Adrenomedullin reduces antioxidant defense system and enhances kidney tissue damage in cadmium and lead exposed rats.

abstract：:7,12-Dimethylbenz[α]anthracene (DMBA) is a hazardous component present in polluted environments. DMBA has been used as an experimental tool for in vivo tumor formation owing to its carcinogenic effects, but the detailed molecular mechanism of DMBA has not been fully established. To comprehend the carcinogenic mechanis...

journal_title：Environmental toxicology

authors： Kwon YJ,Ye DJ,Baek HS,Chun YJ

更新日期：2018-07-01 00:00:00

abstract：:The aim of this study was to evaluate whether the enzyme-linked immunosorbent assay (ELISA) anti-Adda technique could be used to monitor free microcystins (MCs) in biological samples from fish naturally exposed to toxic cyanobacteria by using receiver operating characteristic (ROC) curve software to establish an optim...

journal_title：Environmental toxicology

authors： Moreno IM,Herrador MÁ,Atencio L,Puerto M,González AG,Cameán AM

更新日期：2011-02-01 00:00:00

abstract：:The bioaccumulation of the triazine herbicides terbutryn and terbuthylazine in rainbow trout was investigated at water temperatures of 4 degrees C, 10 degrees C, and 17 degrees C. The synergetic effect of water temperature and herbicide on fish liver detoxification metabolism was also studied by measuring liver ethoxy...

journal_title：Environmental toxicology

authors： Tarja N,Kirsti E,Marja L,Kari E

更新日期：2003-08-01 00:00:00

abstract：:Bisphenol AF (BPAF) has been shown to inhibit testicular steroidogenesis in male rats. However, the precise mechanisms related to the toxic effects of BPAF on reproduction remain poorly understood. In the present study, a mouse Leydig tumor cell line (mLTC-1) was used as a model to investigate the mechanism of steroid...

journal_title：Environmental toxicology

authors： Feng Y,Shi J,Jiao Z,Duan H,Shao B

更新日期：2018-06-01 00:00:00

abstract：:Environmental stress factors may be responsible for biological changes in living species that are able to overcome deleterious effects depending on their detoxifying capacities. Defense systems present in every living species are involved in elimination of reactive chemical species of endogenous or exogenous origin, n...

journal_title：Environmental toxicology

authors： Vasseur P,Leguille C

更新日期：2004-08-01 00:00:00

abstract：:The phthalate plasticizer, di(2-ethyl-hexyl) phthalate (DEHP), and its derived metabolites are common anthropogenic environmental toxins, which are known to act as endocrine disruptors. Numerous studies have associated DEHP with disruption of sex hormones, abnormal development of reproductive organs, allergies, and in...

journal_title：Environmental toxicology

authors： Wong JH,Wang YS,Nam S,Ho KH,Chang CM,Chen KC,Chen YF,Chang WC

更新日期：2019-11-01 00:00:00

abstract：:Effects of perchlorate on sodium-iodide symporter (NIS) and pendrin gene expression in deer mice kidney and stomach were investigated. This was accomplished by isolating a partial cDNA sequence of deer mice NIS gene of 425 bps, and quantitatively analyzing NIS mRNA expression in various deer mouse tissues. The highest...

journal_title：Environmental toxicology

authors： Cheng Q,Smith EE,Liu F,Gentle A,Hooper MJ,Anderson TA

更新日期：2007-08-01 00:00:00

abstract：:Fascinating super paramagnetic uniqueness of iron oxide particles at nano-scale level make them extremely useful in the state of the art therapies, equipments, and techniques. Cobalt ferrite (CoFe2 O4 ) magnetic nanoparticles (MNPs) are extensively used in nano-based medicine and electronics, results in extensive disc...

journal_title：Environmental toxicology

authors： Ahmad F,Liu X,Zhou Y,Yao H,Zhao F,Ling Z,Xu C

更新日期：2016-12-01 00:00:00

abstract：:Lake Elphinstone is a tropical inland water body in the far north of the Fitzroy Catchment in Central Queensland, Australia, and has experienced recurrent toxic cyanoprokaryote blooms since 1997. This article reports on an examination of the environmental conditions of the lake and the concurrent cyanoprokaryote speci...

journal_title：Environmental toxicology

authors： White SH,Fabbro LD,Duivenvoorden LJ

更新日期：2003-12-01 00:00:00

abstract：:Irradiation of polycyclic aromatic hydrocarbons (PAHs) in aqueous solution with simulated solar radiation (SSR; a light source with a visible light: UV-A:UV-B ratio similar to that of sunlight) can greatly enhance their toxicity. Two microbial toxicity tests with Vibrio fischeri were used to investigate the effect of ...

journal_title：Environmental toxicology

authors： el-Alawi YS,Dixon DG,Greenberg BM

更新日期：2001-06-01 00:00:00

abstract：:Microcystin-LR (MC-LR) is the most commonly encountered of the toxic cyclic peptide hepatotoxins occurring in China. It is a model compound for toxicological studies. In this study, the toxicity of MC-LR (50 and 500 micrograms/L) on isolated carp hepatocytes was determined and the ultrastructural alterations of cells ...

journal_title：Environmental toxicology

authors： Li X,Liu Y,Song L

更新日期：2001-01-01 00:00:00

abstract：:Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used therapeutic agents; however, their pharmacological actions raise concerns about potential risks to the reproductive health of aquatic vertebrates. In the present study, a medaka ovulation assay was applied as an in vitro model to evaluate NSAID-induced anti...

journal_title：Environmental toxicology

authors： Yokota H,Eguchi S,Hasegawa S,Okada K,Yamamoto F,Sunagawa A,Tanaka M,Yamamoto R,Nakano E

更新日期：2016-12-01 00:00:00

abstract：:Modulation of microcystin production has been extensively studied in both batch and continuous cultures. Positive correlations with medium nitrogen, medium phosphorous, light intensity, inorganic carbon availability, and growth rate have been reported. Negative correlations have been reported between microcystin conte...

journal_title：Environmental toxicology

authors： Downing TG,Meyer C,Gehringer MM,van de Venter M

更新日期：2005-06-01 00:00:00

abstract：:Thallium (Tl) is a highly toxic heavy metal though up to now its mechanisms are poorly understood. In this study, we comparatively investigated the cytotoxic mechanisms of Tl(I) and Tl(III) in isolated rat hepatocytes. Both Tl(I) and Tl(III) cytotoxicities were associated with reactive oxygen species (ROS) formation, ...

journal_title：Environmental toxicology

authors： Pourahmad J,Eskandari MR,Daraei B

更新日期：2010-10-01 00:00:00

abstract：:This study assessed the potential hepatoprotective effect of telmisartan (TLM), a selective angiotensin II type 1 (AT1 ) receptor blocker, on carbon tetrachloride (CCl4 )-induced acute hepatotoxity in rats. Intraperitoneal injection of male Wistar rats with CCl4 1 mL kg-1 , 1:1 mixture with corn oil for 3 days increas...

journal_title：Environmental toxicology

authors： Atawia RT,Esmat A,Elsherbiny DA,El-Demerdash E

更新日期：2017-02-01 00:00:00

abstract：:Liver is one of the major target organs of arsenic toxicity and carcinogenesis. Nuclear factor (erythroid-2 related) factor 2 (Nrf2) is a redox-sensitive transcription factor, regulating critically cellular defense responses against the toxic metallic arsenic in many cell types and tissues. This study was conducted to...

journal_title：Environmental toxicology

authors： Li B,Li X,Zhu B,Zhang X,Wang Y,Xu Y,Wang H,Hou Y,Zheng Q,Sun G

更新日期：2013-07-01 00:00:00

abstract：:Acetaminophen (AP) is a widely used, cheap, and over-the-counter nonsteroidal anti-inflammatory drug. Its toxicity depends on the cytochrome P-450 (CYP)-mediated oxidation to the toxic metabolite N-acetyl-p-benzoquinoneimine. On the other hand, arsenic, a global groundwater and environmental contaminant of major publi...

journal_title：Environmental toxicology

authors： Manimaran A,Sarkar SN,Sankar P

更新日期：2011-06-01 00:00:00

abstract：:Previous studies indicate that exposure to perfluorooctanesulfonate (PFOS), a ubiquitous and highly persistent environmental contaminant, induces immunotoxicity in mice. However, few studies have specifically assessed the effects of PFOS on inflammation. This study utilized a standard 60-day oral exposure period to as...

journal_title：Environmental toxicology

authors： Dong GH,Zhang YH,Zheng L,Liang ZF,Jin YH,He QC

更新日期：2012-05-01 00:00:00

abstract：:Patulin is a mold toxin secreted mainly by fungi of the Penicillium species. Exposure generally results from consumption of moldy fruits and fruit products. Since recent studies identified mold exposure as a risk factor for allergic diseases, we examined the effects of patulin on human peripheral blood mononuclear cel...

journal_title：Environmental toxicology

authors： Luft P,Oostingh GJ,Gruijthuijsen Y,Horejs-Hoeck J,Lehmann I,Duschl A

更新日期：2008-02-01 00:00:00

abstract：:Di (2-ethylhexyl) phthalate (DEHP) is a plasticizer that gives flexibility to various polyvinyl chloride products. It is a pollutant easily released into the environment and can cause many adverse effects to living organisms including hepatotoxicity. The thioredoxin system is a determining factor in the redox balance ...

journal_title：Environmental toxicology

authors： Amara I,Timoumi R,Annabi E,Di Rosa G,Scuto M,Najjar MF,Calabrese V,Abid-Essefi S

更新日期：2020-01-01 00:00:00

abstract：:The present study was designed to understand the oxidative stress potential of fenthion, an organophosphate (OP) pesticide and its involvement in glutathione metabolism modulated buthionine sulfoximine (BSO, 50 mg/kg) and N-acetylcysteine (NAC, 100 mg/kg) in the brain of fish, Oreochromis niloticus. A sublethal fenthi...

journal_title：Environmental toxicology

authors： Piner P,Sevgiler Y,Uner N

更新日期：2007-12-01 00:00:00

abstract：:Toxins in cyanobacteria are a recognized risk in the treatment of drinking-water treatment. Cyanotoxins can occur in two modifications: cell bound and dissolved in water. The process of toxin release may occur naturally, but it also may be induced through the processes of drinking-water treatment. Both causes of relea...

journal_title：Environmental toxicology

authors： Schmidt W,Willmitzer H,Bornmann K,Pietsch J

更新日期：2002-01-01 00:00:00

abstract：:Manganese (Mn) plays a critical role in individual growth and development, yet excessive exposure can result in neurotoxicity, especially cognitive impairment. Neuronal apoptosis is considered as one of the mechanisms of Mn-induced neurotoxicity. Recent evidence suggests that cAMP-PKA-CREB signaling regulates apoptosi...

journal_title：Environmental toxicology

authors： Yang Y,Ma S,Wei F,Liang G,Yang X,Huang Y,Wang J,Zou Y

更新日期：2019-09-01 00:00:00

abstract：:Two phylogenetically distant types of test-systems-root tip meristems of barley (Hordeum vulgare) and human lymphocytes in vitro were used to detect genotoxicity and cytotoxicity induced by the herbicide paraquat (PQ) in the concentration range (10(-6) to 5 x 10(-4) mol/l). As an endpoint for cytotoxicity the mitotic ...

journal_title：Environmental toxicology

authors： Jovtchev G,Gateva S,Stergios M,Kulekova S

更新日期：2010-06-01 00:00:00

abstract：:The acute toxicity of cylindrospermopsin (CYN) has been established in rodents, based on diverse intraperitoneal an oral exposure studies and more recently in fish. But no data have been reported in fish after subchronic exposure to cyanobacterial cells containing this cyanotoxin, so far. In this work, tilapia (Oreoch...

journal_title：Environmental toxicology

authors： Guzmán-Guillén R,Prieto AI,Moreno I,Vasconcelos VM,Moyano R,Blanco A,Cameán Fernandez AM

更新日期：2015-03-01 00:00:00

abstract：:Lead ions (Pb(2+) ) are toxic industrial pollutants associated with chronic inflammatory diseases in humans and animals. Previously, we found that Pb(2+) ions induce COX-2 gene expression via the EGF receptor/nuclear factor-κB signal transduction pathway in epidermoid carcinoma cell line A431. In this study, to see wh...

journal_title：Environmental toxicology

authors： Tsai YT,Chang CM,Wang JY,Hou MF,Wang JM,Shiurba R,Chang WC,Chang WC

更新日期：2015-09-01 00:00:00

abstract：:An important disturbance of anthropogenic origin frequently occurring in freshwater ecosystems is a rise in the concentration of heavy metals in solution, among which copper stands out due to its known toxicity. However, the study of the chemical behavior of copper in solution is highly dependent on pH. In this study,...

journal_title：Environmental toxicology

authors： Gagneten AM,Vila I

更新日期：2001-10-01 00:00:00

abstract：:Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) is one of the widely used organophosphorus flame retardants (OPFRs), which are regarded as suitable substitutes for brominated flame retardants (BFRs). Previously, we have validated the toxicity of TDCIPP in PC12 cells owing to the induced alterations in GAP43, NF-H, CaM...

journal_title：Environmental toxicology

authors： Li C,Li L,Lin B,Fang Y,Yang H,Liu H,Xi Z

更新日期：2017-06-01 00:00:00

abstract：:The risk presented by β-blockers on aquatic organisms remains uncertain, particularly given the enantiospecific differences in toxicity of chiral β-blockers. In this study, the toxicity of two β-blockers, propranolol and metoprolol, was determined. The 96-h LC50 of propranolol in the zebrafish larvae was 2.48 mg/L, wh...

journal_title：Environmental toxicology

authors： Sun L,Xin L,Peng Z,Jin R,Jin Y,Qian H,Fu Z

更新日期：2014-12-01 00:00:00

abstract：:Micronucleus induction by the diarrhetic shellfish toxin okadaic acid (OA) was investigated in two intestinal models, cultured human Caco-2 cells and colon epithelial cells of mice treated in vivo. Exposure to OA for 4 and 24 h induced dose-responsive increases in the frequency of micronucleated Caco-2 cells; the mini...

journal_title：Environmental toxicology

authors： Le Hégarat L,Jacquin AG,Bazin E,Fessard V

更新日期：2006-02-01 00:00:00