Abstract:
:Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults and the major cause of mortality in urological cancer. Most patients with RCC are asymptomatic until the disease is advanced and unresectable. In this situation, systemic therapy with immunotherapy or molecularly targeted therapy agents play an important role in therapeutic strategy. Everolimus (EVE), an m-TOR inhibitor, has the potential to inhibit tumor progression at multiple levels and is indicated for the treatment of advanced RCC in patients whose disease has metastasis. In this study, we provide molecular evidence associated with the antimetastatic effect of everolimus by demonstrating the suppression of lung metastasis of 786-O cells in mouse model. This effect was associated with reduced protein expressions of p-FAK (Tyr 925), p-Src (Tyr416), Vimentin, and RhoA and also with increased the E-cadherin protein expression. In summary, these findings provide new insights into the molecular mechanisms involved in the antimetastatic effect of everolimus and are thus valuable in the treatment of metastatic RCC.
journal_name
Environ Toxicoljournal_title
Environmental toxicologyauthors
Wu SW,Chen PN,Lin CY,Hsieh YS,Chang HRdoi
10.1002/tox.22411subject
Has Abstractpub_date
2017-07-01 00:00:00pages
1888-1898issue
7eissn
1520-4081issn
1522-7278journal_volume
32pub_type
杂志文章abstract::To evaluate the allergic effect of airborne particulate matter (PM) on the airway, separated soluble supernatant (Sup) and insoluble precipitate (Pre) in suspended PM were inoculated into NC/Nga mice with a high sensitivity for mite allergens. Sup, Pre, or both Sup and Pre with or without pronase treatment were inocul...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21791
更新日期:2014-06-01 00:00:00
abstract::An enormous quantity of pharmacologically active principles are currently being introduced into the environment, with consequent escalation of environmental problems, but only a small number of studies are focusing on an assessment of their genotoxic effects. The aim of this article is to assess the genotoxic effects ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20685
更新日期:2012-10-01 00:00:00
abstract::Environmental stress factors may be responsible for biological changes in living species that are able to overcome deleterious effects depending on their detoxifying capacities. Defense systems present in every living species are involved in elimination of reactive chemical species of endogenous or exogenous origin, n...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20024
更新日期:2004-08-01 00:00:00
abstract::Tributyltin (TBT), a proven endocrine-disrupting chemical, is well known to induce imposex in female gastropods. Herein we demonstrate the effects of low doses of tributyltin chloride (TBTCl) on the female offspring of KM mice. Pregnant mice were administered by gavage with 0, 1, 10, or 100 μg TBTCl/kg body weight/day...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21756
更新日期:2012-11-01 00:00:00
abstract::Acute toxicities of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) were tested on four freshwater species and three plant species. PFOS was more toxic than PFOA for all species tested in this study. Similar time-response patterns of PFOS and PFOA toxicity were observed for each tested species. Valu...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20396
更新日期:2009-02-01 00:00:00
abstract::Chronic lead exposure causes peripheral sympathetic nerve stimulation, including increased blood pressure and heart rate. Purinergic receptors are involved in the sympathoexcitatory response induced by myocardial ischemia injury. However, whether P2X4 receptor participates in sympathoexcitatory response induced by chr...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22547
更新日期:2018-06-01 00:00:00
abstract::Previous studies indicate that exposure to perfluorooctanesulfonate (PFOS), a ubiquitous and highly persistent environmental contaminant, induces immunotoxicity in mice. However, few studies have specifically assessed the effects of PFOS on inflammation. This study utilized a standard 60-day oral exposure period to as...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20642
更新日期:2012-05-01 00:00:00
abstract::Within the last decade, numerous epidemiological studies have demonstrated that endocrine disruptors are a possible cause for a decline in semen quality. Cypermethrin is a widely used pyrethroid insecticide, but little is known about its potentially adverse effects on male reproduction. In the present study, we invest...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20566
更新日期:2011-08-01 00:00:00
abstract::Benchmark dose (BMD) and the lower confidence limit on the benchmark dose (BMDL) of blood lead were estimated to explore the biologic exposure limits for renal dysfunction caused by lead. One hundred thirty-five workers from one storage battery plant were selected as lead exposure group while 143 mechanics as the cont...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20260
更新日期:2007-06-01 00:00:00
abstract::PM10 was collected in a Milan urban site, representative of the city air quality, during winter and summer 2006. Mean daily PM10 concentration was 48 μg m(-3) during summer and 148 μg m(-3) during winter. Particles collected on Teflon filters were chemically characterized and the endotoxin content determined by the ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20611
更新日期:2012-02-01 00:00:00
abstract::A high throughput culture methodology of unicellular eukaryote Tetrahymena pyriformis, strain GL were used for the determination of catecholamines toxicity and their metabolism. Catecholamines exhibited acute toxicity to Tetrahymena cells where dopamine and L-DOPA showed higher toxic potential of EC(10) (0.39 and 0.63...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20457
更新日期:2009-12-01 00:00:00
abstract::Recent interest in adverse effects of infrasound on organisms arises from health concerns. We assessed the association between infrasound exposure of 5 Hz at 130 dB and changes of cardiac ultrastructure and function in rats. Thirty-two Sprague-Dawley rats were randomized into control, 1, 7, and 14 days groups for 2 h ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20244
更新日期:2007-04-01 00:00:00
abstract::The correlation between the content of three microcystins (types LR, RR and YR) and the cell cycle of an axenic strain of Microcystis viridis, NIES-102, was investigated under conditions of high (16 mg L(-1)) and low (1.0 mg L(-1)) nitrate (NO(3)-N) concentrations. Each phase of the cell cycle was identified using a f...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.10147
更新日期:2004-02-01 00:00:00
abstract::Antioxidative enzymes (superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), ascorbate peroxidase (APX)), as well as lipid peroxidation and proline were studied in moss Brachythecium piligerum Card. collected from different sites in Shanghai, China, to validate the physiological parameters as biomarkers of atm...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20571
更新日期:2011-10-01 00:00:00
abstract::Alpha-cypermethrin (α-CYP) is one of the most widely used insecticides. It may become an air pollutant and adversely affect the health. The present study was designed to determine whether treatment with N-acetyl cysteine (NAC), a well-known antioxidant, can be useful for the management of the deleterious effects of α-...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21891
更新日期:2015-01-01 00:00:00
abstract::We hypothesized that chronic exposure to arsenic would deplete the reduced glutathione (GSH) and methionine in vivo, thereby impair the methylation capacity of inorganic arsenic (iAs) ingested. Our experiment was designed to explore the effects of exogenous GSH and methionine on arsenic methylation in mice exposed to ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20509
更新日期:2010-08-01 00:00:00
abstract::Malathion is one of the most commonly used insecticides. Recent findings have demonstrated that it induces oxidative stress in somatic cells, but there are not enough studies that have demonstrated this effect in germ cells. Malathion impairs porcine oocyte viability and maturation, but studies have not shown how oxid...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22384
更新日期:2017-06-01 00:00:00
abstract::The phthalate plasticizer, di(2-ethyl-hexyl) phthalate (DEHP), and its derived metabolites are common anthropogenic environmental toxins, which are known to act as endocrine disruptors. Numerous studies have associated DEHP with disruption of sex hormones, abnormal development of reproductive organs, allergies, and in...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22820
更新日期:2019-11-01 00:00:00
abstract::Effects of perchlorate on sodium-iodide symporter (NIS) and pendrin gene expression in deer mice kidney and stomach were investigated. This was accomplished by isolating a partial cDNA sequence of deer mice NIS gene of 425 bps, and quantitatively analyzing NIS mRNA expression in various deer mouse tissues. The highest...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20271
更新日期:2007-08-01 00:00:00
abstract::Patulin is a mold toxin secreted mainly by fungi of the Penicillium species. Exposure generally results from consumption of moldy fruits and fruit products. Since recent studies identified mold exposure as a risk factor for allergic diseases, we examined the effects of patulin on human peripheral blood mononuclear cel...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20309
更新日期:2008-02-01 00:00:00
abstract::Crude extract of Rheum palmatum L (CERP) has been used to treat different diseases in the Chinese population for decades. In this study, we investigated the effects of CERP on LS1034 human colorectal cancer cells in vitro and also examined possible mechanisms of cell death. Flow cytometric assays were used to measure ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21827
更新日期:2014-09-01 00:00:00
abstract::Multi-walled carbon nanotubes (MWCNTs) have many applications in industry and used as additives in polymers, catalysts, anodes in lithium-battery and drug delivery. There is little information about MWCNTs' (210 nm) genotoxic potential on juvenile freshwater fish Channa punctatus. Therefore, in this study, we have det...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22871
更新日期:2020-03-01 00:00:00
abstract::The toxicity of petroleum hydrocarbons to marine aquatic organisms has been widely investigated; however, the effects on freshwater environments have largely been ignored. Selected biomarkers were measured in a freshwater species, the crimson-spotted rainbowfish (Melanotaenia fluviatilis). Fish were exposed to either ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.10098
更新日期:2003-02-01 00:00:00
abstract::Bisphenol A (BPA) and cadmium (Cd) are environmental pollutants that are implicated in potential reproductive effects, including damage to the prostate gland. Their action during puberty requires analysis to determine the relationship of these compounds with the testosterone peak that occurs during this phase. This st...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22211
更新日期:2017-01-01 00:00:00
abstract::Perfluorooctane sulfonate (PFOS) is an animal carcinogen. However, the underlying mechanism in cancer initiation is still largely unknown. Recently identified microRNAs (miRNAs) may play an important role in toxicant exposure and in the process of toxicant-induced tumorigenesis. We used PFOS to investigate PFOS-induce...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.21949
更新日期:2015-05-01 00:00:00
abstract::Several estuaries along the Pacific Ocean coast of North America were identified recently as having elevated 4-nonylphenol (4-NP) in sediments and biota, raising concerns about reproductive impacts for wildlife given 4-NP's established estrogenic activity as an endocrine-disrupting compound. Here we characterize 4-NP ...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22371
更新日期:2017-05-01 00:00:00
abstract::Females are born with a finite number of oocyte-containing follicles and ovary damage results in reduced fertility. Cadmium accumulates in the reproductive system, damaging it, and the cigarette smoke is a potential exposure route. Natural therapies are relevant to health benefits and disease prevention. This study ve...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22225
更新日期:2017-01-01 00:00:00
abstract::Fluorescent pseudomonads were a major component [log (10) 4.2-6.1 colony-forming units mL-1] of the culturable heterotrophic gram-negative bacterioplankton observed in three Mississippi Delta oxbow lakes in this study. Pure cultures of fluorescent pseudomonads were isolated from three Mississippi Delta oxbow lakes (18...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/1522-7278(2001)16:1<9::aid-tox20>3.0.co;2-
更新日期:2001-01-01 00:00:00
abstract::Recent epidemiological studies have revealed significant positive associations between exposure to organochlorine (OC) pesticides and occurrence of the metabolic syndrome and there are a growing number of animal-based studies to support causality. However, the cellular mechanisms linking OC compound exposure and metab...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.22583
更新日期:2018-09-01 00:00:00
abstract::Ecological risk assessments are, in part, based on results of toxicity tests conducted under standard exposure conditions. Global climate change will have a wide range of effects on estuarine habitats, including potentially increasing water temperature and salinity, which may alter the risk assessment of estuarine pol...
journal_title:Environmental toxicology
pub_type: 杂志文章
doi:10.1002/tox.20726
更新日期:2013-07-01 00:00:00