Abstract:
:di-N-butylphthalate (DBP) is a ubiquitous environmental pollutant used for plastic coating and in the cosmetics industry. It has toxic effects on body health, especially the male reproductive system. Here, we investigated the effects of DBP on the male reproductive system of pubertal mice and explored the protective role of sulforaphane (SFN). The results showed that DBP significantly reduced the anogenital distance, testicular weight, sperm count and motility, and plasma and testicular testosterone levels and significantly increased the oxidative stress, sperm abnormalities, and testicular cell apoptosis. SFN supplementation ameliorated these effects. After DBP stimulation, the transcription factor nuclear factor erythroid-related factor 2 (Nrf2) was adaptively increased together with its target genes, such as HO-1 and NQO1. Upregulation of Nrf2 by SFN reduced the DBP-mediated intracellular oxidative toxicity and also increased testosterone secretion and spermatogenesis, which were decreased by DBP. These findings indicate that SFN can attenuate DBP-induced reproductive damage in pubertal mice via Nrf2-associated pathways.
journal_name
Environ Toxicoljournal_title
Environmental toxicologyauthors
Jiang XP,Tang JY,Xu Z,Han P,Qin ZQ,Yang CD,Wang SQ,Tang M,Wang W,Qin C,Xu Y,Shen BX,Zhou WM,Zhang Wdoi
10.1002/tox.22413subject
Has Abstractpub_date
2017-07-01 00:00:00pages
1908-1917issue
7eissn
1520-4081issn
1522-7278journal_volume
32pub_type
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