulence

authors： Yu Y,Wang J,Han R,Wang L,Zhang L,Zhang AY,Xin J,Li S,Zeng Y,Shao G,Feng Z,Xiong Q

更新日期：2020-12-01 00:00:00

abstract：:The twin-arginine translocation (Tat) system is involved in a variety of important bacterial physiological processes. Conserved among bacteria and crucial for virulence, the Tat system is deemed as a promising anti-microbial drug target. However, the mechanism of how the Tat system functions in bacterial pathogenesis ...

journal_title：Virulence

authors： Liu J,Yin F,Liu T,Li S,Tan C,Li L,Zhou R,Huang Q

更新日期：2020-12-01 00:00:00

abstract：:Pathogenic bacteria produce virulence factors called effectors, which are important components of the infection process. Effectors aid in pathogenesis by facilitating bacterial attachment, pathogen entry into or exit from the host cell, immunoevasion, and immunosuppression. Effectors also have the ability to subvert h...

journal_title：Virulence

authors： Rajamuthiah R,Mylonakis E

更新日期：2014-01-01 00:00:00

abstract：:Burkholderia pseudomallei: is the etiological agent of the disease melioidosis and is a Tier 1 select agent. It survives and replicates inside phagocytic cells by escaping from the endocytic vacuole, replicating in the cytosol, spreading to other cells via actin polymerization and promoting the fusion of infected and ...

journal_title：Virulence

authors： Welkos S,Blanco I,Okaro U,Chua J,DeShazer D

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Reports show that more than 20 million infants world-wide are born prematurely with 95% of all pre-term births occurring in developing countries. Oral colonization of gram-negative anaerobes has been implicated as a risk factor for preterm delivery of low birth weight infants. MATERIALS AND METHODS:This stu...

journal_title：Virulence

authors： Africa C,Kayitenkore J,Bayingana C

更新日期：2010-07-01 00:00:00

abstract：:Francisella tularensis is a highly virulent bacterial pathogen that is easily aerosolized and has a low infectious dose. As an intracellular pathogen, entry of Francisella into host cells is critical for its survival and virulence. However, the initial steps of attachment and internalization of Francisella into host c...

journal_title：Virulence

authors： Moreau GB,Mann BJ

更新日期：2013-11-15 00:00:00

abstract：:Acinetobacter nosocomialis is an important nosocomial pathogen that causes a variety of human infections. However, the specific virulence factors of this microorganism have not yet been determined. We investigated the role of outer membrane protein A (OmpA) in the pathogenesis of A. nosocomialis. A ΔompA mutant of the...

journal_title：Virulence

authors： Kim SW,Oh MH,Jun SH,Jeon H,Kim SI,Kim K,Lee YC,Lee JC

更新日期：2016-05-18 00:00:00

abstract：:Bacteria interact with their host through protein secretion systems and surface structures. Pathogenic bacteria encode protein secretion systems that promote the invasion of the host's tissue, the evasion of the host's immune response, the thwarting microbial competitors, and ultimately survival within the host. For m...

journal_title：Virulence

authors： Troxell B

更新日期：2018-01-01 00:00:00

abstract：:Novel approaches to treat carbapenem-resistant Acinetobacter baumannii (CRAB) infections are urgently needed and anti-virulence drugs represent promising alternatives, but our knowledge on potential targets is scarce. We searched for potential A. baumannii virulence factors by whole-genome sequencing-based comparisons...

journal_title：Virulence

authors： Labrador-Herrera G,Pérez-Pulido AJ,Álvarez-Marín R,Casimiro-Soriguer CS,Cebrero-Cangueiro T,Morán-Barrio J,Pachón J,Viale AM,Pachón-Ibáñez ME

更新日期：2020-12-01 00:00:00

abstract：:Drugs such as linezolid that inhibit bacterial protein synthesis may be beneficial in treating infections caused by toxigenic Staphylococcus aureus. As protein synthesis inhibitors have no effect on preformed toxins, neutralization of pathogenic exotoxins with anti-toxin antibodies may be beneficial in conjunction wit...

journal_title：Virulence

authors： Karau MJ,Tilahun ME,Krogman A,Osborne BA,Goldsby RA,David CS,Mandrekar JN,Patel R,Rajagopalan G

更新日期：2017-10-03 00:00:00

abstract：:Carbapenem-Resistant Enterobacteriaceae (CRE) are an emerging healthcare crisis. Infections due to CRE are associated with high morbidity and mortality, especially in critically ill patients. Due to the multi-drug resistant nature of these infections only limited treatment options are available. Antimicrobials that ha...

journal_title：Virulence

authors： Neuner EA,Gallagher JC

更新日期：2017-05-19 00:00:00

abstract：:Many of the alterations that affect innate and adaptive immune cell compartments in HIV-infected patients are reminiscent of the process of immune aging, characteristic of old age. These alterations define the immunological age of individuals and are likely to participate to the decline of immune competence with HIV d...

journal_title：Virulence

authors： Appay V,Sauce D

更新日期：2017-07-04 00:00:00