Perinatal exposure to low doses of tributyltin chloride advances puberty and affects patterns of estrous cyclicity in female mice.

abstract：:The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) has been widely used in agriculture and forestry since the 1940s. 2,4-D has been shown to produce a wide range of adverse effects-from embryotoxicity and teratogenicity to neurotoxicity-on animal and human health. The purpose of this study was to determine the possi...

journal_title：Environmental toxicology

authors： Pochettino AA,Bongiovanni B,Duffard RO,Evangelista de Duffard AM

更新日期：2013-01-01 00:00:00

abstract：:Adrenomedullin (AdM) is synthesized and secreted by a number of cells and tissue. AdM is a potent vasodilator but it is also considered a neuromodulator, an angiogenic factor, and a hormone regulator. AdM possess antiapoptotic, antioxidant, and antimicrobial properties. Heavy metals such as cadmium and lead are found ...

journal_title：Environmental toxicology

authors： Yurekli M,Esrefoglu M,Ilker Doğru M,Doğru A,Gul M,Whidden M

更新日期：2009-06-01 00:00:00

abstract：:The cytotoxic and genotoxic effects induced by alachlor and dichlorvos, two pesticides broadly used, were studied on RTG-2 fish cell line. As measure of cytotoxicity, neutral red assay was used to determine the cellular viability. Toxicity ranking based on IC(50) values found that alachlor was more cytotoxic than dich...

journal_title：Environmental toxicology

authors： Parra JM,Sánchez-Fortún S,Castaño A

更新日期：2012-03-01 00:00:00

abstract：:An unexpectedly high frequency of skeletal deformations in brown trout has previously been observed in the brook Vallkärrabäcken in southern Sweden. Environmental pollutants from storm water and leachate from an old landfill have been suggested as responsible for the observed deformations. Biomarkers in farmed rainbow...

journal_title：Environmental toxicology

authors： Hanson N,Larsson Å

更新日期：2011-06-01 00:00:00

abstract：:Seasonal changes in developmental stages, condition factor (CF), gonadosomatic index, and plasma vitellogenin (Vtg) concentrations in male and female hornyhead turbot were examined at the wastewater outfall (T1) of the Orange County Sanitation District, and two farfield sites T11 (7.7 km northwest of the outfall) and ...

journal_title：Environmental toxicology

authors： Deng X,Rempel MA,Armstrong J,Schlenk D

更新日期：2007-10-01 00:00:00

abstract：:This work investigated the effects of mercury chloride (HgCl2 ) acute exposure on virgin, pregnant and lactating rats by determination of renal and hepatic morphological and ultrastructural parameters and the expression of oxidative stress and stress tolerance markers, due to kidney and liver are the organs that more ...

journal_title：Environmental toxicology

authors： Oliveira VA,Favero G,Stacchiotti A,Giugno L,Buffoli B,de Oliveira CS,Lavazza A,Albanese M,Rodella LF,Pereira ME,Rezzani R

更新日期：2017-05-01 00:00:00

abstract：:There is increasing worldwide interest in developing of markers for tumor diagnosis and identification of individuals who are at high cancer risk. Cancer, like other diseases accompanied by metabolic disorders, causes characteristic effects on cell turnover rate, activity of modifying enzymes, and RNA/DNA modification...

journal_title：Environmental toxicology

authors： Seidel A,Seidel P,Manuwald O,Herbarth O

更新日期：2015-07-08 00:00:00

abstract：:The toxicity and chemical quality of surface water and sediment in the River Traun in Austria were studied because of recurrent fish mortality in some alpine rivers over the last few years. The analyses were carried out on samples collected during winter and summer upstream and downstream of two municipal wastewater t...

journal_title：Environmental toxicology

authors： Latif M,Licek E

更新日期：2004-08-01 00:00:00

abstract：:The incidence of type 1 diabetes (T1D) and its associated risks of chronic kidney disease or end-stage renal disease development are on the rise. T1D is an autoimmune disease in which insulin-producing beta cells are destroyed. Increased incidence of T1D has been suggested to be a result of environmental factors such ...

journal_title：Environmental toxicology

authors： Pierre TH,Reynolds AS,Seise I,Pilz Z,McHale BJ,Gato WE

更新日期：2020-02-01 00:00:00

abstract：:Alpha-cypermethrin (α-CYP) is one of the most widely used insecticides. It may become an air pollutant and adversely affect the health. The present study was designed to determine whether treatment with N-acetyl cysteine (NAC), a well-known antioxidant, can be useful for the management of the deleterious effects of α-...

journal_title：Environmental toxicology

authors： Arafa MH,Mohamed DA,Atteia HH

更新日期：2015-01-01 00:00:00

abstract：:Bisphenol A (BPA) has been widely reported to exert endocrine disrupting effects, including the induction of adipogenesis in cultured preadipocytes and intact animals. Because of the potential harm to human health, BPA is being substituted by structurally related bisphenols. Whether or not such BPA analogues are safe ...

journal_title：Environmental toxicology

authors： Ramskov Tetzlaff CN,Svingen T,Vinggaard AM,Rosenmai AK,Taxvig C

更新日期：2020-05-01 00:00:00

abstract：:Chlorpyrifos (CPF) is one of the most widely used organophosphorus, which has spurred renewed interest. This study was conducted to investigate the protective effect of ziziphora tenuior extract against CPF-induced liver and lung toxicity. This study conducted 8-week rat sub-chronic toxicity study and then the effect ...

journal_title：Environmental toxicology

authors： Yazdinezhad A,Abbasian M,Hojjat Hosseini S,Naserzadeh P,Agh-Atabay AH,Hosseini MJ

更新日期：2017-09-01 00:00:00

abstract：:In the present study, responses of the Chinese brown frog (Rana chensinensis) to exposure to di-2-ethylhexyl phthalate (DEHP), a common plasticizer, during the larval period were characterized. The effects of DEHP on metamorphosis rate, thyroid hormone, thyroid histology and the expression of genes involved in the ste...

journal_title：Environmental toxicology

authors： Zhang Y,Li X,Gao J,Wang H

更新日期：2018-01-01 00:00:00

abstract：:Nickel nanoparticles (Ni NPs) are associated with reproductive toxicity. However, the mechanisms of reproductive toxicity are unclear. Our goal was to explore further reproductive toxicity induced by nickel nanoparticle and mechanisms involved in this process, including the role of oxidative stress and apoptosis. Acco...

journal_title：Environmental toxicology

authors： Kong L,Gao X,Zhu J,Cheng K,Tang M

更新日期：2016-11-01 00:00:00

abstract：:The genotoxic effects of a particular mixture of acetamiprid (Acm, neonicotinoid insecticide) and alpha-cypermethrin (alpha-cyp, pyrethroid insecticide) on human peripheral lymphocytes were examined in vitro by chromosomal aberrations (CAs), sister chromatid exchange (SCE), and micronucleus (MN) tests. The human perip...

journal_title：Environmental toxicology

authors： Kocaman AY,Topaktaş M

更新日期：2010-04-01 00:00:00

abstract：:Structure-activity relationships for oestrogenicity were developed based on 120 aromatic chemicals evaluated in the Saccharomyces cerevisiae-based Lac-Z reporter assay. Relative gene activation was compared to 17 beta-estradiol and varied over eight orders of magnitude. Analysis of the data compared to 17 beta-estradi...

journal_title：Environmental toxicology

authors： Schultz TW,Sinks GD,Cronin MT

更新日期：2002-02-01 00:00:00

abstract：:In the present study, the modulatory effect of phytol against benzo(a)pyrene [B(a)P] induced lung carcinogenesis was investigated in Swiss albino mice. During the experimental period, phytol treatment showed no adverse toxic effect and mortality to the experimental animals. Lung tumor was observed in B(a)P treated gro...

journal_title：Environmental toxicology

authors： Sakthivel R,Sheeja Malar D,Archunan G,Pandima Devi K

更新日期：2019-04-01 00:00:00

abstract：:Within the last decade, numerous epidemiological studies have demonstrated that endocrine disruptors are a possible cause for a decline in semen quality. Cypermethrin is a widely used pyrethroid insecticide, but little is known about its potentially adverse effects on male reproduction. In the present study, we invest...

journal_title：Environmental toxicology

authors： Wang H,Wang SF,Ning H,Ji YL,Zhang C,Zhang Y,Yu T,Ma XH,Zhao XF,Wang Q,Liu P,Meng XH,Xu DX

更新日期：2011-08-01 00:00:00

abstract：:Environmental stress factors may be responsible for biological changes in living species that are able to overcome deleterious effects depending on their detoxifying capacities. Defense systems present in every living species are involved in elimination of reactive chemical species of endogenous or exogenous origin, n...

journal_title：Environmental toxicology

authors： Vasseur P,Leguille C

更新日期：2004-08-01 00:00:00

abstract：:Bisphenol AF (BPAF) has been shown to inhibit testicular steroidogenesis in male rats. However, the precise mechanisms related to the toxic effects of BPAF on reproduction remain poorly understood. In the present study, a mouse Leydig tumor cell line (mLTC-1) was used as a model to investigate the mechanism of steroid...

journal_title：Environmental toxicology

authors： Feng Y,Shi J,Jiao Z,Duan H,Shao B

更新日期：2018-06-01 00:00:00

abstract：:Fluorescent pseudomonads were a major component [log (10) 4.2-6.1 colony-forming units mL-1] of the culturable heterotrophic gram-negative bacterioplankton observed in three Mississippi Delta oxbow lakes in this study. Pure cultures of fluorescent pseudomonads were isolated from three Mississippi Delta oxbow lakes (18...

journal_title：Environmental toxicology

authors： Zablotowicz RM,Locke MA,Hoagland RE,Knight SS,Cash B

更新日期：2001-01-01 00:00:00

abstract：:Fluoride exposure is widespread, with drinking water commonly containing natural and artificially added sources of the ion. Ingested fluoride undergoes absorption across the gastric and intestinal epithelia. Previous studies have reported adverse gastrointestinal effects with high levels of fluoride exposure. Here, we...

journal_title：Environmental toxicology

authors： Amadeu de Oliveira F,MacVinish LJ,Amin S,Herath D,Jeggle P,Mela I,Pieri M,Sharma C,Jarvis GE,Levy FM,Santesso MR,Khan ZN,Leite AL,Oliveira RC,Buzalaf MAR,Edwardson JM

更新日期：2018-01-01 00:00:00

abstract：:Crude extract of Rheum palmatum L (CERP) has been used to treat different diseases in the Chinese population for decades. In this study, we investigated the effects of CERP on LS1034 human colorectal cancer cells in vitro and also examined possible mechanisms of cell death. Flow cytometric assays were used to measure ...

journal_title：Environmental toxicology

authors： Ma YS,Hsu SC,Weng SW,Yu CC,Yang JS,Lai KC,Lin JP,Lin JG,Chung JG

更新日期：2014-09-01 00:00:00

abstract：:Casticin, a polymethoxyflavone, is one of the major active components obtained from Fructus viticis, which have been shown to have anticancer activities including induce cell apoptosis in human cancer cells. The aim of this study was to investigate the molecular mechanisms by which casticin inhibits cell migration and...

journal_title：Environmental toxicology

authors： Shih YL,Chou HM,Chou HC,Lu HF,Chu YL,Shang HS,Chung JG

更新日期：2017-09-01 00:00:00

abstract：:Microcystins (MCs), as the most dominant bloom-forming strains in eutrophic surface water, can induce hepatotoxicity by oxidative stress. Alpha-lipoic acid (α-LA) is a super antioxidant that can induce the synthesis of antioxidants, such as glutathione (GSH), by nuclear factor erythroid 2-related factor 2 (Nrf2). Howe...

journal_title：Environmental toxicology

authors： Gu L,Li S,Bai J,Zhang Q,Han Z

更新日期：2020-07-01 00:00:00

abstract：:Dicrotophos is a systemic insecticide with a wide range of applications. We investigated the genotoxicity of dicrotophos using the Ames test, the chromosome aberration test in CHO-K1 cells, and the comet assay in the Hep G2 cells, while this chemicals' toxicity to both the cell lines was evaluated with the MTT assay. ...

journal_title：Environmental toxicology

authors： Wu JC,Chye SM,Shih MK,Chen CH,Yang HL,Chen SC

更新日期：2012-05-01 00:00:00

abstract：:Liver is one of the major target organs of arsenic toxicity and carcinogenesis. Nuclear factor (erythroid-2 related) factor 2 (Nrf2) is a redox-sensitive transcription factor, regulating critically cellular defense responses against the toxic metallic arsenic in many cell types and tissues. This study was conducted to...

journal_title：Environmental toxicology

authors： Li B,Li X,Zhu B,Zhang X,Wang Y,Xu Y,Wang H,Hou Y,Zheng Q,Sun G

更新日期：2013-07-01 00:00:00

abstract：:Widespread occupational and environmental exposure to benzene is unavoidable and poses a public health threat. Studies of potential interventions to prevent or relieve benzene toxicity are, thus, essential. Research has shown l-carnitine (LC) has beneficial effects against various pathological processes and diseases. ...

journal_title：Environmental toxicology

authors： Sun R,Man Z,Ji J,Ji S,Xu K,Pu Y,Yu L,Zhang J,Yin L,Pu Y

更新日期：2020-10-01 00:00:00

abstract：:Tributyltin (TBT), a well-known endocrine disruptor, is an omnipresent environmental pollutant and is explicitly used in many industrial applications. Previously we have shown its neurotoxic potential on cerebral cortex of male Wistar rats. As the effect of TBT on other brain regions is not known, we planned this stud...

journal_title：Environmental toxicology

authors： Mitra S,Siddiqui WA,Khandelwal S

更新日期：2015-12-01 00:00:00

abstract：:Di(2-ethylhexyl) phthalate, which is a ubiquitous environmental contaminant because of its extensive use as a plasticizer, is a potential nongenotoxic carcinogen. To assess the effects of DEHP exposure on the cytoskeleton of Chironomus, we characterized full-length cDNA sequences of the calponin gene from Chironomus r...

journal_title：Environmental toxicology

authors： Park K,Kwak IS

更新日期：2009-12-01 00:00:00