abstract：:Aspartame is one of the most common consumed artificial sweeteners utilized in many food products and beverages. It has been indicated that long-term consumption of aspartame leads to reproductive toxicity but its mechanism is not well-clear. In this study we investigated mechanism of aspartame-induced reproductive to...

journal_title：Environmental toxicology

authors： Anbara H,Sheibani MT,Razi M,Kian M

更新日期：2021-02-01 00:00:00

abstract：:Metal oxide nanoparticles and carbon nanoparticles, as common nanoparticles (NPs), can cause autophagy in certain cells, which will lead to biohealth risk issues. This study determined the difference in autophagy induced by zinc oxide nanoparticles (ZnO NPs) and single-walled carbon nanotubes (SWCNTs) in respiratory e...

journal_title：Environmental toxicology

authors： Zhang H,Chen F,Li Y,Shan X,Yin L,Hao X,Zhong Y

更新日期：2021-02-01 00:00:00

abstract：:Colorectal cancer (CC) is an important human malignancy with high cancer related death worldwide. The chemotherapy using doxorubicin hydrochloride is one of the most common cancer therapeutic methods. However, drug resistance lowers the treatment efficacy in CC patients. The combination therapies seem to be more promi...

journal_title：Environmental toxicology

authors： Jadid MFS,Aghaei E,Taheri E,Seyyedsani N,Chavoshi R,Abbasi S,Khorrami A,Goleij P,Hajazimian S,Taefehshokr S,Isazadeh A,Shanehbandi D

更新日期：2021-01-28 00:00:00

abstract：:Acetaminophen (APAP) is one of the few recommended analgesic and antipyretic drugs in some critical cases such as viral disease COVID-19. However, the unrestricted use of APAP develops liver disorders. Hepatotoxicity and liver injury can also be induced by ionizing radiation (IR) during radiotherapy. The data of the c...

journal_title：Environmental toxicology

authors： Eassawy MMT,Salem AA,Ismail AFM

更新日期：2020-12-17 00:00:00

abstract：:Butein is a flavonoid isolated from various medicinal plants. It is known to have different biological activities including anti-inflammation, anti-adipogenesis, and anti-angiogenesis. In the study, we demonstrated the anti-proliferative effect of butein in human osteosarcoma U-2 OS cells. Our data showed that butein ...

journal_title：Environmental toxicology

authors： Hsu YK,Chen HY,Wu CC,Huang YC,Hsieh CP,Su PF,Huang YF

更新日期：2020-12-16 00:00:00

abstract：:Cancer cell stemness results in the occurrence and progression of tumors and Oct4 (octamer-binding transcription factor) has been confirmed to be a critical contributor and marker of cancer cell stemness. Here, we aimed to explore the underlying mechanisms contributing to Oct4 protein stability, which is necessary for...

journal_title：Environmental toxicology

authors： Xu Y,Xu G,Dang H,Qu W,Chang D,He X,Li M,Wang Q

更新日期：2020-12-03 00:00:00

abstract：:There is emerging evidence suggesting that oxidative stress and DNA methylation can alter miRNA expression. However, little is known on the mechanism of miR-17-5p expression changes in paraquat (PQ)-induced nerve cell damage. In the present study, neuro-2a cells were pretreated with antioxidant N-acetylcysteine (NAC) ...

journal_title：Environmental toxicology

authors： Zhan Y,Guo Z,Zheng F,Zhang Z,Li K,Wang Q,Wang L,Cai Z,Chen N,Wu S,Li H

更新日期：2020-12-01 00:00:00

abstract：:Polybrominated diphenyl ethers (PBDEs) are ubiquitous and prolific contaminant in both the abiotic and biotic environment because of the wide industrial applications of these chemicals. In the present study, the effects of 2,2',4,4'-tetrabrominateddiphenyl ether (BDE-47) and 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE...

journal_title：Environmental toxicology

authors： Meng S,Chen X,Gyimah E,Xu H,Chen J

更新日期：2020-11-01 00:00:00

abstract：:Being one of the notorious weed P. hysterophorus has invaded almost every part India and is the lead cause of skin allergies and severe dermatitis among farmers and rural population. It is an invasive obnoxious weed capable of surviving extreme environmental conditions and various parts of this plant are reported to c...

journal_title：Environmental toxicology

authors： Kaur M,Gupta KB,Thakur S,Kaur S,Dhiman M

更新日期：2020-11-01 00:00:00

abstract：:Widespread occupational and environmental exposure to benzene is unavoidable and poses a public health threat. Studies of potential interventions to prevent or relieve benzene toxicity are, thus, essential. Research has shown l-carnitine (LC) has beneficial effects against various pathological processes and diseases. ...

journal_title：Environmental toxicology

authors： Sun R,Man Z,Ji J,Ji S,Xu K,Pu Y,Yu L,Zhang J,Yin L,Pu Y

更新日期：2020-10-01 00:00:00

abstract：:Particulate matter 2.5 (PM2.5)-induced pulmonary inflammation has become a public concern in recent years. In which, the activation of the NLRP3/caspase-1 pathway was closely related to the inflammatory response of various diseases. However, the promotion effect of the NLRP3/caspase-1 pathway on PM2.5-induced pulmonar...

journal_title：Environmental toxicology

authors： Jia H,Liu Y,Guo D,He W,Zhao L,Xia S

更新日期：2020-09-30 00:00:00

abstract：:Petroleum products-petrol, kerosene, and diesel-composed of volatile organic constituents contribute to air pollution. Exposure of gas station attendants (GSAs) to petroleum products fumes (PPFs) may account for occupation-related predisposition to respiratory toxicity and disease pathogenesis. We simulated GSA exposu...

journal_title：Environmental toxicology

authors： Owumi SE,Elebiyo TC,Oladimeji BN

更新日期：2020-09-07 00:00:00

abstract：:The roles of long noncoding RNA (lncRNA) MACC1-AS1 have been revealed in various tumors. This work aims to explore the roles of lncRNA MACC1-AS1 in the stemness of nonsmall cell lung cancer (NSCLC) cells and the underlying mechanism. We showed that overexpression of MACC1-AS1 enhanced the stemness of NSCLC cells, whic...

journal_title：Environmental toxicology

authors： Wang X,Yu X,Wei W,Liu Y

更新日期：2020-09-01 00:00:00

abstract：:Microcystins (MCs), as the most dominant bloom-forming strains in eutrophic surface water, can induce hepatotoxicity by oxidative stress. Alpha-lipoic acid (α-LA) is a super antioxidant that can induce the synthesis of antioxidants, such as glutathione (GSH), by nuclear factor erythroid 2-related factor 2 (Nrf2). Howe...

journal_title：Environmental toxicology

authors： Gu L,Li S,Bai J,Zhang Q,Han Z

更新日期：2020-07-01 00:00:00

abstract：:Bisphenol A (BPA) has been widely reported to exert endocrine disrupting effects, including the induction of adipogenesis in cultured preadipocytes and intact animals. Because of the potential harm to human health, BPA is being substituted by structurally related bisphenols. Whether or not such BPA analogues are safe ...

journal_title：Environmental toxicology

authors： Ramskov Tetzlaff CN,Svingen T,Vinggaard AM,Rosenmai AK,Taxvig C

更新日期：2020-05-01 00:00:00

abstract：:Multi-walled carbon nanotubes (MWCNTs) have many applications in industry and used as additives in polymers, catalysts, anodes in lithium-battery and drug delivery. There is little information about MWCNTs' (210 nm) genotoxic potential on juvenile freshwater fish Channa punctatus. Therefore, in this study, we have det...

journal_title：Environmental toxicology

authors： Ali D,Falodah FA,Almutairi B,Alkahtani S,Alarifi S

更新日期：2020-03-01 00:00:00

abstract：:In recent years, the protective effect of hydrogensulfide donor sodium hydrosulfide(NaHS) on multiple organs has been widely reported. The study aimed to explorethe effect of commonly used concentration of NaHS on theliver and its potential damage mechanism. Rats divided into 4 groups: control, NaHS I (1 mg/kg), II (3...

journal_title：Environmental toxicology

authors： Feng X,Zhang H,Shi M,Chen Y,Yang T,Fan H

更新日期：2020-03-01 00:00:00

abstract：:As a widely used plasticizer in industry, di-2-ethylhexylphthalate (DEHP) can cause testicular toxicity, yet little is known about the potential mechanism. In this study, DEHP exposure dramatically inhibited cellviability and induced apoptosis of mouse GC-1 spg cells. Furthermore, DEHP significantly increased the leve...

journal_title：Environmental toxicology

authors： Gan Y,Yang D,Yang S,Wang J,Wei J,Chen J

更新日期：2020-02-01 00:00:00

abstract：:The incidence of type 1 diabetes (T1D) and its associated risks of chronic kidney disease or end-stage renal disease development are on the rise. T1D is an autoimmune disease in which insulin-producing beta cells are destroyed. Increased incidence of T1D has been suggested to be a result of environmental factors such ...

journal_title：Environmental toxicology

authors： Pierre TH,Reynolds AS,Seise I,Pilz Z,McHale BJ,Gato WE

更新日期：2020-02-01 00:00:00

abstract：:Global use of azole fungicides is expected to increase over the next several years. Triticonazole is a triazole fungicide that is used for turf protection, residential, and other commercial applications. As such, it can enter local rural and urban water systems via run-off and rain events. Early life stages of aquatic...

journal_title：Environmental toxicology

authors： Souders CL 2nd,Perez-Rodriguez V,El Ahmadie N,Zhang X,Tischuk C,Martyniuk CJ

更新日期：2020-02-01 00:00:00

abstract：:Di (2-ethylhexyl) phthalate (DEHP) is a plasticizer that gives flexibility to various polyvinyl chloride products. It is a pollutant easily released into the environment and can cause many adverse effects to living organisms including hepatotoxicity. The thioredoxin system is a determining factor in the redox balance ...

journal_title：Environmental toxicology

authors： Amara I,Timoumi R,Annabi E,Di Rosa G,Scuto M,Najjar MF,Calabrese V,Abid-Essefi S

更新日期：2020-01-01 00:00:00

abstract：:The prostate is an accessory reproductive gland that is sensitive to the action of exogenous compounds known as endocrine disrupters that alter normal hormonal function. Finasteride is a widely used chemical that acts to inhibit the conversion of testosterone in its most active form, dihydrotestosterone. It is known t...

journal_title：Environmental toxicology

authors： Maldarine JS,Sanches BDA,Santos VA,Amaro GM,Calmon MF,Rahal P,Góes RM,Vilamaior PSL,Taboga SR

更新日期：2020-01-01 00:00:00

abstract：:The phthalate plasticizer, di(2-ethyl-hexyl) phthalate (DEHP), and its derived metabolites are common anthropogenic environmental toxins, which are known to act as endocrine disruptors. Numerous studies have associated DEHP with disruption of sex hormones, abnormal development of reproductive organs, allergies, and in...

journal_title：Environmental toxicology

authors： Wong JH,Wang YS,Nam S,Ho KH,Chang CM,Chen KC,Chen YF,Chang WC

更新日期：2019-11-01 00:00:00

abstract：:Manganese (Mn) plays a critical role in individual growth and development, yet excessive exposure can result in neurotoxicity, especially cognitive impairment. Neuronal apoptosis is considered as one of the mechanisms of Mn-induced neurotoxicity. Recent evidence suggests that cAMP-PKA-CREB signaling regulates apoptosi...

journal_title：Environmental toxicology

authors： Yang Y,Ma S,Wei F,Liang G,Yang X,Huang Y,Wang J,Zou Y

更新日期：2019-09-01 00:00:00

abstract：:The synergic allergic inflammatory effects of particulate matter (PM) 2.5 and human albumin were investigated in NC/Nga mice, which are hypersensitive to mite allergens. PM2.5 or PM2.5 plus human albumin with aluminum oxide was injected twice intraperitoneally for sensitization. After 7 days, PM2.5 or PM2.5 plus human...

journal_title：Environmental toxicology

authors： Nagaoka K,Ogino K,Ogino N,Ito T,Takemoto K,Ogino S,Seki Y,Hamada H,Fujikura Y

更新日期：2019-07-01 00:00:00

abstract：:Doxorubicin (DOX)-induced cardiomyopathy is a lethal disease. DOX-induced cardiotoxic effects are attributed towards increased redox status and apoptotic signaling. In this study, we show that genistein offers protection against DOX-induced cardio toxicity in the mice model. DOX-mediated increase in serum cardiac trop...

journal_title：Environmental toxicology

authors： Bai Z,Wang Z

更新日期：2019-05-01 00:00:00

abstract：:Ouabain, a cardiotonic steroid, was used for the treatment of heart failure and atrial fibrillation and induces cancer cell apoptosis in many human cancer cells including human leukemia cells. However, there are no reports to show the effects on immune responses in a leukemia mouse model. In this study, WEHI-3 cell ge...

journal_title：Environmental toxicology

authors： Shih YL,Shang HS,Chen YL,Hsueh SC,Chou HM,Lu HF,Lee MZ,Hou HT,Chuang YY,Lee MH,Chen KW,Chung JG

更新日期：2019-05-01 00:00:00

abstract：:In the present study, the modulatory effect of phytol against benzo(a)pyrene [B(a)P] induced lung carcinogenesis was investigated in Swiss albino mice. During the experimental period, phytol treatment showed no adverse toxic effect and mortality to the experimental animals. Lung tumor was observed in B(a)P treated gro...

journal_title：Environmental toxicology

authors： Sakthivel R,Sheeja Malar D,Archunan G,Pandima Devi K

更新日期：2019-04-01 00:00:00

abstract：:Long non-coding RNA (lncRNA) plays a critical role in male germline development. Atrazine (AZ) as an environmental endocrine disrupting chemical (EDCs) can induce male reproductive toxicity in amphibians. Our previous studies demonstrated that AZ can alter gene and circular RNA (circRNA) expression of damaged testes i...

journal_title：Environmental toxicology

authors： Sai L,Qu B,Zhang J,Liu J,Jia Q,Bo C,Zhang Y,Yu G,Han R,Peng C

更新日期：2019-04-01 00:00:00

abstract：:Bergapten is a natural compound and has potent anticancer activities. In this study, we explored the cytotoxicity of bergapten on colorectal cancer (CRC) cell DLD-1 and LoVo and its underlying mechanisms. We observed that bergapten (30 and 50 μM) decreased the viability of the CRC cells and induced the G0/G1 and sub-G...

journal_title：Environmental toxicology

authors： Lin CP,Lin CS,Lin HH,Li KT,Kao SH,Tsao SM

更新日期：2019-03-01 00:00:00

abstract：:Intake of arsenic (As) via drinking water has been a serious threat to global public health. Though there are numerous reports of As neurotoxicity, its pathogenesis mechanisms remain vague especially its chronic effects on metabolic network. Hippocampus is a renowned area in relation to learning and memory, whilst rec...

journal_title：Environmental toxicology

authors： Mo TT,Dai H,Du H,Zhang RY,Chai KP,An Y,Chen JJ,Wang JK,Chen ZJ,Chen CZ,Jiang XJ,Tang R,Wang LP,Tan Q,Tang P,Miao XY,Meng P,Zhang LB,Cheng SQ,Peng B,Tu BJ,Han TL,Xia YY,Baker PN

更新日期：2019-02-01 00:00:00

abstract：:For the first time, juvenile toxicity of inorganic arsenic (As) was investigated in male rats, focusing on reproductive effects. As is a metalloid naturally occurring in the environment, being the inorganic forms the most toxics. Contaminated drinking water and agricultural products are the main prospectors of intoxic...

journal_title：Environmental toxicology

authors： da Cunha de Medeiros P,Samelo RR,Silva APG,da Silva Araujo Santiago M,Duarte FA,de Castro ÍB,Perobelli JE

更新日期：2019-01-01 00:00:00

abstract：:Particulate matter the environmental toxicant, with a diameter less than or equal to 2.5 μm (PM2.5 ) is a common cause of several respiratory diseases. In recent years, several studies have suggested that PM2.5 can influence diverse diseases, such as respiratory diseases, cardiovascular diseases, metabolic diseases, d...

journal_title：Environmental toxicology

authors： Kim W,Cho Y,Song MK,Lim JH,Kim JY,Gye MC,Ryu JC

更新日期：2018-11-01 00:00:00

abstract：:Inflammation generated by environmental toxicants including pesticides could be one of the factors underlying neuronal cell damage in neurodegenerative diseases. In this study, we investigated the mechanisms by which inflammatory responses contribute to apoptosis in PC12 cells treated with diquat. We found that diquat...

journal_title：Environmental toxicology

authors： Choi SE,Park YS,Koh HC

更新日期：2018-10-01 00:00:00

abstract：:Recent epidemiological studies have revealed significant positive associations between exposure to organochlorine (OC) pesticides and occurrence of the metabolic syndrome and there are a growing number of animal-based studies to support causality. However, the cellular mechanisms linking OC compound exposure and metab...

journal_title：Environmental toxicology

authors： Howell GE 3rd,McDevitt E,Henein L,Mulligan C,Young D

更新日期：2018-09-01 00:00:00

abstract：:7,12-Dimethylbenz[α]anthracene (DMBA) is a hazardous component present in polluted environments. DMBA has been used as an experimental tool for in vivo tumor formation owing to its carcinogenic effects, but the detailed molecular mechanism of DMBA has not been fully established. To comprehend the carcinogenic mechanis...

journal_title：Environmental toxicology

authors： Kwon YJ,Ye DJ,Baek HS,Chun YJ

更新日期：2018-07-01 00:00:00

abstract：:Cardiomyocyte apoptosis is the major risk factor for the development of heart failure (HF). The purpose of this study was to evaluate the effects of Gamma-aminobutyric acid (GABA) tea on hypertension-induced cardiac apoptotic pathways in spontaneously hypertensive rats (SHR). In order to reveal the mechanisms, 36 male...

journal_title：Environmental toxicology

authors： Chen BC,Hung MY,Wang HF,Yeh LJ,Pandey S,Chen RJ,Chang RL,Viswanadha VP,Lin KH,Huang CY

更新日期：2018-07-01 00:00:00

abstract：:Bisphenol AF (BPAF) has been shown to inhibit testicular steroidogenesis in male rats. However, the precise mechanisms related to the toxic effects of BPAF on reproduction remain poorly understood. In the present study, a mouse Leydig tumor cell line (mLTC-1) was used as a model to investigate the mechanism of steroid...

journal_title：Environmental toxicology

authors： Feng Y,Shi J,Jiao Z,Duan H,Shao B

更新日期：2018-06-01 00:00:00

abstract：:Chronic lead exposure causes peripheral sympathetic nerve stimulation, including increased blood pressure and heart rate. Purinergic receptors are involved in the sympathoexcitatory response induced by myocardial ischemia injury. However, whether P2X4 receptor participates in sympathoexcitatory response induced by chr...

journal_title：Environmental toxicology

authors： Zhu G,Chen Z,Dai B,Zheng C,Jiang H,Xu Y,Sheng X,Guo J,Dan Y,Liang S,Li G

更新日期：2018-06-01 00:00:00

abstract：:Toxicity of lead on male reproductive functions has raised wide public concern as environmental lead contamination remains common worldwide. Conflicting and controversial data are available regarding effects of lead on male fertility. More importantly, our knowledge on effects of lead on sperm DNA integrity is signifi...

journal_title：Environmental toxicology

authors： Li C,Zhao K,Zhang H,Liu L,Xiong F,Wang K,Chen B

更新日期：2018-05-01 00:00:00