Targeting Candida albicans filamentation for antifungal drug development.

abstract：:Entomopathogenic fungi are potential biological control agents of mosquitoes. Our group observed that not all mosquitoes were equally susceptible to fungal infection and observed significant differences in virulence of different spore types. Conidiospores and blastospores were tested against Culex quinquefasciatus lar...

journal_title：Virulence

authors： Alkhaibari AM,Lord AM,Maffeis T,Bull JC,Olivares FL,Samuels RI,Butt TM

更新日期：2018-01-01 00:00:00

abstract：:Aeromonas hydrophila (A. hydrophila) can cause a number of diseases in both human and animals. A. hydrophila-related infections in aquaculture cause severe economic losses every year throughout the world. The emergence of antibiotic resistance that is due to the abuse of antibiotics has limited the application of anti...

journal_title：Virulence

authors： Dong J,Zhang L,Liu Y,Xu N,Zhou S,Yang Y,Yang Q,Ai X

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVES:Hypervirulent Klebsiella pneumoniae(hvKp) is an increasingly important pathogen. Tracking its epidemiology and evolving antimicrobial resistance will facilitate care. METHODS:A retrospective study was conducted in two hospitals. We collected the clinical data. Antimicrobial and virulence-associated phenotyp...

journal_title：Virulence

authors： Liu C,Du P,Xiao N,Ji F,Russo TA,Guo J

更新日期：2020-12-01 00:00:00

abstract：:The Gram-negative enteropathogen Yersinia pseudotuberculosis possesses a number of regulatory systems that detect cell envelope damage caused by noxious extracytoplasmic stresses. The CpxA sensor kinase and CpxR response regulator two-component regulatory system is one such pathway. Active Cpx signalling upregulates v...

journal_title：Virulence

authors： Thanikkal EJ,Gahlot DK,Liu J,Fredriksson Sundbom M,Gurung JM,Ruuth K,Francis MK,Obi IR,Thompson KM,Chen S,Dersch P,Francis MS

更新日期：2019-12-01 00:00:00

abstract：:Many studies have found that abnormalities in the proportion and differentiation of CD4+ T cells (Th cells) are closely related to the pathogenesis of viral myocarditis (VMC). Our previous research indicates that the cholinergic anti-inflammatory pathway (CAP) attenuates the inflammatory response of VMC and downregula...

journal_title：Virulence

authors： De-Pu Z,Li-Sha G,Guang-Yi C,Xiaohong G,Chao X,Cheng Z,Wen-Wu Z,Jia L,Jia-Feng L,Maoping C,Yue-Chun L

更新日期：2018-01-01 00:00:00

abstract：:Ebola virus (EBOV) is a member of the filoviridae family that causes severe hemorrhagic fever during sporadic outbreaks, and no approved treatments are currently available. The multifunctional EBOV VP35 protein facilitates immune evasion by antagonizing antiviral signaling pathways and is important for viral RNA synth...

journal_title：Virulence

authors： Leung DW,Prins KC,Basler CF,Amarasinghe GK

更新日期：2010-11-01 00:00:00

abstract：:Retrotransposons constitute a major part of the genome in a number of eukaryotes. Long-terminal repeat (LTR) retrotransposons are one type of the retrotransposons. Candida albicans have 34 distinct LTR-retrotransposon families. They respectively belong to the Ty1/copia and Ty3/gypsy groups which have been extensively ...

journal_title：Virulence

authors： Zhang L,Yan L,Jiang J,Wang Y,Jiang Y,Yan T,Cao Y

更新日期：2014-08-15 00:00:00

abstract：:A number of abundant mobile genetic elements called retrotransposons reverse transcribe RNA to generate DNA for insertion into eukaryotic genomes. Non-long-terminal repeat (non-LTR) retrotransposons represent a major class of retrotransposons, and transposons that move by target-primed reverse transcription lack LTRs ...

journal_title：Virulence

authors： Jiang J,Zhao L,Yan L,Zhang L,Cao Y,Wang Y,Jiang Y,Yan T,Cao Y

更新日期：2014-02-15 00:00:00

abstract：:Development of new therapeutics against Select Agents such as Francisella is critical preparation in the event of bioterrorism. Testing FDA-approved drugs for this purpose may yield new activities unrelated to their intended purpose and may hasten the discovery of new therapeutics. A library of 420 FDA-approved drugs ...

journal_title：Virulence

authors： Dean SN,van Hoek ML

更新日期：2015-01-01 00:00:00

abstract：:We describe a young woman with profound anemia whose serum iron studies were incongruous with what we expected from iron deficiency anemia. Her high serum iron was not fully explainable until we examined the patient and noticed a large black tattoo on her left flank area. Apparently iron oxide in the ink used for the ...

journal_title：Virulence

authors： Fircanis S,Shields R,Castillo J,Mega A,Schiffman F

更新日期：2012-11-15 00:00:00

abstract：:Bacteria interact with their host through protein secretion systems and surface structures. Pathogenic bacteria encode protein secretion systems that promote the invasion of the host's tissue, the evasion of the host's immune response, the thwarting microbial competitors, and ultimately survival within the host. For m...

journal_title：Virulence

authors： Troxell B

更新日期：2018-01-01 00:00:00

abstract：:The Campylobacter jejuni N-linked protein glycosylation pathway produces a heptasaccharide that is added to >65 periplasmic and membrane proteins and is also released into the periplasm as the free oligosaccharide (fOS). The fOS is a novel soluble component of the C. jejuni periplasmic space that exists in 10-fold gre...

journal_title：Virulence

authors： Nothaft H,Liu X,Li J,Szymanski CM

更新日期：2010-11-01 00:00:00

abstract：:Several human pathogens bind and respond to host cytokines, which can be considered a virulence mechanism that communicates defensive actions of the host to the pathogen. This review summarizes the current knowledge of bacterial cytokine-binding proteins, with a particular focus on their functional and structural char...

journal_title：Virulence

authors： Högbom M,Ihalin R

更新日期：2017-11-17 00:00:00

abstract：:Quorum-sensing (QS), the regulation of bacterial gene expression in response to changes in cell density, involves pathways that synthesize signaling molecules (auto-inducers). The luxS/AI-2-mediated QS system has been identified in both gram-positive and gram-negative bacteria. Bacillus anthracis, the etiological agen...

journal_title：Virulence

authors： Jones MB,Peterson SN,Benn R,Braisted JC,Jarrahi B,Shatzkes K,Ren D,Wood TK,Blaser MJ

更新日期：2010-03-01 00:00:00

abstract：:The twin-arginine translocation (Tat) system is involved in a variety of important bacterial physiological processes. Conserved among bacteria and crucial for virulence, the Tat system is deemed as a promising anti-microbial drug target. However, the mechanism of how the Tat system functions in bacterial pathogenesis ...

journal_title：Virulence

authors： Liu J,Yin F,Liu T,Li S,Tan C,Li L,Zhou R,Huang Q

更新日期：2020-12-01 00:00:00

abstract：:Bacillus anthracis, the causative agent of anthrax, is a zoonotic pathogen that is relatively common throughout the world and may cause life threatening diseases in animals and humans. There are many PCR-based assays in use for the detection of B. anthracis. While most of the developed assays rely on unique markers pr...

journal_title：Virulence

authors： Ågren J,Hamidjaja RA,Hansen T,Ruuls R,Thierry S,Vigre H,Janse I,Sundström A,Segerman B,Koene M,Löfström C,Van Rotterdam B,Derzelle S

更新日期：2013-11-15 00:00:00

abstract：:Particle size dictates where aerosolized pathogens deposit in the respiratory tract, thereafter the pathogens potential to cause disease is influenced by tissue tropism, clearance kinetics and the host immunological response. This interplay brings pathogens into contact with a range of tissues spanning the respiratory...

journal_title：Virulence

authors： Thomas RJ

更新日期：2013-11-15 00:00:00

abstract：:Many of the alterations that affect innate and adaptive immune cell compartments in HIV-infected patients are reminiscent of the process of immune aging, characteristic of old age. These alterations define the immunological age of individuals and are likely to participate to the decline of immune competence with HIV d...

journal_title：Virulence

authors： Appay V,Sauce D

更新日期：2017-07-04 00:00:00

abstract：:Anthrax toxins and capsule are the major virulence factors of Bacillus anthracis. They are encoded by genes located on the plasmids pXO1 and pXO2, respectively. The vaccine strain Pasteur II was produced from high temperature subcultures of B. anthracis, which resulted in virulence attenuation through the loss of the ...

journal_title：Virulence

authors： Liang X,Zhang H,Zhang E,Wei J,Li W,Wang B,Dong S,Zhu J

更新日期：2016-07-03 00:00:00

abstract：:Rift Valley fever is a mosquito-borne zoonotic disease affecting ruminants and humans. Rift Valley fever virus (RVFV: family Bunyaviridae, genus Phlebovirus) causes abortions and fetal malformations in ruminants, and hemorrhagic fever, encephalitis, or retinitis in humans. The live-attenuated MP-12 vaccine is conditio...

journal_title：Virulence

authors： Nishiyama S,Slack OA,Lokugamage N,Hill TE,Juelich TL,Zhang L,Smith JK,Perez D,Gong B,Freiberg AN,Ikegami T

更新日期：2016-11-16 00:00:00

abstract：:Pathogens frequently exist in an immunological balancing act with their host. Pathogens must not only replicate within a host but also transmit effectively between hosts to perpetuate their species. On the other hand, the host seeks to maintain homeostasis by clearing pathogens. The inflammasome is a multi-protein com...

journal_title：Virulence

authors： Lupfer CR,Kanneganti TD

更新日期：2012-05-01 00:00:00

abstract：:Novel approaches to treat carbapenem-resistant Acinetobacter baumannii (CRAB) infections are urgently needed and anti-virulence drugs represent promising alternatives, but our knowledge on potential targets is scarce. We searched for potential A. baumannii virulence factors by whole-genome sequencing-based comparisons...

journal_title：Virulence

authors： Labrador-Herrera G,Pérez-Pulido AJ,Álvarez-Marín R,Casimiro-Soriguer CS,Cebrero-Cangueiro T,Morán-Barrio J,Pachón J,Viale AM,Pachón-Ibáñez ME

更新日期：2020-12-01 00:00:00

abstract：:Mycoplasmas persist in the host for a long time, suggesting that they possess mechanisms for immune evasion. Factor H is a negative regulator of the complement system, which binds to host cells to avoid unexpected complement activation. In this study, we revealed that many mycoplasmas, such as Mycoplasma hyopneumoniae...

journal_title：Virulence

authors： Yu Y,Wang J,Han R,Wang L,Zhang L,Zhang AY,Xin J,Li S,Zeng Y,Shao G,Feng Z,Xiong Q

更新日期：2020-12-01 00:00:00

abstract：:Burkholderia pseudomallei: is the etiological agent of the disease melioidosis and is a Tier 1 select agent. It survives and replicates inside phagocytic cells by escaping from the endocytic vacuole, replicating in the cytosol, spreading to other cells via actin polymerization and promoting the fusion of infected and ...

journal_title：Virulence

authors： Welkos S,Blanco I,Okaro U,Chua J,DeShazer D

更新日期：2020-12-01 00:00:00

abstract：:Trehalose is a disaccharide formed from two glucose molecules. This sugar molecule can be isolated from a range of organisms including bacteria, fungi, plants and invertebrates. Trehalose has a variety of functions including a role as an energy storage molecule, a structural component of glycolipids and plays a role i...

journal_title：Virulence

authors： Vanaporn M,Sarkar-Tyson M,Kovacs-Simon A,Ireland PM,Pumirat P,Korbsrisate S,Titball RW,Butt A

更新日期：2017-01-02 00:00:00

abstract：:Biofilm-degrading enzymes could be used for the gentle cleaning of industrial and medical devices and the manufacture of biofilm-resistant materials. We therefore investigated 20 species and strains of the bacterial genus Lysobacter for their ability to degrade experimental biofilms formed by Staphylococcus epidermidi...

journal_title：Virulence

authors： Gökçen A,Vilcinskas A,Wiesner J

更新日期：2014-04-01 00:00:00

abstract：:Drugs such as linezolid that inhibit bacterial protein synthesis may be beneficial in treating infections caused by toxigenic Staphylococcus aureus. As protein synthesis inhibitors have no effect on preformed toxins, neutralization of pathogenic exotoxins with anti-toxin antibodies may be beneficial in conjunction wit...

journal_title：Virulence

authors： Karau MJ,Tilahun ME,Krogman A,Osborne BA,Goldsby RA,David CS,Mandrekar JN,Patel R,Rajagopalan G

更新日期：2017-10-03 00:00:00

abstract：:Until recently, epithelial cells have been a largely ignored component of host responses to microbes. However, this has been largely overturned over the last decade as an ever increasing number of studies have highlighted the key role that these cells play in many of our interactions with our microbiota and pathogens....

journal_title：Virulence

authors： Moyes DL,Richardson JP,Naglik JR

更新日期：2015-01-01 00:00:00

abstract：:Current treatment for combatting Chagas disease, a life-threatening illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi is inadequate, and thus the discovery of new antiparasitic compounds is of prime importance. Previous studies identified the indirubins, a class of ATP kinase inhibitors, as pote...

journal_title：Virulence

authors： Efstathiou A,Meira CS,Gaboriaud-Kolar N,Bastos TM,Rocha VPC,Vougogiannopoulou K,Skaltsounis AL,Smirlis D,Soares MBP

更新日期：2018-01-01 00:00:00

abstract：:Helicobacter pylori infection can result in non-ulcer dyspepsia (NUD), peptic ulcer disease (PUD), adenocarcinoma, and gastric lymphoma. H. pylori reside within the gastric mucus layer, mainly composed of mucins carrying an array of glycan structures that can serve as bacterial adhesion epitopes. The aim of the presen...

journal_title：Virulence

authors： Quintana-Hayashi MP,Rocha R,Padra M,Thorell A,Jin C,Karlsson NG,Roxo-Rosa M,Oleastro M,Lindén SK

更新日期：2018-01-01 00:00:00