Oxidative stress in ventral prostate, ovary, and breast by 2,4-dichlorophenoxyacetic acid in pre- and postnatal exposed rats.

Abstract:

:The herbicide 2,4-dichlorophenoxyacetic acid (2,4-D) has been widely used in agriculture and forestry since the 1940s. 2,4-D has been shown to produce a wide range of adverse effects-from embryotoxicity and teratogenicity to neurotoxicity-on animal and human health. The purpose of this study was to determine the possible effects of pre- and postnatal exposure to 2,4-D on oxidative stress in ventral prostate, ovary and breast. Pregnant rats were daily exposed to oral doses of 70 mg/kg/day of 2,4-D from 16 days of gestation up to 23 days after delivery. Then, the pups were sacrificed by decapitation at postnatal day (PND) 45, 60, or 90. Antioxidant enzyme activities and some parameters of the oxidative stress were assessed in ventral prostate, breast, and ovary. Results show that 2,4-D produced three different effects. First, it increased the concentration of some radical oxygen species and the rates of lipid peroxidation and protein oxidation in ventral prostate, thereby causing oxidative stress at all ages studied. Although an increase in the activity of some antioxidant enzymes was detected, this seemed to have been not enough to counteract the oxidative stress. Second, 2,4-D promoted the oxidative stress in the breasts, mainly during puberty and adulthood, probably because the developing gland is more sensitive to xenobiotics than the adult organ. Third, 2,4-D altered the activity of some antioxidant enzymes and increased lipid peroxide concentration in the ovary. This effect could reflect the variety of ovarian cell types and their different responses to endocrine changes during development.

journal_name

Environ Toxicol

journal_title

Environmental toxicology

authors

Pochettino AA,Bongiovanni B,Duffard RO,Evangelista de Duffard AM

doi

10.1002/tox.20690

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

1-10

issue

1

eissn

1520-4081

issn

1522-7278

journal_volume

28

pub_type

杂志文章
  • Physiological responses of Microcystis aeruginosa PCC7806 to nonanoic acid stress.

    abstract::A recent study has shown that nonanoic acid (NA) is one of the strongest allelochemicals to a cyanobacterium Microcystis aeruginosa, but the physiological responses of M. aeruginosa to NA stress remain unknown. In this study, physiological characters such as the growth rate, photosynthetic processes, phosphorus and ni...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20462

    authors: Shao JH,Wu XQ,Li RH

    更新日期:2009-12-01 00:00:00

  • Seasonal evaluation of reproductive status and exposure to environmental estrogens in hornyhead turbot at the municipal wastewater outfall of Orange County, CA.

    abstract::Seasonal changes in developmental stages, condition factor (CF), gonadosomatic index, and plasma vitellogenin (Vtg) concentrations in male and female hornyhead turbot were examined at the wastewater outfall (T1) of the Orange County Sanitation District, and two farfield sites T11 (7.7 km northwest of the outfall) and ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20287

    authors: Deng X,Rempel MA,Armstrong J,Schlenk D

    更新日期:2007-10-01 00:00:00

  • Investigation into the sub-lethal effects of the triazole fungicide triticonazole in zebrafish (Danio rerio) embryos/larvae.

    abstract::Global use of azole fungicides is expected to increase over the next several years. Triticonazole is a triazole fungicide that is used for turf protection, residential, and other commercial applications. As such, it can enter local rural and urban water systems via run-off and rain events. Early life stages of aquatic...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22862

    authors: Souders CL 2nd,Perez-Rodriguez V,El Ahmadie N,Zhang X,Tischuk C,Martyniuk CJ

    更新日期:2020-02-01 00:00:00

  • Biochemical study on the protective effect of curcumin on acetaminophen and gamma-irradiation induced hepatic toxicity in rats.

    abstract::Acetaminophen (APAP) is one of the few recommended analgesic and antipyretic drugs in some critical cases such as viral disease COVID-19. However, the unrestricted use of APAP develops liver disorders. Hepatotoxicity and liver injury can also be induced by ionizing radiation (IR) during radiotherapy. The data of the c...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.23077

    authors: Eassawy MMT,Salem AA,Ismail AFM

    更新日期:2020-12-17 00:00:00

  • Microcystin-LR induces protein phosphatase 2A alteration in a human liver cell line.

    abstract::Microcystin-LR (MC-LR) is a potent inhibitor of protein phosphatases 1 and 2A, and has potent hepatotoxicity and tumor promotion activity. Numerous studies on MC-LR toxicity have been conducted in rat hepatocytes, but few studies of the effects of microcystins on human hepatocytes have been done. In this study, HL7702...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.21854

    authors: Sun Y,Zheng Q,Sun YT,Huang P,Guo ZL,Xu LH

    更新日期:2014-11-01 00:00:00

  • Bisphenols B, E, F, and S and 4-cumylphenol induce lipid accumulation in mouse adipocytes similarly to bisphenol A.

    abstract::Bisphenol A (BPA) has been widely reported to exert endocrine disrupting effects, including the induction of adipogenesis in cultured preadipocytes and intact animals. Because of the potential harm to human health, BPA is being substituted by structurally related bisphenols. Whether or not such BPA analogues are safe ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22889

    authors: Ramskov Tetzlaff CN,Svingen T,Vinggaard AM,Rosenmai AK,Taxvig C

    更新日期:2020-05-01 00:00:00

  • Phytol ameliorated benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice via inhibition of oxidative stress and apoptosis.

    abstract::In the present study, the modulatory effect of phytol against benzo(a)pyrene [B(a)P] induced lung carcinogenesis was investigated in Swiss albino mice. During the experimental period, phytol treatment showed no adverse toxic effect and mortality to the experimental animals. Lung tumor was observed in B(a)P treated gro...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22690

    authors: Sakthivel R,Sheeja Malar D,Archunan G,Pandima Devi K

    更新日期:2019-04-01 00:00:00

  • Oral administration of cyanobacterial bloom extract induced the altered expression of the PP2A, Bax, and Bcl-2 in mice.

    abstract::The frequent occurrences of the toxic cyanobacterial (specifically Microcystis aeruginosa) bloom are becoming a global environmental issue. Lots of researches have been focused on the pure cyanobacterial toxins, but little on the natural cyanobacterial bloom. This study was undertaken to investigate the effect of the ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20374

    authors: Huang P,Zheng YF,Xu LH

    更新日期:2008-12-01 00:00:00

  • Genotoxicity of the marine toxin okadaic acid, in human Caco-2 cells and in mice gut cells.

    abstract::Micronucleus induction by the diarrhetic shellfish toxin okadaic acid (OA) was investigated in two intestinal models, cultured human Caco-2 cells and colon epithelial cells of mice treated in vivo. Exposure to OA for 4 and 24 h induced dose-responsive increases in the frequency of micronucleated Caco-2 cells; the mini...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20154

    authors: Le Hégarat L,Jacquin AG,Bazin E,Fessard V

    更新日期:2006-02-01 00:00:00

  • Insight into the mechanism of aspartame-induced toxicity in male reproductive system following long-term consumption in mice model.

    abstract::Aspartame is one of the most common consumed artificial sweeteners utilized in many food products and beverages. It has been indicated that long-term consumption of aspartame leads to reproductive toxicity but its mechanism is not well-clear. In this study we investigated mechanism of aspartame-induced reproductive to...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.23028

    authors: Anbara H,Sheibani MT,Razi M,Kian M

    更新日期:2021-02-01 00:00:00

  • Lead toxicity in Brassica pekinensis Rupr.: effect on nitrate assimilation and growth.

    abstract::Lead is a major heavy-metal contaminant in the environment that has various anthropogenic and natural sources. To study the phytotoxic effects of Pb on the popular vegetable Chinese cabbage (Brassica pekinensis Rupr.) via depression of nitrogen assimilation, pot culture experiments with three concentrations of treatme...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20167

    authors: Xiong ZT,Zhao F,Li MJ

    更新日期:2006-04-01 00:00:00

  • Nonylphenol regulates cyclooxygenase-2 expression via Ros-activated NF-κB pathway in sertoli TM4 cells.

    abstract::The aim of this study was to investigate the signaling pathways involved in the cyclooxygenase (COX)-2 regulation induced by nonylphenol (NP) in mouse testis Sertoli TM4 cells. Our results showed that treatment of TM4 cells with NP increased COX-2 protein expression and interleukin-6 (IL)-6 and prostaglandin E2 (PGE2)...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.21987

    authors: Liu X,Nie S,Huang D,Xie M

    更新日期:2015-09-01 00:00:00

  • Depletion of Kupffer cells modulates ethanol-induced hepatocyte DNA synthesis in C57Bl/6 mice.

    abstract::Kupffer cells (KCs) are important in hepatic homeostasis and responses to xenobiotics. KCs are activated on interaction with endotoxin, releasing cytokines, and reactive oxygen species normally associated with increased gene expression, cellular growth, or hepatic injury. Ethanol-induced endotoxemia is one means of KC...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.21814

    authors: Owumi SE,Corthals SM,Uwaifo AO,Kamendulis LM,Klaunig JE

    更新日期:2014-08-01 00:00:00

  • Biochemical, histopathological, and transmission electron microscopic ultrastructural changes in mice after exposure to silver nanoparticles.

    abstract::Four-week-old mice, weighing about 25-35 g were divided into five groups (8 mice in each group): vehicle control, low- (0.5 g/kg), middle- (1 g/kg), high- (3 g/kg), and exceptionally high-dose (5 g/kg). After first and second weeks of intraperitoneal exposure to AgNPs, biochemical, histopathological, and electron micr...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22104

    authors: Ansari MA,Khan HM,Khan AA,Alzohairy MA,Waseem M,Ahmad MK,Mahdi AA

    更新日期:2016-08-01 00:00:00

  • Aroclor 1254 causes atrophy of exocrine pancreas in mice and the mechanism involved.

    abstract::Polychlorinated biphenyls (PCBs) are a class of organic pollutants that have been linked to pancreatic disease. However, their role in affecting the exocrine function of pancreas and the underlying mechanism remains elusive. In the present study, male C57 mice were treated with Aroclor 1254, a commercially available P...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22079

    authors: Lin M,Wu T,Sun L,Lin JJ,Zuo Z,Wang C

    更新日期:2016-06-01 00:00:00

  • Cytological alterations in isolated hepatocytes from common carp (Cyprinus carpio L.) exposed to microcystin-LR.

    abstract::Microcystin-LR (MC-LR) is the most commonly encountered of the toxic cyclic peptide hepatotoxins occurring in China. It is a model compound for toxicological studies. In this study, the toxicity of MC-LR (50 and 500 micrograms/L) on isolated carp hepatocytes was determined and the ultrastructural alterations of cells ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.10012

    authors: Li X,Liu Y,Song L

    更新日期:2001-01-01 00:00:00

  • Adrenomedullin reduces antioxidant defense system and enhances kidney tissue damage in cadmium and lead exposed rats.

    abstract::Adrenomedullin (AdM) is synthesized and secreted by a number of cells and tissue. AdM is a potent vasodilator but it is also considered a neuromodulator, an angiogenic factor, and a hormone regulator. AdM possess antiapoptotic, antioxidant, and antimicrobial properties. Heavy metals such as cadmium and lead are found ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20430

    authors: Yurekli M,Esrefoglu M,Ilker Doğru M,Doğru A,Gul M,Whidden M

    更新日期:2009-06-01 00:00:00

  • Acute toxicity of fatty acids to the freshwater green alga Selenastrum capricornutum.

    abstract::The acute toxicity of fatty acids (C14 to C18) commonly found in wood was determined by the standard algal growth inhibition test using the freshwater green alga Selenastrum capricornutum. Toxicity, quantified as IC50 values, varied depending on the number of total carbons and double bonds. Of the tested acids, oleic ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.10127

    authors: Kamaya Y,Kurogi Y,Suzuki K

    更新日期:2003-10-01 00:00:00

  • Toxicity of perfluorooctane sulfonate and perfluorooctanoic acid to plants and aquatic invertebrates.

    abstract::Acute toxicities of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) were tested on four freshwater species and three plant species. PFOS was more toxic than PFOA for all species tested in this study. Similar time-response patterns of PFOS and PFOA toxicity were observed for each tested species. Valu...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20396

    authors: Li MH

    更新日期:2009-02-01 00:00:00

  • PM2.5-induced pulmonary inflammation via activating of the NLRP3/caspase-1 signaling pathway.

    abstract::Particulate matter 2.5 (PM2.5)-induced pulmonary inflammation has become a public concern in recent years. In which, the activation of the NLRP3/caspase-1 pathway was closely related to the inflammatory response of various diseases. However, the promotion effect of the NLRP3/caspase-1 pathway on PM2.5-induced pulmonar...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.23035

    authors: Jia H,Liu Y,Guo D,He W,Zhao L,Xia S

    更新日期:2020-09-30 00:00:00

  • Sulforaphane attenuates di-N-butylphthalate-induced reproductive damage in pubertal mice: Involvement of the Nrf2-antioxidant system.

    abstract::di-N-butylphthalate (DBP) is a ubiquitous environmental pollutant used for plastic coating and in the cosmetics industry. It has toxic effects on body health, especially the male reproductive system. Here, we investigated the effects of DBP on the male reproductive system of pubertal mice and explored the protective r...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22413

    authors: Jiang XP,Tang JY,Xu Z,Han P,Qin ZQ,Yang CD,Wang SQ,Tang M,Wang W,Qin C,Xu Y,Shen BX,Zhou WM,Zhang W

    更新日期:2017-07-01 00:00:00

  • Inflammatory airway responses by nasal inoculation of suspended particulate matter in NC/Nga mice.

    abstract::To evaluate the allergic effect of airborne particulate matter (PM) on the airway, separated soluble supernatant (Sup) and insoluble precipitate (Pre) in suspended PM were inoculated into NC/Nga mice with a high sensitivity for mite allergens. Sup, Pre, or both Sup and Pre with or without pronase treatment were inocul...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.21791

    authors: Ogino K,Takahashi N,Kubo M,Takeuchi A,Nakagiri M,Fujikura Y

    更新日期:2014-06-01 00:00:00

  • Toxicity assessment of wastewaters, river waters, and sediments in Austria using cost-effective microbiotests.

    abstract::The toxicity and chemical quality of surface water and sediment in the River Traun in Austria were studied because of recurrent fish mortality in some alpine rivers over the last few years. The analyses were carried out on samples collected during winter and summer upstream and downstream of two municipal wastewater t...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20027

    authors: Latif M,Licek E

    更新日期:2004-08-01 00:00:00

  • The role of oxidative stress in Sudan IV-induced DNA damage in human liver-derived HepG2 cells.

    abstract:OBJECTIVES:We evaluated the role of oxidative stress in Sudan IV-induced DNA damage, using human liver-derived HepG2 cells. METHODS:The DNA damaging effects of Sudan IV in HepG2 cells were evaluated by alkaline single cell gel electrophoresis assay and micronucleus test (MNT). To clarify the underlying mechanisms, we ...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20558

    authors: Zhang Y,An Y,Jiang L,Geng C,Cao J,Jiang L,Zhong L

    更新日期:2011-06-01 00:00:00

  • Influence of increasing temperature and salinity on herbicide toxicity in estuarine phytoplankton.

    abstract::Ecological risk assessments are, in part, based on results of toxicity tests conducted under standard exposure conditions. Global climate change will have a wide range of effects on estuarine habitats, including potentially increasing water temperature and salinity, which may alter the risk assessment of estuarine pol...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20726

    authors: DeLorenzo ME,Danese LE,Baird TD

    更新日期:2013-07-01 00:00:00

  • Neural tube defects in mice exposed to tap water.

    abstract::In May of 2006 we suddenly began to observe neural tube defects (NTDs) in embryos of untreated control mice. We hypothesized the mice were being exposed unknowingly to a teratogenic agent and investigated the cause. Our results suggested that NTDs were not resulting from bedding material, feed, strain, or source of th...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20600

    authors: Mallela MK,Werre SR,Hrubec TC

    更新日期:2011-11-01 00:00:00

  • Evaluating genotoxicity associated with microcystin-LR and its risk to source water safety in Meiliang Bay, Taihu Lake.

    abstract::In recent years cyanobacteria blooms have become a severe problem in Taihu Lake, a large shallow eutrophic lake in China. Microcystins produced by certain genera of cyanobacteria can affect public health in this area because of their acute and chronic toxic effects. In this study, samples of cyanobacteria were collect...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20178

    authors: Wu JY,Xu QJ,Gao G,Shen JH

    更新日期:2006-06-01 00:00:00

  • Effect of particulate matter 2.5 on gene expression profile and cell signaling in JEG-3 human placenta cells.

    abstract::Particulate matter the environmental toxicant, with a diameter less than or equal to 2.5 μm (PM2.5 ) is a common cause of several respiratory diseases. In recent years, several studies have suggested that PM2.5 can influence diverse diseases, such as respiratory diseases, cardiovascular diseases, metabolic diseases, d...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22591

    authors: Kim W,Cho Y,Song MK,Lim JH,Kim JY,Gye MC,Ryu JC

    更新日期:2018-11-01 00:00:00

  • cDNA cloning and expression of a xenobiotic metabolizing cytochrome P4501A (CYP1A) from the yellow catfish, Pelteobagrus fulvidraco (Siluriformes).

    abstract::We cloned the full-length cDNA sequence of xenobiotic metabolizing cytochrome P4501A (CYP1A) gene from the yellow catfish (Pelteobagrus fulvidraco, Siluriformes, Bagridae). P. fulvidraco is a commercially important fish generally distributed in Southeast Asian countries and Korea. This is the first report of any xenob...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.20333

    authors: Kim JH,Hwang DS,Son KH,Raisuddin S,Ki JS,Lee JS,Han KN

    更新日期:2008-06-01 00:00:00

  • Assessment of thyroid endocrine system impairment and oxidative stress mediated by cobalt ferrite (CoFe2 O4 ) nanoparticles in zebrafish larvae.

    abstract::Fascinating super paramagnetic uniqueness of iron oxide particles at nano-scale level make them extremely useful in the state of the art therapies, equipments, and techniques. Cobalt ferrite (CoFe2 O4 ) magnetic nanoparticles (MNPs) are extensively used in nano-based medicine and electronics, results in extensive disc...

    journal_title:Environmental toxicology

    pub_type: 杂志文章

    doi:10.1002/tox.22206

    authors: Ahmad F,Liu X,Zhou Y,Yao H,Zhao F,Ling Z,Xu C

    更新日期:2016-12-01 00:00:00