A mutation in C. neoformans mitochondrial NADH dehydrogenase results in increased virulence in mice.

abstract：:The Gram-negative enteropathogen Yersinia pseudotuberculosis possesses a number of regulatory systems that detect cell envelope damage caused by noxious extracytoplasmic stresses. The CpxA sensor kinase and CpxR response regulator two-component regulatory system is one such pathway. Active Cpx signalling upregulates v...

journal_title：Virulence

authors： Thanikkal EJ,Gahlot DK,Liu J,Fredriksson Sundbom M,Gurung JM,Ruuth K,Francis MK,Obi IR,Thompson KM,Chen S,Dersch P,Francis MS

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:Reports show that more than 20 million infants world-wide are born prematurely with 95% of all pre-term births occurring in developing countries. Oral colonization of gram-negative anaerobes has been implicated as a risk factor for preterm delivery of low birth weight infants. MATERIALS AND METHODS:This stu...

journal_title：Virulence

authors： Africa C,Kayitenkore J,Bayingana C

更新日期：2010-07-01 00:00:00

abstract：:Viral infections of the respiratory tract can be complicated by bacterial superinfection, resulting in a significantly longer duration of illness and even a fatal outcome. In this review, we focused on interactions between S. aureus and non-influenza viruses. Clinical data evidenced that rhinovirus infection may incre...

journal_title：Virulence

authors： Morgene MF,Botelho-Nevers E,Grattard F,Pillet S,Berthelot P,Pozzetto B,Verhoeven PO

更新日期：2018-01-01 00:00:00

abstract：:Maternal antibodies induced by vaccination during pregnancy cross the placental barrier and can close the susceptibility gap to pertussis in young infants up to the start of primary immunization. As not only the quantity but also the quality of circulating antibodies is important for protection, we assessed whether ma...

journal_title：Virulence

authors： Caboré RN,Maertens K,Dobly A,Leuridan E,Van Damme P,Huygen K

更新日期：2017-10-03 00:00:00

abstract：:In the present study, we examined prolonged infection after antigenic co-stimulation by inoculation of the fungus Fonsecaea pedrosoi at two different sites in three mouse strains (BALB/c, Swiss, and C57BL/6). Using this murine model of infection, we showed that antigen induction of infection at more than one site led ...

journal_title：Virulence

authors： Machado AP,Silva MR,Fischman O

更新日期：2010-01-01 00:00:00

abstract：:Chloroquine (CQ) was the best and most heavily used drug in the fight against malaria. However, the effectiveness of CQ has declined with the emergence and spread of CQ-resistant (CQR) Plasmodium falciparum parasites. The primary determinant of CQ resistance in P. falciparum is mutations in the parasite's 'chloroquine...

journal_title：Virulence

authors： Summers RL,Martin RE

更新日期：2010-07-01 00:00:00

abstract：:Rat bite fever (RBF), a worldwide occurring and most likely under-diagnosed zoonosis caused by Streptobacillus moniliformis, represents the most prominent disease of Streptobacillus infections. Recently, novel members have been described, from which a reservoir in rats and other animal species and a zoonotic potential...

journal_title：Virulence

authors： Eisenberg T,Ewers C,Rau J,Akimkin V,Nicklas W

更新日期：2016-08-17 00:00:00

abstract：:Rift Valley fever is a mosquito-borne zoonotic disease affecting ruminants and humans. Rift Valley fever virus (RVFV: family Bunyaviridae, genus Phlebovirus) causes abortions and fetal malformations in ruminants, and hemorrhagic fever, encephalitis, or retinitis in humans. The live-attenuated MP-12 vaccine is conditio...

journal_title：Virulence

authors： Nishiyama S,Slack OA,Lokugamage N,Hill TE,Juelich TL,Zhang L,Smith JK,Perez D,Gong B,Freiberg AN,Ikegami T

更新日期：2016-11-16 00:00:00

abstract：:Gram-negative bacterial (GNB) infections are a leading cause of serious infections both in hospitals and the community. The mortality remains high despite potent antimicrobials and modern supportive care. In the last decade invasive GNB have become increasingly resistant to commonly used antibiotics, and attempts to i...

journal_title：Virulence

authors： Cross AS

更新日期：2014-01-01 00:00:00

abstract：:Anthrax toxins and capsule are the major virulence factors of Bacillus anthracis. They are encoded by genes located on the plasmids pXO1 and pXO2, respectively. The vaccine strain Pasteur II was produced from high temperature subcultures of B. anthracis, which resulted in virulence attenuation through the loss of the ...

journal_title：Virulence

authors： Liang X,Zhang H,Zhang E,Wei J,Li W,Wang B,Dong S,Zhu J

更新日期：2016-07-03 00:00:00

abstract：:Legionella pneumophila, the causative agent of Legionnaires' disease, is widely distributed throughout natural and artificial water systems and can replicate in macrophages and amoebae. Amoebae are the natural hosts of L. pneumophila, whereas macrophages are incidentally infected. The life cycle of L. pneumophila comp...

journal_title：Virulence

authors： Mou Q,Leung PHM

更新日期：2018-01-01 00:00:00

abstract：:Periodontitis is an infectious inflammatory disease that destroys the tooth-supporting tissues. It is caused by the formation of subgingival biofilms on the surface of the tooth. Characteristic bacteria associated with subgingival biofilms are the Gram-negative anaerobes Porphyromonas gingivalis, Tannerella forsythia ...

journal_title：Virulence

authors： Belibasakis GN,Kast JI,Thurnheer T,Akdis CA,Bostanci N

更新日期：2015-01-01 00:00:00

abstract：:Intrinsically disordered proteins (IDPs) do not have a well-defined and stable 3-dimensional fold. Some IDPs can function as either transient or permanent binders of other proteins and may interact with an array of ligands by adopting different conformations. A novel outer membrane lipoprotein, bacterial interleukin r...

journal_title：Virulence

authors： Ahlstrand T,Tuominen H,Beklen A,Torittu A,Oscarsson J,Sormunen R,Pöllänen MT,Permi P,Ihalin R

更新日期：2017-02-17 00:00:00

abstract：:Helicobacter pylori infection can result in non-ulcer dyspepsia (NUD), peptic ulcer disease (PUD), adenocarcinoma, and gastric lymphoma. H. pylori reside within the gastric mucus layer, mainly composed of mucins carrying an array of glycan structures that can serve as bacterial adhesion epitopes. The aim of the presen...

journal_title：Virulence

authors： Quintana-Hayashi MP,Rocha R,Padra M,Thorell A,Jin C,Karlsson NG,Roxo-Rosa M,Oleastro M,Lindén SK

更新日期：2018-01-01 00:00:00

abstract：:Aeromonas hydrophila (A. hydrophila) can cause a number of diseases in both human and animals. A. hydrophila-related infections in aquaculture cause severe economic losses every year throughout the world. The emergence of antibiotic resistance that is due to the abuse of antibiotics has limited the application of anti...

journal_title：Virulence

authors： Dong J,Zhang L,Liu Y,Xu N,Zhou S,Yang Y,Yang Q,Ai X

更新日期：2021-12-01 00:00:00

abstract：:Particle size dictates where aerosolized pathogens deposit in the respiratory tract, thereafter the pathogens potential to cause disease is influenced by tissue tropism, clearance kinetics and the host immunological response. This interplay brings pathogens into contact with a range of tissues spanning the respiratory...

journal_title：Virulence

authors： Thomas RJ

更新日期：2013-11-15 00:00:00

abstract：:Candida albicans remains the main etiological agent of candidiasis, as this otherwise normal commensal of humans is capable of causing active infection in immune- and medically-compromised patients. The high morbidity and mortality rates associated with candidiasis, coupled with the emergence of drug resistance demand...

journal_title：Virulence

authors： Vila T,Romo JA,Pierce CG,McHardy SF,Saville SP,Lopez-Ribot JL

更新日期：2017-02-17 00:00:00

abstract：:Golden hamsters were inoculated with Schistosoma haematobium cercariae to examine histological lesions at different time points over an 18 month period of infection. Hamsters were sacrificed 26 weeks and 82 weeks after inoculation. The parasite was found in the blood and in the liver of infected animals as was expecte...

journal_title：Virulence

authors： Botelho MC,Oliveira PA,Vieira P,Delgado Mde L,Lourenço L,Lopes C,Machado JC,da Costa JM

更新日期：2010-05-01 00:00:00

abstract：:In all eukaryotic cells, the ER stress response is pivotal to survival and adaptation under stress conditions. During temperature adaptation in the human fungal pathogen Cryptococcus neoformans, ER stress is engaged transiently. Studies of this response have demonstrated that both the engagement (turning on the respon...

journal_title：Virulence

authors： Glazier VE,Panepinto JC

更新日期：2014-02-15 00:00:00

abstract：:The twin-arginine translocation (Tat) system is involved in a variety of important bacterial physiological processes. Conserved among bacteria and crucial for virulence, the Tat system is deemed as a promising anti-microbial drug target. However, the mechanism of how the Tat system functions in bacterial pathogenesis ...

journal_title：Virulence

authors： Liu J,Yin F,Liu T,Li S,Tan C,Li L,Zhou R,Huang Q

更新日期：2020-12-01 00:00:00

abstract：:Acinetobacter nosocomialis is an important nosocomial pathogen that causes a variety of human infections. However, the specific virulence factors of this microorganism have not yet been determined. We investigated the role of outer membrane protein A (OmpA) in the pathogenesis of A. nosocomialis. A ΔompA mutant of the...

journal_title：Virulence

authors： Kim SW,Oh MH,Jun SH,Jeon H,Kim SI,Kim K,Lee YC,Lee JC

更新日期：2016-05-18 00:00:00

abstract：:The emergence of multiresistant Gram-negative bacteria requires new therapies for combating bacterial infections. Targeting the biogenesis of virulence factors could be an alternative strategy instead of killing bacteria with antibiotics. The outer membrane (OM) of Gram-negative bacteria acts as a physical barrier. At...

journal_title：Virulence

authors： Weirich J,Bräutigam C,Mühlenkamp M,Franz-Wachtel M,Macek B,Meuskens I,Skurnik M,Leskinen K,Bohn E,Autenrieth I,Schütz M

更新日期：2017-10-03 00:00:00

abstract：:A new hypervirulent (hypermucoviscous) variant of Klebsiella pneumoniae has emerged. First described in the Asian Pacific Rim, it now increasingly recognized in Western countries. Defining clinical features are the ability to cause serious, life-threatening community-acquired infection in younger healthy hosts, includ...

journal_title：Virulence

authors： Shon AS,Bajwa RP,Russo TA

更新日期：2013-02-15 00:00:00

abstract：:Francisella tularensis is a highly virulent bacterial pathogen that is easily aerosolized and has a low infectious dose. As an intracellular pathogen, entry of Francisella into host cells is critical for its survival and virulence. However, the initial steps of attachment and internalization of Francisella into host c...

journal_title：Virulence

authors： Moreau GB,Mann BJ

更新日期：2013-11-15 00:00:00

abstract：:Citrobacter rodentium is an attaching and effacing intestinal murine pathogen which shares similar virulence strategies with the human pathogens enteropathogenic- and enterohemorrhagic Escherichia coli to infect their host. C. rodentium is spontaneously cleared by healthy wild-type (WT) mice whereas mice lacking Muc2 ...

journal_title：Virulence

authors： Sharba S,Venkatakrishnan V,Padra M,Winther M,Gabl M,Sundqvist M,Wang J,Forsman H,Linden SK

更新日期：2019-12-01 00:00:00

abstract：:Carbapenem-Resistant Enterobacteriaceae (CRE) are an emerging healthcare crisis. Infections due to CRE are associated with high morbidity and mortality, especially in critically ill patients. Due to the multi-drug resistant nature of these infections only limited treatment options are available. Antimicrobials that ha...

journal_title：Virulence

authors： Neuner EA,Gallagher JC

更新日期：2017-05-19 00:00:00

abstract：:In immune-competent hosts, adenoviruses (Ads) are mild pathogens that cause mainly infections of the respiratory and ocular tracks. The advent of Ad-based gene transfer vectors made the understanding of their interaction with the host cellular machinery an intensive field of research over the last decade. As studies f...

journal_title：Virulence

authors： Henaff D,Salinas S

更新日期：2010-05-01 00:00:00

abstract：:The interaction between the fungal pathogen Paracoccidioides brasiliensis and host cells is usually mediated by specific binding events between adhesins on the fungal surface and receptors on the host extracellular matrix or cell surface. One molecule implicated in the P. brasiliensis-host interaction is the 14-3-3 pr...

journal_title：Virulence

authors： Marcos CM,Silva Jde F,Oliveira HC,Assato PA,Singulani Jde L,Lopez AM,Tamayo DP,Hernandez-Ruiz O,McEwen JG,Mendes-Giannini MJ,Fusco-Almeida AM

更新日期：2016-01-01 00:00:00

abstract：:The hemagglutinin (HA) proteins derived from avian influenza viruses bind specifically to the α2-3 sialoglycan (Sia glycan), whereas human-adapted influenza viruses prefer to bind to the α2-6 Sia glycan. A switch of glycan specificity from α2-3 Sia glycan to α2-6 Sia glycan appears to be critical for a virus to become...

journal_title：Virulence

authors： Suenaga E,Mizuno H,Kumar PK

更新日期：2012-08-15 00:00:00

abstract：:Bacterial eukaryotic-like serine threonine kinases (eSTKs) and serine threonine phosphatases (eSTPs) have emerged as important signaling elements that are indispensable for pathogenesis. Differing considerably from their histidine kinase counterparts, few eSTK genes are encoded within the average bacterial genome, and...

journal_title：Virulence

authors： Wright DP,Ulijasz AT

更新日期：2014-01-01 00:00:00