Hypervirulent (hypermucoviscous) Klebsiella pneumoniae: a new and dangerous breed.

abstract：OBJECTIVES:Hypervirulent Klebsiella pneumoniae(hvKp) is an increasingly important pathogen. Tracking its epidemiology and evolving antimicrobial resistance will facilitate care. METHODS:A retrospective study was conducted in two hospitals. We collected the clinical data. Antimicrobial and virulence-associated phenotyp...

journal_title：Virulence

authors： Liu C,Du P,Xiao N,Ji F,Russo TA,Guo J

更新日期：2020-12-01 00:00:00

abstract：:Current treatment for combatting Chagas disease, a life-threatening illness caused by the kinetoplastid protozoan parasite Trypanosoma cruzi is inadequate, and thus the discovery of new antiparasitic compounds is of prime importance. Previous studies identified the indirubins, a class of ATP kinase inhibitors, as pote...

journal_title：Virulence

authors： Efstathiou A,Meira CS,Gaboriaud-Kolar N,Bastos TM,Rocha VPC,Vougogiannopoulou K,Skaltsounis AL,Smirlis D,Soares MBP

更新日期：2018-01-01 00:00:00

abstract：:The virulence behaviors of many Gram-negative bacterial pathogens are governed by quorum-sensing (QS), a hierarchical system of gene regulation that relies on population density by producing and detecting extracellular signaling molecules. Although extensively studied under in vitro conditions, adaptation of QS system...

journal_title：Virulence

authors： Kuang Z,Bennett RC,Lin J,Hao Y,Zhu L,Akinbi HT,Lau GW

更新日期：2020-12-01 00:00:00

abstract：:Sepsis remains a common, serious, and heterogeneous clinical entity that is difficult to define adequately. Despite its importance as a public health problem, efforts to develop and gain regulatory approval for a specific therapeutic agent for the adjuvant treatment of sepsis have been remarkably unsuccessful. One ste...

journal_title：Virulence

authors： Fink MP

更新日期：2014-01-01 00:00:00

abstract：:Neurodegenerative human CJD and sheep scrapie are diseases caused by several different transmissible encephalopathy (TSE) agents. These infectious agents provoke innate immune responses in the brain, including late-onset abnormal prion protein (PrP-res) amyloid. Agent particles that lack detectable PrP sequences by de...

journal_title：Virulence

authors： Botsios S,Tittman S,Manuelidis L

更新日期：2015-01-01 00:00:00

abstract：:Cryptococcus neoformans: (H99W) was serially passaged in the invertebrate wax moth Galleria mellonella fifteen times to study how fungal virulence evolves under selection and whether those adaptations affect virulence. The G. mellonella passaged strain (P15) and the pre-passage H99W strains were used to infect three d...

journal_title：Virulence

authors： Merryman M,Crigler J,Seipelt-Thiemann R,McClelland E

更新日期：2020-12-01 00:00:00

abstract：:Particle size dictates where aerosolized pathogens deposit in the respiratory tract, thereafter the pathogens potential to cause disease is influenced by tissue tropism, clearance kinetics and the host immunological response. This interplay brings pathogens into contact with a range of tissues spanning the respiratory...

journal_title：Virulence

authors： Thomas RJ

更新日期：2013-11-15 00:00:00

abstract：:Entomopathogenic fungi are potential biological control agents of mosquitoes. Our group observed that not all mosquitoes were equally susceptible to fungal infection and observed significant differences in virulence of different spore types. Conidiospores and blastospores were tested against Culex quinquefasciatus lar...

journal_title：Virulence

authors： Alkhaibari AM,Lord AM,Maffeis T,Bull JC,Olivares FL,Samuels RI,Butt TM

更新日期：2018-01-01 00:00:00

abstract：:Th1-polarized host response, mediated by IFN-γ, has been associated with increased severity of periodontal disease as well as control of periodontal infection. The functional polymorphism TBX21-1993T/C (rs4794067) increases the transcriptional activity of the TBX21 gene (essential for Th1 polarization) resulting in a ...

journal_title：Virulence

authors： Cavalla F,Biguetti CC,Colavite PM,Silveira EV,Martins W Jr,Letra A,Trombone AP,Silva RM,Garlet GP

更新日期：2015-01-01 00:00:00

abstract：:The aim of this study was to investigate if the alternative in vivo model Galleria mellonella can be used (i) to determine differences in pathogenicity of amphotericin B (AMB) resistant and susceptible A. terreus isolates, (ii) to evaluate AMB efficacy in vivo (iii) and to correlate outcome to in vitro susceptibility ...

journal_title：Virulence

authors： Maurer E,Browne N,Surlis C,Jukic E,Moser P,Kavanagh K,Lass-Flörl C,Binder U

更新日期：2015-01-01 00:00:00

abstract：:Legionella pneumophila, the causative agent of Legionnaires' disease, is widely distributed throughout natural and artificial water systems and can replicate in macrophages and amoebae. Amoebae are the natural hosts of L. pneumophila, whereas macrophages are incidentally infected. The life cycle of L. pneumophila comp...

journal_title：Virulence

authors： Mou Q,Leung PHM

更新日期：2018-01-01 00:00:00

abstract：:Staphylococcus aureus infections are becoming a major global health issue due to the rapid emergence of multidrug-resistant strains. Therefore, there is an urgent need to develop an effective vaccine to prevent and control these infections. In order to develop a universal immunization strategy, we constructed a mutant...

journal_title：Virulence

authors： Moscoso M,García P,Cabral MP,Rumbo C,Bou G

更新日期：2018-01-01 00:00:00

abstract：:In immune-competent hosts, adenoviruses (Ads) are mild pathogens that cause mainly infections of the respiratory and ocular tracks. The advent of Ad-based gene transfer vectors made the understanding of their interaction with the host cellular machinery an intensive field of research over the last decade. As studies f...

journal_title：Virulence

authors： Henaff D,Salinas S

更新日期：2010-05-01 00:00:00

abstract：:The Gram-negative enteropathogen Yersinia pseudotuberculosis possesses a number of regulatory systems that detect cell envelope damage caused by noxious extracytoplasmic stresses. The CpxA sensor kinase and CpxR response regulator two-component regulatory system is one such pathway. Active Cpx signalling upregulates v...

journal_title：Virulence

authors： Thanikkal EJ,Gahlot DK,Liu J,Fredriksson Sundbom M,Gurung JM,Ruuth K,Francis MK,Obi IR,Thompson KM,Chen S,Dersch P,Francis MS

更新日期：2019-12-01 00:00:00

abstract：:Carbapenem-Resistant Enterobacteriaceae (CRE) are an emerging healthcare crisis. Infections due to CRE are associated with high morbidity and mortality, especially in critically ill patients. Due to the multi-drug resistant nature of these infections only limited treatment options are available. Antimicrobials that ha...

journal_title：Virulence

authors： Neuner EA,Gallagher JC

更新日期：2017-05-19 00:00:00

abstract：:Periodontitis is an infectious inflammatory disease that destroys the tooth-supporting tissues. It is caused by the formation of subgingival biofilms on the surface of the tooth. Characteristic bacteria associated with subgingival biofilms are the Gram-negative anaerobes Porphyromonas gingivalis, Tannerella forsythia ...

journal_title：Virulence

authors： Belibasakis GN,Kast JI,Thurnheer T,Akdis CA,Bostanci N

更新日期：2015-01-01 00:00:00

abstract：:Bacterial pathogenicity deeply depends on the ability to secrete virulence factors that bind specific targets on host cells and manipulate host responses. The Gram-positive bacterium Listeria monocytogenes is a human foodborne pathogen that remains a serious public health concern. To transport proteins across its cell...

journal_title：Virulence

authors： Pinheiro J,Reis O,Vieira A,Moura IM,Zanolli Moreno L,Carvalho F,Pucciarelli MG,García-Del Portillo F,Sousa S,Cabanes D

更新日期：2017-08-18 00:00:00

abstract：:Invasive pulmonary aspergillosis (IPA) is a severe infection that is difficult to diagnose due to the ubiquitous presence of fungal spores, the underlying diseases of risk patients, and limitations of currently available markers. In this study, we performed a comprehensive liquid chromatography tandem mass spectrometr...

journal_title：Virulence

authors： Machata S,Müller MM,Lehmann R,Sieber P,Panagiotou G,Carvalho A,Cunha C,Lagrou K,Maertens J,Slevogt H,Jacobsen ID

更新日期：2020-12-01 00:00:00

abstract：:Multi-antibiotic drug-resistant (MDR) gram-negative bacilli are becoming a major threat to the standard care of septic patients. Empiric antimicrobial drug regimens to cover likely bacterial pathogens have to be altered in keeping with the spread of MDR pathogens in the health care setting and in the community. Reliab...

journal_title：Virulence

authors： Pop-Vicas A,Opal SM

更新日期：2014-01-01 00:00:00

abstract：:Many of the alterations that affect innate and adaptive immune cell compartments in HIV-infected patients are reminiscent of the process of immune aging, characteristic of old age. These alterations define the immunological age of individuals and are likely to participate to the decline of immune competence with HIV d...

journal_title：Virulence

authors： Appay V,Sauce D

更新日期：2017-07-04 00:00:00

abstract：:Streptococcus agalactiae, or group B Streptococcus (GBS), infects diverse hosts including humans and economically important species such as cattle and fishes. In the context of human health, GBS is a major cause of neonatal infections and an emerging cause of invasive disease in adults and of foodborne disease in Sout...

journal_title：Virulence

authors： Six A,Krajangwong S,Crumlish M,Zadoks RN,Walker D

更新日期：2019-12-01 00:00:00

abstract：:In this issue of Virulence, Ban E et al. described the complete sequence of the pEntYN10 plasmid of Escherichia coli O169:H41. The plasmid has 182 coding sequences (CDs); among the identified CDs, some were identified as colonization factors (CFs), one was an enterotoxin and others were insertion sequences (IS). In th...

journal_title：Virulence

authors： Navarro A

更新日期：2015-01-01 00:00:00

abstract：:Trehalose is a disaccharide formed from two glucose molecules. This sugar molecule can be isolated from a range of organisms including bacteria, fungi, plants and invertebrates. Trehalose has a variety of functions including a role as an energy storage molecule, a structural component of glycolipids and plays a role i...

journal_title：Virulence

authors： Vanaporn M,Sarkar-Tyson M,Kovacs-Simon A,Ireland PM,Pumirat P,Korbsrisate S,Titball RW,Butt A

更新日期：2017-01-02 00:00:00

abstract：:The hemagglutinin (HA) proteins derived from avian influenza viruses bind specifically to the α2-3 sialoglycan (Sia glycan), whereas human-adapted influenza viruses prefer to bind to the α2-6 Sia glycan. A switch of glycan specificity from α2-3 Sia glycan to α2-6 Sia glycan appears to be critical for a virus to become...

journal_title：Virulence

authors： Suenaga E,Mizuno H,Kumar PK

更新日期：2012-08-15 00:00:00

abstract：:The interaction between the fungal pathogen Paracoccidioides brasiliensis and host cells is usually mediated by specific binding events between adhesins on the fungal surface and receptors on the host extracellular matrix or cell surface. One molecule implicated in the P. brasiliensis-host interaction is the 14-3-3 pr...

journal_title：Virulence

authors： Marcos CM,Silva Jde F,Oliveira HC,Assato PA,Singulani Jde L,Lopez AM,Tamayo DP,Hernandez-Ruiz O,McEwen JG,Mendes-Giannini MJ,Fusco-Almeida AM

更新日期：2016-01-01 00:00:00

abstract：:Patients undergoing haematopoietic stem cell transplantation (HSCT) are highly exposed to infectious agents. However, it is not known why certain HSCT recipients rapidly develop severe infections while other, despite similar immunosuppressive conditions, do not. Increasing evidence suggests that such differences may b...

journal_title：Virulence

authors： Wójtowicz A,Bochud PY

更新日期：2016-11-16 00:00:00

abstract：:Lipid mediators, derived from arachidonic acid metabolism, play an important role in immune regulation. The functions of bioactive eicosanoids range from modulating cytokine signaling and inflammasome formation to anti-inflammatory and pro-resolving activities. Human pathogenic fungi such as Candida albicans, Candida ...

journal_title：Virulence

authors： Chakraborty T,Thuer E,Heijink M,Tóth R,Bodai L,Vágvölgyi C,Giera M,Gabaldón T,Gácser A

更新日期：2018-01-01 00:00:00

abstract：:A greater ethical conscience, new global rules and a modified perception of ethical consciousness entail a more rigorous control on utilizations of vertebrates for in vivo studies. To cope with this new scenario, numerous alternatives to rodents have been proposed. Among these, the greater wax moth Galleria mellonella...

journal_title：Virulence

authors： Cutuli MA,Petronio Petronio G,Vergalito F,Magnifico I,Pietrangelo L,Venditti N,Di Marco R

更新日期：2019-12-01 00:00:00

abstract：:Citrobacter rodentium is an attaching and effacing intestinal murine pathogen which shares similar virulence strategies with the human pathogens enteropathogenic- and enterohemorrhagic Escherichia coli to infect their host. C. rodentium is spontaneously cleared by healthy wild-type (WT) mice whereas mice lacking Muc2 ...

journal_title：Virulence

authors： Sharba S,Venkatakrishnan V,Padra M,Winther M,Gabl M,Sundqvist M,Wang J,Forsman H,Linden SK

更新日期：2019-12-01 00:00:00

abstract：:We describe a young woman with profound anemia whose serum iron studies were incongruous with what we expected from iron deficiency anemia. Her high serum iron was not fully explainable until we examined the patient and noticed a large black tattoo on her left flank area. Apparently iron oxide in the ink used for the ...

journal_title：Virulence

authors： Fircanis S,Shields R,Castillo J,Mega A,Schiffman F

更新日期：2012-11-15 00:00:00