Abstract:
:Petroleum products-petrol, kerosene, and diesel-composed of volatile organic constituents contribute to air pollution. Exposure of gas station attendants (GSAs) to petroleum products fumes (PPFs) may account for occupation-related predisposition to respiratory toxicity and disease pathogenesis. We simulated GSA exposure to PPF inhalation and examined their effect on oxido-inflammatory responses, toxicity, and histopathological alterations in rat lungs, following 8-hours daily exposure for 60 and 90 days. Reactive oxygen and nitrogen species (RONS), oxidative stress and inflammatory biomarkers, namely: superoxide dismutase (SOD), reduced glutathione (GSH), glutathione peroxidase (GPx), glutathione-S-transferase (GST), TNF-α, IL-1β, xanthine oxidase (XO), nitric oxide (NO) activity were evaluated. Besides, histopathological examination of the lungs and trachea of exposed rats, PPF exposure resulted in significant (P < .05) increases in RONS, biomarkers of oxidative stress, pro-inflammation cytokines, and reduced (P < .05) GSH levels in rats, secondary to histopathological alteration in lungs and trachea cytoarchitecture examined in an exposure-duration-dependent manner. We conclude, therefore, that the observed biochemical and histological changes create a microenvironment that is permissive to diseases pathogenesis of the respiratory system via oxido-inflammatory mechanistic pathways.
journal_name
Environ Toxicoljournal_title
Environmental toxicologyauthors
Owumi SE,Elebiyo TC,Oladimeji BNdoi
10.1002/tox.23019subject
Has Abstractpub_date
2020-09-07 00:00:00eissn
1520-4081issn
1522-7278pub_type
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journal_title:Environmental toxicology
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journal_title:Environmental toxicology
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20509
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journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20558
更新日期:2011-06-01 00:00:00
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journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21867
更新日期:2014-12-01 00:00:00
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journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20652
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Environmental toxicology
pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章
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journal_title:Environmental toxicology
pub_type: 杂志文章
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journal_title:Environmental toxicology
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pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00