Abstract:
:Polybrominated diphenyl ethers (PBDEs) are ubiquitous and prolific contaminant in both the abiotic and biotic environment because of the wide industrial applications of these chemicals. In the present study, the effects of 2,2',4,4'-tetrabrominateddiphenyl ether (BDE-47) and 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE-153) exposure on the induction of hepatic oxidative stress, DNA damage, and the expression of apoptosis-related genes in adult zebrafish were investigated. The activities of antioxidant enzymes, such as catalase and superoxide dimutase, significantly increased when adult zebrafish was exposed to various concentrations of BDE-47 and BDE-153 for 7 and 15 days. BDE-47 and BDE-153 elicited significant alterations in zebrafish 7-Ethoxyresorufin-O-deethylase activity at 3, 7, or 15 days of exposure. In addition, the significant increase in comet assay parameters of zebrafish hepatocytes in a concentration-dependent manner indicated BDE-47 and BDE-153 induced DNA damage, probably due to observed oxidative stress. Furthermore, a monotonically upregulation of p53 and Caspase3, which are apoptotic-regulated genes, and decreased expression ratio of the anti-apoptotic B-cell lymphoma/leukaemia-2 and Bcl2-associated X protein genes for all BDE-47 and BDE-153 treatments at 7 and 15 days indicated apoptosis induction in zebrafish liver. Our findings help elucidate the mechanisms of BDE-47- and BDE-153-induced toxicity in zebrafish hepatocytes.
journal_name
Environ Toxicoljournal_title
Environmental toxicologyauthors
Meng S,Chen X,Gyimah E,Xu H,Chen Jdoi
10.1002/tox.22985subject
Has Abstractpub_date
2020-11-01 00:00:00pages
1202-1211issue
11eissn
1520-4081issn
1522-7278journal_volume
35pub_type
杂志文章abstract::Airborne particulates, especially fine particles and bound chemical compounds, are a potential mediator of adverse health effects. In this study an analysis was done of the concentration and size distribution of air particulate matter, the content of bound polycyclic aromatic hydrocarbons (PAHs), and the biological ef...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.10054
更新日期:2002-01-01 00:00:00
abstract::2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and polychlorinated biphenyls (PCBs) are persistent organic pollutants which coexist in environment, and human are co-exposed to these chemicals. Our present study was aimed to investigate the possible enhanced nonalcoholic fatty liver disease (NAFLD) in ApoE(-/-) mice co-exp...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22006
更新日期:2015-12-01 00:00:00
abstract::To evaluate the allergic effect of airborne particulate matter (PM) on the airway, separated soluble supernatant (Sup) and insoluble precipitate (Pre) in suspended PM were inoculated into NC/Nga mice with a high sensitivity for mite allergens. Sup, Pre, or both Sup and Pre with or without pronase treatment were inocul...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21791
更新日期:2014-06-01 00:00:00
abstract::An important disturbance of anthropogenic origin frequently occurring in freshwater ecosystems is a rise in the concentration of heavy metals in solution, among which copper stands out due to its known toxicity. However, the study of the chemical behavior of copper in solution is highly dependent on pH. In this study,...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.10001
更新日期:2001-10-01 00:00:00
abstract::The incidence of type 1 diabetes (T1D) and its associated risks of chronic kidney disease or end-stage renal disease development are on the rise. T1D is an autoimmune disease in which insulin-producing beta cells are destroyed. Increased incidence of T1D has been suggested to be a result of environmental factors such ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22857
更新日期:2020-02-01 00:00:00
abstract::Bisphenol A (BPA) and cadmium (Cd) are environmental pollutants that are implicated in potential reproductive effects, including damage to the prostate gland. Their action during puberty requires analysis to determine the relationship of these compounds with the testosterone peak that occurs during this phase. This st...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22211
更新日期:2017-01-01 00:00:00
abstract::Toxicity of lead on male reproductive functions has raised wide public concern as environmental lead contamination remains common worldwide. Conflicting and controversial data are available regarding effects of lead on male fertility. More importantly, our knowledge on effects of lead on sperm DNA integrity is signifi...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22545
更新日期:2018-05-01 00:00:00
abstract::Acetaminophen (APAP) is one of the few recommended analgesic and antipyretic drugs in some critical cases such as viral disease COVID-19. However, the unrestricted use of APAP develops liver disorders. Hepatotoxicity and liver injury can also be induced by ionizing radiation (IR) during radiotherapy. The data of the c...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.23077
更新日期:2020-12-17 00:00:00
abstract::Wood dusts, as a group, are categorized as known human carcinogens, but the risks of exposure to specific types of wood dusts and the carcinogenic chemicals they contain are not well studied. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is linked to the carcinogenic action of specifi...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22007
更新日期:2015-12-01 00:00:00
abstract::Particulate matter the environmental toxicant, with a diameter less than or equal to 2.5 μm (PM2.5 ) is a common cause of several respiratory diseases. In recent years, several studies have suggested that PM2.5 can influence diverse diseases, such as respiratory diseases, cardiovascular diseases, metabolic diseases, d...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22591
更新日期:2018-11-01 00:00:00
abstract::Endotoxins exist anywhere including in water pools, dust, humidifier systems, and machining fluids. The major causal factor is endotoxins in many serious diseases, such as fever, sepsis, multi-organ failure, meningococcemia, and severe morbidities like neurologic disability, or hearing loss. Endotoxins are also called...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22033
更新日期:2016-02-01 00:00:00
abstract::Hexavalent chromium (CrVI) is a highly toxic metal and a major environmental pollutant. Several studies indicate that CrVI exposure adversely affects reproductive function. We reported that maternal Cr exposure resulted in Cr accumulation in the reproductive organs of female offsprings. CrVI can cross the placental ba...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21810
更新日期:2014-05-01 00:00:00
abstract::di-N-butylphthalate (DBP) is a ubiquitous environmental pollutant used for plastic coating and in the cosmetics industry. It has toxic effects on body health, especially the male reproductive system. Here, we investigated the effects of DBP on the male reproductive system of pubertal mice and explored the protective r...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22413
更新日期:2017-07-01 00:00:00
abstract::Microcystin-LR (MC-LR) is a potent inhibitor of protein phosphatases 1 and 2A, and has potent hepatotoxicity and tumor promotion activity. Numerous studies on MC-LR toxicity have been conducted in rat hepatocytes, but few studies of the effects of microcystins on human hepatocytes have been done. In this study, HL7702...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21854
更新日期:2014-11-01 00:00:00
abstract::This study investigated lethal effects (i.e., survival) and sublethal effects (glutathione, GSH; lipid peroxidation, LPx; cholesterol, CHL; and acetylcholinesterase, AChE) of the antihyperlipidemic drug simvastatin on larval and adult grass shrimp (Palaemonetes pugio). The 96-h LC50 test for larvae resulted in an esti...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20318
更新日期:2008-04-01 00:00:00
abstract::Colorectal cancer (CRC) is one of the most common cancers and causes of cancer-related death. There are several first-line chemotherapeutic drugs used to treat CRC. Oxaliplatin (OXA) is an alkylating cytotoxic agent that is usually combined with other chemotherapeutic drugs to treat stage II and stage III CRC. However...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22544
更新日期:2018-05-01 00:00:00
abstract::Culture-independent methods employed in fungal genetic studies using in vitro amplification (PCR) and analysis of specific genes or gene fragments have proved to be useful for detection, identification, and molecular taxonomy of various plant pathogens including Fusarium spp. This approach may be faster than culture-d...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20193
更新日期:2006-08-01 00:00:00
abstract::Water bodies are routinely monitored for the presence of potentially toxic cyanobacteria; however, the methodology for confirming toxicity is currently complex and expensive. Here we describe the application of gene-based technology to rapidly identify cylindrospermopsin-producing cyanobacteria, specifically, Cylindro...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.10108
更新日期:2003-04-01 00:00:00
abstract::In this study, toxic effects of the cypermethrin in Allium cepa L. cells were investigated. For this aim, we investigated the changes in pigment contents, antioxidant enzymes, mitotic index and chromosomal abnormalities as indicators of toxicity. The seeds were treated with different doses (1.5, 3.0, 6.0 ppm) of cyper...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20681
更新日期:2012-10-01 00:00:00
abstract::Perfluorooctane sulfonate (PFOS) is an animal carcinogen. However, the underlying mechanism in cancer initiation is still largely unknown. Recently identified microRNAs (miRNAs) may play an important role in toxicant exposure and in the process of toxicant-induced tumorigenesis. We used PFOS to investigate PFOS-induce...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21949
更新日期:2015-05-01 00:00:00
abstract::Intake of arsenic (As) via drinking water has been a serious threat to global public health. Though there are numerous reports of As neurotoxicity, its pathogenesis mechanisms remain vague especially its chronic effects on metabolic network. Hippocampus is a renowned area in relation to learning and memory, whilst rec...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22662
更新日期:2019-02-01 00:00:00
abstract::The use of malachite green (MG) in fish farming is prohibited in China due to its potentially toxicological and carcinogenic nature, but it is still illegally used in some places. The aim of this study was to investigate the time and concentration-dependent responses of xenobiotic metabolizing and detoxification-relat...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20706
更新日期:2013-03-01 00:00:00
abstract::Two phylogenetically distant types of test-systems-root tip meristems of barley (Hordeum vulgare) and human lymphocytes in vitro were used to detect genotoxicity and cytotoxicity induced by the herbicide paraquat (PQ) in the concentration range (10(-6) to 5 x 10(-4) mol/l). As an endpoint for cytotoxicity the mitotic ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20503
更新日期:2010-06-01 00:00:00
abstract::Previous studies indicate that exposure to perfluorooctanesulfonate (PFOS), a ubiquitous and highly persistent environmental contaminant, induces immunotoxicity in mice. However, few studies have specifically assessed the effects of PFOS on inflammation. This study utilized a standard 60-day oral exposure period to as...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20642
更新日期:2012-05-01 00:00:00
abstract::7,12-Dimethylbenz[α]anthracene (DMBA) is a hazardous component present in polluted environments. DMBA has been used as an experimental tool for in vivo tumor formation owing to its carcinogenic effects, but the detailed molecular mechanism of DMBA has not been fully established. To comprehend the carcinogenic mechanis...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22560
更新日期:2018-07-01 00:00:00
abstract::This study assessed the potential hepatoprotective effect of telmisartan (TLM), a selective angiotensin II type 1 (AT1 ) receptor blocker, on carbon tetrachloride (CCl4 )-induced acute hepatotoxity in rats. Intraperitoneal injection of male Wistar rats with CCl4 1 mL kg-1 , 1:1 mixture with corn oil for 3 days increas...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22240
更新日期:2017-02-01 00:00:00
abstract::Lake Elphinstone is a tropical inland water body in the far north of the Fitzroy Catchment in Central Queensland, Australia, and has experienced recurrent toxic cyanoprokaryote blooms since 1997. This article reports on an examination of the environmental conditions of the lake and the concurrent cyanoprokaryote speci...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.10142
更新日期:2003-12-01 00:00:00
abstract::Crude extract of Rheum palmatum L (CERP) has been used to treat different diseases in the Chinese population for decades. In this study, we investigated the effects of CERP on LS1034 human colorectal cancer cells in vitro and also examined possible mechanisms of cell death. Flow cytometric assays were used to measure ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21827
更新日期:2014-09-01 00:00:00
abstract::Nickel nanoparticles (Ni NPs) are associated with reproductive toxicity. However, the mechanisms of reproductive toxicity are unclear. Our goal was to explore further reproductive toxicity induced by nickel nanoparticle and mechanisms involved in this process, including the role of oxidative stress and apoptosis. Acco...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22288
更新日期:2016-11-01 00:00:00
abstract::Butein is a flavonoid isolated from various medicinal plants. It is known to have different biological activities including anti-inflammation, anti-adipogenesis, and anti-angiogenesis. In the study, we demonstrated the anti-proliferative effect of butein in human osteosarcoma U-2 OS cells. Our data showed that butein ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.23079
更新日期:2020-12-16 00:00:00