Trehalase plays a role in macrophage colonization and virulence of Burkholderia pseudomallei in insect and mammalian hosts.

Abstract:

:Trehalose is a disaccharide formed from two glucose molecules. This sugar molecule can be isolated from a range of organisms including bacteria, fungi, plants and invertebrates. Trehalose has a variety of functions including a role as an energy storage molecule, a structural component of glycolipids and plays a role in the virulence of some microorganisms. There are many metabolic pathways that control the biosynthesis and degradation of trehalose in different organisms. The enzyme trehalase forms part of a pathway that converts trehalose into glucose. In this study we set out to investigate whether trehalase plays a role in both stress adaptation and virulence of Burkholderia pseudomallei. We show that a trehalase deletion mutant (treA) had increased tolerance to thermal stress and produced less biofilm than the wild type B. pseudomallei K96243 strain. We also show that the ΔtreA mutant has reduced ability to survive in macrophages and that it is attenuated in both Galleria mellonella (wax moth larvae) and a mouse infection model. This is the first report that trehalase is important for bacterial virulence.

journal_name

Virulence

journal_title

Virulence

authors

Vanaporn M,Sarkar-Tyson M,Kovacs-Simon A,Ireland PM,Pumirat P,Korbsrisate S,Titball RW,Butt A

doi

10.1080/21505594.2016.1199316

subject

Has Abstract

pub_date

2017-01-02 00:00:00

pages

30-40

issue

1

eissn

2150-5594

issn

2150-5608

journal_volume

8

pub_type

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