Toxicity and enantiospecific differences of two β-blockers, propranolol and metoprolol, in the embryos and larvae of zebrafish (Danio rerio).

Abstract:

:The risk presented by β-blockers on aquatic organisms remains uncertain, particularly given the enantiospecific differences in toxicity of chiral β-blockers. In this study, the toxicity of two β-blockers, propranolol and metoprolol, was determined. The 96-h LC50 of propranolol in the zebrafish larvae was 2.48 mg/L, whereas 50 mg/L metoprolol did not result in death. Both β-blockers decreased the heart rate and hatching rate and increased the mortality of the zebrafish embryos. Among these indicators, the heart rate was the most sensitive. However, the acute larval and embryo toxicity results displayed no enantioselectivity. Additionally, the transcriptional response of the genes encoding the β-adrenergic receptors and those involved in other physiological processes, including the antioxidant response, detoxification, and apoptosis, in zebrafish larvae exposed to the β-blockers was examined. Although the changes in gene transcription were fairly minor, significant enantioselectivity was observed for β-blockers, suggesting that the transcriptional response was more sensitive for the evaluation of enantiospecific toxicity. Based on these results, the pharmaceutical drugs were not expected to pose a risk to fish; however, this conclusion should not be considered final. These results also demonstrated that the enantiospecific toxicity of chiral β-blockers should be investigated when performing an ecological risk assessment.

journal_name

Environ Toxicol

journal_title

Environmental toxicology

authors

Sun L,Xin L,Peng Z,Jin R,Jin Y,Qian H,Fu Z

doi

10.1002/tox.21867

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

1367-78

issue

12

eissn

1520-4081

issn

1522-7278

journal_volume

29

pub_type

杂志文章
  • Differential susceptibility of brain regions to tributyltin chloride toxicity.

    abstract::Tributyltin (TBT), a well-known endocrine disruptor, is an omnipresent environmental pollutant and is explicitly used in many industrial applications. Previously we have shown its neurotoxic potential on cerebral cortex of male Wistar rats. As the effect of TBT on other brain regions is not known, we planned this stud...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22009

    authors: Mitra S,Siddiqui WA,Khandelwal S

    更新日期:2015-12-01 00:00:00

  • Depletion of Kupffer cells modulates ethanol-induced hepatocyte DNA synthesis in C57Bl/6 mice.

    abstract::Kupffer cells (KCs) are important in hepatic homeostasis and responses to xenobiotics. KCs are activated on interaction with endotoxin, releasing cytokines, and reactive oxygen species normally associated with increased gene expression, cellular growth, or hepatic injury. Ethanol-induced endotoxemia is one means of KC...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.21814

    authors: Owumi SE,Corthals SM,Uwaifo AO,Kamendulis LM,Klaunig JE

    更新日期:2014-08-01 00:00:00

  • Toxic effects of hydrogen sulfide donor NaHS induced liver apoptosis is regulated by complex IV subunits and reactive oxygen species generation in rats.

    abstract::In recent years, the protective effect of hydrogensulfide donor sodium hydrosulfide(NaHS) on multiple organs has been widely reported. The study aimed to explorethe effect of commonly used concentration of NaHS on theliver and its potential damage mechanism. Rats divided into 4 groups: control, NaHS I (1 mg/kg), II (3...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22868

    authors: Feng X,Zhang H,Shi M,Chen Y,Yang T,Fan H

    更新日期:2020-03-01 00:00:00

  • Bisphenols B, E, F, and S and 4-cumylphenol induce lipid accumulation in mouse adipocytes similarly to bisphenol A.

    abstract::Bisphenol A (BPA) has been widely reported to exert endocrine disrupting effects, including the induction of adipogenesis in cultured preadipocytes and intact animals. Because of the potential harm to human health, BPA is being substituted by structurally related bisphenols. Whether or not such BPA analogues are safe ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22889

    authors: Ramskov Tetzlaff CN,Svingen T,Vinggaard AM,Rosenmai AK,Taxvig C

    更新日期:2020-05-01 00:00:00

  • Rapid algal toxicity assay using variable chlorophyll fluorescence for Chlorella kessleri (chlorophyta).

    abstract::Three methods of algal assays--the standard assay, microassay, and the proposed fluorescence assay--are compared from the point of view of reliability of EC50 detection, the minimum required time for the detection, sensitivity of individual measurement, i.e. at which cell density the particular assay can be used for E...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20516

    authors: Kvíderová J

    更新日期:2010-12-01 00:00:00

  • Crude extract of Rheum palmatum L induced cell death in LS1034 human colon cancer cells acts through the caspase-dependent and -independent pathways.

    abstract::Crude extract of Rheum palmatum L (CERP) has been used to treat different diseases in the Chinese population for decades. In this study, we investigated the effects of CERP on LS1034 human colorectal cancer cells in vitro and also examined possible mechanisms of cell death. Flow cytometric assays were used to measure ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.21827

    authors: Ma YS,Hsu SC,Weng SW,Yu CC,Yang JS,Lai KC,Lin JP,Lin JG,Chung JG

    更新日期:2014-09-01 00:00:00

  • Toxicity profiles of four metals and 17 xenobiotics in the human hepatoma cell line HepG2 and the protozoa Tetrahymena pyriformis--a comparison.

    abstract::We performed an interspecies comparison for the human hepatoma cell line HepG2 and the eukaryotic single cell organism Tetrahymena pyriformis (T. pyriformis) for 17 xenobiotics with diverse structures and four metals. The cytotoxicity was assessed by four different cell viability assays (3-[4,5-dimethylthiazol-2-yl]-2...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20541

    authors: Rudzok S,Krejči S,Graebsch C,Herbarth O,Mueller A,Bauer M

    更新日期:2011-04-01 00:00:00

  • Pesticide induced alterations in marrow physiology and depletion of stem and stromal progenitor population: an experimental model to study the toxic effects of pesticide.

    abstract::Long-term exposure of agriculturally used organochloride and organophosphate pesticides have been shown to cause long-lasting hematotoxicity and increased incidence of aplastic anemia in humans. The mechanisms involved in pesticide induced hematotoxicity and the features of toxicity that may play a major role in bone ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20775

    authors: Chatterjee S,Basak P,Chaklader M,Das P,Pereira JA,Chaudhuri S,Law S

    更新日期:2014-01-01 00:00:00

  • Toxicity assessment of wastewaters, river waters, and sediments in Austria using cost-effective microbiotests.

    abstract::The toxicity and chemical quality of surface water and sediment in the River Traun in Austria were studied because of recurrent fish mortality in some alpine rivers over the last few years. The analyses were carried out on samples collected during winter and summer upstream and downstream of two municipal wastewater t...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20027

    authors: Latif M,Licek E

    更新日期:2004-08-01 00:00:00

  • Acute exposure to bisphenol A and cadmium causes changes in the morphology of gerbil ventral prostates and promotes alterations in androgen-dependent proliferation and cell death.

    abstract::Bisphenol A (BPA) and cadmium (Cd) are environmental pollutants that are implicated in potential reproductive effects, including damage to the prostate gland. Their action during puberty requires analysis to determine the relationship of these compounds with the testosterone peak that occurs during this phase. This st...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22211

    authors: Colleta SJ,Antoniassi JQ,Zanatelli M,Santos FC,Góes RM,Vilamaior PS,Taboga SR

    更新日期:2017-01-01 00:00:00

  • Ameliorative effect of N-acetyl cysteine on alpha-cypermethrin-induced pulmonary toxicity in male rats.

    abstract::Alpha-cypermethrin (α-CYP) is one of the most widely used insecticides. It may become an air pollutant and adversely affect the health. The present study was designed to determine whether treatment with N-acetyl cysteine (NAC), a well-known antioxidant, can be useful for the management of the deleterious effects of α-...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.21891

    authors: Arafa MH,Mohamed DA,Atteia HH

    更新日期:2015-01-01 00:00:00

  • Hepatic oxidative stress, DNA damage and apoptosis in adult zebrafish following sub-chronic exposure to BDE-47 and BDE-153.

    abstract::Polybrominated diphenyl ethers (PBDEs) are ubiquitous and prolific contaminant in both the abiotic and biotic environment because of the wide industrial applications of these chemicals. In the present study, the effects of 2,2',4,4'-tetrabrominateddiphenyl ether (BDE-47) and 2,2',4,4',5,5'-hexabromodiphenyl ether (BDE...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22985

    authors: Meng S,Chen X,Gyimah E,Xu H,Chen J

    更新日期:2020-11-01 00:00:00

  • Protective effects of Ziziphora tenuior extract against chlorpyrifos induced liver and lung toxicity in rat: Mechanistic approaches in subchronic study.

    abstract::Chlorpyrifos (CPF) is one of the most widely used organophosphorus, which has spurred renewed interest. This study was conducted to investigate the protective effect of ziziphora tenuior extract against CPF-induced liver and lung toxicity. This study conducted 8-week rat sub-chronic toxicity study and then the effect ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22432

    authors: Yazdinezhad A,Abbasian M,Hojjat Hosseini S,Naserzadeh P,Agh-Atabay AH,Hosseini MJ

    更新日期:2017-09-01 00:00:00

  • Chronic nasal exposure to nanoparticulate TiO2 causes pulmonary tumorigenesis in male mice.

    abstract::Chronic inhalation bioassays in rodents are used to assess pulmonary carcinogenicity for purposes of hazard identification and potentially for risk characterization. Numerous studies have been confirmed that exposure to titanium dioxide nanoparticles (TiO2 NPs) may result in chronic pulmonary inflammation in both mice...

    journal_title:Environmental toxicology

    pub_type: 杂志文章,收录出版

    doi:10.1002/tox.22393

    authors: Hong F,Ji L,Zhou Y,Wang L

    更新日期:2017-05-01 00:00:00

  • Low-dose in utero exposure to finasteride promotes developmental changes in both male and female gerbil prostates.

    abstract::The prostate is an accessory reproductive gland that is sensitive to the action of exogenous compounds known as endocrine disrupters that alter normal hormonal function. Finasteride is a widely used chemical that acts to inhibit the conversion of testosterone in its most active form, dihydrotestosterone. It is known t...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22838

    authors: Maldarine JS,Sanches BDA,Santos VA,Amaro GM,Calmon MF,Rahal P,Góes RM,Vilamaior PSL,Taboga SR

    更新日期:2020-01-01 00:00:00

  • Fluorescent Pseudomonas isolates from Mississippi Delta oxbow lakes: in vitro herbicide biotransformations.

    abstract::Fluorescent pseudomonads were a major component [log (10) 4.2-6.1 colony-forming units mL-1] of the culturable heterotrophic gram-negative bacterioplankton observed in three Mississippi Delta oxbow lakes in this study. Pure cultures of fluorescent pseudomonads were isolated from three Mississippi Delta oxbow lakes (18...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/1522-7278(2001)16:1<9::aid-tox20>3.0.co;2-

    authors: Zablotowicz RM,Locke MA,Hoagland RE,Knight SS,Cash B

    更新日期:2001-01-01 00:00:00

  • Butein induces cellular senescence through reactive oxygen species-mediated p53 activation in osteosarcoma U-2 OS cells.

    abstract::Butein is a flavonoid isolated from various medicinal plants. It is known to have different biological activities including anti-inflammation, anti-adipogenesis, and anti-angiogenesis. In the study, we demonstrated the anti-proliferative effect of butein in human osteosarcoma U-2 OS cells. Our data showed that butein ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.23079

    authors: Hsu YK,Chen HY,Wu CC,Huang YC,Hsieh CP,Su PF,Huang YF

    更新日期:2020-12-16 00:00:00

  • In situ evaluation of sediment toxicity in Guadalete Estuary (SW Spain) after exposure of caged Arenicola marina.

    abstract::A 7 day in situ assay to assess sediment toxicity was carried out per replicate in two sites from Guadalete Estuary (Guad1 and Guad2) (South-West, Spain) using the polychaete Arenicola marina (n = 20) in benthic cages. After the exposure period, a battery of biomarkers were determined to asses the sediment toxicity. F...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20416

    authors: Ramos-Gómez J,Martín-Díaz ML,Rodríguez A,Riba I,DelValls TA

    更新日期:2008-10-01 00:00:00

  • Protection of Nrf2 against arsenite-induced oxidative damage is regulated by the cyclic guanosine monophosphate-protein kinase G signaling pathway.

    abstract::Arsenite has been shown to induce a variety of oxidative damage in mammalian cells. However, the mechanisms underlying cellular responses to its adverse effects remain unknown. We previously showed that the level of Nrf2, a nuclear transcription factor significantly increased in arsenite-treated human bronchial epithe...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22374

    authors: Chen C,Jiang X,Gu S,Lai Y,Liu Y,Zhang Z

    更新日期:2017-08-01 00:00:00

  • Biochemical study on the protective effect of curcumin on acetaminophen and gamma-irradiation induced hepatic toxicity in rats.

    abstract::Acetaminophen (APAP) is one of the few recommended analgesic and antipyretic drugs in some critical cases such as viral disease COVID-19. However, the unrestricted use of APAP develops liver disorders. Hepatotoxicity and liver injury can also be induced by ionizing radiation (IR) during radiotherapy. The data of the c...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.23077

    authors: Eassawy MMT,Salem AA,Ismail AFM

    更新日期:2020-12-17 00:00:00

  • Multiplex PCR assay for Cylindrospermopsis raciborskii and cylindrospermopsin-producing cyanobacteria.

    abstract::Water bodies are routinely monitored for the presence of potentially toxic cyanobacteria; however, the methodology for confirming toxicity is currently complex and expensive. Here we describe the application of gene-based technology to rapidly identify cylindrospermopsin-producing cyanobacteria, specifically, Cylindro...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.10108

    authors: Fergusson KM,Saint CP

    更新日期:2003-04-01 00:00:00

  • Evaluating genotoxicity associated with microcystin-LR and its risk to source water safety in Meiliang Bay, Taihu Lake.

    abstract::In recent years cyanobacteria blooms have become a severe problem in Taihu Lake, a large shallow eutrophic lake in China. Microcystins produced by certain genera of cyanobacteria can affect public health in this area because of their acute and chronic toxic effects. In this study, samples of cyanobacteria were collect...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20178

    authors: Wu JY,Xu QJ,Gao G,Shen JH

    更新日期:2006-06-01 00:00:00

  • Carboxy terminus of HSP70-interacting protein (CHIP) attenuates the stemness of thyroid cancer cells through decreasing OCT4 protein stability.

    abstract::Cancer cell stemness results in the occurrence and progression of tumors and Oct4 (octamer-binding transcription factor) has been confirmed to be a critical contributor and marker of cancer cell stemness. Here, we aimed to explore the underlying mechanisms contributing to Oct4 protein stability, which is necessary for...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.23072

    authors: Xu Y,Xu G,Dang H,Qu W,Chang D,He X,Li M,Wang Q

    更新日期:2020-12-03 00:00:00

  • Thermal and metabolic factors affecting bioaccumulation of triazine herbicides by rainbow trout (Oncorhynchus mykiss).

    abstract::The bioaccumulation of the triazine herbicides terbutryn and terbuthylazine in rainbow trout was investigated at water temperatures of 4 degrees C, 10 degrees C, and 17 degrees C. The synergetic effect of water temperature and herbicide on fish liver detoxification metabolism was also studied by measuring liver ethoxy...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.10118

    authors: Tarja N,Kirsti E,Marja L,Kari E

    更新日期:2003-08-01 00:00:00

  • G-CSF administration attenuates brain injury in rats following carbon monoxide poisoning via different mechanisms.

    abstract::Acute severe carbon monoxide (CO) poisoning induces hypoxia that leads to cardiovascular and nervous systems disturbances. Different complex mechanisms lead to CO neurotoxicity including lipid peroxidation, inflammatory and immune-mediated reactions, myelin degeneration and finally neuronal apoptosis and necrosis. Gra...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22210

    authors: Ghorbani M,Mohammadpour AH,Abnous K,Movassaghi AR,Sarshoori JR,Shahsavand S,Hashemzaei M,Moallem SA

    更新日期:2017-01-01 00:00:00

  • Retracted: Pulmonary fibrosis of mice and its molecular mechanism following chronic inhaled exposure to TiO2 nanoparticles.

    abstract::Nanoparticulate titanium dioxide (nano-TiO2 ) has been widely used in industry, medicine and daily life. However, assessment of nano-TiO2 toxicity on health is an important occupational safety issue. Numerous studies have demonstrated that nano-TiO2 can induced sustained pulmonary inflammation, but whether chronic exp...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22493

    authors: Hong F,Ji L,Zhou Y,Wang L

    更新日期:2017-09-25 00:00:00

  • Safrole induces cell death in human tongue squamous cancer SCC-4 cells through mitochondria-dependent caspase activation cascade apoptotic signaling pathways.

    abstract::Safrole is one of important food-borne phytotoxin that exhibits in many natural products such as oil of sassafras and spices such as anise, basil, nutmeg, and pepper. This study was performed to elucidate safrole-induced apoptosis in human tongue squamous carcinoma SCC-4 cells. The effect of safrole on apoptosis was m...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20658

    authors: Yu FS,Huang AC,Yang JS,Yu CS,Lu CC,Chiang JH,Chiu CF,Chung JG

    更新日期:2012-07-01 00:00:00

  • Toxicity of ammonia to three marine fish and three marine invertebrates.

    abstract::Laboratory toxicity tests were performed to obtain more data on the toxicity of ammonia to saltwater organisms. The standards for in-stream ammonia limits in marine environments presently are based on toxicity tests involving both freshwater and saltwater organisms. Acute tests (48 and 96 h) were performed at 20 degre...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20006

    authors: Boardman GD,Starbuck SM,Hudgins DB,Li X,Kuhn DD

    更新日期:2004-04-01 00:00:00

  • Development of a free beta-galactosidase in vitro test for the assessment of heavy metal toxicity.

    abstract::The effect of heavy metals and organic compounds on the activity of the enzyme beta-galactosidase in a standardized bioassay has been evaluated, considering future applications in environmental monitoring. The tests were done using a commercial extract of a hydrolase from the eukaryote yeast Kluyveromyces lactis and o...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.1014

    authors: Apartin C,Ronco A

    更新日期:2001-01-01 00:00:00

  • Cantharidin induces DNA damage and inhibits DNA repair-associated protein levels in NCI-H460 human lung cancer cells.

    abstract::Cantharidin is one of the major compounds from mylabris and it has cytotoxic effects in many different types of human cancer cells. Previously, we found that cantharidin induced cell death through cell cycle arrest and apoptosis induction in human lung cancer NCI-H460 cells. However, cantharidin-affected DNA damage, r...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.21986

    authors: Hsia TC,Lin JH,Hsu SC,Tang NY,Lu HF,Wu SH,Lin JG,Chung JG

    更新日期:2015-09-01 00:00:00