Abstract:
:The bioaccumulation of the triazine herbicides terbutryn and terbuthylazine in rainbow trout was investigated at water temperatures of 4 degrees C, 10 degrees C, and 17 degrees C. The synergetic effect of water temperature and herbicide on fish liver detoxification metabolism was also studied by measuring liver ethoxyresorufin-O-deethylase (EROD) and UDP-glucuronosyltransferase (UDPGT) activities. The bioaccumulation of terbutryn increased significantly with increasing water temperature. However, temperature seemed to have no effect on the bioaccumulation of terbuthylazine. Both chemicals decreased the measured enzyme activities. Also, temperature effects were significant. In all tests the highest liver EROD activities were measured in fish exposed to a water temperature of 4 degrees C, and the activities decreased with increasing water temperature. The thermal effects on fish liver UDPGT activity differed between the herbicides. The highest activities at a water temperature of 4 degrees C were measured in fish exposed to terbutryn, whereas fish exposed to terbuthylazine had the highest liver UDPGT activities at 17 degrees C. Measuring liver detoxification metabolism together with bioaccumulation increases the understanding of bioaccumulation of chemicals in different environmental conditions.
journal_name
Environ Toxicoljournal_title
Environmental toxicologyauthors
Tarja N,Kirsti E,Marja L,Kari Edoi
10.1002/tox.10118keywords:
subject
Has Abstractpub_date
2003-08-01 00:00:00pages
219-26issue
4eissn
1520-4081issn
1522-7278journal_volume
18pub_type
杂志文章abstract::Adrenomedullin (AdM) is synthesized and secreted by a number of cells and tissue. AdM is a potent vasodilator but it is also considered a neuromodulator, an angiogenic factor, and a hormone regulator. AdM possess antiapoptotic, antioxidant, and antimicrobial properties. Heavy metals such as cadmium and lead are found ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20430
更新日期:2009-06-01 00:00:00
abstract::The synergic allergic inflammatory effects of particulate matter (PM) 2.5 and human albumin were investigated in NC/Nga mice, which are hypersensitive to mite allergens. PM2.5 or PM2.5 plus human albumin with aluminum oxide was injected twice intraperitoneally for sensitization. After 7 days, PM2.5 or PM2.5 plus human...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22751
更新日期:2019-07-01 00:00:00
abstract::The aim of this study was to determine whether repeated exposure to iron oxide nanoparticles (Fe2 O3 -NPs) could be toxic to mice testis. Fe2 O3 -NPs (25 and 50 mg/kg) were intraperitoneally administered into mice once a week for 4 weeks. Our study showed that Fe2 O3 -NPs have the ability to cross the blood-testis bar...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22262
更新日期:2017-02-01 00:00:00
abstract::Titanium dioxide nanoparticles (TiO2 NPs) have been used in environmental management, food, medicine, and industry. But TiO2 NPs have been demonstrated to cross the blood-brain barrier and store up in the brain organization, leading to glutamate-mediated neurotoxicity. However, the neurotoxicity in the brain is not we...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22077
更新日期:2016-06-01 00:00:00
abstract::An important disturbance of anthropogenic origin frequently occurring in freshwater ecosystems is a rise in the concentration of heavy metals in solution, among which copper stands out due to its known toxicity. However, the study of the chemical behavior of copper in solution is highly dependent on pH. In this study,...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.10001
更新日期:2001-10-01 00:00:00
abstract::Culture-independent methods employed in fungal genetic studies using in vitro amplification (PCR) and analysis of specific genes or gene fragments have proved to be useful for detection, identification, and molecular taxonomy of various plant pathogens including Fusarium spp. This approach may be faster than culture-d...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20193
更新日期:2006-08-01 00:00:00
abstract::Fluoride exposure is widespread, with drinking water commonly containing natural and artificially added sources of the ion. Ingested fluoride undergoes absorption across the gastric and intestinal epithelia. Previous studies have reported adverse gastrointestinal effects with high levels of fluoride exposure. Here, we...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22495
更新日期:2018-01-01 00:00:00
abstract::Chronic inhalation bioassays in rodents are used to assess pulmonary carcinogenicity for purposes of hazard identification and potentially for risk characterization. Numerous studies have been confirmed that exposure to titanium dioxide nanoparticles (TiO2 NPs) may result in chronic pulmonary inflammation in both mice...
journal_title:Environmental toxicology
pub_type: 杂志文章,收录出版
doi:10.1002/tox.22393
更新日期:2017-05-01 00:00:00
abstract::Nickel oxide nanoparticles (nano NiO) could induce hepatocyte apoptosis, while its potential mechanisms are unclear. This study aimed to explore the role of endoplasmic reticulum (ER) stress pathways in hepatocyte apoptosis induced by nano NiO. Male Wistar rats were administrated with nano NiO (0.015, 0.06, and 0.24 m...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22492
更新日期:2017-12-01 00:00:00
abstract::The microbial assay for risk assessment (MARA) is an innovative system based on an array of 11 different microbial species freeze-dried in a 96-well micro-titer plate. Developed for testing the toxicity of chemicals, mixtures, and environmental samples, the assay employs species of a taxonomically diverse range. In ad...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20419
更新日期:2008-10-01 00:00:00
abstract::Acute severe carbon monoxide (CO) poisoning induces hypoxia that leads to cardiovascular and nervous systems disturbances. Different complex mechanisms lead to CO neurotoxicity including lipid peroxidation, inflammatory and immune-mediated reactions, myelin degeneration and finally neuronal apoptosis and necrosis. Gra...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22210
更新日期:2017-01-01 00:00:00
abstract::The genotoxic effects of a particular mixture of acetamiprid (Acm, neonicotinoid insecticide) and alpha-cypermethrin (alpha-cyp, pyrethroid insecticide) on human peripheral lymphocytes were examined in vitro by chromosomal aberrations (CAs), sister chromatid exchange (SCE), and micronucleus (MN) tests. The human perip...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20485
更新日期:2010-04-01 00:00:00
abstract::The freshwater crabs Sinopotamon henanense were exposed to different concentrations of waterborne cadmium (Cd). The relationship between tissue-specific Cd accumulation and metallothionein (MT) induction was investigated using the Cd saturation assay and atomic absorption spectrophotometry method. The results showed t...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20339
更新日期:2008-06-01 00:00:00
abstract::Fluorescent pseudomonads were a major component [log (10) 4.2-6.1 colony-forming units mL-1] of the culturable heterotrophic gram-negative bacterioplankton observed in three Mississippi Delta oxbow lakes in this study. Pure cultures of fluorescent pseudomonads were isolated from three Mississippi Delta oxbow lakes (18...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/1522-7278(2001)16:1<9::aid-tox20>3.0.co;2-
更新日期:2001-01-01 00:00:00
abstract::Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults and the major cause of mortality in urological cancer. Most patients with RCC are asymptomatic until the disease is advanced and unresectable. In this situation, systemic therapy with immunotherapy or molecularly targeted therapy agents play...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22411
更新日期:2017-07-01 00:00:00
abstract::Malathion is one of the most commonly used insecticides. Recent findings have demonstrated that it induces oxidative stress in somatic cells, but there are not enough studies that have demonstrated this effect in germ cells. Malathion impairs porcine oocyte viability and maturation, but studies have not shown how oxid...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22384
更新日期:2017-06-01 00:00:00
abstract::Rheumatoid arthritis (RA) is the most common type of chronic inflammatory disease which is triggered by dysfunction in the immune system which in turn affects synovial joints. Current treatment of RA with NSAIDs and DMRDs is limited by their side effect. As a result, the interest in alternative, well tolerated anti-in...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22264
更新日期:2017-02-01 00:00:00
abstract::di-N-butylphthalate (DBP) is a ubiquitous environmental pollutant used for plastic coating and in the cosmetics industry. It has toxic effects on body health, especially the male reproductive system. Here, we investigated the effects of DBP on the male reproductive system of pubertal mice and explored the protective r...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22413
更新日期:2017-07-01 00:00:00
abstract::Indium, a rare earth metal characterized by high plasticity, corrosion resistance, and a low melting point, is widely used in the electronics industry, but has been reported to be an environmental pollutant and a health hazard. We designed a study to investigate the effects of subacute exposure of indium compounds on ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22022
更新日期:2016-01-01 00:00:00
abstract::T-2 toxin is the most toxic among mycotoxins and poses a potential health hazard for both humans and animals. At high doses, T-2 toxin can cause shock-like syndrome that can result in death. We evaluated the effect of time course and route of exposure on hepatic oxidative damage in mice and it is only such study so fa...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21895
更新日期:2015-01-01 00:00:00
abstract::Within the last decade, numerous epidemiological studies have demonstrated that endocrine disruptors are a possible cause for a decline in semen quality. Cypermethrin is a widely used pyrethroid insecticide, but little is known about its potentially adverse effects on male reproduction. In the present study, we invest...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20566
更新日期:2011-08-01 00:00:00
abstract::Widespread occupational and environmental exposure to benzene is unavoidable and poses a public health threat. Studies of potential interventions to prevent or relieve benzene toxicity are, thus, essential. Research has shown l-carnitine (LC) has beneficial effects against various pathological processes and diseases. ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22939
更新日期:2020-10-01 00:00:00
abstract::Thallium (Tl) is a highly toxic heavy metal though up to now its mechanisms are poorly understood. In this study, we comparatively investigated the cytotoxic mechanisms of Tl(I) and Tl(III) in isolated rat hepatocytes. Both Tl(I) and Tl(III) cytotoxicities were associated with reactive oxygen species (ROS) formation, ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20590
更新日期:2010-10-01 00:00:00
abstract::Global use of azole fungicides is expected to increase over the next several years. Triticonazole is a triazole fungicide that is used for turf protection, residential, and other commercial applications. As such, it can enter local rural and urban water systems via run-off and rain events. Early life stages of aquatic...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22862
更新日期:2020-02-01 00:00:00
abstract::Aluminum methylcyclohexylphosphinate (AMHP), calcium methylcyclohexylphosphinate (CMHP), aluminum diethylphosphinate (ADEP), and aluminum methylethylphosphinate (AMEP) are organic dialkyl phosphinates (DPs) and emerging phosphorus-based flame retardants. The broad-spectrum DPs flame retardants occupy high-end industri...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22383
更新日期:2017-05-01 00:00:00
abstract::The environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is known to affect bone metabolism. We evaluated the protective effects of the triterpene glycoside actein from the herb black cohosh against TCDD-induced toxicity in MC3T3-E1 osteoblastic cells. We found that TCDD significantly reduced cell viabil...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22459
更新日期:2017-12-01 00:00:00
abstract::Bisphenol AF (BPAF) has been shown to inhibit testicular steroidogenesis in male rats. However, the precise mechanisms related to the toxic effects of BPAF on reproduction remain poorly understood. In the present study, a mouse Leydig tumor cell line (mLTC-1) was used as a model to investigate the mechanism of steroid...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22554
更新日期:2018-06-01 00:00:00
abstract::Wood dusts, as a group, are categorized as known human carcinogens, but the risks of exposure to specific types of wood dusts and the carcinogenic chemicals they contain are not well studied. Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that is linked to the carcinogenic action of specifi...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22007
更新日期:2015-12-01 00:00:00
abstract::Inflammation generated by environmental toxicants including pesticides could be one of the factors underlying neuronal cell damage in neurodegenerative diseases. In this study, we investigated the mechanisms by which inflammatory responses contribute to apoptosis in PC12 cells treated with diquat. We found that diquat...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22552
更新日期:2018-10-01 00:00:00
abstract::Melamine is a heterocyclic, aromatic amine and nitrogen-enriched environmental toxicant, found in not only adulterated foodstuffs but also industrial household tableware and paints. Previous studies demonstrated adverse effects of high-dose melamine on human infants and pregnant animals, but effects of low-dose melami...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22218
更新日期:2017-01-01 00:00:00