Identification of the pXO1 plasmid in attenuated Bacillus anthracis vaccine strains.

abstract：:In previous studies we demonstrated that the staphylococcal α-toxin inhibits adhesion and invasion of S. aureus by epithelial cells through binding to α5β1 integrin, a receptor of fibronectin. Moreover, we revealed that a H35A mutation abolishes the cytotoxicity of α-toxin completely. These findings led us to hypothes...

journal_title：Virulence

authors： Yang J,Liang X,Ji Y

更新日期：2013-01-01 00:00:00

abstract：:Rat bite fever (RBF), a worldwide occurring and most likely under-diagnosed zoonosis caused by Streptobacillus moniliformis, represents the most prominent disease of Streptobacillus infections. Recently, novel members have been described, from which a reservoir in rats and other animal species and a zoonotic potential...

journal_title：Virulence

authors： Eisenberg T,Ewers C,Rau J,Akimkin V,Nicklas W

更新日期：2016-08-17 00:00:00

abstract：:Francisella tularensis is a highly virulent bacterial pathogen that is easily aerosolized and has a low infectious dose. As an intracellular pathogen, entry of Francisella into host cells is critical for its survival and virulence. However, the initial steps of attachment and internalization of Francisella into host c...

journal_title：Virulence

authors： Moreau GB,Mann BJ

更新日期：2013-11-15 00:00:00

abstract：:Mucormycosis is an uncommon fungal infection that has been increasingly reported in severely immunocompromised patients receiving Aspergillus-active antifungals. Although clinical studies and pre-clinical animal models have suggested a unique predisposition for breakthrough mucormycoses in patients receiving voriconaz...

journal_title：Virulence

authors： Lewis RE,Liao G,Wang W,Prince RA,Kontoyiannis DP

更新日期：2011-07-01 00:00:00

abstract：:Novel approaches to treat carbapenem-resistant Acinetobacter baumannii (CRAB) infections are urgently needed and anti-virulence drugs represent promising alternatives, but our knowledge on potential targets is scarce. We searched for potential A. baumannii virulence factors by whole-genome sequencing-based comparisons...

journal_title：Virulence

authors： Labrador-Herrera G,Pérez-Pulido AJ,Álvarez-Marín R,Casimiro-Soriguer CS,Cebrero-Cangueiro T,Morán-Barrio J,Pachón J,Viale AM,Pachón-Ibáñez ME

更新日期：2020-12-01 00:00:00

abstract：:Staphylococcus aureus infections are becoming a major global health issue due to the rapid emergence of multidrug-resistant strains. Therefore, there is an urgent need to develop an effective vaccine to prevent and control these infections. In order to develop a universal immunization strategy, we constructed a mutant...

journal_title：Virulence

authors： Moscoso M,García P,Cabral MP,Rumbo C,Bou G

更新日期：2018-01-01 00:00:00

abstract：:In the present study, we examined prolonged infection after antigenic co-stimulation by inoculation of the fungus Fonsecaea pedrosoi at two different sites in three mouse strains (BALB/c, Swiss, and C57BL/6). Using this murine model of infection, we showed that antigen induction of infection at more than one site led ...

journal_title：Virulence

authors： Machado AP,Silva MR,Fischman O

更新日期：2010-01-01 00:00:00

abstract：:Carbapenem-Resistant Enterobacteriaceae (CRE) are an emerging healthcare crisis. Infections due to CRE are associated with high morbidity and mortality, especially in critically ill patients. Due to the multi-drug resistant nature of these infections only limited treatment options are available. Antimicrobials that ha...

journal_title：Virulence

authors： Neuner EA,Gallagher JC

更新日期：2017-05-19 00:00:00

abstract：:Retrotransposons constitute a major part of the genome in a number of eukaryotes. Long-terminal repeat (LTR) retrotransposons are one type of the retrotransposons. Candida albicans have 34 distinct LTR-retrotransposon families. They respectively belong to the Ty1/copia and Ty3/gypsy groups which have been extensively ...

journal_title：Virulence

authors： Zhang L,Yan L,Jiang J,Wang Y,Jiang Y,Yan T,Cao Y

更新日期：2014-08-15 00:00:00

abstract：:In this issue of Virulence, Ban E et al. described the complete sequence of the pEntYN10 plasmid of Escherichia coli O169:H41. The plasmid has 182 coding sequences (CDs); among the identified CDs, some were identified as colonization factors (CFs), one was an enterotoxin and others were insertion sequences (IS). In th...

journal_title：Virulence

authors： Navarro A

更新日期：2015-01-01 00:00:00

abstract：:Rift Valley fever is a mosquito-borne zoonotic disease affecting ruminants and humans. Rift Valley fever virus (RVFV: family Bunyaviridae, genus Phlebovirus) causes abortions and fetal malformations in ruminants, and hemorrhagic fever, encephalitis, or retinitis in humans. The live-attenuated MP-12 vaccine is conditio...

journal_title：Virulence

authors： Nishiyama S,Slack OA,Lokugamage N,Hill TE,Juelich TL,Zhang L,Smith JK,Perez D,Gong B,Freiberg AN,Ikegami T

更新日期：2016-11-16 00:00:00

abstract：:Cryptococcus neoformans undergoes phenotypical changes during host infection in order to promote persistence and survival. Studies have demonstrated that such adaptations require alterations in gene transcription networks by distinct mechanisms. Drugs such as the histone deacetylases inhibitors (HDACi) Sodium Butyrate...

journal_title：Virulence

authors： Brandão FA,Derengowski LS,Albuquerque P,Nicola AM,Silva-Pereira I,Poças-Fonseca MJ

更新日期：2015-01-01 00:00:00

abstract：:Until recently, epithelial cells have been a largely ignored component of host responses to microbes. However, this has been largely overturned over the last decade as an ever increasing number of studies have highlighted the key role that these cells play in many of our interactions with our microbiota and pathogens....

journal_title：Virulence

authors： Moyes DL,Richardson JP,Naglik JR

更新日期：2015-01-01 00:00:00

abstract：:A greater ethical conscience, new global rules and a modified perception of ethical consciousness entail a more rigorous control on utilizations of vertebrates for in vivo studies. To cope with this new scenario, numerous alternatives to rodents have been proposed. Among these, the greater wax moth Galleria mellonella...

journal_title：Virulence

authors： Cutuli MA,Petronio Petronio G,Vergalito F,Magnifico I,Pietrangelo L,Venditti N,Di Marco R

更新日期：2019-12-01 00:00:00

abstract：:Trehalose is a disaccharide formed from two glucose molecules. This sugar molecule can be isolated from a range of organisms including bacteria, fungi, plants and invertebrates. Trehalose has a variety of functions including a role as an energy storage molecule, a structural component of glycolipids and plays a role i...

journal_title：Virulence

authors： Vanaporn M,Sarkar-Tyson M,Kovacs-Simon A,Ireland PM,Pumirat P,Korbsrisate S,Titball RW,Butt A

更新日期：2017-01-02 00:00:00

abstract：:The innate immune system plays a critical role in host defense against mucosal bacteria. Campylobacter jejuni is a major cause of human gastroenteritis that usually resolves spontaneously within several days, suggesting that innate mechanisms are important to control the infection. However, the specific means by which...

journal_title：Virulence

authors： Keo T,Collins J,Kunwar P,Blaser MJ,Iovine NM

更新日期：2011-01-01 00:00:00

abstract：:Bacterial pathogens release a number of toxins that are able to form pores in target host cells, which can result in their destruction. Due to this property of this subgroup of toxins, they are considered virulence factors. A lesser known ability of these toxins when present at lower concentrations that are insufficie...

journal_title：Virulence

authors： Yoong P

更新日期：2010-09-01 00:00:00

abstract：:Helicobacter pylori infection can result in non-ulcer dyspepsia (NUD), peptic ulcer disease (PUD), adenocarcinoma, and gastric lymphoma. H. pylori reside within the gastric mucus layer, mainly composed of mucins carrying an array of glycan structures that can serve as bacterial adhesion epitopes. The aim of the presen...

journal_title：Virulence

authors： Quintana-Hayashi MP,Rocha R,Padra M,Thorell A,Jin C,Karlsson NG,Roxo-Rosa M,Oleastro M,Lindén SK

更新日期：2018-01-01 00:00:00

abstract：:Biofilm-degrading enzymes could be used for the gentle cleaning of industrial and medical devices and the manufacture of biofilm-resistant materials. We therefore investigated 20 species and strains of the bacterial genus Lysobacter for their ability to degrade experimental biofilms formed by Staphylococcus epidermidi...

journal_title：Virulence

authors： Gökçen A,Vilcinskas A,Wiesner J

更新日期：2014-04-01 00:00:00

abstract：:The exploration of epidemic dynamics on dynamically evolving ("adaptive") networks poses nontrivial challenges to the modeler, such as the determination of a small number of informative statistics of the detailed network state (that is, a few "good observables") that usefully summarize the overall (macroscopic, system...

journal_title：Virulence

authors： Kattis AA,Holiday A,Stoica AA,Kevrekidis IG

更新日期：2016-01-01 00:00:00

abstract：:Bloodstream infections (BSI) carry a heavy burden of morbidity and mortality in modern internal medicine wards (IMW). These wards are often filled with elderly subjects with several risk factors for BSI, such as multiple comorbidities, polypharmacy, immunosuppression, and indwelling devices. Diagnosing BSI in such a s...

journal_title：Virulence

authors： Del Bono V,Giacobbe DR

更新日期：2016-04-02 00:00:00

abstract：:Particle size dictates where aerosolized pathogens deposit in the respiratory tract, thereafter the pathogens potential to cause disease is influenced by tissue tropism, clearance kinetics and the host immunological response. This interplay brings pathogens into contact with a range of tissues spanning the respiratory...

journal_title：Virulence

authors： Thomas RJ

更新日期：2013-11-15 00:00:00

abstract：:Bacteria interact with their host through protein secretion systems and surface structures. Pathogenic bacteria encode protein secretion systems that promote the invasion of the host's tissue, the evasion of the host's immune response, the thwarting microbial competitors, and ultimately survival within the host. For m...

journal_title：Virulence

authors： Troxell B

更新日期：2018-01-01 00:00:00

abstract：:Gram-negative bacterial (GNB) infections are a leading cause of serious infections both in hospitals and the community. The mortality remains high despite potent antimicrobials and modern supportive care. In the last decade invasive GNB have become increasingly resistant to commonly used antibiotics, and attempts to i...

journal_title：Virulence

authors： Cross AS

更新日期：2014-01-01 00:00:00

abstract：:Citrobacter rodentium is an attaching and effacing intestinal murine pathogen which shares similar virulence strategies with the human pathogens enteropathogenic- and enterohemorrhagic Escherichia coli to infect their host. C. rodentium is spontaneously cleared by healthy wild-type (WT) mice whereas mice lacking Muc2 ...

journal_title：Virulence

authors： Sharba S,Venkatakrishnan V,Padra M,Winther M,Gabl M,Sundqvist M,Wang J,Forsman H,Linden SK

更新日期：2019-12-01 00:00:00

abstract：:Viral infections of the respiratory tract can be complicated by bacterial superinfection, resulting in a significantly longer duration of illness and even a fatal outcome. In this review, we focused on interactions between S. aureus and non-influenza viruses. Clinical data evidenced that rhinovirus infection may incre...

journal_title：Virulence

authors： Morgene MF,Botelho-Nevers E,Grattard F,Pillet S,Berthelot P,Pozzetto B,Verhoeven PO

更新日期：2018-01-01 00:00:00

abstract：:A number of abundant mobile genetic elements called retrotransposons reverse transcribe RNA to generate DNA for insertion into eukaryotic genomes. Non-long-terminal repeat (non-LTR) retrotransposons represent a major class of retrotransposons, and transposons that move by target-primed reverse transcription lack LTRs ...

journal_title：Virulence

authors： Jiang J,Zhao L,Yan L,Zhang L,Cao Y,Wang Y,Jiang Y,Yan T,Cao Y

更新日期：2014-02-15 00:00:00

abstract：:Chloroquine (CQ) was the best and most heavily used drug in the fight against malaria. However, the effectiveness of CQ has declined with the emergence and spread of CQ-resistant (CQR) Plasmodium falciparum parasites. The primary determinant of CQ resistance in P. falciparum is mutations in the parasite's 'chloroquine...

journal_title：Virulence

authors： Summers RL,Martin RE

更新日期：2010-07-01 00:00:00

abstract：:The hemagglutinin (HA) proteins derived from avian influenza viruses bind specifically to the α2-3 sialoglycan (Sia glycan), whereas human-adapted influenza viruses prefer to bind to the α2-6 Sia glycan. A switch of glycan specificity from α2-3 Sia glycan to α2-6 Sia glycan appears to be critical for a virus to become...

journal_title：Virulence

authors： Suenaga E,Mizuno H,Kumar PK

更新日期：2012-08-15 00:00:00

abstract：:Bacterial pathogenicity deeply depends on the ability to secrete virulence factors that bind specific targets on host cells and manipulate host responses. The Gram-positive bacterium Listeria monocytogenes is a human foodborne pathogen that remains a serious public health concern. To transport proteins across its cell...

journal_title：Virulence

authors： Pinheiro J,Reis O,Vieira A,Moura IM,Zanolli Moreno L,Carvalho F,Pucciarelli MG,García-Del Portillo F,Sousa S,Cabanes D

更新日期：2017-08-18 00:00:00